CN1155346C - Low temp. equipment - Google Patents
Low temp. equipment Download PDFInfo
- Publication number
- CN1155346C CN1155346C CNB001344587A CN00134458A CN1155346C CN 1155346 C CN1155346 C CN 1155346C CN B001344587 A CNB001344587 A CN B001344587A CN 00134458 A CN00134458 A CN 00134458A CN 1155346 C CN1155346 C CN 1155346C
- Authority
- CN
- China
- Prior art keywords
- microcapillary
- cryogenic system
- cryogenic
- nozzle
- mentioned
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Landscapes
- Surgical Instruments (AREA)
- Nozzles (AREA)
- Filling Or Discharging Of Gas Storage Vessels (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
Abstract
The present invention relates to a cryogenic device for precise adjustment of the quantity of a cryogenic refrigerant, capable of being made to a hand held type device. The device comprises a sealing means for storing a definite store of cryogenic refrigerant; a tubular element extending downwards from the sealing means and comprising a channel by which a cryogenic liquid can pass through; a fine capillary tube comprising a channel which is in alignment with the channel of the tubular element; the fine capillary tube may comprising a tubular sleeve and a polymers layer enclosing the inner side of the sleeve, or the tube is configured to allow the liquid gas to get pass and reach to the nozzle of the end opening located on the tube terminal at room temperature and without heat insulation, or reach to one or more nozzles of the groove or cavity adjacent to the nozzle opening.
Description
Technical field
The present invention relates to a kind of cryogenic system, in more detail, the present invention relates to a kind of be used for accurately cryogen is applied to device on the desired position by single liquid phase.
Background technology
Cryotherapy and cryosurgery are to be usually directed to freezing tissue so that destroy the process of this tissue.Cryosurgery and cryotherapy can be used to handle various medical condition.A purpose of this process is only to destroy unwished-for tissue, and does not destroy healthy tissue.
Having known has various method and apparatus to be used for contact refrigeration and/or sprays freezing unsound tissue.This freezing be by using for example N
2Liquid state that O is such or gaseous state cryogen (cryogen or low temperature media) are carried out.A kind of method commonly used comprises with soaking into liquid N
2The cotton yarn eraser of O is put the zone of smearing tissue to be processed on the skin.The shortcoming of the method is, because the bigger and liquid N of surface area of cotton yarn eraser
2The cryogenic temperature of O usually makes healthy tissue be damaged inevitably.Another shortcoming of the method is that cotton swab has absorbed the cryogen of organizing required cryogen to Duo than processing target, thereby causes the waste of relatively large cryogen.
Summary of the invention
One object of the present invention is to provide a kind of device, it is except volume the less and simple structure, can also be by cryogenic media being concentrated on the cryogenic media of realizing using exact dose on the refrigerated surf zone of desire, and reduce needed cryogenic media amount by on above-mentioned zone, directly or closely applying above-mentioned cryogenic media.Capillary tube plays a part a nozzle, makes cryogen through this capillary tube, so that be applied to ruined tissue.
Cause by the thermal conductance that evaporation produced of cryogen and to form bloom, the latter can be by supercool near shrinking capillary component in position capillaceous, and further causing various faults thus, this is because be difficult to be avoided exist ice crystal on tiny the be deposited on capillary tube inner wall in the cryogenic media of pressurization.For fear of this situation occurring, another object of the present invention is by providing microcapillary as described below to avoid above-mentioned shortcoming, promptly this microcapillary has tubular sheath and a polymeric layer that surrounds the inner surface of tubular sheath, this sheath has outer surface, inner surface, top and bottom, and wherein the lower end of tubular sheath has a hole of extending therein; Polymeric layer limits a passage.
Because refrigerated microcapillary contacts with the tissue of health and can cause the unwished-for destructive fact to this tissue in some applications, so this microcapillary must be heat insulation.According to prior art, a kind of heat-insulating method is to prepare a microcapillary with vacuum jacket of an airtight condition of high vacuum degree, can prevent from thus tissue is caused unwished-for destruction, this is because the temperature on the outer surface of above-mentioned chuck can not drop to below 0 ℃.But, heat insulation for example owing to homeostatic control, observe the necessary security measure and upgrade fine vacuum frequently and make that very high requirement is arranged technically.Other shortcoming of this solution is, because the size of pipe is bigger, thereby causes the patient to feel very uncomfortable.
Therefore, another object of the present invention is for providing a kind of device of avoiding microcapillary heat insulation of being used to.
Another above-mentioned purpose is to realize by technical scheme as described below, promptly for example makes for example N of cryogenic liquid gas under 20 ℃ the room temperature
2O, directly the microcapillary in the scope of 30-40 μ m arrives the nozzle for the opening of 30-40 μ m that has of described microcapillary less than 1mm and internal diameter through its external diameter for argon or other suitable cryogenic gas, do not freeze on the outer surface between cryogenic liquid gas source and the nozzle segment, can not producing of above-mentioned tube wall thus, this be because, organize the angry volume expansion of real estate or in this hole, producing gas expansion under near the situation that the hole is set the nozzle directly entering under the situation of open-ended nozzle, its result is, only in the breathing space of gas and produce freezing in the localized area adjacent with the above-mentioned breathing space of above-mentioned gas.Therefore, remove the external surface peripheral of avoiding at above-mentioned microcapillary that leads to nozzle segment and form outside the freeze space that produces owing to evaporation, around microcapillary and along pipe, rise to the tissue outside from the hole and enter atmospheric gas and can be heated owing to the liquid gas of the heat in the microcapillary self.Other advantage is can can't harm the lost territory substantially and directly the evaporation of liquid gas can be used for freezing tissue, and above-mentioned evaporation can be by ideal mode very near theoretic required consumption.Last but not least is, can simplify device of the present invention significantly and reduce its size, by using said apparatus, can alleviate the patient's who is treated burden widely thus.
The present invention is used to overcome the defective of above-mentioned prior art.One object of the present invention is for providing a kind of device that the cryogen of exact dose can be applied on the desired area.
Another object of the present invention provides a kind of like this cryogenic system, and promptly it has simpler structure, can hand-held and can work reliably.
Another purpose of the present invention provides a kind of cryogenic system that is suitable for discharging by single liquid phase basically cryogen.
Another object of the present invention is the contraction of avoiding by the supercool capillary component that causes.
A further object of the present invention is at room temperature to be applied to liquid gas on the nozzle through microcapillary with improved form.
According to a first aspect of the present invention, the invention provides a kind of being used for by batch the subtly device of cryogen of single liquid phase.This device comprises a sealed container that is used to keep a certain amount of cryogen, one is extended downwards and comprises a tubular element that can make the passage of cryogen process from sealed container, the nozzle opening or the hole of the end of a nozzle that removably is fixed on the tubular element and extends downwards from this member and extend past one microcapillary, wherein said nozzle comprises the passage that above-mentioned microcapillary and align with passage in the tubular element.
In an improved embodiment of the present invention, on the inner surface of microcapillary, can be embedded into the polymeric material layer that one deck is used to prevent to form bloom, reduced thus by causing possibility of jamming at the freezing of nozzle opening place.
According to another aspect of the present invention, the invention provides an external diameter is the microcapillary of 30-40 μ m less than 1mm and internal diameter, the gas of liquefaction can be at room temperature passes to one through this microcapillary and is located at the groove that forms on the outer wall section of above-mentioned pipe or near the nozzle opening the hole the open-ended nozzle of above-mentioned tube end or one, so that produce gas expansion.
Other purpose of the present invention, feature and advantage can be easily from below in conjunction with accompanying drawing given to being better understood the DETAILED DESCRIPTION OF THE PREFERRED.
Description of drawings
For the present invention being described, at present preferred form of implementation shown in the drawings; Should be understood that the present invention is not limited to shown accurate layout and structure.Among the figure:
Fig. 1 is the partial sectional view of cryogenic system of the present invention;
Fig. 2 is the cutaway view of the nozzle of cryogenic system;
Fig. 3 improves the cutaway view of the microcapillary of embodiment according to of the present invention another;
Fig. 4 be nozzle body and with the cutaway view of the amplification of the connecting portion of pipe;
Fig. 5 shows an improvement embodiment of nozzle body; And
Fig. 6 shows a lid that is used to cover and lock or unclamp (opening) nozzle with the form of example.
The specific embodiment
The present invention relates to a kind of being used for accurately is applied to cryogen on the desired area cryogenic system for use in therapeutic treatment and other technical field by single liquid phase.At length accompanying drawing is described now, wherein, in whole views with the element of same reference number TYP.Figure 1 illustrates a cryogenic system 10, it comprises a sealed container 20, a tubular element 30 and the nozzle 50 with a choke valve that links with it 40, in first embodiment, cryogen is discharged under the pressure that obviously reduces through this nozzle, and this nozzle removably is fixed on the end of tubular element 30.
In the sealed container 20 preferably fillings be approximately a certain amount of cryogen 60 (for example liquid N of 3/4 of its volume
2O, argon or any other suitable cryogenic gas), and be maintained at about under the substantially invariable pressure of 50bar (depending on main ambient temperature).Tubular element 30 limits an elongated passage (not shown), and cryogen can be passed through this passage.Tubular element comprises a upper end 70 and a lower end 80.The upper end 70 of tubular element 30 is stretched in the container 20 of sealing, and its lower end is then stretched in the nozzle 50 with an opening 160.A containment member 90 is set, is fixed on the sealed container reliably in order to upper end with tubular element.Preferably, sealed container can be changed.In addition, the size of nozzle can change, to change the input dosage of the cryogen that is applied.The size of cryogenic system and layout can be made hand-held.
Choke valve 40 is arranged along the length of tubular element 30, and is allowed cryogen to discharge from its lower end 80 then through tubular element selectively.In a preferred embodiment, choke valve 40 is the sort of valves by the spring bias voltage that are known in the art.But, can adopt other various existing valve arrangements.
In second embodiment as shown in Figure 2, show a nozzle 50 that is used for cryogenic system 10.Nozzle 50 comprises a microcapillary 90, a heat insulating component 100 and a micro-filter 110 of using upper O-shape ring 120 and lower O-shape ring 130 fix in position respectively.Microcapillary 90 preferably includes a tubular sheath 95 with lower end 140 and upper end 150.Tubular sheath 95 preferably includes an inner surface, as what will illustrate in further detail hereinafter, and embedding one deck polymeric material layer on it.The lower end 140 of tubular sheath 95 ends at a dome-shaped end and has a hole (nozzle opening) 160 of passing wherein and forming.The preferred sizes scope of nozzle opening 160 is about 30-40 μ m, is preferably 33-37 μ m.Have been found that this size range allows accurately to apply cryogen with cryogenic system in check mode.The most handy laser becomes a predetermined angular ground to form above-mentioned hole with respect to the vertical axis of sheath 95.This structure allows the operator who handles the cryogenic system that this nozzle 50 is housed to treat inaccessible zone.
Can utilize a hole 160 in the enclosing cover (not shown) sealed tubular sheath 95.Preferably there is a press polished surface lower end 140 of tubular sheath 95, is sealed reliably guaranteeing.
In a preferred embodiment, tubular sheath 95 preferably have approximately less than the thickness of 0.15mm and by metal preferably gold constitute.Also can use meet DIN EN30993-1 by other material of can biocompatible material forming.
Embedding on the inner surface of tubular sheath 95 have a polymeric material layer 170.This polymeric material layer limits one can make the therefrom passage 180 of process of cryogen.Passage 180 has the diameter of substantial constant.The preferable range of its diameter is approximately 30-40 μ m, is preferably 33-37 μ m.The tubular sheath 95 of metal is given polymeric material layer 170 with stability.When make cryogenic material as hereinafter will further describing through out-of-date, the probability that polymeric material layer freezes nozzle greatly reduces.Preferred polymeric material is a polytetrafluoroethylene (PTFE).Should be pointed out that and also can use and with the tubular sheath bio-compatible of metal and to demonstrate chemical inertness and other heavy polymer of heat stability.Should also be noted that polymeric material can be made into independent sleeve and be placed with inner surface CONTACT WITH FRICTION with sheath.
Heat insulating component 100 can and be suitable for suitable heat-barrier material manufacturing engaging with the upper end 150 of sheath 95.In a preferred embodiment, be formed with the female thread (not shown) on the heat insulating component, it is suitable for and near the external screw thread (not shown) threads engage that forms the upper end 150 of sheath 95.The screw thread of the engagement of sheath 95 and heat insulating component 100 makes can easily change sheath where necessary.Device of the present invention allows the tubular sheath of different-diameter is fixed on the tubular element, thereby can control permission arrives the cryogen in the zone of wanting processed by device amount especially.So greatly reduced the waste of cryogen and to the destruction of health tissues.
Micro-filter 110 is fixed in the heat insulating component 100 and between upper O-shape ring 120 and lower O-shape ring 130.The lower end of O shape circle 130 is positioned near the upper end 150 of sheath 95.The inner surface frictional engagement with heat insulating component 100 is preferably all made and all be configured to respectively to upper and lower O shape circle by polymeric material.O shape circle preferably defines out a passage 190 that cryogen is therefrom passed through.Passage 190 preferably has and passage 180 essentially identical diameters.
In first embodiment as shown in Figure 1, the user of cryogenic system 10 is pushed in use by spring-loaded choke valve 40, and the cryogen 60 of pressurization is discharged through tubular element 30 and to drip shape form nozzle opening 160 from nozzle 50 under the pressure that obviously reduces from sealed container.As mentioned above, sealed container is filled with 3/4 the liquid N that is approximately its volume usually
2O, argon or other any suitable cryogenic material.Cryogenic material is preferably in that (according to ambient temperature) is maintained at about 50bar in the sealed container.When cryogenic material entered nozzle, it passed micro-filter and by by O shape circle 120 and 180 passages that limit 190.After this, cryogen is through the passage 180 that limited by polymeric layer 170 and from hole 160 discharges that the end at tubular sheath 95 forms.
Nozzle according to as shown in Figure 2 second embodiment is designed to make liquid cryogenic media (for example liquid N
2O, argon or any other suitable cryogenic liquid gas) pressure, volume and/or temperature pass passage 190 with substantially the same diameter and 180 and when nozzle opening 160 is discharged, do not have a very big change at it.This project organization has prevented to occur two-phase mixture and unwished-for the ice crystal that forms unwished-forly.In addition, since liquid cryogen its by nozzle 50 and when nozzle opening 160 is discharged without the cross section of stenosis, so avoided existing joule-Thomson effect.
In addition,, can avoid on jacket inner surface, forming bloom, thereby prevent that further 160 places are stopped up in the hole by potting one deck polymeric material layer 170 on the inner surface of metallic tubular sheath 95.
According to another improved embodiment shown in Figure 3, microcapillary 200 usefulness high-quality steels are made, but do not have this sheath made from polymeric material.Above-mentioned pipe 200 preferably passes through a valve (see figure 1) and for example N at the one end
2The cryogenic liquid gas source of O, argon or any other suitable cryogenic gas links to each other, and its other end then stretches in the nozzle body 202.Aforementioned tube 200 comprises a passage 203, and it is used for making fluid preferably to arrive said nozzle part 202 via above-mentioned valve from above-mentioned fluid source (fluid passage that is equivalent to Fig. 1).Above-mentioned passage 203 stretches in one or several opening 204 of said nozzle part 202, so that discharge above-mentioned cryogenic gas.Said nozzle part 202 also is provided with a groove that forms from the outside or cut-out 205 the wall of nozzle segment 202, this groove or cut-out 205 and adjacent with it hole 206 of the common formation of tissue, being used for the expansion of above-mentioned gas, and freezing rapidly and in depth surrounding tissue to be processed.Because the pressure that is approximately 5N that gas applied, above-mentioned gas by shown in the arrow among Fig. 3 along the outer surface of the wall of aforementioned tube 200 and surround spill between the tissue of aforementioned tube 200 or along therebetween through and discharge into the atmosphere from above-mentioned hole 206.Go in the tissue for the ease of said nozzle body 202 and aforementioned tube 200 being inserted together (or thorn), said nozzle part 202 extends in the arrow shaped end portion 207 of a sharp cone distal.
In Fig. 4, show the improvement modification of the combination of aforementioned tube 200 and said nozzle with the cutaway view that amplifies.Herein, pipe 200 still comprises a passage 203, and its end for example for example links to each other with identical container among Fig. 1 by a valve (not shown among Fig. 4) and a cryogenic liquid gas source, and the other end then links to each other with a nozzle body 202.With embodiment illustrated in fig. 3 different be, said nozzle body among Fig. 4 does not form one with pipe 200, but forming an independent main body, its end is inserted in the end of aforementioned tube 200 a little and is welded on the above-mentioned tube end or is screwed into by screw thread in the inwall of end of aforementioned tube 200.Said nozzle body 202 comprises the passage 208 of an internal diameter less than the above-mentioned passage 203 of aforementioned tube 200.The internal diameter of the passage 203 of aforementioned tube 200 is about 0.5mm, and the internal diameter of the passage 208 in the said nozzle body 202 is in the scope of 30-40 μ m.The external diameter of aforementioned tube 200 is preferably less than 1mm, and near the external diameter of said nozzle body 202 above-mentioned passage 208 preferably is approximately 0.5mm.Above-mentioned passage 208 both sides stretch at least two nozzle openings 209,209 that are the form in the hole on the conduit wall ' in, gas can be released through above-mentioned hole.Said nozzle opening 209,209 ' diameter range be 30-40 μ m.Said nozzle body 202 extends the arrow shaped ends 210 that becomes a sharp cone distal.The width that above-mentioned end 210 has flange shape step 211 these steps equals the thickness of the wall of aforementioned tube 200.The wall end of aforementioned tube and above-mentioned flange shape step 211, together with the outer surface of said nozzle body 202 and surrounding tissue (not shown among Fig. 4) form a hole 112,112 ', with expansion area as above-mentioned gas from said nozzle opening 209,209 ' ejection.Nozzle body 202 can cover with a lid (not shown among Fig. 4), and this lid can play a part the locking device or the valve gear of above-mentioned gas simultaneously.
Another modification embodiment illustrated in fig. 4 has been shown among Fig. 5.Similar to Fig. 4, nozzle body 202 is not made an integral body with pipe 200, but forms an independent member.With Fig. 4 in the same manner, Guan Youyi passage 203, the one end be kept at cryogenic liquid gas such as N in container or the box
2The source of supply of O, argon or any other suitable cryogenic liquid gas (not shown among Fig. 5) is connected, and the other end then links to each other with nozzle body 202.Different with Fig. 4 is, under the situation of Fig. 5, the outer wall surface of nozzle body 202 is deeper inserted in the passage 203, and in the longitudinal direction, along said nozzle body 202 and a microcapillary passage 213 is set near its neighboring, its diameter is less than the passage in the aforementioned tube 200 203.And the diameter of passage 203 is approximately about 0.5mm, and the diameter of passage 213 is in the scope of 30-40 μ m.Above-mentioned passage extends to the nozzle opening 214 on the side that is arranged in said nozzle body 202, stretches into another passage 213 simultaneously, and the latter is crossed the circumferential opposite side that passes to the said nozzle body of said nozzle body 202 or edge with centering on this nozzle body.Above-mentioned another passage 213 end at another nozzle opening 214 '.The diameter of this nozzle opening is in the scope of 30-40 μ m.With Fig. 4 similarly be, the flange shape step 211 of the sharp cone distal arrow shaped ends 210 of pipe 200 wall end parts and nozzle body 202 together with the outer surface of the wall of the nozzle body 202 that is positioned near nozzle opening 214,214 ' form a groove or hole 212,212 '; Under one situation of back, also form described hole together with surrounding tissue.
One or several microcapillary passage and one or several nozzle opening also can be set on nozzle body within the scope of the invention.In fact, by being provided with, may gas be uniformly distributed on the bigger zone of the processed tissue of desire better around several nozzle openings of the circle distribution of nozzle body 202.
The channel diameter of cryotronl or the diameter of nozzle opening should be selected according to kind, temperature, pressure or the volume of ambient temperature or cryogenic liquid gas.
In fact, determining of the diameter of nozzle opening is relevant with the existing pressure that acts on the gas with the kind of selecting direct and used cryogenic gas, the another aspect of this pressure depends on ambient temperature, and depend on the amount of required freezing energy on the other hand, the latter is depended on the amount (in other words, this means near the evaporation energy that has utilized the boiling point of adding gas or in its scope) of used liquid cryogenic gas.In addition, the embodiment according to the nozzle arrangements of Fig. 2 is to be to adopt N
2O is as above-mentioned gas and definite.As what pointed out hereinbefore, its diameter range is 30-40 μ m.Less than 30 μ m, just can not produce in fact useful freezing energy, and greater than 40 μ m, then because the precommpression of liquid gas, reduced useful freezing energy, this precommpression erupts into uncertain granule with liquid gas when making gas pass nozzle opening to enter atmosphere, in a kind of uncontrolled mode it is diffused on the freezing target of tissue for example.By selecting nozzle opening, can avoid above-mentioned shortcoming according to a feature of the present invention ground.
In all embodiments, particularly in those embodiment shown in Fig. 1 and 2, can alternative valve device ground or in addition a lid that is used to lock or unclamp nozzle opening is set.
Fig. 6 shows an embodiment of this lid, it is made up of a lid 215, one end of lid is provided with the female thread 216 that can engage with the external screw thread 217 of nozzle body 202, the opposite side of above-mentioned lid 215 then be provided with one can with the adjustment screw 218 of lid 215 threads engage.A ring-type block 223 that integrally forms with lid 215 is set, and this block is outstanding from the inner wall surface of described lid 215.The incus shape locking piece 220 of the ferrum that the most handy polytetrafluoroethylene (PTFE) is made is by spring 219 carryings that are fixed on the above-mentioned adjustment screw 218, and this locking piece is configured to and can moves under the effect of above-mentioned spring 219.When being screwed in above-mentioned lid 215 on the said nozzle body, the nozzle 221 of said nozzle body 202 is pinned or sealing by above-mentioned locking piece 220 under the effect of the elastic force of above-mentioned spring, and when when above-mentioned seal is backed out above-mentioned lid, above-mentioned locking piece 220 is leaned against on the above-mentioned ring-type block 223 by trying hard to recommend of above-mentioned spring 219, and this spring force can be regulated by above-mentioned screw 218.In addition, near the female thread portion 216 of above-mentioned lid 215, be provided with one or several and two passage 221 preferably.
The present invention can implement and not break away from its spirit and purport by other form, therefore, when determining scope of the present invention, should be with reference to claims, rather than the explanation of front.
Claims (26)
1. one kind is used for cryogen accurately is applied to cryogenic system on the desired area, and it comprises:
A sealed container that is used to preserve a certain amount of cryogen;
Tubular element with a upper end and a lower end, the upper end of this tubular element is stretched in the sealed container, tubular element also have one that extend along its length, with so that the passage that cryogen is passed through;
Be used for reliably upper end with tubular element and be fixed on sealing device on the sealed container;
Microcapillary, this microcapillary with a upper end and a lower end further be provided with one along its length extend, with so that the passage that cryogen is passed through, the passage of microcapillary aligns with passage in the tubular element; And
Be used for microcapillary removably is fixed on device on the lower end of tubular element.
2. cryogenic system as claimed in claim 1 is characterized by, and it is hand-holdable operation that its size and layout are determined to be.
3. cryogenic system as claimed in claim 1 further comprises being used to control permission from the valve gear of sealed container through the amount of the cryogen of tubular element and microcapillary.
4. cryogenic system as claimed in claim 2 is characterized by, and valve gear is spring biased.
5. cryogenic system as claimed in claim 1 is characterized in that,
Microcapillary further comprises:
Tubular sheath with an outer surface, an inner surface, a upper end and a lower end, the lower end of tubular sheath have the hole passing it and extend; And the polymeric layer of the inner surface of one deck encirclement tubular sheath, polymeric layer limits a passage.
6. cryogenic system as claimed in claim 5 is characterized by, and the lower end of tubular sheath is a cheese.
7. cryogenic system as claimed in claim 6 is characterized by, and polymeric material is made up of politef.
8. cryogenic system as claimed in claim 5 is characterized by, and tubular sheath is made of metal.
9. cryogenic system as claimed in claim 5 is characterized by, and tubular sheath is by meeting can constituting with biocompatible material of DIN EN30993-1.
10. cryogenic system as claimed in claim 8 is characterized by, and tubular sheath is made of gold.
11. cryogenic system as claimed in claim 5 is characterized by, and arranges described hole in the mode of the angle of outlet predetermined with respect to the passage one-tenth that is limited by polymeric layer.
12. cryogenic system as claimed in claim 5 is characterized by, the thickness of tubular sheath is less than about 0.15mm.
13. cryogenic system as claimed in claim 5 is characterized by, the passage that is limited by polymeric layer has the diameter that its scope is about the substantial constant of 0.5mm.
14. cryogenic system as claimed in claim 5 is characterized by, microcapillary has a nozzle, and its opening is 30-40 μ m.
15. cryogenic system as claimed in claim 14 is characterized by, microcapillary removably engages with nozzle.
16. one kind is used for cryogen accurately is applied to cryogenic system on the desired area, it comprises:
A sealed container that is used to preserve a certain amount of cryogen;
Microcapillary, microcapillary with a upper end and a lower end further be provided with one along its length extend, with so that the passage that cryogen is approximately at room temperature passed through, the external diameter of above-mentioned microcapillary is less than 1mm;
Spray nozzle device, it is provided with an open-ended nozzle or one or several opening at the end of pipe, with so that above-mentioned cryogenic flow physical ability is discharged into groove or the hole near the outer wall section that is arranged in above-mentioned microcapillary above-mentioned one or several nozzle opening, be used to make above-mentioned gas to be expanded; And
Be used for microcapillary removably is fixed on device on the above-mentioned sealed container.
17. cryogenic system as claimed in claim 16 is characterized by, nozzle opening is in the scope of 30-40 μ m.
18. cryogenic system as claimed in claim 16 is characterized by, above-mentioned microcapillary is made with the high-quality steel.
19. cryogenic system as claimed in claim 16 is characterized by, the said nozzle device extends into the arrow shaped ends of a sharp cone distal at its end.
20. cryogenic system as claimed in claim 16 is characterized by, it is arranged by inserting the mode that is used for handling the tissue that medical condition handles.
21. cryogenic system as claimed in claim 16 is characterized by, spray nozzle device is provided with one and is used to the threaded lid that covers and lock and unclamp nozzle opening.
22. as claim 1,5 or 16 described cryogenic systems, it is characterized by, the internal diameter of above-mentioned microcapillary depends on kind, pressure and the volume of ambient temperature or used liquid gas.
23. as claim 1,5 or 16 described cryogenic systems, it is characterized by, the internal diameter of above-mentioned microcapillary is in the scope of 30-40 μ m.
24. cryogenic system as claimed in claim 16 is characterized by, the diameter of nozzle opening depends on kind, pressure and the volume of ambient temperature or used liquid gas.
25. cryogenic system as claimed in claim 16 is characterized by, the diameter of nozzle opening is in the scope of 30-40 μ m.
26. as claim 1,5 or 16 described cryogenic systems, it is characterized by, cryogenic liquid gas is N
2O, argon or any other have desiring the suitable gas that processed group is woven with local refrigeration.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1999158988 DE19958988A1 (en) | 1999-12-07 | 1999-12-07 | Applicator for cryogenic liquids consists of a capillary unit with a nozzle and a pointed end. |
| DE1999161722 DE19961722A1 (en) | 1999-12-21 | 1999-12-21 | Applicator for cryogenic liquids consists of a capillary unit with a nozzle and a pointed end. |
| DE10040583.5 | 2000-08-15 | ||
| DE19958988.7 | 2000-08-15 | ||
| DE10040583 | 2000-08-15 | ||
| DE19961722.8 | 2000-08-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1310984A CN1310984A (en) | 2001-09-05 |
| CN1155346C true CN1155346C (en) | 2004-06-30 |
Family
ID=27214020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB001344587A Expired - Fee Related CN1155346C (en) | 1999-12-07 | 2000-12-01 | Low temp. equipment |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP2001178737A (en) |
| CN (1) | CN1155346C (en) |
| BR (1) | BR0006337A (en) |
| HK (1) | HK1038686B (en) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7713266B2 (en) | 2005-05-20 | 2010-05-11 | Myoscience, Inc. | Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat) |
| US7850683B2 (en) | 2005-05-20 | 2010-12-14 | Myoscience, Inc. | Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat) |
| US9254162B2 (en) * | 2006-12-21 | 2016-02-09 | Myoscience, Inc. | Dermal and transdermal cryogenic microprobe systems |
| US8409185B2 (en) * | 2007-02-16 | 2013-04-02 | Myoscience, Inc. | Replaceable and/or easily removable needle systems for dermal and transdermal cryogenic remodeling |
| US8298216B2 (en) | 2007-11-14 | 2012-10-30 | Myoscience, Inc. | Pain management using cryogenic remodeling |
| AU2009330012A1 (en) | 2008-12-22 | 2011-07-21 | Myoscience, Inc. | Integrated cryosurgical system with refrigerant and electrical power source |
| US20100274236A1 (en) * | 2009-04-23 | 2010-10-28 | Krimsky William S | Apparatuses and methods for applying a cryogenic effect to tissue and cutting tissue |
| US8888768B2 (en) * | 2009-04-30 | 2014-11-18 | Cryomedix, Llc | Cryoablation system having docking station for charging cryogen containers and related method |
| WO2013106859A1 (en) | 2012-01-13 | 2013-07-18 | Myoscience, Inc. | Cryogenic needle with freeze zone regulation |
| BR112014017175A8 (en) | 2012-01-13 | 2017-07-04 | Myoscience Inc | skin protection for subdermal cryogenic remodeling for cosmetic and other treatments |
| WO2013106860A1 (en) | 2012-01-13 | 2013-07-18 | Myoscience, Inc. | Cryogenic probe filtration system |
| US9017318B2 (en) | 2012-01-20 | 2015-04-28 | Myoscience, Inc. | Cryogenic probe system and method |
| WO2014146122A1 (en) | 2013-03-15 | 2014-09-18 | Myoscience, Inc. | Methods and systems for treatment of occipital neuralgia |
| US9295512B2 (en) | 2013-03-15 | 2016-03-29 | Myoscience, Inc. | Methods and devices for pain management |
| US20140350536A1 (en) | 2013-03-15 | 2014-11-27 | Myoscience, Inc. | Cryogenic Blunt Dissection Methods and Devices |
| US9610112B2 (en) | 2013-03-15 | 2017-04-04 | Myoscience, Inc. | Cryogenic enhancement of joint function, alleviation of joint stiffness and/or alleviation of pain associated with osteoarthritis |
| EP3065658B1 (en) | 2013-11-05 | 2021-03-31 | Pacira CryoTech, Inc. | Secure cryosurgical treatment system |
| US11311327B2 (en) | 2016-05-13 | 2022-04-26 | Pacira Cryotech, Inc. | Methods and systems for locating and treating nerves with cold therapy |
| CN106726102A (en) * | 2017-01-13 | 2017-05-31 | 镇江市宜尔医疗器械有限公司 | One kind injection cold therapy device |
| WO2019099677A1 (en) | 2017-11-15 | 2019-05-23 | Myoscience, Inc. | Integrated cold therapy and electrical stimulation systems for locating and treating nerves and associated methods |
| FR3082712B1 (en) * | 2018-06-26 | 2020-07-31 | Oreal | NEEDLELESS INJECTION SYSTEM |
| CN111594626B (en) * | 2019-02-20 | 2023-05-16 | 浙江三花商用制冷有限公司 | Temperature-sensing driving device and flow regulating valve using same |
| CN110410680A (en) * | 2019-07-17 | 2019-11-05 | 河北冀研能源科学技术研究院有限公司 | A kind of spray gun anti-jamming plug spray head of pierceable insulating layer |
-
2000
- 2000-10-20 JP JP2000321774A patent/JP2001178737A/en active Pending
- 2000-12-01 CN CNB001344587A patent/CN1155346C/en not_active Expired - Fee Related
- 2000-12-06 BR BR0006337-1A patent/BR0006337A/en not_active Application Discontinuation
-
2002
- 2002-01-15 HK HK02100292.3A patent/HK1038686B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BR0006337A (en) | 2001-07-24 |
| HK1038686B (en) | 2005-04-08 |
| CN1310984A (en) | 2001-09-05 |
| HK1038686A1 (en) | 2002-03-28 |
| JP2001178737A (en) | 2001-07-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1155346C (en) | Low temp. equipment | |
| EP2687173B1 (en) | Bone anchor with plug member and tool for inserting the plug member into the bone anchor | |
| CA2114465C (en) | Method and apparatus for cooling surfaces | |
| EP2570093B1 (en) | Instruments for use with a bone anchor with plug member | |
| US4043341A (en) | Portable cryosurgical instrument | |
| US4022215A (en) | Cryosurgical system | |
| DE69827804T2 (en) | ENDOSCOPIC DEVICE FOR DELIVERING KRYO SPRAYING AGENT | |
| DE4401237C2 (en) | Trocar device | |
| AU2008261145B2 (en) | Radially dilatable percutaneous access apparatus with introducer seal in handle | |
| US6508814B2 (en) | Method and apparatus for rupturing targeted cells | |
| US5217497A (en) | Apparatus for use in the treatment of spinal disorders | |
| WO2000047121A2 (en) | Device for carrying out cryosurgical interventions, especially for treating tumors | |
| EP1076528B1 (en) | Cryogenic system, especially for performing cryosurgical surgery | |
| KR20110055559A (en) | Cryosurgical device with metered dose | |
| WO1992016155A1 (en) | Cryosurgical spraying apparatus | |
| CN112566571A (en) | Cryoprobe | |
| US8647337B2 (en) | Devices and methods for dispensing a cryogenic fluid | |
| Torre | Alternate cryogens for cryosurgery | |
| EP3146925B1 (en) | Cryotip | |
| EP1408861A2 (en) | Applicator for the application of cryogenic refrigerants and application device | |
| EP3806763B1 (en) | Pedicle marker | |
| DE1064681B (en) | Device intended for medical or cosmetic purposes to cool down surfaces of limited size | |
| DE1566168C2 (en) | Device for cryosurgery | |
| DE3436430A1 (en) | Container for the evaporation of nitrogen, preferably in liquid form | |
| DE7129229U (en) | Cryosurgical instrument |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1038686 Country of ref document: HK |
|
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20040630 Termination date: 20101201 |