CN115553470A - Antioxidant hydrogen-rich nutrient element supplement and application thereof - Google Patents

Antioxidant hydrogen-rich nutrient element supplement and application thereof Download PDF

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CN115553470A
CN115553470A CN202211157750.0A CN202211157750A CN115553470A CN 115553470 A CN115553470 A CN 115553470A CN 202211157750 A CN202211157750 A CN 202211157750A CN 115553470 A CN115553470 A CN 115553470A
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hydrogen
antioxidant
rich nutrient
supplement
acid
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刘健
甘礼惠
林鹿
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Xiamen University
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/32—Manganese; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
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Abstract

The invention relates to the field of health-care food, in particular to an antioxidant hydrogen-rich nutrient element supplement and application thereof. The invention provides an antioxidant hydrogen-rich nutrient element supplement which comprises the following components in percentage by mass: 1 part of metal and 1-10000 parts of auxiliary materials; the metal comprises one or more of calcium, magnesium, zinc, iron, strontium, manganese, aluminium and lithium. The antioxidant hydrogen-rich nutrient element supplement provided by the invention can provide sufficient hydrogen for a human body and can provide metal elements required by the human body. Particularly, the antioxidant hydrogen-rich nutrient element supplement continuously generates hydrogen in the stomach, so that the problem of low hydrogen concentration of most products in the current market is solved, and an excellent antioxidant effect can be achieved; the intake of important metal nutrient elements can improve the health condition of human body while taking hydrogen.

Description

Antioxidant hydrogen-rich nutrient element supplement and application thereof
Technical Field
The invention relates to the field of health-care food, in particular to an antioxidant hydrogen-rich nutrient element supplement and application thereof.
Background
Hydrogen is composed of hydrogen molecules, which are the molecules with the smallest molecular weight and the simplest molecular structure in nature. The hydrogen has extremely strong penetrability, is easy to penetrate the skin and the mucous membrane to enter cells, cell nucleuses and mitochondria, and is easy to be absorbed and utilized by the human body. The hydrogen has an anti-oxidation effect, can efficiently remove malignant free radicals, maintain the internal environment balance of the body fluid inside and outside the cell, and keep effective immunity and self-repairing capability; but also can improve allergic constitution and play a good role in losing weight; meanwhile, researches prove that the hydrogen can improve the insulin secretion function, regulate glycolipid metabolism, reduce blood sugar, improve microcirculation, reduce eyeground pathological changes of diabetes, prevent and treat skin ulcer and the like caused by the diabetes.
Currently, hydrogen intake is generally achieved by drinking hydrogen rich water. Among them, products such as hydrogen water rods, hydrogen-rich water machines (electrolytic or filter element type) and bottled/bagged hydrogen-rich water store hydrogen in water, while hydrogen molecules are easy to escape, and even if the products are packaged and stored in a better way, the hydrogen has the possibility of slow leakage, so that the hydrogen in the products is not easy to store. Meanwhile, the hydrogen concentration of hydrogen-rich water prepared by most of products is below 1.4ppm, and sufficient hydrogen is difficult to supplement at one time.
The main component of the existing solid hydrogen-rich water is calcium hydride or magnesium hydride, which generates hydrogen when meeting water after being orally taken into the stomach. Calcium hydride or magnesium hydride is not stable enough in nature and has a certain toxicity, and therefore, is not an optimal choice. Therefore, there is a need for a product that can provide sufficient hydrogen gas.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides an antioxidant hydrogen-rich nutrient element supplement and application thereof.
In order to solve the above problems, the present invention provides the following technical solutions:
the invention aims to provide an antioxidant hydrogen-rich nutrient element supplement which comprises the following components in percentage by mass: 1 part of metal and 1-10000 parts of auxiliary materials;
the metal comprises one or more of calcium, magnesium, zinc, iron, strontium, manganese, aluminium and lithium.
Preferably, the auxiliary materials include one or more of antioxidants, fortifiers, fillers, flavors, colors and sweeteners.
Preferably, the antioxidant comprises one or more of ascorbic acid, sodium ascorbate and potassium ascorbate.
Preferably, the fortifier comprises one or more of citric acid, malic acid, fumaric acid, succinic acid, tartaric acid, salicylic acid, gluconic acid and amino acids.
Preferably, the filler is one or more of starch, dextrin, sucrose, maltose, glucose, sugar alcohol, microcrystalline cellulose and lactose.
Preferably, the dosage form of the antioxidant hydrogen-rich nutrient supplement is powder, granules or tablets.
Preferably, when the dosage form of the antioxidant hydrogen-rich nutrient supplement is granules or tablets, the auxiliary materials further comprise a disintegrant and/or a lubricant.
Preferably, the disintegrant comprises one or more of dry starch, sodium carboxymethyl starch, hydroxypropyl cellulose, crospovidone, and croscarmellose sodium.
Preferably, the lubricant comprises one or more of stearic acid, magnesium stearate, calcium stearate, sodium lauryl sulfate, powdered silica gel, talc, hydrogenated vegetable oil, polyethylene glycols and magnesium lauryl sulfate.
The invention also provides application of the antioxidant hydrogen-rich nutrient element supplement in the technical scheme in the field of food or medicines.
The invention provides an antioxidant hydrogen-rich nutrient element supplement which comprises the following components in percentage by mass: 1 part of metal and 1-10000 parts of auxiliary materials; the metal comprises one or more of calcium, magnesium, zinc, iron, strontium, manganese, aluminium and lithium. The antioxidant hydrogen-rich nutrient element supplement provided by the invention can provide sufficient hydrogen for a human body and can provide metal elements required by the human body. Particularly, the antioxidant hydrogen-rich nutrient element supplement continuously generates hydrogen in the stomach, so that the problem of low hydrogen concentration of most products in the current market is solved, and an excellent antioxidant effect can be achieved; the intake of important metal nutrient elements can improve the health condition of human body while taking hydrogen.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the experimental methods required in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only used for illustrating the experimental methods in some embodiments of the present invention. For a person skilled in the art, other figures can also be obtained from these figures without inventive exercise.
Fig. 1 is a schematic view of a hydrogen gas production and collection device according to an embodiment of the present disclosure.
Detailed Description
The invention provides an antioxidant hydrogen-rich nutrient element supplement which comprises the following components in percentage by mass: 1 part of metal and 1-10000 parts of auxiliary materials;
the metal comprises one or more of calcium, magnesium, zinc, iron, strontium, manganese, aluminium and lithium.
In the present invention, all the raw material components are commercially available products well known to those skilled in the art, unless otherwise specified.
The antioxidant hydrogen-rich nutrient element supplement comprises 1 part of metal in parts by mass; the metal comprises one or more of calcium, magnesium, zinc, iron, strontium, manganese, aluminium and lithium, preferably one or more of calcium, magnesium, zinc and iron, more preferably one or more of calcium, magnesium and zinc. When the metal is more than two of the specific choices, the proportion of the specific materials is not limited in any way, and the specific materials can be mixed according to any proportion. In an embodiment of the invention, the metals are in particular magnesium, iron and zinc in a mass ratio of 9:1 and iron and zinc in a mass ratio of 1:9. In the present invention, the metal is preferably a metal powder; the particle size of the metal powder is preferably 0.001 to 1000. Mu.m, more preferably 0.01 to 100. Mu.m, and most preferably 0.1 to 80 μm.
In the invention, the metal has the function of generating hydrogen by reacting with gastric acid after being taken, and simultaneously supplementing hydrogen and metal trace elements for human bodies.
Based on the mass parts of the metal, the antioxidant hydrogen-rich nutrient element supplement comprises 1-10000 parts of auxiliary materials, preferably 10-1000 parts. In the present invention, the auxiliary material preferably comprises one or more of an antioxidant, an enhancer, a filler, a flavor, a pigment and a sweetener, more preferably comprises one or more of an antioxidant, an enhancer and a filler, and most preferably comprises an antioxidant and/or a filler. When the auxiliary materials are two or more of the above specific choices, the present invention does not have any special limitation on the ratio of the specific materials, and the ratio of the auxiliary materials can be determined according to the ratio well known to those skilled in the art.
In the present invention, the antioxidant preferably comprises one or more of ascorbic acid, sodium ascorbate and potassium ascorbate, more preferably comprises one or more of ascorbic acid and sodium ascorbate, most preferably ascorbic acid. When the antioxidant is more than two of the above specific choices, the invention does not have any special limitation on the proportion of the specific substances, and the specific substances can be mixed according to any proportion. In an embodiment of the invention, the antioxidant is in particular ascorbic acid.
In the invention, the antioxidant has the functions of preventing metal oxidation, avoiding an oxidation layer from hindering the reaction and fully generating hydrogen.
In the present invention, the fortifier preferably comprises one or more of citric acid, malic acid, fumaric acid, succinic acid, tartaric acid, salicylic acid, gluconic acid and amino acids, more preferably comprises one or more of citric acid, malic acid, salicylic acid, gluconic acid and amino acids, and most preferably comprises one or more of citric acid, malic acid and salicylic acid. When the reinforcers are more than two of the specific choices, the proportion of the specific substances is not limited in any way, and the specific substances are mixed according to any proportion. In an embodiment of the present invention, the enhancer is specifically citric acid.
In the invention, the enhancer is used for enhancing the reaction of the antioxidant hydrogen-rich nutrient element supplement in a gastric acid environment, and hydrogen can be better generated even in an environment with insufficient gastric acid.
In the present invention, the filler is preferably one or more of starch, dextrin, sucrose, maltose, glucose, microcrystalline cellulose and lactose, more preferably one or more of dextrin, sucrose, sugar alcohol, microcrystalline cellulose and lactose, and most preferably one or more of dextrin, sugar alcohol and lactose. When the fillers are more than two of the specific choices, the proportion of the specific materials is not limited in any way, and the specific materials can be mixed according to any proportion. In the present invention, the dextrin preferably comprises maltodextrin and/or cyclodextrin; the cyclodextrin preferably comprises one or more of alpha-cyclodextrin, beta-cyclodextrin and gamma-cyclodextrin. When the dextrin is more than two of the specific choices, the specific proportion of the specific substances is not limited in any way, and the specific substances can be mixed according to any proportion. In an embodiment of the invention, the filler is in particular maltodextrin or alpha-cyclodextrin and maltodextrin in a mass ratio of 2:1.
The present invention does not have any particular limitation on the types of the flavors and colors, and conventional products well known to those skilled in the art can be used.
In the present invention, the sweetener preferably includes one or more of aspartame, stevioside, acesulfame and sugar alcohol, more preferably one or more of aspartame, stevioside and sugar alcohol. When the sweetener is more than two of the specific choices, the proportion of the specific substances is not limited in any way, and the specific substances can be mixed according to any proportion. In the present invention, the sugar alcohol is preferably one or more of sorbitol, maltitol, xylitol, isomalt, mannitol, lactitol and erythritol, and more preferably one or more of xylitol, isomalt and mannitol. When the sugar alcohol is two or more of the above specific choices, the present invention does not have any particular limitation on the ratio of the specific substances, and the specific substances may be mixed in any ratio. In the examples of the present invention, the sweetener is specifically isomalt, xylitol or mannitol and isomalt in a mass ratio of 3:1.
In the present invention, the dosage form of the antioxidant hydrogen-rich nutrient supplement is preferably a powder, a granule or a tablet, and more preferably a granule or a tablet. In an embodiment of the invention, the dosage form is in particular a tablet.
In the present invention, when the dosage form of the antioxidant hydrogen-rich nutrient supplement is a granule or a tablet, the auxiliary material preferably further includes a disintegrant and/or a lubricant.
In the present invention, when the auxiliary material includes a disintegrant, the mass percentage of the disintegrant in the auxiliary material is 0.5 to 40%, more preferably 0.5 to 20%, and most preferably 0.5 to 10%. In the present invention, the disintegrant preferably comprises one or more of dry starch, sodium carboxymethyl starch, hydroxypropyl cellulose, crospovidone, and croscarmellose sodium, and more preferably one or more of dry starch, sodium carboxymethyl starch, and hydroxypropyl cellulose. When the disintegrating agent is more than two of the above specific choices, the invention has no special limitation on the proportion of the specific substances, and the specific substances can be mixed according to any proportion. In an embodiment of the invention, the disintegrant is in particular dry starch.
In the present invention, when the auxiliary material includes a lubricant, the lubricant is 0.1 to 10% by mass of the auxiliary material, more preferably 0.1 to 8% by mass, and most preferably 0.3 to 0.6% by mass. In the present invention, the lubricant preferably includes one or more of stearic acid, magnesium stearate, calcium stearate, sodium lauryl sulfate, silica gel powder, talc, hydrogenated vegetable oil, polyethylene glycol, and magnesium lauryl sulfate, and more preferably one or more of magnesium stearate, calcium stearate, silica gel powder, and talc. When the lubricant is more than two of the above specific choices, the present invention does not have any special limitation on the proportion of the above specific substances, and the specific substances can be mixed according to any proportion. In an embodiment of the invention, the lubricant is in particular magnesium stearate or calcium stearate.
In the present invention, the tablets are preferably prepared by compression using a tablet press; the pressure of the tablet press is preferably 1-100 MPa, more preferably 5-50 MPa, and most preferably 10-30 MPa; the tabletting time is preferably 1 to 10min, more preferably 1 to 8min.
The preparation method of the antioxidant hydrogen-rich nutrient supplement powder and the antioxidant hydrogen-rich nutrient supplement granule is not limited in any way, and the method for preparing the powder and the granule which is well known to the technical personnel in the field can be adopted.
In the invention, the antioxidant hydrogen-rich nutrient element supplement can provide sufficient hydrogen for a human body and can provide metal elements required by the human body. Particularly, the antioxidant hydrogen-rich nutrient element supplement continuously generates hydrogen in the stomach, so that the problem of low hydrogen concentration of most products in the current market is solved, and an excellent antioxidant effect can be achieved; the intake of important metal nutrient elements can improve the health condition of human body while taking hydrogen.
The invention also provides application of the antioxidant hydrogen-rich nutrient element supplement in the technical scheme in the field of food or medicines.
In the invention, when the antioxidant hydrogen-rich nutrient element supplement is applied to food or medicines, the intake amount of metal in the antioxidant hydrogen-rich nutrient element supplement preferably refers to the national people's republic of China health industry standard (WS/T578.3-2017, WS/T578.2-2018).
To further illustrate the present invention, the antioxidant hydrogen-rich nutrient supplement provided by the present invention and its use are described in detail below with reference to examples, which should not be construed as limiting the scope of the present invention.
Example 1
Fully mixing 1g of magnesium powder with the granularity of 200 meshes (the screening pore size is 74 mu m), 15g of mannitol, 7g of maltodextrin, 20g of dry starch, 2g of magnesium stearate and 5g of isomaltitol, and pressing for 1min on a 10MPa tablet press to obtain 100 tablets of the antioxidant hydrogen-rich nutrient supplement tablet, wherein the mass of each tablet is about 500mg, and the mass of magnesium-containing metal is about 10mg;
10mL hydrochloric acid with the concentration of 0.1mol/L, pH value of about 1.0 is adopted to simulate gastric juice, 1 antioxidant hydrogen-rich nutrient element supplement tablet is added, the mixture is fully vibrated for 10min to simulate the digestion process, the generated hydrogen is collected by a device shown in FIG. 1 to obtain 12.0mL hydrogen, the purity is 78.4 percent through gas chromatography detection, the hydrogen amount is about 0.42mmol, and the hydrogen intake is equivalent to drinking about 500mL saturated hydrogen-rich water once. The embodiment supplements magnesium element in the range recommended by the national standard, and is beneficial to correcting electrolyte metabolism disorder.
Example 2
Fully mixing 0.9g of iron powder with a mesh size of 200 meshes (with a screening aperture of 74 mu m), 0.1g of zinc powder with a mesh size of 200 meshes (with a screening aperture of 74 mu m), 20g of alpha-cyclodextrin, 10g of maltodextrin, 7g of ascorbic acid, 10g of isomaltitol and 2g of calcium stearate, and pressing the mixture on a 10MPa tablet press for 1min to obtain 100 tablets of the antioxidant hydrogen-rich nutrient supplement, wherein the mass of each tablet is about 500mg, the mass of each tablet is about 9mg of iron metal, and the mass of the zinc metal is about 1mg;
simulating gastric juice by 10mL hydrochloric acid with the concentration of 0.1mol/L, pH value of about 1.0, adding 1 antioxidant hydrogen-rich nutrient element supplement tablet, fully shaking for 10min to simulate digestion process, collecting generated hydrogen by using a device shown in FIG. 1 to obtain 6.1mL hydrogen, wherein the purity is 65.8 percent through gas chromatography detection, the hydrogen amount is about 0.18mmol, and the hydrogen intake amount is equivalent to drinking about 220mL saturated hydrogen-rich water once. Meanwhile, the iron element, the zinc element and the ascorbic acid are taken, and the embodiment is more suitable for supplementing the iron element in the national standard recommended range, so that the anemia can be relieved.
Example 3
Fully mixing 0.1g of iron powder with 200 meshes (the screening aperture is 74 mu m), 0.9g of zinc powder with 200 meshes (the screening aperture is 74 mu m), 20g of alpha-cyclodextrin, 10g of maltodextrin, 5g of ascorbic acid, 2g of citric acid, 10g of xylitol and 2g of calcium stearate, and pressing for 1min on a 10MPa tablet press to obtain 100 tablets of the antioxidant hydrogen-rich nutrient supplement tablet, wherein the mass of each tablet is about 500mg, the iron metal is about 1mg and the zinc metal is about 9mg;
simulating gastric juice by 10mL hydrochloric acid with the concentration of 0.001mol/L, pH value of about 3.0, adding 1 antioxidant hydrogen-rich nutrient element supplement tablet, fully shaking for 10min to simulate digestion process, collecting generated hydrogen by using a device shown in FIG. 1 to obtain 5.6mL hydrogen, wherein the purity is 64.4% by gas chromatography detection, the hydrogen amount is about 0.16mmol, and the hydrogen intake amount is equivalent to about 190mL saturated hydrogen-rich water drunk once. Meanwhile, zinc element, iron element and ascorbic acid are ingested, and the embodiment is more suitable for supplementing zinc element in the recommended range of national standard, thereby being beneficial to promoting the intelligence development of children and maintaining the male reproductive health. In this example, citric acid is used as a fortifier to produce hydrogen gas even in the presence of insufficient stomach acid.
The embodiment shows that the antioxidant hydrogen-rich nutrient element supplement provided by the invention can provide sufficient hydrogen for a human body, about 0.001-3 mmol of hydrogen can be generated in a single time, which is equivalent to that 0.7-2000 mL of hydrogen-rich water is introduced once, so that the problem of low hydrogen concentration of most products in the current market is avoided, and an excellent antioxidant effect can be achieved; the intake of important metal nutrient elements can improve the health condition of human body while taking hydrogen.
Although the above embodiments have been described in detail, they are only a part of the embodiments of the present invention, not all of the embodiments, and other embodiments can be obtained without inventive step according to the embodiments, and all of the embodiments belong to the protection scope of the present invention.

Claims (10)

1. An antioxidant hydrogen-rich nutrient element supplement is characterized by comprising the following components in percentage by mass: 1 part of metal and 1-10000 parts of auxiliary materials;
the metal comprises one or more of calcium, magnesium, zinc, iron, strontium, manganese, aluminium and lithium.
2. The antioxidant hydrogen-rich nutrient supplement of claim 1, wherein the auxiliary materials comprise one or more of antioxidants, fortifiers, fillers, flavors, colors, and sweeteners.
3. The antioxidant hydrogen-rich nutrient supplement of claim 2, wherein the antioxidant comprises one or more of ascorbic acid, sodium ascorbate, and potassium ascorbate.
4. The antioxidant hydrogen-rich nutrient supplement of claim 2, wherein the fortifier comprises one or more of citric acid, malic acid, fumaric acid, succinic acid, tartaric acid, salicylic acid, gluconic acid, and amino acids.
5. The antioxidant hydrogen-rich nutrient supplement of claim 2, wherein the filler is one or more of starch, dextrin, sucrose, maltose, glucose, microcrystalline cellulose, and lactose.
6. The antioxidant hydrogen-rich nutritional supplement of any one of claims 1-5, wherein the antioxidant hydrogen-rich nutritional supplement is in the form of a powder, granule or tablet.
7. The antioxidant hydrogen-rich nutrient supplement of claim 6, wherein when the dosage form of the antioxidant hydrogen-rich nutrient supplement is a granule or a tablet, the auxiliary material further comprises a disintegrant and/or a lubricant.
8. The antioxidant hydrogen-rich nutrient supplement of claim 7, wherein the disintegrant comprises one or more of dry starch, sodium carboxymethyl starch, hydroxypropyl cellulose, crospovidone, and croscarmellose sodium.
9. The antioxidant hydrogen rich nutrient supplement of claim 7, wherein the lubricant comprises one or more of stearic acid, magnesium stearate, calcium stearate, sodium lauryl sulfate, powdered silica gel, talc, hydrogenated vegetable oils, polyethylene glycols, and magnesium lauryl sulfate.
10. Use of the antioxidant hydrogen-rich nutritional supplement of any one of claims 1-9 in the food or pharmaceutical field.
CN202211157750.0A 2022-09-22 2022-09-22 Antioxidant hydrogen-rich nutrient element supplement and application thereof Pending CN115553470A (en)

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102000109A (en) * 2010-09-30 2011-04-06 泰山医学院 Pharmaceutical preparation using hydrogen as therapeutic substance and preparation method thereof
US20170209486A1 (en) * 2017-04-06 2017-07-27 Shanghai Jiao Tong University Health-care preparation simultaneously with magnesium supplement and antioxidant functions and preparation method thereof
CN110089590A (en) * 2019-04-14 2019-08-06 武汉宝盈普济科技有限公司 Application of the calcium hydrogen-rich water additive in tealeaves, milk powder, coffee or the extract of malt and milk
CN110200991A (en) * 2019-07-10 2019-09-06 陈天朗 Facilitate hydrogen manufacturing product and its application for remove human body active oxygen radical
CN110250498A (en) * 2019-07-03 2019-09-20 浙江大学 A kind of response of intestinal environment produces hydrogen particle and preparation method thereof
CN114766663A (en) * 2022-03-01 2022-07-22 霍永强 Food material with comprehensive conditioning effect and preparation method thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102000109A (en) * 2010-09-30 2011-04-06 泰山医学院 Pharmaceutical preparation using hydrogen as therapeutic substance and preparation method thereof
US20170209486A1 (en) * 2017-04-06 2017-07-27 Shanghai Jiao Tong University Health-care preparation simultaneously with magnesium supplement and antioxidant functions and preparation method thereof
CN110089590A (en) * 2019-04-14 2019-08-06 武汉宝盈普济科技有限公司 Application of the calcium hydrogen-rich water additive in tealeaves, milk powder, coffee or the extract of malt and milk
CN110250498A (en) * 2019-07-03 2019-09-20 浙江大学 A kind of response of intestinal environment produces hydrogen particle and preparation method thereof
CN110200991A (en) * 2019-07-10 2019-09-06 陈天朗 Facilitate hydrogen manufacturing product and its application for remove human body active oxygen radical
CN114766663A (en) * 2022-03-01 2022-07-22 霍永强 Food material with comprehensive conditioning effect and preparation method thereof

Non-Patent Citations (1)

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Title
苏军凯;李佩;刘妍;邓立新;温春虹;张鸣青;: "不同给药途径的外源性氢气制备方法", 医疗装备, no. 04, pages 25 - 26 *

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