CN115485282A - 一种氧氮杂螺环化合物、其盐型及其晶型 - Google Patents
一种氧氮杂螺环化合物、其盐型及其晶型 Download PDFInfo
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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Abstract
涉及一种氧氮杂螺环化合物、其盐型及其晶型。具体涉及化合物Ⅲ及其药学上可接受的盐，及其盐型的晶型以及制备方法，及其作为LSD1抑制剂在治疗血液肿瘤、小细胞肺癌、鳞状非小细胞肺癌、乳腺癌、前列腺癌、肝癌、胰腺癌、胶质瘤或尤文氏肉瘤等疾病中的应用。
Description
PCT国内申请，说明书已公开。
Claims (17)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110179260X | 2021-02-09 | ||
| CN202110179260 | 2021-02-09 | ||
| PCT/CN2022/075259 WO2022171044A1 (zh) | 2021-02-09 | 2022-01-30 | 一种氧氮杂螺环化合物、其盐型及其晶型 |
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|---|---|
| CN115485282A true CN115485282A (zh) | 2022-12-16 |
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| CN202280003890.4A Pending CN115485282A (zh) | 2021-02-09 | 2022-01-30 | 一种氧氮杂螺环化合物、其盐型及其晶型 |
Country Status (2)
| Country | Link |
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| CN (1) | CN115485282A (zh) |
| WO (1) | WO2022171044A1 (zh) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023217784A1 (en) | 2022-05-09 | 2023-11-16 | Oryzon Genomics, S.A. | Methods of treating nf1-mutant tumors using lsd1 inhibitors |
| WO2023217758A1 (en) | 2022-05-09 | 2023-11-16 | Oryzon Genomics, S.A. | Methods of treating malignant peripheral nerve sheath tumor (mpnst) using lsd1 inhibitors |
| WO2024110649A1 (en) | 2022-11-24 | 2024-05-30 | Oryzon Genomics, S.A. | Combinations of lsd1 inhibitors and menin inhibitors for treating cancer |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103857393B (zh) * | 2011-03-25 | 2016-08-17 | 葛兰素史密斯克莱知识产权（第2号）有限公司 | 环丙基胺作为lsd1抑制剂 |
| CN107266345B (zh) * | 2011-10-20 | 2021-08-17 | 奥瑞泽恩基因组学股份有限公司 | 作为lsd1抑制剂的(杂)芳基环丙胺化合物 |
| EP3455204A1 (en) * | 2016-05-09 | 2019-03-20 | Jubilant Biosys Ltd. | Cyclopropyl-amide compounds as dual lsd1/hdac inhibitors |
| EP3851440A4 (en) * | 2018-09-13 | 2022-06-08 | Helioeast Pharmaceutical Co., Ltd. | CYCLOPROPYLAMINE COMPOUND AS AN LSD1 INHIBITOR AND USE OF IT |
-
2022
- 2022-01-30 WO PCT/CN2022/075259 patent/WO2022171044A1/zh active Application Filing
- 2022-01-30 CN CN202280003890.4A patent/CN115485282A/zh active Pending
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| Publication number | Publication date |
|---|---|
| WO2022171044A1 (zh) | 2022-08-18 |
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