CN115518031A - Carbomer hemorrhoid gel - Google Patents

Carbomer hemorrhoid gel Download PDF

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Publication number
CN115518031A
CN115518031A CN202211331978.7A CN202211331978A CN115518031A CN 115518031 A CN115518031 A CN 115518031A CN 202211331978 A CN202211331978 A CN 202211331978A CN 115518031 A CN115518031 A CN 115518031A
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CN
China
Prior art keywords
carbomer
portions
parts
gel
hemorrhoid
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Pending
Application number
CN202211331978.7A
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Chinese (zh)
Inventor
白云飞
李富彪
李一伦
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Yunfei Biopharmaceutical Jilin Co ltd
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Yunfei Biopharmaceutical Jilin Co ltd
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Priority to CN202211331978.7A priority Critical patent/CN115518031A/en
Publication of CN115518031A publication Critical patent/CN115518031A/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention discloses carbomer hemorrhoid gel which comprises the following raw materials in parts by weight: 0.1 to 10 portions of carbomer, 2 to 10 portions of glycerol, 0.1 to 1.0 portion of triethanolamine, 0.01 to 1.0 portion of ethylene diamine tetraacetic acid disodium, 0.03 to 5.0 portions of benzyl alcohol and 100 to 1000 portions of purified water, wherein the content of COOH groups is 0.1 to 0.3g, and also comprises 0.1 to 10.0 portions of antibacterial agent, 0.1 to 10 portions of antibiotic medicament, 0.1 to 0.25 portion of anti-inflammatory agent, 0.1 to 10 portions of absorption enhancer, 100 to 200 portions of propylene glycol and 0.1 to 10 portions of lubricant. The antibacterial property of the gel is improved by using the arrangement mode of matching the aluminum potassium sulfate dodecahydrate, the clindamycin, the tretinoin, the laurocapram and the polysorbate-80, and the absorption of antibiotic medicament clindamycin is promoted by the aluminum potassium sulfate dodecahydrate, so that inflammation is conveniently eliminated, the curative effect of the carbomer hemorrhoid gel is enhanced when the carbomer hemorrhoid gel is used, the raw materials are sufficient in China, the production cost is low, and the large-scale industrial production is facilitated.

Description

Carbomer hemorrhoid gel
Technical Field
The invention relates to the technical field of preparation of gel, and particularly relates to carbomer hemorrhoid gel.
Background
The carbomer haemorrhoids gel product is water-soluble gel mainly prepared from carbomer high polymer material, is slightly acidic, is not influenced by microorganisms, does not destroy flora, and has strong antibacterial property; a layer of protective film is formed on the anorectal mucosa and is physically isolated from external bacteria, so that pathogenic microorganisms are prevented from being planted, the propagation of pathogens is inhibited, the resistance of a diseased part to the bacteria and the pathogenic microorganisms is enhanced, and the bacteria and the pathogenic microorganisms wrapping the wound surface are adsorbed on a mucosa system for a long time due to the biological barrier effect.
At present, the required viscosity can be achieved only by a small amount of carbomer, and the carbomer has the functions of thickening and stabilizing, so that emulsion, cream and gel products with wide viscosity range and different rheological properties are prepared, but when haemorrhoids in the anus and the intestine are already inflamed, the carbomer haemorrhoids gel has poor curative effect when in use.
Disclosure of Invention
The invention aims to provide carbomer hemorrhoid gel to solve the problems in the background art.
In order to achieve the purpose, the invention provides the following technical scheme: carbomer hemorrhoid gel comprises the following raw materials in parts by weight: 0.1 to 10 portions of carbomer, 2 to 10 portions of glycerol, 0.1 to 1.0 portion of triethanolamine, 0.01 to 1.0 portion of disodium ethylene diamine tetraacetate, 0.03 to 5.0 portions of benzyl alcohol and 100 to 1000 portions of purified water, wherein the content of COOH groups is 0.1 to 0.3g, and also comprises 0.1 to 10.0 portions of antibacterial agent, 0.1 to 10 portions of antibiotic medicament, 0.1 to 0.25 portion of anti-inflammatory agent, 0.1 to 10 portions of absorption enhancer, 100 to 200 portions of propylene glycol and 0.1 to 10 portions of lubricant.
Preferably, the aluminum potassium sulfate dodecahydrate, clindamycin, retinoic acid, laurocapram and polysorbate-80 are added in the same parts as the carbomer during preparation.
Preferably, the absorption enhancer is laurocapram, and the lubricant is polysorbate-80.
Preferably, the carbomer consists of acrylic acid, ethyl acetate, potassium carbonate and peroxydicarbonate, and the preparation steps of the carbomer are as follows:
the method comprises the following steps: dissolving acrylic acid and potassium carbonate in a reaction vessel containing an ethyl acetate solvent to obtain a mixture;
step two: heating the resulting mixture to 50 ℃ under nitrogen atmosphere and slowly adding the peroxycarbonic acid diester to the reaction vessel over a period of 6 hours;
step three: as the reaction proceeds, insoluble carbomer product precipitates from the solvent, forming a slurry of carbomer particles in the solvent;
step four: after the reaction is complete, the carbomer is isolated from the slurry, dried as a solid, and ground to obtain the carbomer in powder form.
Preferably, the preparation method of the carbomer hemorrhoid gel comprises the following steps:
the method comprises the following steps: sequentially adding 0.1-10 parts of carbomer into a reaction kettle, adding 2-10 parts of glycerol and 0.1-10.0 parts of laurocapram, grinding to wet the carbomer, adding 0.1-1.0 part of triethanolamine and 100-1000 parts of water, stirring, standing at normal temperature for a period of time or heating in water bath for 1-3 hours to fully swell the carbomer to obtain a carbomer solution;
step two: adding 0.1-10.0 parts of potassium aluminum sulfate dodecahydrate, 0.1-10.0 parts of clindamycin, 0.1-10.0 parts of retinoic acid, 800.1-10 parts of polysorbate-10 and 100-200 parts of propylene glycol into the other reaction vessel, mixing, heating and dissolving to obtain a liquid medicine;
step three: and (3) slowly adding the liquid medicine obtained in the step (II) into the carbomer solution obtained in the step (I), slowly and quickly stirring, heating to 85-95 ℃, and continuously and uniformly stirring to obtain the golden yellow transparent gel.
The invention has the technical effects and advantages that:
(1) According to the invention, the arrangement mode that aluminum potassium sulfate dodecahydrate, clindamycin, tretinoin, laurocapram and polysorbate-80 are matched is utilized, the antibacterial property of the gel is increased through the aluminum potassium sulfate dodecahydrate, and the absorption of antibiotic medicament clindamycin is promoted through the laurocapram, so that inflammation is conveniently eliminated, and the curative effect of the carbomer hemorrhoid gel is enhanced when the carbomer hemorrhoid gel is used;
(2) The raw materials of the invention are sufficient in China and proper in price, so that the large-scale production of the invention is not limited by too high cost, and meanwhile, the preparation method is simple, the total production cost is not high, and the invention is beneficial to industrial large-scale production.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be obtained by a person skilled in the art without making any creative effort based on the embodiments in the present invention, belong to the protection scope of the present invention.
The invention provides carbomer hemorrhoid gel which comprises the following raw materials in parts by weight: 0.1 to 10 portions of carbomer, 2 to 10 portions of glycerol, 0.1 to 1.0 portion of triethanolamine, 0.01 to 1.0 portion of disodium ethylene diamine tetraacetate, 0.03 to 5.0 portions of benzyl alcohol and 100 to 1000 portions of purified water, wherein the content of COOH groups is 0.1 to 0.3g, and also comprises 0.1 to 10.0 portions of antibacterial agent, 0.1 to 10 portions of antibiotic medicament, 0.1 to 0.25 portion of anti-inflammatory agent, 0.1 to 10 portions of absorption enhancer, 100 to 200 portions of propylene glycol and 0.1 to 10 portions of lubricant.
The antibacterial agent is aluminum potassium sulfate dodecahydrate, also called alum, which mainly has the effect of gel, the aluminum potassium sulfate dodecahydrate has the effects of antibiosis, astringency and the like and can be used as a traditional Chinese medicine, the traditional Chinese medicine considers that the alum has the effects of detoxifying, killing parasites, eliminating dampness, relieving itching, stopping bleeding, relieving diarrhea, clearing heat and eliminating phlegm, the recent research proves that the alum also has the effects of antibiosis, resisting trichomonas vaginalis and the like, the alum is used for treating diseases such as hyperlipoidemia, duodenal ulcer, phthisis, hemoptysis and the like, and the alum has the inhibiting effect on various gram negative and positive cocci and bacilli; the antibacterial agent has strong antibacterial effect on common suppurative bacteria, and experiments show that: alum has an inhibitory effect on staphylococcus aureus and proteus, has an inhibitory effect on escherichia coli, pseudomonas aeruginosa, bacillus anthracis, freund and Shigella He Liji bacillus, typhoid bacillus, paratyphoid bacillus, proteus and staphylococcus, has the strongest effect on green streptococcus, hemolytic streptococcus, pneumococcus and diphtheria bacillus, has the second effect on brucella bovis, bordetella pertussis and meningococcus, has no effect on influenza bacteria, and has an inhibitory effect on human (H37 RV) and mycobacterium bovis by high-concentration alum suspension, so that the 0.75% alum suspension is clinically effective in controlling pseudomonas aeruginosa infection of burn wounds;
the antibiotic medicament is clindamycin which is an antibiotic medicament and is mainly used for abdominal cavity and gynecological infection caused by anaerobic bacteria clinically, the clindamycin is the first choice medicament for treating staphylococcus aureus osteomyelitis, the antibacterial spectrum of the clindamycin is the same as that of the lincomycin, but the antibacterial activity of the clindamycin is strong and is 4-8 times that of the lincomycin.
The absorption enhancer is laurocapram, and laurocapram is nonpolar transdermal enhancer, and it can soften cutin, enhance permeability, make medicine penetrate skin barrier, improve local or systemic blood concentration, and improve bioavailability of the preparation. The skin penetration enhancer has the skin penetration promoting effect on lipophilic and hydrophilic medicines, the lubricant is polysorbate-80, the polysorbate-80 is a nonionic surfactant, the hydrophilicity is strong, the toxicity is low, and the skin penetration enhancer is widely used as a solubilizer, an emulsifier and a lubricant for daily preparation. The injection and the oral preparation mostly contain polysorbate-80, and the polysorbate-80 is slightly bitter and astringent, smelly and has warm feeling due to different added doses in different treatment ways. The polysorbate-80 is easy to dissolve in water, ethanol, methanol and the like, is slightly soluble in mineral oil, is one of common surfactants in liquid preparations, has more effects, has larger clinical and industrial effects and more purposes, and has different dosages according to different effects and different treatment effects.
The aluminum potassium sulfate dodecahydrate, the clindamycin, the retinoic acid, the laurocapram and the polysorbate-80 are added in the same parts as the carbomer during preparation, the aluminum potassium sulfate dodecahydrate, the clindamycin, the retinoic acid, the laurocapram and the polysorbate-80 are added according to the number of parts of the carbomer during preparation so as to keep the stability of the internal composition, the antibacterial property of the gel is improved through the aluminum potassium sulfate dodecahydrate, and the absorption of antibiotic medicament clindamycin is promoted through the laurocapram, so that the inflammation is conveniently eliminated, and the curative effect of the carbomer hemorrhoid gel is enhanced when the carbomer hemorrhoid gel is used.
Carbomer is composed of acrylic acid, ethyl acetate, potassium carbonate and peroxydicarbonate, carbomer has the effect of protecting skin, because there is certain affinity with skin, can reduce irritation and injury to skin and mucous membrane of the irritant substance, can also reduce the consistency, carbomer has certain looseness, and it is a very strong subacid material of dilutability, so can add right amount of carbomer in making gel or cosmetic, reduce the viscosity of these materials, to maintain the stability of the active substance, and carbomer has effects of diminishing inflammation and sterilizing, carbomer itself is a natural medicinal component, can sterilize and diminish inflammation, carbomer gel forms a layer of protective film on the anorectal mucosa when using, isolate with external bacterium physics, thus prevent pathogenic microorganism from planting. Can be used for the adjuvant treatment of internal hemorrhoid, external hemorrhoid, mixed hemorrhoid and postoperative hemorrhoid, and can relieve symptoms of anal distention, pain and hematochezia caused by internal hemorrhoid and mixed hemorrhoid.
The preparation method of the carbomer comprises the following steps:
the method comprises the following steps: dissolving acrylic acid and potassium carbonate in a reaction vessel containing an ethyl acetate solvent to obtain a mixture;
step two: heating the resulting mixture to 50 ℃ under nitrogen atmosphere and slowly adding the peroxycarbonic acid diester to the reaction vessel over a period of 6 hours;
step three: as the reaction proceeds, insoluble carbomer product precipitates from the solvent, forming a slurry of carbomer particles in the solvent;
step four: after the reaction is complete, the carbomer is isolated from the slurry, dried as a solid, and ground to form the carbomer in powder form.
Example (b): the preparation method of the carbomer hemorrhoid gel comprises the following specific steps:
the method comprises the following steps: sequentially adding 0.1-10 parts of carbomer into a reaction kettle, adding 2-10 parts of glycerol and 0.1-10.0 parts of laurocapram, grinding to wet the carbomer, adding 0.1-1.0 part of triethanolamine and 100-1000 parts of water, stirring, standing at normal temperature for a period of time or heating in water bath for 1-3 hours to fully swell the carbomer to obtain a carbomer solution;
step two: adding 0.1-10.0 parts of potassium aluminum sulfate dodecahydrate, 0.1-10.0 parts of clindamycin, 0.1-10.0 parts of retinoic acid, 800.1-10 parts of polysorbate-10 and 100-200 parts of propylene glycol into the other reaction vessel, mixing, heating and dissolving to obtain a liquid medicine;
step three: and (3) slowly adding the liquid medicine obtained in the step (II) into the carbomer solution obtained in the step (I), slowly and quickly stirring, heating to 85-95 ℃, and continuously and uniformly stirring to obtain the golden yellow transparent gel.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments or portions thereof without departing from the spirit and scope of the invention.

Claims (6)

1. Carbomer hemorrhoid gel comprises the following raw materials in parts by weight: 0.1 to 10 portions of carbomer, 2 to 10 portions of glycerol, 0.1 to 1.0 portion of triethanolamine, 0.01 to 1.0 portion of disodium ethylenediamine tetraacetic acid, 0.03 to 5.0 portions of benzyl alcohol and 100 to 1000 portions of purified water, wherein the content of COOH groups is 0.1 to 0.3g, and the carbomer is characterized by also comprising 0.1 to 10.0 portions of antibacterial agent, 0.1 to 10 portions of antibiotic medicament, 0.1 to 0.25 portion of anti-inflammatory agent, 0.1 to 10 portions of absorption enhancer, 100 to 200 portions of propylene glycol and 0.1 to 10 portions of lubricant.
2. The carbomer hemorrhoid gel of claim 1, wherein said antimicrobial agent is aluminum potassium sulfate dodecahydrate and said antibiotic agent is clindamycin.
3. The carbomer hemorrhoid gel of claim 1, wherein said absorption enhancer is laurocapram and said lubricant is polysorbate-80.
4. The carbomer hemorrhoid gel of claim 1, wherein the aluminum potassium sulfate dodecahydrate, clindamycin, retinoic acid, laurocapram and polysorbate-80 are added in the same parts as the carbomer during the preparation.
5. The carbomer hemorrhoid gel in accordance with claim 1, wherein said carbomer is comprised of acrylic acid, ethyl acetate, potassium carbonate and peroxydicarbonate, said carbomer being prepared by the steps of:
the method comprises the following steps: dissolving acrylic acid and potassium carbonate in a reaction vessel containing an ethyl acetate solvent to obtain a mixture;
step two: heating the resulting mixture to 50 ℃ under nitrogen atmosphere and slowly adding the peroxycarbonic acid diester to the reaction vessel over a period of 6 hours;
step three: as the reaction proceeds, insoluble carbomer product precipitates from the solvent, forming a slurry of carbomer particles in the solvent;
step four: after the reaction is complete, the carbomer is isolated from the slurry, dried as a solid, and ground to obtain the carbomer in powder form.
6. The carbomer hemorrhoid gel of claim 1, wherein the method of making the carbomer hemorrhoid gel comprises the steps of:
the method comprises the following steps: sequentially adding 0.1-10 parts of carbomer into a reaction kettle, adding 2-10 parts of glycerol and 0.1-10.0 parts of laurocapram, grinding to wet the carbomer, adding 0.1-1.0 part of triethanolamine and 100-1000 parts of water, stirring, standing at normal temperature for a period of time or heating in water bath for 1-3 hours to fully swell the carbomer to obtain a carbomer solution;
step two: adding 0.1-10.0 parts of aluminum potassium sulfate dodecahydrate, 0.1-10.0 parts of clindamycin, 0.1-10.0 parts of retinoic acid, 800.1-10 parts of polysorbate-10 and 100-200 parts of propylene glycol into the other reaction container, mixing, heating and dissolving to obtain a liquid medicine;
step three: and (3) slowly adding the liquid medicine obtained in the step (II) into the carbomer solution obtained in the step (I), slowly and quickly stirring, heating to 85-95 ℃, and continuously and uniformly stirring to obtain the golden yellow transparent gel.
CN202211331978.7A 2022-10-28 2022-10-28 Carbomer hemorrhoid gel Pending CN115518031A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202211331978.7A CN115518031A (en) 2022-10-28 2022-10-28 Carbomer hemorrhoid gel

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202211331978.7A CN115518031A (en) 2022-10-28 2022-10-28 Carbomer hemorrhoid gel

Publications (1)

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CN115518031A true CN115518031A (en) 2022-12-27

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1850101A (en) * 2006-03-06 2006-10-25 李海涛 Compound vitamin A acid gel preparation for treating acne and its preparing method
US20140256688A1 (en) * 2013-03-10 2014-09-11 Peritech Pharma Ltd. Topical compositions and methods of treatment of anorectal disorders
CN108853167A (en) * 2018-09-13 2018-11-23 广州润虹医药科技股份有限公司 A kind of hemorrhoid composition containing chitosan, preparation method and applications

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1850101A (en) * 2006-03-06 2006-10-25 李海涛 Compound vitamin A acid gel preparation for treating acne and its preparing method
US20140256688A1 (en) * 2013-03-10 2014-09-11 Peritech Pharma Ltd. Topical compositions and methods of treatment of anorectal disorders
CN108853167A (en) * 2018-09-13 2018-11-23 广州润虹医药科技股份有限公司 A kind of hemorrhoid composition containing chitosan, preparation method and applications

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
庞俊忠: "临床中药学", 中国医药科技出版社, pages: 420 - 422 *

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