CN115487164A - Praziquantel pill capable of being thrown by unmanned aerial vehicle - Google Patents
Praziquantel pill capable of being thrown by unmanned aerial vehicle Download PDFInfo
- Publication number
- CN115487164A CN115487164A CN202211144214.7A CN202211144214A CN115487164A CN 115487164 A CN115487164 A CN 115487164A CN 202211144214 A CN202211144214 A CN 202211144214A CN 115487164 A CN115487164 A CN 115487164A
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- China
- Prior art keywords
- praziquantel
- vitamin
- pill
- parts
- unmanned aerial
- Prior art date
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- Granted
Links
- 229940081055 praziquantel pill Drugs 0.000 title claims abstract description 30
- 229960002957 praziquantel Drugs 0.000 claims abstract description 23
- FSVJFNAIGNNGKK-UHFFFAOYSA-N 2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one Chemical compound C1C(C2=CC=CC=C2CC2)N2C(=O)CN1C(=O)C1CCCCC1 FSVJFNAIGNNGKK-UHFFFAOYSA-N 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000003755 preservative agent Substances 0.000 claims abstract description 11
- 230000002335 preservative effect Effects 0.000 claims abstract description 11
- 235000013372 meat Nutrition 0.000 claims description 30
- 229930003270 Vitamin B Natural products 0.000 claims description 25
- 235000019156 vitamin B Nutrition 0.000 claims description 25
- 239000011720 vitamin B Substances 0.000 claims description 25
- 238000010438 heat treatment Methods 0.000 claims description 22
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims description 20
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 20
- 235000015097 nutrients Nutrition 0.000 claims description 19
- 239000000796 flavoring agent Substances 0.000 claims description 16
- 239000003981 vehicle Substances 0.000 claims description 16
- 108010005094 Advanced Glycation End Products Proteins 0.000 claims description 15
- 239000003963 antioxidant agent Substances 0.000 claims description 15
- 230000003078 antioxidant effect Effects 0.000 claims description 15
- 235000006708 antioxidants Nutrition 0.000 claims description 15
- 235000013355 food flavoring agent Nutrition 0.000 claims description 15
- 239000002994 raw material Substances 0.000 claims description 15
- 239000007788 liquid Substances 0.000 claims description 14
- 235000013312 flour Nutrition 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 11
- 229920002774 Maltodextrin Polymers 0.000 claims description 10
- 239000005913 Maltodextrin Substances 0.000 claims description 10
- VLSOAXRVHARBEQ-UHFFFAOYSA-N [4-fluoro-2-(hydroxymethyl)phenyl]methanol Chemical compound OCC1=CC=C(F)C=C1CO VLSOAXRVHARBEQ-UHFFFAOYSA-N 0.000 claims description 10
- 235000010489 acacia gum Nutrition 0.000 claims description 10
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 10
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims description 10
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims description 10
- 239000012153 distilled water Substances 0.000 claims description 10
- 229940035034 maltodextrin Drugs 0.000 claims description 10
- 238000006243 chemical reaction Methods 0.000 claims description 9
- 239000004151 Calcium iodate Substances 0.000 claims description 7
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 7
- 235000019764 Soybean Meal Nutrition 0.000 claims description 7
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 7
- 240000008042 Zea mays Species 0.000 claims description 7
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 7
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 7
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims description 7
- UHWJJLGTKIWIJO-UHFFFAOYSA-L calcium iodate Chemical compound [Ca+2].[O-]I(=O)=O.[O-]I(=O)=O UHWJJLGTKIWIJO-UHFFFAOYSA-L 0.000 claims description 7
- 235000019390 calcium iodate Nutrition 0.000 claims description 7
- 229960002079 calcium pantothenate Drugs 0.000 claims description 7
- 239000003026 cod liver oil Substances 0.000 claims description 7
- 235000012716 cod liver oil Nutrition 0.000 claims description 7
- 229910000365 copper sulfate Inorganic materials 0.000 claims description 7
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims description 7
- 235000005822 corn Nutrition 0.000 claims description 7
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims description 7
- BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 claims description 7
- 235000003891 ferrous sulphate Nutrition 0.000 claims description 7
- 239000011790 ferrous sulphate Substances 0.000 claims description 7
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims description 7
- 229910000359 iron(II) sulfate Inorganic materials 0.000 claims description 7
- 229940099596 manganese sulfate Drugs 0.000 claims description 7
- 235000007079 manganese sulphate Nutrition 0.000 claims description 7
- 239000011702 manganese sulphate Substances 0.000 claims description 7
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 claims description 7
- 229960000342 retinol acetate Drugs 0.000 claims description 7
- 235000019173 retinyl acetate Nutrition 0.000 claims description 7
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 claims description 7
- 239000011770 retinyl acetate Substances 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 7
- 235000002639 sodium chloride Nutrition 0.000 claims description 7
- 235000015921 sodium selenite Nutrition 0.000 claims description 7
- 229960001471 sodium selenite Drugs 0.000 claims description 7
- 239000011781 sodium selenite Substances 0.000 claims description 7
- 239000004455 soybean meal Substances 0.000 claims description 7
- 229940042585 tocopherol acetate Drugs 0.000 claims description 7
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 7
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 7
- 229960001763 zinc sulfate Drugs 0.000 claims description 7
- 235000012054 meals Nutrition 0.000 claims description 6
- 244000215068 Acacia senegal Species 0.000 claims description 5
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical group CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims description 5
- 229920000084 Gum arabic Polymers 0.000 claims description 5
- 108090000526 Papain Proteins 0.000 claims description 5
- 239000004365 Protease Substances 0.000 claims description 5
- 229930003316 Vitamin D Natural products 0.000 claims description 5
- 239000000205 acacia gum Substances 0.000 claims description 5
- 239000001785 acacia senegal l. willd gum Substances 0.000 claims description 5
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims description 5
- 238000000227 grinding Methods 0.000 claims description 5
- 229940055729 papain Drugs 0.000 claims description 5
- 235000019834 papain Nutrition 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 235000010199 sorbic acid Nutrition 0.000 claims description 5
- 229940075582 sorbic acid Drugs 0.000 claims description 5
- 239000004334 sorbic acid Substances 0.000 claims description 5
- 238000001694 spray drying Methods 0.000 claims description 5
- 235000019166 vitamin D Nutrition 0.000 claims description 5
- 239000011710 vitamin D Substances 0.000 claims description 5
- 150000003710 vitamin D derivatives Chemical class 0.000 claims description 5
- 229940046008 vitamin d Drugs 0.000 claims description 5
- XPCTZQVDEJYUGT-UHFFFAOYSA-N 3-hydroxy-2-methyl-4-pyrone Chemical compound CC=1OC=CC(=O)C=1O XPCTZQVDEJYUGT-UHFFFAOYSA-N 0.000 claims description 4
- NEGYEDYHPHMHGK-UHFFFAOYSA-N para-methoxyamphetamine Chemical compound COC1=CC=C(CC(C)N)C=C1 NEGYEDYHPHMHGK-UHFFFAOYSA-N 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 4
- 241000287828 Gallus gallus Species 0.000 claims description 3
- 239000011347 resin Substances 0.000 claims description 3
- 229920005989 resin Polymers 0.000 claims description 3
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 2
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 2
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 2
- HYMLWHLQFGRFIY-UHFFFAOYSA-N Maltol Natural products CC1OC=CC(=O)C1=O HYMLWHLQFGRFIY-UHFFFAOYSA-N 0.000 claims description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 2
- 229930003451 Vitamin B1 Natural products 0.000 claims description 2
- 229930003779 Vitamin B12 Natural products 0.000 claims description 2
- 229930003471 Vitamin B2 Natural products 0.000 claims description 2
- 229930003537 Vitamin B3 Natural products 0.000 claims description 2
- 235000013330 chicken meat Nutrition 0.000 claims description 2
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 claims description 2
- 229960000355 copper sulfate Drugs 0.000 claims description 2
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 2
- 229960001781 ferrous sulfate Drugs 0.000 claims description 2
- 229940043353 maltol Drugs 0.000 claims description 2
- 239000002103 nanocoating Substances 0.000 claims description 2
- 229960003512 nicotinic acid Drugs 0.000 claims description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 235000010241 potassium sorbate Nutrition 0.000 claims description 2
- 239000004302 potassium sorbate Substances 0.000 claims description 2
- 229940069338 potassium sorbate Drugs 0.000 claims description 2
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 2
- 229960002477 riboflavin Drugs 0.000 claims description 2
- 229960003495 thiamine Drugs 0.000 claims description 2
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 2
- 235000010374 vitamin B1 Nutrition 0.000 claims description 2
- 239000011691 vitamin B1 Substances 0.000 claims description 2
- 235000019163 vitamin B12 Nutrition 0.000 claims description 2
- 239000011715 vitamin B12 Substances 0.000 claims description 2
- 235000019164 vitamin B2 Nutrition 0.000 claims description 2
- 239000011716 vitamin B2 Substances 0.000 claims description 2
- 235000019160 vitamin B3 Nutrition 0.000 claims description 2
- 239000011708 vitamin B3 Substances 0.000 claims description 2
- 235000019158 vitamin B6 Nutrition 0.000 claims description 2
- 239000011726 vitamin B6 Substances 0.000 claims description 2
- 235000005282 vitamin D3 Nutrition 0.000 claims description 2
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims description 2
- 239000011647 vitamin D3 Substances 0.000 claims description 2
- 229940011671 vitamin b6 Drugs 0.000 claims description 2
- 229940021056 vitamin d3 Drugs 0.000 claims description 2
- 239000008188 pellet Substances 0.000 claims 2
- 235000019634 flavors Nutrition 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 10
- 229940079593 drug Drugs 0.000 abstract description 9
- 206010014096 Echinococciasis Diseases 0.000 abstract description 7
- 208000009366 Echinococcosis Diseases 0.000 abstract description 7
- 241000244160 Echinococcus Species 0.000 abstract description 6
- 230000000507 anthelmentic effect Effects 0.000 abstract description 5
- 244000045947 parasite Species 0.000 abstract description 4
- 241000282465 Canis Species 0.000 abstract description 3
- 241000282324 Felis Species 0.000 abstract description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract description 2
- 230000004083 survival effect Effects 0.000 abstract description 2
- 235000012041 food component Nutrition 0.000 abstract 1
- 230000002940 repellent Effects 0.000 abstract 1
- 239000005871 repellent Substances 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 description 5
- 241000238631 Hexapoda Species 0.000 description 3
- 108091028664 Ribonucleotide Proteins 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 239000002336 ribonucleotide Substances 0.000 description 3
- WSWCOQWTEOXDQX-MQQKCMAXSA-N sorbic acid group Chemical group C(\C=C\C=C\C)(=O)O WSWCOQWTEOXDQX-MQQKCMAXSA-N 0.000 description 3
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 108010009736 Protein Hydrolysates Proteins 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
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- 210000003608 fece Anatomy 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
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- 206010048282 zoonosis Diseases 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/288—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Botany (AREA)
- Zoology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Fodder In General (AREA)
Abstract
The invention discloses a praziquantel pill capable of being thrown in by an unmanned aerial vehicle, and relates to the technical field of echinococcosis parasite repellent medicines, wherein the praziquantel pill capable of being thrown in by the unmanned aerial vehicle consists of praziquantel, and a bait layer and a waterproof layer which are sequentially wrapped outside the praziquantel from inside to outside, and the waterproof layer is also provided with air holes; the bait layer comprises nutritional components, a phagostimulant and a preservative. The praziquantel pill for unmanned aerial vehicle administration provided by the invention can be used for parasites infected by canine and feline intestinal tracts in villages and field environments, including echinococcus anthelmintica, and can improve the feeding, water resistance and usability of anthelmintic drugs and improve the survival time of the anthelmintic drugs before being eaten in the field environments. The praziquantel pill for unmanned aerial vehicle delivery provided by the invention can be used for delivery in field environment, can also be used for delivery in home environment, and does not comprise a waterproof layer when being delivered in home environment.
Description
Technical Field
The invention relates to the technical field of echinococcosis parasite expelling medicines, in particular to a praziquantel pill for unmanned aerial vehicle administration.
Background
Echinococcosis, also known as echinococcosis, is a zoonosis caused by infection of human or animal body with echinococcus larvae. Echinococcus is often parasitic in the liver of the patient, resulting in abdominal pain and cysts. For patients already suffering from the disease, surgery is required to treat the disease.
Echinococcosis is mainly prevalent in western China, northern China and northwest pasturing areas and farming and pasturing areas, and the problems of high terminal host feces positive rate of wild echinococcus tenuis and severe field environmental pollution exist at present. The infection risk of people, dogs and other intermediate hosts is greatly increased by field infection sources.
The existing method for preventing echinococcosis is artificial administration. Due to wide field regions, complex geographical environment and severe natural conditions, the wild propagation hosts of echinococcus are numerous and widely distributed, and the problems of high difficulty, high cost, poor insect expelling effect and the like exist when the artificial dosing is used for expelling insects. At present, manual administration often adopts a mode of wrapping food as bait to induce wild animals to swallow actively. However, animals cannot swallow the bait immediately after administration, and the bait is easily washed by rainwater in the wild environment to cause the dissolution of the drug, thereby affecting the insect expelling effect.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides a praziquantel pill for unmanned aerial vehicle delivery. Solves the problems that the existing echinococcosis field anthelmintic has limited waterproof function, is easy to be influenced by environmental factors to reduce the drug effect, and can not adapt to large-area field release.
The invention aims to protect a praziquantel pill capable of being thrown by an unmanned aerial vehicle, wherein the praziquantel pill capable of being thrown by the unmanned aerial vehicle consists of praziquantel, a bait layer and a waterproof layer, wherein the bait layer and the waterproof layer are sequentially wrapped outside the praziquantel from inside to outside; the bait layer consists of nutrient components, a phagostimulant and a preservative; the nutrient components comprise the following raw material components: corn flour, soybean meal, chicken meal, fishbone meal, salt and cod-liver oil; the nutrient components also comprise the following raw material components: vitamin A acetate, vitamin D3, vitamin E acetate, vitamin B1, vitamin B2, vitamin B3, calcium pantothenate, vitamin B6, vitamin B12, ferrous sulfate, copper sulfate, manganese sulfate, zinc sulfate, sodium selenite, and calcium iodate; the waterproof layer is one of wax, food-grade resin and food-grade anticorrosive nano-coating.
Preferably, the weight part ratio of the praziquantel to the bait layer to the waterproof layer is 10:85-81.2:5-8.8.
Preferably, the nutrient components comprise the following raw material components in parts by weight: 35-40 parts of corn flour, 10-20 parts of flour, 30-35 parts of soybean meal, 5-6 parts of chicken powder, 6-8 parts of fishbone powder, 1 part of salt and 1-2 parts of cod-liver oil.
Preferably, the nutrient composition also comprises the following raw material components in parts by weight: 10000IU/kg of vitamin A acetate, 3000IU/kg of vitamin D, 100IU/kg of vitamin E acetate, 15mg/kg of vitamin B, 5mg/kg of vitamin B, 50mg/kg of vitamin B, 30mg/kg of calcium pantothenate, 6mg/kg of vitamin B, 12.1 mg/kg of vitamin B, 250mg/kg of ferrous sulfate, 14mg/kg of copper sulfate, 60mg/kg of manganese sulfate, 60mg/kg of zinc sulfate, 0.15mg/kg of sodium selenite and 2mg/kg of calcium iodate.
Preferably, the preparation method of the phagostimulant comprises the following steps:
s1, adding distilled water into fresh meat, grinding the fresh meat into pulp, heating, adjusting the pH value, adding papain to carry out enzymolysis to obtain fresh meat enzymolysis liquid;
s2, adding xylose, L-cysteine hydrochloride, phosphoric acid, a flavoring agent and an antioxidant into the fresh meat enzymolysis liquid, adjusting the pH value again, heating, and carrying out Maillard reaction to obtain a Maillard reaction product;
s3, adding Arabic gum and maltodextrin into the Maillard reaction product to prepare a mixture, and performing spray drying to prepare the phagostimulant.
Further preferably, in step S1, the heating is performed to 45 ℃, and the PH is adjusted to 6.5; the weight part ratio of the fresh meat to the distilled water is 1:2.
more preferably, in step S2, the fresh meat enzymolysis liquid, xylose, L-cysteine hydrochloride, phosphoric acid, flavoring agent, and antioxidant are in a weight ratio of 100:4:1:1:5:0.05. in the step S2, the PH is adjusted again and the heating is carried out until the PH is adjusted to 5.0 and the temperature is 115 ℃, and the Maillard reaction time is 50min;
further preferably, in step S3, the concentration of the maillard reaction products in the mixture is 28-32%; the gum arabic and the maltodextrin are mixed according to the weight part ratio of 1:8.
preferably, the flavoring agent comprises one or more of disodium taste-imparting nucleotide and maltol; the antioxidant is 2, 6-di-tert-butyl-p-cresol; the preservative is one of sorbic acid and potassium sorbate.
Preferably, the number of the air holes is 4-8, and the diameter of the air holes is 1-2mm.
The invention has the beneficial effects that:
(1) The praziquantel pill for unmanned aerial vehicle administration provided by the invention is wrapped with the bait layer outside the praziquantel, so that special smell of the medicine can be shielded, and wild animals can be induced to swallow actively; the waterproof layer outside the bait layer can prevent the drug from being dissolved due to the fact that rainwater soaks the drug, and further can preserve the drug effect of the praziquantel; the air holes arranged on the waterproof layer can diffuse the bait smell and guide the canine or feline to eat.
(2) The praziquantel pill for unmanned aerial vehicle administration provided by the invention can be used for parasites infected by canine and feline intestinal tracts in villages and field environments, including echinococcus anthelmintica, and can improve the feeding, water resistance and usability of anthelmintic drugs and improve the survival time of the anthelmintic drugs before being eaten in the field environments.
(3) The praziquantel pill for unmanned aerial vehicle feeding provided by the invention is suitable for large-area feeding of unmanned aerial vehicles, can effectively cover the bad smell of praziquantel, and increases the feeding attraction effect on wild animals.
(4) The praziquantel pill for unmanned aerial vehicle delivery provided by the invention can be used for delivery in field environment, can also be used for delivery in home environment, and does not comprise a waterproof layer when being delivered in home environment.
Drawings
In order to more clearly illustrate the detailed description of the invention or the technical solutions in the prior art, the drawings that are needed in the detailed description of the invention or the prior art will be briefly described below. Throughout the drawings, like elements or portions are generally identified by like reference numerals. In the drawings, elements or portions are not necessarily drawn to scale.
FIG. 1 is a schematic structural diagram of a praziquantel pill provided by the invention and applicable to unmanned aerial vehicle delivery;
in the attached figure, 1-praziquantel, 2-bait layer, 3-air vent and 4-waterproof layer.
Detailed Description
Embodiments of the present invention will be described in detail below with reference to the accompanying drawings. The following examples are only for illustrating the technical solutions of the present invention more clearly, and therefore are only examples, and the protection scope of the present invention is not limited thereby.
It is to be noted that, unless otherwise specified, technical or scientific terms used herein shall have the ordinary meaning as understood by those skilled in the art to which the invention pertains.
Example 1
The embodiment provides a praziquantel pill for unmanned aerial vehicle delivery, as shown in fig. 1, the praziquantel pill comprises praziquantel 1, and a bait layer 2 and a waterproof layer 4 which are sequentially wrapped outside the praziquantel 1 from inside to outside, wherein the waterproof layer 4 is also provided with an air hole 3; the bait layer 2 consists of nutrient components, a phagostimulant and a preservative; the waterproof layer 4 is wax.
The nutrient components comprise the following raw material components in parts by weight: 35 parts of corn flour, 10 parts of flour, 30 parts of soybean meal, 5 parts of chicken powder, 6 parts of fishbone powder, 1 part of salt and 1 part of cod-liver oil. The nutrient components also comprise the following raw material components in parts by weight: 10000IU/kg of vitamin A acetate, 3000IU/kg of vitamin D, 100IU/kg of vitamin E acetate, 15mg/kg of vitamin B, 5mg/kg of vitamin B, 50mg/kg of vitamin B, 30mg/kg of calcium pantothenate, 6mg/kg of vitamin B, 12.1 mg/kg of vitamin B, 250mg/kg of ferrous sulfate, 14mg/kg of copper sulfate, 60mg/kg of manganese sulfate, 60mg/kg of zinc sulfate, 0.15mg/kg of sodium selenite and 2mg/kg of calcium iodate.
Wherein, the weight portion ratio of the praziquantel 1 to the bait layer 2 to the waterproof layer 4 is 10:85:5.
the flavoring agent comprises disodium ribonucleotide;
the antioxidant is 2, 6-di-tert-butyl-p-cresol;
the preservative is sorbic acid.
The number of the air holes 3 is 8, and the diameter of the air holes 3 is 1mm.
The preparation method of the phagostimulant comprises the following steps:
s1, adding distilled water into fresh meat, grinding the fresh meat into pulp, heating, adjusting the pH value, adding papain to carry out enzymolysis to obtain fresh meat enzymolysis liquid;
s2, adding xylose, L-cysteine hydrochloride, phosphoric acid, a flavoring agent and an antioxidant into the fresh meat enzymolysis liquid, adjusting the pH value again, heating, and carrying out Maillard reaction to obtain a Maillard reaction product;
s3, adding Arabic gum and maltodextrin into the Maillard reaction product to prepare a mixture, and performing spray drying to prepare the phagostimulant.
In the step S1, heating is carried out until the temperature is 45 ℃, and the PH is adjusted to 6.5; the weight portion ratio of the fresh meat to the distilled water is 1:2.
in the step S2, the fresh meat enzymolysis liquid, xylose, L-cysteine hydrochloride, phosphoric acid, a flavoring agent and an antioxidant are mixed according to the following weight ratio of 100:4:1:1:5:0.05. adjusting pH again, heating to pH 5.0, heating to 115 deg.C, and Maillard reaction for 50min.
In step S3, the concentration of Maillard reaction products in the mixture is 28%; the gum arabic and the maltodextrin are mixed according to the weight part ratio of 1:8.
example 2
The embodiment provides a praziquantel pill for unmanned aerial vehicle delivery, as shown in fig. 1, the praziquantel pill comprises praziquantel 1, and a bait layer 2 and a waterproof layer 4 which are sequentially wrapped outside the praziquantel 1 from inside to outside, wherein the waterproof layer 4 is also provided with an air hole 3; the bait layer 2 consists of nutrient components, a phagostimulant and a preservative; the waterproof layer 4 is food-grade resin.
The nutrient components comprise the following raw material components in parts by weight: 35 parts of corn flour, 10 parts of flour, 30 parts of soybean meal, 5 parts of chicken powder, 6 parts of fishbone powder, 1 part of salt and 1 part of cod-liver oil. The nutrient components also comprise the following raw material components in parts by weight: 10000IU/kg of vitamin A acetate, 3000IU/kg of vitamin D, 100IU/kg of vitamin E acetate, 15mg/kg of vitamin B, 5mg/kg of vitamin B, 50mg/kg of vitamin B, 30mg/kg of calcium pantothenate, 6mg/kg of vitamin B, 12.1 mg/kg of vitamin B, 250mg/kg of ferrous sulfate, 14mg/kg of copper sulfate, 60mg/kg of manganese sulfate, 60mg/kg of zinc sulfate, 0.15mg/kg of sodium selenite and 2mg/kg of calcium iodate.
Wherein, the weight portion ratio of the praziquantel 1, the bait layer 2 and the waterproof layer 4 is 10:85:5.
the flavoring agent comprises disodium ribonucleotide;
the antioxidant is 2, 6-di-tert-butyl-p-cresol;
the preservative is sorbic acid.
The number of the air holes 3 is 8, and the diameter of the air holes 3 is 1mm.
The preparation method of the phagostimulant comprises the following steps:
s1, adding distilled water into fresh meat, grinding the fresh meat into pulp, heating, adjusting the pH value, adding papain to carry out enzymolysis to obtain fresh meat enzymolysis liquid;
s2, adding xylose, L-cysteine hydrochloride, phosphoric acid, a flavoring agent and an antioxidant into the fresh meat enzymatic hydrolysate, adjusting the pH value again, heating, and carrying out Maillard reaction to obtain a Maillard reaction product;
s3, adding Arabic gum and maltodextrin to the Maillard reaction product to prepare a mixture, and performing spray drying to prepare the phagostimulant.
In the step S1, heating is carried out until the temperature is 45 ℃, and the PH is adjusted to 6.5; the weight portion ratio of the fresh meat to the distilled water is 1:2.
in the step S2, the fresh meat enzymolysis liquid, xylose, L-cysteine hydrochloride, phosphoric acid, a flavoring agent and an antioxidant are mixed according to the following weight ratio of 100:4:1:1:5:0.05. adjusting pH again, heating to pH 5.0, heating to 115 deg.C, and Maillard reaction for 50min.
In step S3, the concentration of Maillard reaction products in the mixture is 30%; the gum arabic and the maltodextrin are mixed according to the weight part ratio of 1:8.
example 3
The embodiment provides a praziquantel pill which can be thrown in by an unmanned aerial vehicle, as shown in fig. 1, the praziquantel pill consists of praziquantel 1, and a bait layer 2 and a waterproof layer 4 which are sequentially wrapped outside the praziquantel 1 from inside to outside, and the waterproof layer 4 is also provided with an air hole 3; the bait layer 2 consists of nutrient components, a phagostimulant and a preservative; the waterproof layer 4 is food-grade anticorrosive nano-paint.
The nutrient components comprise the following raw material components in parts by weight: 35 parts of corn flour, 10 parts of flour, 30 parts of soybean meal, 5 parts of chicken meal, 6 parts of fishbone meal, 1 part of salt and 1 part of cod-liver oil. The nutrient components also comprise the following raw material components in parts by weight: 10000IU/kg of vitamin A acetate, 3000IU/kg of vitamin D, 100IU/kg of vitamin E acetate, 15mg/kg of vitamin B, 5mg/kg of vitamin B, 50mg/kg of vitamin B, 30mg/kg of calcium pantothenate, 6mg/kg of vitamin B, 12.1 mg/kg of vitamin B, 250mg/kg of ferrous sulfate, 14mg/kg of copper sulfate, 60mg/kg of manganese sulfate, 60mg/kg of zinc sulfate, 0.15mg/kg of sodium selenite and 2mg/kg of calcium iodate.
Wherein, the weight portion ratio of the praziquantel 1 to the bait layer 2 to the waterproof layer 4 is 10:85:5.
the flavoring agent comprises disodium ribonucleotide;
the antioxidant is 2, 6-di-tert-butyl-p-cresol;
the preservative is sorbic acid.
The number of the air holes 3 is 8, and the diameter of the air holes 3 is 1mm.
The preparation method of the phagostimulant comprises the following steps:
s1, adding distilled water into fresh meat, grinding the fresh meat into pulp, heating, adjusting the pH value, adding papain to carry out enzymolysis to obtain fresh meat enzymolysis liquid;
s2, adding xylose, L-cysteine hydrochloride, phosphoric acid, a flavoring agent and an antioxidant into the fresh meat enzymolysis liquid, adjusting the pH value again, heating, and carrying out Maillard reaction to obtain a Maillard reaction product;
s3, adding Arabic gum and maltodextrin into the Maillard reaction product to prepare a mixture, and performing spray drying to prepare the phagostimulant.
In the step S1, heating is carried out until the temperature is 45 ℃, and the PH is adjusted to 6.5; the weight portion ratio of the fresh meat to the distilled water is 1:2.
in the step S2, the fresh meat enzymolysis liquid, xylose, L-cysteine hydrochloride, phosphoric acid, a flavoring agent and an antioxidant are mixed according to the following weight ratio of 100:4:1:1:5:0.05. adjusting pH again, heating to pH 5.0, heating to 115 deg.C, and Maillard reaction for 50min.
In step S3, the concentration of Maillard reaction products in the mixture is 32%; the gum arabic and the maltodextrin are mixed according to the weight part ratio of 1:8.
finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; such modifications and substitutions do not depart from the spirit and scope of the embodiments of the present invention, and they should be construed as being covered by the appended claims and their equivalents.
Claims (10)
1. A praziquantel pill that can be used for unmanned aerial vehicle to throw, its characterized in that: the praziquantel pill for the unmanned aerial vehicle to throw in consists of praziquantel, a bait layer and a waterproof layer, wherein the bait layer and the waterproof layer are sequentially wrapped outside the praziquantel from inside to outside; the bait layer consists of nutrient components, a phagostimulant and a preservative; the nutrient components comprise the following raw material components: corn flour, soybean meal, chicken meal, fishbone meal, salt and cod-liver oil; the nutrient components also comprise the following raw material components: vitamin A acetate, vitamin D3, vitamin E acetate, vitamin B1, vitamin B2, vitamin B3, calcium pantothenate, vitamin B6, vitamin B12, ferrous sulfate, copper sulfate, manganese sulfate, zinc sulfate, sodium selenite, and calcium iodate; the waterproof layer is one of wax, food-grade resin and food-grade anticorrosive nano-coating.
2. The praziquantel pill useful for drone delivery according to claim 1, wherein: the weight part ratio of the praziquantel to the bait layer to the waterproof layer is 10:85-81.2:5-8.8.
3. A praziquantel pellet for drone delivery according to claim 1, wherein: the nutrient components comprise the following raw material components in parts by weight: 35-40 parts of corn flour, 10-20 parts of flour, 30-35 parts of soybean meal, 5-6 parts of chicken powder, 6-8 parts of fishbone powder, 1 part of salt and 1-2 parts of cod-liver oil.
4. A praziquantel pellet for drone delivery according to claim 1, wherein: the nutrient components also comprise the following raw material components in parts by weight: 10000IU/kg of vitamin A acetate, 33000 IU/kg of vitamin D, 100IU/kg of vitamin E acetate, 115 mg/kg of vitamin B, 25 mg/kg of vitamin B, 350 mg/kg of vitamin B, 30mg/kg of calcium pantothenate, 66 mg/kg of vitamin B, 120.1 mg/kg of vitamin B, 250mg/kg of ferrous sulfate, 14mg/kg of copper sulfate, 60mg/kg of manganese sulfate, 60mg/kg of zinc sulfate, 0.15mg/kg of sodium selenite and 2mg/kg of calcium iodate.
5. The praziquantel pill useful for drone delivery according to claim 1, wherein: the preparation method of the phagostimulant comprises the following steps:
s1, adding distilled water into fresh meat, grinding the fresh meat into pulp, heating, adjusting the pH value, adding papain to carry out enzymolysis to obtain fresh meat enzymolysis liquid;
s2, adding xylose, L-cysteine hydrochloride, phosphoric acid, a flavoring agent and an antioxidant into the fresh meat enzymolysis liquid, adjusting the pH value again, heating, and carrying out Maillard reaction to obtain a Maillard reaction product;
s3, adding Arabic gum and maltodextrin into the Maillard reaction product to prepare a mixture, and performing spray drying to prepare the phagostimulant.
6. The praziquantel pill useful for drone delivery of claim 5, wherein: in the step S1, the heating is carried out to 45 ℃, and the PH is adjusted to 6.5; the weight part ratio of the fresh meat to the distilled water is 1:2.
7. the praziquantel pill useful for drone delivery of claim 5, wherein: in the step S2, the fresh meat enzymolysis liquid, xylose, L-cysteine hydrochloride, phosphoric acid, a flavoring agent and an antioxidant are mixed according to the following weight part ratio of 100:4:1:1:5:0.05; in step S2, the PH is adjusted again and heated to 5.0 and 115 ℃, and the Maillard reaction is carried out for 50min.
8. The praziquantel pill useful for drone delivery of claim 5, wherein: in the step S3, the concentration of Maillard reaction products in the mixture is 28-32%; the gum arabic and the maltodextrin are prepared from the following raw materials in parts by weight: 8.
9. the praziquantel pill useful for drone delivery according to claim 1, wherein: the flavoring agent comprises one or more of flavour nucleotide disodium and maltol; the antioxidant is 2, 6-di-tert-butyl-p-cresol; the preservative is one of sorbic acid and potassium sorbate.
10. The praziquantel pill useful for drone delivery according to claim 1, wherein: the number of the air holes is 4-8, and the diameter of the air holes is 1-2mm.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211144214.7A CN115487164B (en) | 2022-09-20 | 2022-09-20 | Praziquantel pill capable of being put in unmanned aerial vehicle |
| PCT/CN2023/110076 WO2024060838A1 (en) | 2022-09-20 | 2023-07-31 | Praziquantel pill suitable for distribution by unmanned aerial vehicles |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202211144214.7A CN115487164B (en) | 2022-09-20 | 2022-09-20 | Praziquantel pill capable of being put in unmanned aerial vehicle |
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| CN115487164A true CN115487164A (en) | 2022-12-20 |
| CN115487164B CN115487164B (en) | 2023-08-18 |
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| CN202211144214.7A Active CN115487164B (en) | 2022-09-20 | 2022-09-20 | Praziquantel pill capable of being put in unmanned aerial vehicle |
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| WO (1) | WO2024060838A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024060838A1 (en) * | 2022-09-20 | 2024-03-28 | 中农华威生物制药(湖北)有限公司 | Praziquantel pill suitable for distribution by unmanned aerial vehicles |
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| CN107496368A (en) * | 2016-06-14 | 2017-12-22 | 游锡火 | A kind of dog containing anti-parasite medicine and phagostimulant, cat pill |
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| CN108451912A (en) * | 2018-03-13 | 2018-08-28 | 南京制药厂有限公司 | A kind of praziquantel pill for animals and preparation method thereof |
| CN111214657A (en) * | 2018-11-23 | 2020-06-02 | 北京中农华威制药股份有限公司 | Soft capsule containing phagostimulant for dogs and cats |
| WO2022171150A1 (en) * | 2021-02-09 | 2022-08-18 | Tongli Biomedical Co., Ltd. | Methods and pharmaceutical composition for treating diseases |
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| CN201813753U (en) * | 2009-10-21 | 2011-05-04 | 麦汉平 | Waterproof type rat-exterminating poisoning bait |
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| CN112220769A (en) * | 2020-08-13 | 2021-01-15 | 浙江海正动物保健品有限公司 | Milbemycin oxime praziquantel flavored tablet and preparation method thereof |
| CN115487164B (en) * | 2022-09-20 | 2023-08-18 | 中农华威生物制药(湖北)有限公司 | Praziquantel pill capable of being put in unmanned aerial vehicle |
-
2022
- 2022-09-20 CN CN202211144214.7A patent/CN115487164B/en active Active
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- 2023-07-31 WO PCT/CN2023/110076 patent/WO2024060838A1/en unknown
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107496368A (en) * | 2016-06-14 | 2017-12-22 | 游锡火 | A kind of dog containing anti-parasite medicine and phagostimulant, cat pill |
| CN107510669A (en) * | 2016-06-16 | 2017-12-26 | 游锡火 | A kind of dog containing phagostimulant, cat dropping pill formulation |
| CN108451912A (en) * | 2018-03-13 | 2018-08-28 | 南京制药厂有限公司 | A kind of praziquantel pill for animals and preparation method thereof |
| CN111214657A (en) * | 2018-11-23 | 2020-06-02 | 北京中农华威制药股份有限公司 | Soft capsule containing phagostimulant for dogs and cats |
| WO2022171150A1 (en) * | 2021-02-09 | 2022-08-18 | Tongli Biomedical Co., Ltd. | Methods and pharmaceutical composition for treating diseases |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2024060838A1 (en) * | 2022-09-20 | 2024-03-28 | 中农华威生物制药(湖北)有限公司 | Praziquantel pill suitable for distribution by unmanned aerial vehicles |
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| Publication number | Publication date |
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| CN115487164B (en) | 2023-08-18 |
| WO2024060838A1 (en) | 2024-03-28 |
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