CN115515599A - 化合物在真菌感染的治疗中的用途 - Google Patents

化合物在真菌感染的治疗中的用途 Download PDF

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Publication number
CN115515599A
CN115515599A CN202180033043.8A CN202180033043A CN115515599A CN 115515599 A CN115515599 A CN 115515599A CN 202180033043 A CN202180033043 A CN 202180033043A CN 115515599 A CN115515599 A CN 115515599A
Authority
CN
China
Prior art keywords
spp
compound
pharmaceutically acceptable
acceptable salt
solvate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180033043.8A
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English (en)
Chinese (zh)
Inventor
K·J·肖
M·霍奇斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Basil Pharmaceuticals Allschwil International Ag
Original Assignee
Amplex Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amplex Pharmaceutical Co filed Critical Amplex Pharmaceutical Co
Publication of CN115515599A publication Critical patent/CN115515599A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202180033043.8A 2020-03-04 2021-03-02 化合物在真菌感染的治疗中的用途 Pending CN115515599A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062985274P 2020-03-04 2020-03-04
US62/985274 2020-03-04
PCT/US2021/020471 WO2021178406A1 (en) 2020-03-04 2021-03-02 Use of compounds in the treatment of fungal infections

Publications (1)

Publication Number Publication Date
CN115515599A true CN115515599A (zh) 2022-12-23

Family

ID=77612811

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180033043.8A Pending CN115515599A (zh) 2020-03-04 2021-03-02 化合物在真菌感染的治疗中的用途

Country Status (11)

Country Link
US (2) US12521406B2 (https=)
EP (1) EP4114405A4 (https=)
JP (1) JP2023516648A (https=)
KR (1) KR20220148881A (https=)
CN (1) CN115515599A (https=)
AU (1) AU2021230529B2 (https=)
BR (1) BR112022017653A2 (https=)
CA (1) CA3174065A1 (https=)
IL (1) IL296093A (https=)
MX (1) MX2022010804A (https=)
WO (1) WO2021178406A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115884775A (zh) * 2020-06-17 2023-03-31 Amplyx制药公司 用于治疗真菌感染的化合物及方法
CN116687929A (zh) * 2023-06-16 2023-09-05 山东省妇幼保健院 血根碱在制备防治临床罕见真菌相关感染性疾病药物中的应用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2026020112A1 (en) * 2024-07-19 2026-01-22 Sun Pharmaceutical Industries, Inc. Oral formulations of deuruxolitinib
CN119915948B (zh) * 2025-04-02 2025-07-08 天津辰欣药物研究有限公司 一种小分子真菌肌醇酰基转移酶1抑制剂原料药中致突变杂质的分析方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130288956A1 (en) * 2010-11-05 2013-10-31 Eisai R&D Management Co., Ltd. Combined pharmaceutical composition as antifungal agent
WO2019113542A1 (en) * 2017-12-07 2019-06-13 Amplyx Pharmaceuticals, Inc. Heterocycle substituted pyridine derivative antifungal agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8513287B2 (en) 2007-12-27 2013-08-20 Eisai R&D Management Co., Ltd. Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same
EP2345641A1 (en) 2009-12-29 2011-07-20 Polichem S.A. New secondary 8-hydroxyquinoline-7-carboxamide derivatives
WO2020047510A1 (en) 2018-08-31 2020-03-05 Amplyx Pharmaceuticals, Inc. Compounds and methods for treating fungal infections
CA3187268A1 (en) 2020-06-17 2021-12-23 Amplyx Pharmaceuticals, Inc. Compounds and methods for treating fungal infections

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130288956A1 (en) * 2010-11-05 2013-10-31 Eisai R&D Management Co., Ltd. Combined pharmaceutical composition as antifungal agent
WO2019113542A1 (en) * 2017-12-07 2019-06-13 Amplyx Pharmaceuticals, Inc. Heterocycle substituted pyridine derivative antifungal agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ADRIANA M RAUSEO等: "Hope on the Horizon: Novel Fungal Treatments in Development", OPEN FORUM INFECT DIS., vol. 7, no. 2, pages 1 - 19 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115884775A (zh) * 2020-06-17 2023-03-31 Amplyx制药公司 用于治疗真菌感染的化合物及方法
CN116687929A (zh) * 2023-06-16 2023-09-05 山东省妇幼保健院 血根碱在制备防治临床罕见真菌相关感染性疾病药物中的应用

Also Published As

Publication number Publication date
US20260102419A1 (en) 2026-04-16
CA3174065A1 (en) 2021-09-10
AU2021230529A1 (en) 2022-09-29
NZ792042A (en) 2025-09-26
JP2023516648A (ja) 2023-04-20
AU2021230529B2 (en) 2024-09-05
EP4114405A4 (en) 2024-03-13
WO2021178406A1 (en) 2021-09-10
KR20220148881A (ko) 2022-11-07
US12521406B2 (en) 2026-01-13
EP4114405A1 (en) 2023-01-11
US20230102036A1 (en) 2023-03-30
BR112022017653A2 (pt) 2022-10-18
MX2022010804A (es) 2023-01-16
IL296093A (en) 2022-11-01

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