CN115551532A - 在淋巴细胞中按需表达外源性因子以治疗hiv - Google Patents

在淋巴细胞中按需表达外源性因子以治疗hiv Download PDF

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Publication number
CN115551532A
CN115551532A CN202180032693.0A CN202180032693A CN115551532A CN 115551532 A CN115551532 A CN 115551532A CN 202180032693 A CN202180032693 A CN 202180032693A CN 115551532 A CN115551532 A CN 115551532A
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seq
cells
hiv
promoter
cell
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Chinese (zh)
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李海山
T·拉胡森
C·D·保扎
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American Gene Technologies International Inc
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American Gene Technologies International Inc
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    • C12N15/86—Viral vectors
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    • A—HUMAN NECESSITIES
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    • C12N5/0602—Vertebrate cells
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    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
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    • A61K2121/00—Preparations for use in therapy
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2319/00—Fusion polypeptide
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
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    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16051—Methods of production or purification of viral material
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

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CN202180032693.0A 2020-03-03 2021-03-03 在淋巴细胞中按需表达外源性因子以治疗hiv Pending CN115551532A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062984716P 2020-03-03 2020-03-03
US62/984,716 2020-03-03
PCT/US2021/020721 WO2021178571A1 (en) 2020-03-03 2021-03-03 On demand expression of exogenous factors in lymphocytes to treat hiv

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Publication Number Publication Date
CN115551532A true CN115551532A (zh) 2022-12-30

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US (2) US20240279678A1 (https=)
EP (1) EP4114439A4 (https=)
JP (1) JP2023516685A (https=)
KR (1) KR20220150320A (https=)
CN (1) CN115551532A (https=)
AU (1) AU2021232603A1 (https=)
BR (1) BR112022017678A2 (https=)
CA (1) CA3170630A1 (https=)
IL (1) IL296096A (https=)
WO (1) WO2021178571A1 (https=)

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Publication number Priority date Publication date Assignee Title
CN116064678A (zh) 2016-01-15 2023-05-05 美国基因技术国际有限公司 用于活化γ-δT细胞的方法和组合物
WO2017156311A2 (en) 2016-03-09 2017-09-14 American Gene Technologies International Inc. Combination vectors and methods for treating cancer
JP2020524996A (ja) 2017-06-16 2020-08-27 アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド ヒトガンマデルタｔ細胞を介する腫瘍細胞傷害性の活性化のための方法および組成物
US11352646B2 (en) 2018-11-05 2022-06-07 American Gene Technologies International Inc. Vector system for expressing regulatory RNA
JP2023525969A (ja) * 2020-05-19 2023-06-20 イグザカ フランス インビトロおよびインビボでのｃｄ３＋細胞における遺伝子治療産物の発現のためのプロモータ配列

Citations (3)

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US20160083748A1 (en) * 2013-04-29 2016-03-24 The Trustees Of The University Of Pennsylvania Tissue preferential codon modified expression cassettes, vectors containing same, and uses thereof
WO2018129540A1 (en) * 2017-01-09 2018-07-12 American Gene Technologies International Inc. Hiv immunotherapy with no pre-immunization step
WO2019191314A1 (en) * 2018-03-27 2019-10-03 American Gene Technologies International Inc. Methods of manufacturing genetically-modified lymphocytes

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WO1998011244A2 (en) * 1996-09-11 1998-03-19 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Aav4 vector and uses thereof
WO2003040311A2 (en) * 2001-10-25 2003-05-15 The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services Efficient inhibition of hiv-1 viral entry through a novel fusion protein including of cd4
AU2003301556A1 (en) * 2002-05-07 2004-05-13 Chiron Corporation Hiv envelope-cd4 complexes and hybrids
MX2018003463A (es) * 2015-09-22 2018-09-06 Univ Pennsylvania Método de redireccionamiento de células t para tratar la infección por virus de inmunodeficiencia humana (vih).
EP3468617A4 (en) * 2016-06-08 2020-01-22 American Gene Technologies International Inc. SYSTEM FOR THE NON-INTEGRAL VIRAL ISSUE AND PROCEDURE RELATING TO IT
AU2017292582C1 (en) * 2016-07-08 2021-11-11 American Gene Technologies International Inc. HIV pre-immunization and immunotherapy
JP2020524996A (ja) * 2017-06-16 2020-08-27 アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド ヒトガンマデルタｔ細胞を介する腫瘍細胞傷害性の活性化のための方法および組成物
AU2019302603A1 (en) * 2018-07-13 2021-01-14 Nanjing Legend Biotech Co., Ltd. Co-receptor systems for treating infectious diseases

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
US20160083748A1 (en) * 2013-04-29 2016-03-24 The Trustees Of The University Of Pennsylvania Tissue preferential codon modified expression cassettes, vectors containing same, and uses thereof
WO2018129540A1 (en) * 2017-01-09 2018-07-12 American Gene Technologies International Inc. Hiv immunotherapy with no pre-immunization step
WO2019191314A1 (en) * 2018-03-27 2019-10-03 American Gene Technologies International Inc. Methods of manufacturing genetically-modified lymphocytes

Non-Patent Citations (3)

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Title
FALKENHAGEN ALEXANDER ET AL: "Control of HIV Infection In Vivo Using Gene Therapy with a Secreted Entry Inhibitor", MOLECULAR THERAPY-NUCLEIC ACIDS, vol. 9, 1 December 2017 (2017-12-01), pages 132 - 144 *
KUHLMANN ANNE-SOPHIE ET AL: "Long-Term Persistence of Anti-HIV Broadly Neutralizing Antibody-Secreting Hematopoietic Cells in Humanized Mice", MOLECULAR THERAPY, vol. 27, no. 1, 1 January 2019 (2019-01-01), pages 164 - 177 *
YU YONGJIAO ET AL: "Expression of HIV-1 broadly neutralizing antibodies mediated by recombinant adeno-associated virus 8 in vitro and in vivo", MOLECULAR IMMUNOLOGY, vol. 80, 31 December 2016 (2016-12-31), pages 68 - 77 *

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Publication number Publication date
US20240141374A1 (en) 2024-05-02
EP4114439A1 (en) 2023-01-11
BR112022017678A2 (pt) 2022-11-08
US20240279678A1 (en) 2024-08-22
IL296096A (en) 2022-11-01
JP2023516685A (ja) 2023-04-20
AU2021232603A1 (en) 2022-10-20
CA3170630A1 (en) 2021-09-10
KR20220150320A (ko) 2022-11-10
EP4114439A4 (en) 2024-04-17
WO2021178571A1 (en) 2021-09-10

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