CN115515631A - 一种药物组合及其应用 - Google Patents
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- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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Abstract
提供一种药物组合及其应用。所述的药物组合用于制备治疗高球蛋白血症的药物，其包含免疫球蛋白降解酶和含有Fc的蛋白，所述药物组合通过将免疫球蛋白降解酶与Fc剂联合使用于高球蛋白血症，降低球蛋白对治疗的影响，使得Fc剂可更好的发挥作用，同时也可降低部分Fc剂的临床使用剂量，一方面可以减轻治疗剂的副作用，另一方面也减轻用药经济负担。
Description
PCT国内申请，说明书已公开。
Claims (20)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010996664 | 2020-09-21 | ||
| CN2020109966643 | 2020-09-21 | ||
| PCT/CN2021/119677 WO2022057942A1 (zh) | 2020-09-21 | 2021-09-22 | 一种药物组合及其应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115515631A true CN115515631A (zh) | 2022-12-23 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180013729.0A Pending CN115515631A (zh) | 2020-09-21 | 2021-09-22 | 一种药物组合及其应用 |
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| Country | Link |
|---|---|
| US (1) | US20230374083A1 (zh) |
| EP (1) | EP4215208A1 (zh) |
| JP (1) | JP2023541698A (zh) |
| CN (1) | CN115515631A (zh) |
| WO (1) | WO2022057942A1 (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023250434A2 (en) * | 2022-06-22 | 2023-12-28 | The Regents Of The University Of Michigan | Compositions and methods for targeted ides treatment of igg-related disorders |
| US20240148841A1 (en) * | 2022-08-11 | 2024-05-09 | Selecta Biosciences Inc. | Compositions and methods related to immunoglobulin proteases and fusions thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104519911A (zh) * | 2012-01-26 | 2015-04-15 | 因马格生物股份有限公司 | 抗体和糖苷内切酶的联合治疗应用 |
| CN105368808A (zh) * | 2015-11-30 | 2016-03-02 | 苏州康聚生物科技有限公司 | 一种IdeS蛋白酶、其制备方法及应用 |
| WO2016128559A1 (en) * | 2015-02-12 | 2016-08-18 | Hansa Medical Ab | Cysteine protease |
| CN106714834A (zh) * | 2014-07-25 | 2017-05-24 | 汉萨医疗公司 | 一种方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1901773B1 (en) * | 2005-06-09 | 2012-03-07 | Hansa Medical AB | Use of the ides proteinase (from s. pyogenes) for treating autoimmune diseases and graft rejection |
| GB201115841D0 (en) * | 2011-09-13 | 2011-10-26 | Genovis Ab | Protein and method |
-
2021
- 2021-09-22 EP EP21868764.8A patent/EP4215208A1/en active Pending
- 2021-09-22 JP JP2023518184A patent/JP2023541698A/ja active Pending
- 2021-09-22 CN CN202180013729.0A patent/CN115515631A/zh active Pending
- 2021-09-22 US US18/027,755 patent/US20230374083A1/en active Pending
- 2021-09-22 WO PCT/CN2021/119677 patent/WO2022057942A1/zh unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104519911A (zh) * | 2012-01-26 | 2015-04-15 | 因马格生物股份有限公司 | 抗体和糖苷内切酶的联合治疗应用 |
| CN106714834A (zh) * | 2014-07-25 | 2017-05-24 | 汉萨医疗公司 | 一种方法 |
| WO2016128559A1 (en) * | 2015-02-12 | 2016-08-18 | Hansa Medical Ab | Cysteine protease |
| CN105368808A (zh) * | 2015-11-30 | 2016-03-02 | 苏州康聚生物科技有限公司 | 一种IdeS蛋白酶、其制备方法及应用 |
Non-Patent Citations (1)
| Title |
|---|
| JÄRNUM，S.等: "Enzymatic Inactivation of Endogenous IgG by IdeS Enhances Therapeutic Antibody Efficacy", CANCER THER., vol. 9, no. 16, pages 1887 - 1897 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2023541698A (ja) | 2023-10-03 |
| EP4215208A1 (en) | 2023-07-26 |
| US20230374083A1 (en) | 2023-11-23 |
| WO2022057942A1 (zh) | 2022-03-24 |
| EP4215208A9 (en) | 2023-08-30 |
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