CN115487124A - 一种去除痘印用护肤组合物及其制备方法 - Google Patents
一种去除痘印用护肤组合物及其制备方法 Download PDFInfo
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- CN115487124A CN115487124A CN202111672932.7A CN202111672932A CN115487124A CN 115487124 A CN115487124 A CN 115487124A CN 202111672932 A CN202111672932 A CN 202111672932A CN 115487124 A CN115487124 A CN 115487124A
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Abstract
本发明涉及A61K8/92，具体涉及一种去除痘印用护肤组合物及其制备方法。包括以下原料：祛痘成分5‑10份，油性基体30‑40份，水性基体5‑10份。本发明提供的一种去除痘印用护肤组合物具有祛痘效果好，耐高低温稳定高，铺展性和渗透性好。
Description
技术领域
本发明涉及A61K8/92，具体涉及一种去除痘印用护肤组合物及其制备方法。
背景技术
随着生活压力的提高和生活作息不规律性，人们体内激素水平发生变化，皮脂的分泌增加，导致脸上不断的出现青春痘、粉刺、暗疮等各种皮肤问题，严重影响别人对己第一印象。
专利CN201510945279.5一种含中草药提取物的祛痘膏及其制备方法通过乳化剂，助乳化剂，油脂，抗氧化剂，促吸收剂，祛痘组合物，乳化增稠剂，保湿剂，防腐剂等物质对痤疮杆菌的抑制效果强，祛痘效果好，安全温和。
专利CN201510349175.8一种具有祛痘功效的中药提取物制剂及其制备方法通过中药醇提取物，中药水提取物和余量的乳膏相互配合制备的得到的制剂具有安全温和，祛痘功效明确等优异效果。
但现有技术中制备的祛痘产品由于起效慢，稳定性差等无法充分满足客户的需求。
发明内容
为了解决上述技术问题，本发明的第一个方面提供了一种去除痘印用护肤组合物，包括以下原料：按重量份计，祛痘成分5-10份，油性基体30-40份，水性基体5-10份。
祛痘成分
优选的，所述祛痘成分包括第一植物提取物，第二植物提取物，第三植物提取物，第四植物提取物。
优选的，所述第一植物提取物为含叶黄素的植物提取物。
优选的，所述含叶黄素的植物提取物中叶黄素的含量为85-92％。
优选的，所述含叶黄素的植物提取物来源于菊科植物金盏花的花瓣提取物。
进一步优选的，所述菊科植物金盏花的花瓣提取物为金盏花提取物。
优选的，所述第二植物提取物为含水杨甙的植物提取物。
优选的，所述含水杨甙的植物提取物中水杨甙的含量为55-65％。
优选的，所述含水杨甙的植物提取物为白柳树皮提取物。
优选的，所述第三植物提取物含盐酸小檗碱的植物提取物。
优选的，所述含盐酸小檗碱的植物提取物中盐酸小檗碱含量为95-99％。
优选的，所述含盐酸小檗碱的植物提取物为黄檗皮提取物。
优选的，所述第四植物提取物来源于真菌类子囊菌纲肉座菌科竹黄属真菌竹黄。
优选的，所述第四植物提取物采用喷雾干燥法制备。
优选的，所述第四植物提取物为天竺黄提取物。
优选的，所述第一植物提取物，第二植物提取物，第三植物提取物，第四植物提取物的质量比为(3-5)：(5-8)：(3-5)：(1-2)。
油性基体
优选的，所述油性基体包括亚麻油，蓖麻油，乳木果油，异壬酸异壬酯，辛酸/癸酸甘油三酯，聚硅氧烷的至少一种。
进一步优选的，所述油性基体包括异壬酸异壬酯，聚硅氧烷。所述异壬酸异壬酯，聚硅氧烷的质量比为(3-4)：(5-7)。
优选的，所述聚硅氧烷在25℃下的粘度为3.9mm2/s。
优选的，所述聚硅氧烷为环五聚二甲基硅氧烷。
水性基体
优选的，所述水性基体包括山梨糖醇、D-泛醇、尿囊素，聚苯乙烯磺酸钠的至少一种。
进一步优选的，所述水性基体包括山梨糖醇、D-泛醇。所述山梨糖醇、D-泛醇的质量比为(3-4)：(5-8)。
优选的，所述去除痘印用护肤组合物还包括以下原料乳化剂3-5份，增稠剂0.5-1份，水100份。
优选的，所述乳化体系包括鲸蜡硬脂醇聚醚，脂肪酸甘油酯，聚丙烯酰胺，C13-14异链烷烃，月桂醇聚醚-7的至少一种。
优选的，所述乳化体系包括脂肪酸甘油酯，聚丙烯酰胺，C13-14异链烷烃，月桂醇聚醚-7。
优选的，所述脂肪酸甘油酯的质量与聚丙烯酰胺，C13-14异链烷烃，月桂醇聚醚-7的总质量比为(3-5)：(3-5)。
优选的，所述脂肪酸甘油酯为硬脂酸甘油酯。所述硬脂酸甘油酯包括单硬脂酸甘油酯，双硬脂酸甘油酯，三硬脂酸甘油酯的至少一种。
进一步优选的，所述硬脂酸甘油酯为单硬脂酸甘油酯。
优选的，所述增稠剂包括黄原胶、卡波姆、丙烯酸钠/丙烯酰二甲基牛磺酸钠共聚物和异十六烷和聚山梨醇酯-80、纤维素的至少一种。
进一步优选的，所述增稠剂包括黄原胶和纤维素。所述黄原胶和纤维素的质量比为(5-7)：(2-4)。
优选的，所述黄原胶在25℃时1wt％黄原胶水溶液的粘度为800-1300mPa.s。
优选的，所述纤维素为羟乙基纤维素，所述羟乙基纤维素的摩尔取代度为1.8-2.2。所述纤维素在20℃时2wt％纤维素水溶液的粘度为30000-32000mPa.s。
本发明的第二个方面提供了一种去除痘印用护肤组合物的制备方法，包括以下步骤：将祛痘成分与油性基体混合均匀形成油相，然后将水性基体与水混合均匀形成水相；将油相与水相混合，然后加入乳化剂搅拌混合均匀，再加入增稠剂即得。
有益效果：
1)本发明通过对体系中不同原料种类和含量的进一步限定，通过不同组分之间的相互作用制备得到的去除痘印用护肤组合物具有祛痘效果强，稳定高，铺展性和渗透性好等众多优异效果。
2)本发明通过含叶黄素为85-92％的金盏花提取物，含水杨甙为55-65％的白柳树皮提取物，含盐酸小檗碱为95-99％黄檗皮提取物以及天竺黄提取物之间的相互配合，并限定植物提取物中主要成分的含量及植物提取物的具体种类，避免不正常的角质堆积，促进表皮细胞的活化与更新，抑制痤疮杆菌的繁殖，加速痤疮炎性病灶的缓解，有效去除粉刺，促进表皮细胞的活化与更新，淡化痘疤，提高抗氧化和保湿效果，改善皮肤健康。
3)本发明意外研究发现由于本发明中采取了多种植物提取物，植物提取物中的叶黄素等物质以及体系中的D-泛醇稳定差，易受氧、光、热、金属离子、pH等因素的影响，本发明通过环五聚二甲基硅氧烷的长分子链对其形成一定的包裹，提高体系的稳定性，同时与皮肤接触时携带抗菌，修复成分有效铺展到皮肤表面，加快起效时间，同时本发明采用异壬酸异壬酯，环五聚二甲基硅氧烷复配的形式，增加了多甲基支链结构，有效提高去除痘印用护肤组合物在低温下的稳定性，有效避免聚硅氧烷析出。
4)本发明单硬脂酸甘油酯与体系中植物提取物等抗菌，修复成分之间相互作用，提高对痤疮杆菌的抑制效果，同时和体系中聚丙烯酰胺，C13-14异链烷烃，月桂醇聚醚-7，促进植物提取物中含有的果酸等酸性成分的稳定性，防止由于脂肪酸甘油酯含量过高，导致体系的稳定性降低。
5)本发明通过山梨糖醇和D-泛醇进一步提高了去除痘印用护肤组合物的保湿作用，同时本发明中含有高含量的叶黄素，一方面可以防止D-泛醇过快失效，促进D-泛醇进入人体转化，提高修复痘印效果；另一方面与体系中环五聚二甲基硅氧烷相互作用，保持较高抗氧化效果的同时，避免叶黄素含量过多在皮肤表面形成沉积，导致皮肤发黄变暗。
具体实施方式
实施例
实施例1
一种去除痘印用护肤组合物，包括以下原料：按重量份计，祛痘成分8份，油性基体35份，水性基体8份。
所述祛痘成分包括第一植物提取物，第二植物提取物，第三植物提取物，第四植物提取物。
所述第一植物提取物为含叶黄素的植物提取物。所述含叶黄素的植物提取物中叶黄素的含量为90％。所述含叶黄素的植物提取物来源于菊科植物金盏花的花瓣提取物。所述菊科植物金盏花的花瓣提取物为金盏花提取物(Calendula officinalis L.)。所述第一植物提取物购自西安超邦生物科技有限公司。
所述第二植物提取物为含水杨甙的植物提取物。所述含水杨甙的植物提取物中水杨甙的含量为60％。所述含水杨甙的植物提取物为白柳树皮提取物(Salix alba L.)。所述第二植物提取物购自河南宜新生物科技有限公司。
所述第三植物提取物含盐酸小檗碱的植物提取物。所述含盐酸小檗碱的植物提取物中盐酸小檗碱含量为95-99％。所述含盐酸小檗碱的植物提取物为黄檗皮提取物(CortexPhellodendriChinensis)。所述第三植物提取物购自宁夏香草生物技术有公司。
所述第四植物提取物来源于真菌类子囊菌纲肉座菌科竹黄属真菌竹黄。所述第四植物提取物采用喷雾干燥法制备。所述第四植物提取物为天竺黄提取物(ShiraiabambusicolaHenn.)。所述第四植物提取物购自宁夏香草生物技术有公司，规格为10:1。
所述第一植物提取物，第二植物提取物，第三植物提取物，第四植物提取物的质量比为4：7：3.5：1.5。
所述油性基体包括异壬酸异壬酯，聚硅氧烷。所述异壬酸异壬酯，聚硅氧烷的质量比为3.5：6.5。所述聚硅氧烷在25℃下的粘度为3.9mm2/s。所述聚硅氧烷为环五聚二甲基硅氧烷，购自安徽艾约塔硅油有限公司。
所述水性基体包括山梨糖醇、D-泛醇。所述山梨糖醇、D-泛醇的质量比为3：7。所述山梨糖醇购自广州花之王化工有限公司，所述D-泛醇购自广州科泰化工有限公司。
所述去除痘印用护肤组合物还包括以下原料乳化剂4份，增稠剂0.8份，水100份。
所述乳化体系包括脂肪酸甘油酯，聚丙烯酰胺，C13-14异链烷烃，月桂醇聚醚-7。所述脂肪酸甘油酯的质量与聚丙烯酰胺，C13-14异链烷烃，月桂醇聚醚-7的总质量比为3.5：4.5。所述脂肪酸甘油酯为硬脂酸甘油酯。所述硬脂酸甘油酯为单硬脂酸甘油酯，购自济南金旭缘新材料有限公司。所述聚丙烯酰胺，C13-14异链烷烃，月桂醇聚醚-7来源于305乳化剂，购自广州美懿生物科技有限公司。
所述增稠剂包括黄原胶和纤维素。所述黄原胶和纤维素的质量比为6：3。所述黄原胶在25℃时1wt％黄原胶水溶液的粘度为800-1300mPa.s，购自上海舜水化工有限公司，型号：Keltrol CGT。所述纤维素为羟乙基纤维素，所述羟乙基纤维素的摩尔取代度为2.0。所述纤维素在20℃时2wt％纤维素水溶液的粘度为30000-32000mPa.s。所述纤维素购自肥城雨田化工有限公司。
一种去除痘印用护肤组合物的制备方法，包括以下步骤：将祛痘成分与油性基体混合均匀形成油相，然后将水性基体与水混合均匀形成水相；将油相与水相混合，然后加入乳化剂搅拌混合均匀，再加入增稠剂即得。
实施例2
一种去除痘印用护肤组合物，具体实施方式同实施例1，不同之处在于所述脂肪酸甘油酯的质量与聚丙烯酰胺，C13-14异链烷烃，月桂醇聚醚-7的总质量比为5：5。
实施例3
一种去除痘印用护肤组合物，具体实施方式同实施例1，不同之处在于所述祛痘成分5份，油性基体30份，水性基体5份，乳化剂3份，增稠剂0.5份，水100份。
对比例1
一种去除痘印用护肤组合物，具体实施方式同实施例1，不同之处在于所述异壬酸异壬酯，聚硅氧烷的质量比为1.5：6.5。
对比例2
一种去除痘印用护肤组合物，具体实施方式同实施例1，不同之处在于所述第一植物提取物，第二植物提取物，第三植物提取物，第四植物提取物的质量比为1：7：3.5：1.5。
性能测试
1.抑菌性测试：将1g试样与0.1mL痤疮丙酸杆菌悬液菌悬液(104-106CFU/mL)均匀涂布混合，20min后加入9mL磷酸盐缓冲液(0.03mol/L)充分混匀得到混合物，稀释后取1mL混合物置于含有培养基的平行皿中，在36±1℃厌氧条件下培养24h，计算菌落数，并设置空白对照组，上述试验重复3次，取平均值，抑菌率＝(试样品平均菌落数-空白对照菌落数)/试样品平均菌落数×100％。
2.稳定性测试：将试样在一定温度(高温45℃，低温-5℃)下放置2周，观察有无沉淀、析出、变色。
3.铺展性：在温度为25℃，相对湿度为45％的条件下进行测试，将10uL试样滴在距离手臂弯曲处6cm的前臂，保持前臂水平1min，用笔将试样扩散的外边缘画出，测量椭圆的半长轴a，半短轴b，平行测试三次取平均值，铺展性＝(Π*a*b)/10uL*1min。
表1性能测试结果
Claims (10)
1.一种去除痘印用护肤组合物，其特征在于，包括以下原料：按重量份计，祛痘成分5-10份，油性基体30-40份，水性基体5-10份。
2.根据权利要求1所述的一种去除痘印用护肤组合物，其特征在于，所述祛痘成分包括第一植物提取物，第二植物提取物，第三植物提取物，第四植物提取物。
3.根据权利要求2所述的一种去除痘印用护肤组合物，其特征在于，所述第一植物提取物为含叶黄素的植物提取物。
4.根据权利要求3所述的一种去除痘印用护肤组合物，其特征在于，所述含叶黄素的植物提取物中叶黄素的含量为85-92wt％。
5.根据权利要求2所述的一种去除痘印用护肤组合物，其特征在于，所述第二植物提取物为含水杨甙的植物提取物。
6.根据权利要求1所述的一种去除痘印用护肤组合物，其特征在于，所述油性基体包括亚麻油，蓖麻油，乳木果油，异壬酸异壬酯，辛酸/癸酸甘油三酯，聚硅氧烷的至少一种。
7.根据权利要求1所述的一种去除痘印用护肤组合物，其特征在于，所述水性基体包括山梨糖醇、D-泛醇、尿囊素，聚苯乙烯磺酸钠的至少一种。
8.根据权利要求1-7任一项所述的一种去除痘印用护肤组合物，其特征在于，所述去除痘印用护肤组合物还包括以下原料乳化剂3-5份，增稠剂0.5-1份，水100份。
9.根据权利要求8所述的一种去除痘印用护肤组合物，其特征在于，所述乳化剂包括鲸蜡硬脂醇聚醚，脂肪酸甘油酯，聚丙烯酰胺，C13-14异链烷烃，月桂醇聚醚-7的至少一种。
10.一种根据权利要求8所述的一种去除痘印用护肤组合物的制备方法，其特征在于，包括以下步骤：将祛痘成分与油性基体混合均匀形成油相，然后将水性基体与水混合均匀形成水相；将油相与水相混合，然后加入乳化剂搅拌混合均匀，再加入增稠剂即得。
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| CN106265264A (zh) * | 2016-08-26 | 2017-01-04 | 珀莱雅化妆品股份有限公司 | 一种祛痘组合物及其制备方法 |
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| CN108096142A (zh) * | 2017-12-30 | 2018-06-01 | 广州市中通生化制品有限公司 | 一种高效祛痘精华素及其制备方法 |
| CN110393694A (zh) * | 2019-08-20 | 2019-11-01 | 广州博今生物科技有限公司 | 一种草本植萃祛痘精华液 |
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