CN115530170B - Insecticidal and acaricidal composition - Google Patents

Insecticidal and acaricidal composition Download PDF

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Publication number
CN115530170B
CN115530170B CN202110724439.9A CN202110724439A CN115530170B CN 115530170 B CN115530170 B CN 115530170B CN 202110724439 A CN202110724439 A CN 202110724439A CN 115530170 B CN115530170 B CN 115530170B
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active component
composition
insecticidal
acaricidal
compound
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CN202110724439.9A
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CN115530170A (en
Inventor
班兰凤
宋玉泉
刘少武
范晓溪
张俊龙
孙俊
赵晶
常秀辉
吴鸿飞
于海波
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Jiangsu Yangnong Chemical Co Ltd
Shenyang Sinochem Agrochemicals R&D Co Ltd
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Jiangsu Yangnong Chemical Co Ltd
Shenyang Sinochem Agrochemicals R&D Co Ltd
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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N41/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
    • A01N41/12Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom not containing sulfur-to-oxygen bonds, e.g. polysulfides
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention belongs to the field of insecticidal and acaricidal agents, and relates to an insecticidal and acaricidal composition. The composition comprises an active component A and an active component B, wherein the weight part ratio of the active component A to the active component B is 1:99-99:1; the active component A is selected from a compound I, and the active component B is selected from isoxazolines insecticidal/acaricidal agents; the active component A has the following structure, and the composition has the advantages of obvious synergistic effect, resistance delay and the like, and can be used for preventing and controlling various pests.

Description

Insecticidal and acaricidal composition
Technical Field
The invention belongs to the field of insecticidal and acaricidal agents, and relates to an insecticidal and acaricidal composition.
Background
The insecticidal and acaricidal agent has obvious effect in preventing and controlling agricultural and forestry pests or urban sanitary pests.
Chinese patent No. CN105541682 discloses a biphenyl compound and its use for controlling insect pest and mite pest, wherein compound 1 (hereinafter referred to as compound i) can be used for controlling various insect pests and mites, and has outstanding controlling effect on pest mites.
The insecticidal and acaricidal agent containing single active component can be used continuously in pest control, and is easy to generate drug resistance for pests. The insecticidal and acaricidal agent with two active components is mixed into a mixed component according to a certain proportion, so that the control effect is often improved, the dosage of the active components is reduced, the cost is saved, and the generation of drug resistance of pests can be delayed.
Although the prior art generally discloses insecticidal and acaricidal compositions containing the compound I, the other components are different from one another, and the obtained composition is different from one another in the aspect of expanding insecticidal spectrum, and cannot achieve broad spectrum, and the effect cannot be obtained correspondingly.
Disclosure of Invention
The invention aims to provide an insecticidal and acaricidal composition for meeting the requirements of increasing the effect of insecticidal and acaricidal agents and continuously updating varieties in the aspect of pest control in the fields of agriculture, forestry and urban sanitation.
In order to achieve the above purpose, the invention adopts the following technical scheme:
the insecticidal and acaricidal composition comprises an active component A and an active component B, wherein the weight part ratio of the active component A to the active component B is 1:99-99:1; the active component A is selected from a compound I, and the active component B is selected from isoxazolines insecticidal/acaricidal agents; the active component A compound I has the following structure:
the isoxazoline insecticidal/acaricidal agent is selected from isoxazole insect amide (isocycloseram), fluoxaamide (fluxamide), fluorine Lei Lana (fluralaner), aforana (afxoraner), rotilana (lotilaner) or saeurana (sartaner).
The active component A is a compound I, and the active component B is isoxazole amide, fluxapyroxad, fluorine Lei Lana, aforana, rotirana or sajorana; the method comprises the steps of carrying out a first treatment on the surface of the The weight part ratio of the two active components is 50:1-1:20.
The active component A is a compound I, and the active component B is isoxazole amide or fluxapyroxad amide; the weight part ratio of the two active components is 20:1-1:10.
The active component A is a compound I, and the active component B is isoxazole amide or fluxapyroxad amide; the weight part ratio of the two active components is 10:1-1:5.
The active component A is a compound I, and the active component B is isoxazole amide or fluxapyroxad amide; the weight part ratio of the two active components is 4:1-1:4.
Use of an insecticidal and acaricidal composition for the preparation of an insecticidal and acaricidal agent for controlling agricultural or urban-hygiene pests.
The composition is applied to the pest or medium in which it is grown to be controlled, in an effective dosimeter.
The composition is particularly suitable for controlling a plurality of important agricultural pests, such as the application of the composition in preparing insecticidal and acaricidal preparations for controlling agricultural and forestry pests or urban sanitary pests. Is particularly suitable for preventing and controlling various important agricultural pests such as armyworms, beet armyworms, cotton bollworms, cutworm, cabbage loopers, apple leaf rollers, rice leaf rollers, corn borers, chilo suppressalis, plutella xylostella, cabbage caterpillars, fall webworms, backdrop caterpillars, gypsy moths, east Asia migratory locust, soil insects, leaf miners, aphids, leafhoppers, flower scale insects, potato beetles, flea beetles, thrips, lygus lucorum, vermin, tetranychus cinnabarinus, hawkthorn leaf mites, citrus panonycis, citrus rust, apple leaf mites, two-spotted spider mites, goiter, powder mites and the like, and urban pests such as termites, cockroaches, ants, flies, mosquitoes and the like. Is used for fruit trees such as apples, pears, oranges, litchis and the like, cereals such as wheat, rice and the like, beans such as soybeans, beans and the like, cotton, vegetables such as cabbages, cauliflower, cabbages, rapes, tomatoes, peppers and flowers. When used for preventing and controlling urban pests, the termite-killing agent can be used for families, various public places, office places, trees, dykes and the like with termite damage.
Further, a method for using the insecticidal and acaricidal composition is provided, wherein the prepared insecticidal and acaricidal agent is applied to the insect pests or the growing mediums thereof to be controlled by an effective dosimeter. A more suitable effective dosage is typically selected to be from 10 to 500 grams per hectare, with an effective dosage of from 15 to 100 grams per hectare being preferred.
The composition of the invention can be prepared into preparations by mixing the composition serving as an active ingredient with a carrier and any auxiliary agent.
The cumulative content of active components of the composition in the preparation is between 0.5wt% and 95 wt%. Preferably, the cumulative content of active ingredient in the formulation is between 1% and 85%.
The invention has the following advantages:
1. the composition provided by the invention has obvious synergism on insect and mite killing within a certain proportion range, the control effect of each single active ingredient compound in the composition on pests is improved, and the compositions with different action forms are combined according to a certain proportion, so that the synergistic effect is realized.
2. The dosage of the composition in the insecticidal and acaricidal application is obviously lower than that of a single compound in the composition, so that the use cost is reduced, and the environmental pollution is reduced.
3. The active ingredients in the composition have different action mechanisms in acting on insect killing and mite killing, the problem of cross resistance does not exist, the occurrence of pest resistance can be delayed by using the composition for controlling pests, and the control effect on resistant populations is improved.
4. The compositions of the present invention have improved broad spectrum properties relative to each individual dose, but the synergistic effect is not linearly related to the individual dose.
Detailed Description
The following specific examples serve to further illustrate the invention in detail, but the invention is by no means limited to these examples. The proportion of each component in the examples is calculated by weight.
Indoor biological Activity assay
Example 1 determination of the synergistic Effect of a composition containing Compound I on Tetranychus cinnabarinus
Test subject: tetranychus cinnabarinus (Tetranychus cinnabarinus Boisduval), adult mites, and sensitive lines raised indoors.
Test conditions: temperature: 24-26 ℃, relative humidity: 60%, illumination: l: d=14:10
Preparing a liquid medicine: according to different test requirements, accurately weighing samples (the composition and the raw medicine with different proportions) by using an electronic analytical balance, wherein the raw medicine is dissolved by acetone, and then the solution is diluted into a liquid medicine with a certain concentration by 0.1% Tween 80 water according to the test design dose.
The test method comprises the following steps: the activity of tetranychus cinnabarinus is measured by a potted seedling spraying method. Firstly, 40-60 tetranychus cinnabarinus adults with the same size are connected to young kidney bean seedlings (one leaf of the young kidney bean is reserved) in a first pair of young leaf flattening periods, and the cardinality is counted after the adult tetranychus cinnabarinus adults are stable; then, the test materials are treated with the medicinal liquid by an Airbrush method, 1.5mL of each strain is used, and a blank control is arranged.
After naturally drying in the shade, placing the treated test material in an observation room, adjusting the temperature, humidity and illumination of the observation room according to the requirements, investigating the number of live mites after 72 hours, and calculating the death rate. The evaluation was performed by the Bliss method, which is one of the classical methods for evaluating the effect of the compound. The theoretical mortality rate P of the combination of insecticides and acaricides according to the independent combined action concept proposed by Bliss can be calculated by the following formula:
P=P m +P n (1-P m )
P m mortality (%) of the target at a concentration of m for the first active component; p (P) n Mortality (%) of the target at n concentration was used for the second active component.
If the actual mortality of the target is greater than the theoretical mortality P after the two active components are mixed at a certain concentration, the two active components are judged to have synergistic effect when mixed at a set concentration, and otherwise, antagonistic effect is judged.
The results are shown in Table 1.
Table 1 synergistic effect of Compound I in combination with isoxazolamide on tetranychus cinnabarinus
EXAMPLE 2 determination of indoor Activity of composition containing Compound I against Tetranychus cinnabarinus
The synergistic effect measurement data show that the composition mixed by the compound I and the isoxazole tebufenozide has obvious synergistic effect on tetranychus cinnabarinus, and the indoor activity measurement is carried out by using the compound I and the isoxazole tebufenozide to test a composition consisting of 4:1-1:4 and using a Sun cloud Peel (Sun y-p) method.
Test target: tetranychus cinnabarinus (Tetranychus cinnabarinus Boisduval) is an adult mite, and is a sensitive strain fed indoors.
Preparing a liquid medicine: according to different test requirements, accurately weighing test samples by using an electronic analytical balance, wherein the raw medicines are dissolved by acetone, and then diluted into a series of liquid medicines with a certain concentration gradient by 0.1% Tween 80 water according to the test design dose.
The test method comprises the following steps: the activity of tetranychus cinnabarinus is measured by a potted seedling spraying method. Firstly, tetranychus cinnabarinus with the same size is connected to young kidney bean seedlings (one leaf of the leaf is reserved) in the first pair of leaf-flattening period, and the cardinality is counted after the tetranychus cinnabarinus is stable; and then uniformly spraying the liquid medicine by an Airbrush spraying method according to the sequence from low dose to high dose of the test design, wherein each strain is 1.5mL, each treatment is repeated for 4 times, and a blank control is additionally arranged.
The treated test material is placed in an observation chamber, and the temperature, humidity and illumination of the observation chamber can be adjusted as required. The number of dead mites and live mites was investigated after 72 hours. Calculating corrected mortality using abbott's formula, using DPS dataThe processing software performs statistical analysis to obtain the virulence regression equation and LC of each single agent to be tested and each mixed agent with different proportions 50 And calculating the co-toxicity coefficient of each proportion by using a grand cloud Pei (Sun y-p) method and evaluating the mixed use effect.
The co-toxicity coefficient (CTC value) of the blend was calculated according to the following formula:
wherein: the ATI-mixed agent actually measures the toxicity index; LC of S-standard agent 50 A value; LC of M-mixture 50 Values.
TTI=TIA×PA+TIB×PB
Wherein: TTI-mixed agent theoretical virulence index; TIA-A agent virulence index; the percentage of the PA-A agent in the mixture; TIB-B agent virulence index; the PB-B medicament comprises the following components in percentage by weight.
Wherein: CTC-co-toxicity coefficient; the ATI-mixed agent actually measures the toxicity index; TTI-blend theoretical virulence index.
Co-toxicity coefficient (CTC) of the combination agent: CTC is more than or equal to 120 and shows synergistic effect; ctc.ltoreq.80 shows antagonism; 80< ctc <120 appears as additive.
And LC of the composition 50 LC with a value less than one or two single doses 50 The value means that the composition is used in a dose less than one or both of the single doses when the same effect (50% mortality) is achieved.
The test results are shown in Table 2.
Table 2: indoor combined toxicity test result of compound I-isoxazole insect amide on tetranychus cinnabarinus
From the data, the compound I, isoxazole and tebufenozide compound 5 pairs tetranychus cinnabarinus LC 50 The value is 0.038mg/L, and single dose LC 50 Values of 0.50mg/L and 0.039mg/L, respectively, then mean that the dosage of the composition (0.038 mg/L) is less than the dosage of one or both of the single doses (0.50 mg/L and 0.039 mg/L) when the same effect is achieved (mortality 50%); in addition, from the definition of the co-toxicity coefficient, the control effect of the composition is higher than the theoretical effect of two single agents to different degrees; due to field usage dose and indoor LC 50 The values are positively correlated, so that the field dosage of the composition can be correspondingly reduced, thereby reducing the use cost and reducing the environmental pollution.

Claims (8)

1. An insecticidal and acaricidal composition, which is characterized in that: the composition comprises an active component A and an active component B, wherein the weight part ratio of the active component A to the active component B is 50:1-1:20; the active component A is selected from a compound I, and the active component B is selected from isoxazolines insecticidal/acaricidal agents; the active component A compound I has the following structure:
the isoxazoline insecticidal/acaricidal agent is selected from isoxazole insect amide.
2. A composition according to claim 1, wherein: the active component A is a compound I, and the active component B is selected from isoxazole antraniliprole; the weight part ratio of the two active components is 20:1-1:10.
3. A composition according to claim 2, wherein: the active component A is a compound I, and the active component B is isoxazole antraniliprole; the weight part ratio of the two active components is 10:1-1:5.
4. A composition according to claim 3, characterized in that: the active component A is a compound I, and the active component B is isoxazole antraniliprole; the weight part ratio of the two active components is 4:1-1:4.
5. Use of a pesticidal and acaricidal composition according to claim 1, characterized in that: the use of said composition for the preparation of an insecticidal and acaricidal agent for controlling agricultural or urban sanitary pests.
6. Use of a pesticidal and acaricidal composition according to claim 5, characterized in that: the composition is applied to the pest or medium in which it is grown to be controlled, in an effective dosimeter.
7. An insecticidal and acaricidal preparation, which is characterized in that: a formulation comprising the composition of claim 1 as an active ingredient in admixture with a carrier and any auxiliary agent.
8. The insecticidal and acaricidal preparation according to claim 7, wherein: the cumulative content of active components of the composition in the preparation is between 0.5wt% and 95 wt%.
CN202110724439.9A 2021-06-29 2021-06-29 Insecticidal and acaricidal composition Active CN115530170B (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110037021A (en) * 2019-05-22 2019-07-23 侨昌现代农业有限公司 A kind of acaricidal miticide composition of Synergistic type of class containing biphenyl
CN111226927A (en) * 2018-11-29 2020-06-05 沈阳中化农药化工研发有限公司 Insecticidal and acaricidal composition containing mite growth inhibitor acaricide
CN111226955A (en) * 2018-11-29 2020-06-05 沈阳中化农药化工研发有限公司 Insecticidal and acaricidal composition containing macrolide insect/acarid
CN111657280A (en) * 2019-03-05 2020-09-15 沈阳中化农药化工研发有限公司 Insecticidal and acaricidal composition
CN112704070A (en) * 2019-10-25 2021-04-27 沈阳中化农药化工研发有限公司 Insecticidal and acaricidal composition containing pyrethroid insecticides/acaricides

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111226927A (en) * 2018-11-29 2020-06-05 沈阳中化农药化工研发有限公司 Insecticidal and acaricidal composition containing mite growth inhibitor acaricide
CN111226955A (en) * 2018-11-29 2020-06-05 沈阳中化农药化工研发有限公司 Insecticidal and acaricidal composition containing macrolide insect/acarid
CN111657280A (en) * 2019-03-05 2020-09-15 沈阳中化农药化工研发有限公司 Insecticidal and acaricidal composition
CN110037021A (en) * 2019-05-22 2019-07-23 侨昌现代农业有限公司 A kind of acaricidal miticide composition of Synergistic type of class containing biphenyl
CN112704070A (en) * 2019-10-25 2021-04-27 沈阳中化农药化工研发有限公司 Insecticidal and acaricidal composition containing pyrethroid insecticides/acaricides

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