CN115515983A - 人源化cd19抗体及其应用 - Google Patents

人源化cd19抗体及其应用 Download PDF

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CN115515983A
CN115515983A CN202180033342.1A CN202180033342A CN115515983A CN 115515983 A CN115515983 A CN 115515983A CN 202180033342 A CN202180033342 A CN 202180033342A CN 115515983 A CN115515983 A CN 115515983A
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car
antibody
cells
humanized
variable region
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张华�
沈连军
石欢
曹卫
殷文劼
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Genxi Biotechnology Shanghai Co ltd
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Genxi Biotechnology Shanghai Co ltd
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Abstract

本发明提供了人源化CD19抗体及其嵌合抗原受体、免疫细胞和应用。本发明的人源化CD19抗体是以FMC63嵌合抗体为基础，进行了人源化改造。本发明还提供了基于该人源化抗体构建的CAR‑T细胞和双CAR‑T细胞及其相关应用。与利用FMC63所构建的CAR‑T细胞相比，本发明构建的CAR‑T细胞具有更高的杀伤效果和肿瘤清除能力。

Description

PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN202180033342.1A 2020-05-06 2021-05-06 人源化cd19抗体及其应用 Pending CN115515983A (zh)

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CN2020103747695 2020-05-06
CN202010374769 2020-05-06
PCT/CN2021/091956 WO2021223720A1 (zh) 2020-05-06 2021-05-06 人源化cd19抗体及其应用

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CN115515983A true CN115515983A (zh) 2022-12-23

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CN (1) CN115515983A (zh)
TW (1) TWI797610B (zh)
WO (1) WO2021223720A1 (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116462770A (zh) * 2023-04-18 2023-07-21 上海科棋药业科技有限公司 Cd19的人源化抗体和一种表达双特异性嵌合抗原受体的car-t细胞及其应用
CN116496397A (zh) * 2023-04-03 2023-07-28 上海科棋药业科技有限公司 靶向cd19 car-t细胞人源化抗体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201590208A1 (ru) * 2012-07-13 2015-11-30 Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания Усиление активности т-клеток car путем совместного введения биспецифического антитела
CN107383196B (zh) * 2017-08-30 2019-12-17 广州百暨基因科技有限公司 人源化抗cd19的抗原结合片段
CN109021114B (zh) * 2018-08-08 2020-06-09 武汉波睿达生物科技有限公司 联合两种单链抗体的双特异性嵌合抗原受体及表达载体
CN109879966B (zh) * 2018-12-29 2021-07-20 博生吉医药科技(苏州)有限公司 基于鼠源cd19抗体的人源化设计及表达验证
CN109575143B (zh) * 2018-12-29 2022-06-17 博生吉医药科技(苏州)有限公司 双特异性cd20-cd19-car及其应用
CN118184800A (zh) * 2019-05-07 2024-06-14 亘喜生物科技（上海）有限公司 靶向bcma的工程化免疫细胞及其用途

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116496397A (zh) * 2023-04-03 2023-07-28 上海科棋药业科技有限公司 靶向cd19 car-t细胞人源化抗体
CN116496397B (zh) * 2023-04-03 2024-03-01 科弈(浙江)药业科技有限公司 靶向cd19 car-t细胞人源化抗体
CN116462770A (zh) * 2023-04-18 2023-07-21 上海科棋药业科技有限公司 Cd19的人源化抗体和一种表达双特异性嵌合抗原受体的car-t细胞及其应用
CN116462770B (zh) * 2023-04-18 2024-03-08 科弈(浙江)药业科技有限公司 Cd19的人源化抗体和一种表达双特异性嵌合抗原受体的car-t细胞及其应用

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US20230235052A1 (en) 2023-07-27
WO2021223720A1 (zh) 2021-11-11
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