CN1154497C - 治疗肝脏肿瘤的方法和其中所用的药学组合物 - Google Patents

治疗肝脏肿瘤的方法和其中所用的药学组合物 Download PDF

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Publication number
CN1154497C
CN1154497C CNB988067609A CN98806760A CN1154497C CN 1154497 C CN1154497 C CN 1154497C CN B988067609 A CNB988067609 A CN B988067609A CN 98806760 A CN98806760 A CN 98806760A CN 1154497 C CN1154497 C CN 1154497C
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China
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vitamin
cancer
liver
compound
medicament
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Expired - Fee Related
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CNB988067609A
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English (en)
Chinese (zh)
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CN1261800A (zh
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��ά����ɭ��Ī��˹
戴维·劳森·莫利斯
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MRC HOLDING CO Ltd
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Unisearch Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
CNB988067609A 1997-06-10 1998-06-10 治疗肝脏肿瘤的方法和其中所用的药学组合物 Expired - Fee Related CN1154497C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPO7270A AUPO727097A0 (en) 1997-06-10 1997-06-10 Method of treatment of hepatoma and pharmaceutical compositions for use therein
AUPO7270 1997-06-10

Publications (2)

Publication Number Publication Date
CN1261800A CN1261800A (zh) 2000-08-02
CN1154497C true CN1154497C (zh) 2004-06-23

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Family Applications (1)

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CNB988067609A Expired - Fee Related CN1154497C (zh) 1997-06-10 1998-06-10 治疗肝脏肿瘤的方法和其中所用的药学组合物

Country Status (8)

Country Link
US (1) US6486144B1 (https=)
EP (1) EP1003523A4 (https=)
JP (1) JP2002504100A (https=)
KR (1) KR100382219B1 (https=)
CN (1) CN1154497C (https=)
AU (1) AUPO727097A0 (https=)
WO (1) WO1998056387A1 (https=)
ZA (1) ZA985028B (https=)

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* Cited by examiner, † Cited by third party
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US6538037B2 (en) 1991-01-08 2003-03-25 Bone Care International, Inc. Methods for preparation and use of 1α,24(S)-dihydroxyvitamin D2
US6573256B2 (en) 1996-12-30 2003-06-03 Bone Care International, Inc. Method of inhibiting angiogenesis using active vitamin D analogues
US6566353B2 (en) 1996-12-30 2003-05-20 Bone Care International, Inc. Method of treating malignancy associated hypercalcemia using active vitamin D analogues
US6503893B2 (en) 1996-12-30 2003-01-07 Bone Care International, Inc. Method of treating hyperproliferative diseases using active vitamin D analogues
US6087350A (en) 1997-08-29 2000-07-11 University Of Pittsburgh Of The Commonwealth System Of Higher Education Use of pretreatment chemicals to enhance efficacy of cytotoxic agents
AUPP332898A0 (en) * 1998-05-04 1998-05-28 Unisearch Limited Pharmaceutical composition
AU765846B2 (en) * 1998-05-04 2003-10-02 Mrc Holdings Pty Limited Pharmaceutical composition
US20030031670A1 (en) * 1999-11-08 2003-02-13 Jack R. Wands Diagnosis and treatment of malignant neoplasms
AU1917101A (en) * 1999-11-11 2001-06-06 Eli Lilly And Company Oncolytic combinations for the treatment of cancer
DE10032587A1 (de) * 2000-07-05 2002-01-17 Bayer Ag 4-Alkoxy-cyclohexan-1-amino-carbonsäureester und Verfahren zu ihrer Herstellung
AU781168B2 (en) * 2001-01-26 2005-05-12 Pfizer Products Inc. Method of treating certain cancers using an estrogen agonist/antagonist
WO2002076454A1 (en) * 2001-03-26 2002-10-03 Unisearch Limited Method for treatment of cancer and compositions for use therein
JP2004026811A (ja) * 2002-04-30 2004-01-29 Kiyoshi Hashizume ビタミンｄ３誘導体を含有する抗癌作用を増強させるための薬剤
AU2002330482A1 (en) 2002-09-04 2004-03-29 Perseus Proteomics Inc. Method of diagnosing cancer by detecting gpc3
WO2004047673A2 (en) * 2002-11-21 2004-06-10 Novacea, Inc. Treatment of liver disease with active vitamin d compounds
WO2005027918A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a cyclooxgenase-2 inhibitor
WO2005027928A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. 2-alkylidene-19-nor-vit amin d derivatives for the treatment of hypocalcemic tetany or hyproparathyroidism
WO2005027922A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. 2-alkylidene-19-nor-vitamin d derivatives for the treatment of hypogonadism or andropause
WO2005027916A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and aromatase inhibitors
BRPI0414448A (pt) * 2003-09-19 2006-11-14 Pfizer Prod Inc composições farmacêuticas e métodos compreendendo combinações de derivados de 2-alquilideno-19-nor-vitamina d e um agonista/antagonista de estrogênio
US7094775B2 (en) 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
JP4248544B2 (ja) * 2005-12-19 2009-04-02 株式会社椿本チエイン 伝動装置用可動ガイド
CN102655869B (zh) * 2009-08-14 2016-08-10 博格有限责任公司 用于治疗脱发的维生素d3及其类似物
CN105473147A (zh) 2013-04-24 2016-04-06 萨克生物研究学院 维生素d受体/smad基因组回路门纤维化反应
WO2014197680A1 (en) * 2013-06-05 2014-12-11 Salk Institute For Biological Studies Vitamin d receptor agonists to treat diseases involving cxcl12 activity
JP2016124818A (ja) * 2014-12-26 2016-07-11 日本化薬株式会社 転移性肝癌治療薬及び転移性肝癌の治療方法
WO2016167977A1 (en) 2015-04-14 2016-10-20 Mayo Foundation For Medical Education And Research Methods and materials for delivering agents to liver tissue
WO2019023149A1 (en) 2017-07-24 2019-01-31 Salk Institute For Biological Studies USE OF BROMODOMAIN-CONTAINING PROTEIN-9 ANTAGONISTS IN ASSOCIATION WITH VITAMIN D RECEPTOR AGONISTS IN THE TREATMENT OF DIABETES
CN116059364B (zh) * 2021-11-04 2025-07-11 上海健康医学院 Dhcr7下调剂在减弱酒精诱导的肝脏肿瘤中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3865544D1 (de) 1987-06-23 1991-11-21 Yamanouchi Pharma Co Ltd Vitamin d3-derivate.
US4927815A (en) * 1988-04-29 1990-05-22 Wisconsin Alumni Research Foundation Compounds effective in inducing cell differentiation and process for preparing same
US5798345A (en) 1990-09-21 1998-08-25 Bone Care International, Inc. Method of inhibiting the hyperproliferation of malignant cells
RU2153491C2 (ru) * 1993-07-09 2000-07-27 Лаборатуар Терамекс С.А. Аналоги витамина d, соединения, способы их получения и фармацевтическая композиция
US5856189A (en) * 1997-01-07 1999-01-05 The Regents Of The University Of Michigan Cell culture model for drug bioavailability

Also Published As

Publication number Publication date
US6486144B1 (en) 2002-11-26
HK1030144A1 (en) 2001-04-27
JP2002504100A (ja) 2002-02-05
AUPO727097A0 (en) 1997-07-03
ZA985028B (en) 1999-01-25
EP1003523A1 (en) 2000-05-31
CN1261800A (zh) 2000-08-02
WO1998056387A1 (en) 1998-12-17
KR20010013651A (ko) 2001-02-26
KR100382219B1 (ko) 2003-04-26
EP1003523A4 (en) 2001-08-22

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