CN115414433B

CN115414433B - Vegetable oil compound soft capsule with health care effect and preparation method thereof

Info

Publication number: CN115414433B
Application number: CN202210377899.3A
Authority: CN
Inventors: 胡新民; 范子荣; 戴福林
Original assignee: Guangdong Yikang Biotechnology Co ltd
Current assignee: Guangdong Yikang Biotechnology Co ltd
Priority date: 2021-10-14
Filing date: 2022-04-12
Publication date: 2023-08-18
Anticipated expiration: 2042-04-12
Also published as: CN115414433A

Abstract

The application provides a vegetable oil compound soft capsule with health care effect and a preparation method thereof, and relates to the technical field of health care products. The application uses sea buckthorn seed oil, grape seed oil, pomegranate seed oil and camellia seed oil as main raw materials, and cooperates with perilla seed oil and evening primrose oil to be blended to prepare capsule contents, and the capsule contents are mixed with glue solution prepared from edible gelatin, edible glycerol, polyethylene glycol, water and the like to prepare the compound capsule. According to the Chinese medicine theory of monarch, minister, assistant and guide, the special performances of various raw materials are fully utilized by optimizing the proportion, so that the effects of beautifying, losing weight and enhancing organism immunity are provided, and the Chinese medicine composition is suitable for long-term administration.

Description

Vegetable oil compound soft capsule with health care effect and preparation method thereof

Technical Field

The application relates to the technical field of health products, in particular to a vegetable oil compound soft capsule with health care effect and a preparation method thereof.

Background

The camellia seed oil is an extract obtained by extracting camellia seeds serving as raw materials, is rich in unsaturated fatty acid, particularly oleic acid accounting for more than 80%, and is known as the eastern olive oil. The camellia seed oil has the effects of preventing thrombus, can help to remove cholesterol in serum, increase vascular permeability, can assist in treating arteriosclerosis and cardiovascular and cerebrovascular diseases, prevent senile dementia, clear gastrointestinal tract, improve body immunity, prevent some diseases, maintain beauty and keep young, contain abundant vitamins, have an antioxidant effect, and can prevent skin aging.

Pomegranate seed oil is the only polyunsaturated conjugated fatty acid of vegetable origin and contains six major fatty acids: punicic acid, linolenic acid, linoleic acid, oleic acid, palmitic acid, and stearic acid, wherein punicic acid content is about 80% or more. Punicic acid is omega-3 type highly unsaturated fatty acid, is the most ideal component for supplementing omega-3 series unsaturated fatty acid which is lacking in human body like linolenic acid, and has more functionality than conjugated linoleic acid in general because the structure of punicic acid is closest to Conjugated Linoleic Acid (CLA), which is often called super conjugated linoleic acid. Omega-3 unsaturated fatty acid is necessary factor for maintaining brain and nerve function, and has effects of resisting thrombosis, reducing blood lipid, preventing canceration, inhibiting tumor cell metastasis, inhibiting allergic diseases, and prolonging life after long-term use. Punicic acid can increase mitochondrial activity of brown adipocytes to consume excessive calories in the body, thereby having weight-losing effect. The pomegranate seed oil contains punica granatum acid and multiple vitamins, and has effects of inhibiting bacterial growth, promoting metabolism of skin cells, enhancing cell activity, regulating fat metabolism, promoting excretion of toxic substances caused by fat metabolism disorder through skin, removing endotoxin, and removing enterotoxin.

Grape seed oil contains abundant unsaturated fatty acids, mainly oleic acid and linoleic acid, wherein the content of linoleic acid is up to more than 70%. Linoleic acid is a necessary fatty acid for human body, is easy to be absorbed by human body, can reduce serum cholesterol of human body after long-term eating of grape seed oil, and effectively regulates the autonomic nerve function of human body. In addition, the grape seed oil also contains a plurality of beneficial components such as fatty acid, vitamin E and the like which are necessary for human bodies, and has the effects of reducing cholesterol, preventing cardiovascular diseases, resisting aging and the like.

The sea buckthorn seed oil is prepared from sea buckthorn seed as raw material by supercritical low temperature extraction method, and is generally brown yellow to brownish red transparent oily liquid containing 140 or more bioactive components such as sea buckthorn total flavonoids, organic acids, unsaturated fatty acids, carotene, alkaloids, sterols, triterpenes, various vitamins, etc. The oleum Hippophae has effects of resisting aging, relieving inflammation, promoting granulation, promoting digestion, and protecting liver.

In the prior art, a health care product prepared from single-component vegetable oil has single efficacy, and is difficult to fully meet the health requirements of people. Chinese patent CN 101810339 discloses a formulation of a compound antioxidant edible soft capsule, which is prepared from seabuckthorn seed oil as a raw material, but only plays an antioxidant role. Chinese patent CN 110393759 discloses a camellia oil health-care capsule and a preparation method thereof, and the embodiment shows that the health-care capsule has a good antibacterial effect, but no specific data indicates that the health-care capsule has other effects. Therefore, a product needs to be researched, the special components of four vegetable oils are fully utilized, the synergistic effect is exerted, multiple health care functions are given to the product, and the further requirements of people on health are met.

Disclosure of Invention

In order to solve the technical problems, the application provides a vegetable oil compound soft capsule with health care effect and a preparation method thereof, wherein sea buckthorn seed oil, grape seed oil, pomegranate seed oil and camellia seed oil are used as main raw materials, and are blended together with perilla seed oil and evening primrose oil to prepare capsule contents, and the capsule contents are prepared into compound capsules together with glue solution prepared from edible gelatin, edible glycerol, polyethylene glycol, water and the like. The application adopts the sea buckthorn seed oil as a monarch drug, the grape seed oil as a ministerial drug, and the pomegranate seed oil, the camellia seed oil, the perilla seed oil and the evening primrose oil as auxiliary materials for blending, thereby endowing the application with the effects of losing weight and enhancing immunity and health care.

In order to achieve the above purpose, the present application provides the following technical solutions:

on the one hand, the application provides a vegetable oil compound soft capsule with health care effect, which is prepared from the following raw materials in parts by weight: sea buckthorn seed oil, grape seed oil, pomegranate seed oil, camellia seed oil, perilla seed oil, evening primrose oil, edible gelatin, edible glycerol, polyethylene glycol, titanium dioxide and water.

Further, the vegetable oil compound soft capsule with the health care effect is prepared from the following raw materials in parts by weight: 3-100 parts of sea buckthorn seed oil, 3-100 parts of grape seed oil, 3-100 parts of pomegranate seed oil, 60-500 parts of camellia seed oil, 1-100 parts of perilla seed oil, 1-100 parts of evening primrose oil, 20-500 parts of edible gelatin, 20-500 parts of edible glycerol, 20-500 parts of polyethylene glycol, 20-500 parts of titanium dioxide and 200-1000 parts of water.

Further, the vegetable oil compound soft capsule with the health care effect is prepared from the following raw materials in parts by weight: 10-50 parts of sea buckthorn seed oil, 10-50 parts of grape seed oil, 10-50 parts of pomegranate seed oil, 100-200 parts of camellia seed oil, 10-50 parts of perilla seed oil, 10-50 parts of evening primrose oil, 100-300 parts of edible gelatin, 100-300 parts of edible glycerol, 50-200 parts of polyethylene glycol, 10-100 parts of titanium dioxide and 500 parts of water.

Further, the application provides a vegetable oil compound soft capsule with health care effect, which is prepared from the following raw materials in parts by weight: 30 parts of sea buckthorn seed oil, 30 parts of grape seed oil, 30 parts of pomegranate seed oil, 180 parts of camellia seed oil, 15 parts of perilla seed oil, 15 parts of evening primrose oil, 200 parts of edible gelatin, 200 parts of edible glycerol, 100 parts of polyethylene glycol, 30 parts of titanium dioxide and 500 parts of water.

On the other hand, the application provides a preparation method of a vegetable oil compound soft capsule with health care effect, which comprises the following steps:

1) Measuring sea buckthorn seed oil, grape seed oil, pomegranate seed oil, camellia seed oil, perilla seed oil and evening primrose oil, pouring the sea buckthorn seed oil, the grape seed oil, the pomegranate seed oil, the camellia seed oil, the perilla seed oil and the evening primrose oil into a reaction kettle, introducing ozone for sterilization and disinfection, uniformly stirring, and vacuumizing and defoaming to obtain capsule contents;

2) Weighing a certain amount of edible gelatin, edible glycerol, purified water, polyethylene glycol and titanium dioxide, putting into a reaction kettle, uniformly stirring, heating, preserving heat, vacuumizing, and controlling water to obtain a glue solution;

3) Pouring the capsule content prepared in the step 1) and the glue solution prepared in the step 2) into a soft capsule machine to prepare a soft capsule primary product;

4) And (3) drying the soft capsule primary product prepared in the step (3) in a roller dryer, washing, drying, bottling and packaging to obtain a vegetable oil compound soft capsule finished product.

Further, the total water content of the finished product of the vegetable oil compound soft capsule is less than or equal to 0.5 percent.

Further, the temperature in step 1) should be controlled between 20 ℃ and 25 ℃.

Further, the heat preservation temperature in the step 2) is 40-80 ℃, and the heat preservation time is 0.1-3.0 hours; the moisture is controlled to be 20% -50%.

Further, the specification of the content in the soft capsule is 0.5g-1.0 g/granule.

Still further, the vacuum degree in step 2) is 0.01 to 0.5MPa, preferably, the vacuum degree in step 2) is 0.01 to 0.3MPa, and in particular, the vacuum degree in step 2) is 0.01 to 0.2MPa.

Still further, the moisture in step 2) is controlled to 20% -50%, preferably the moisture in step 2) is controlled to 25% -45%, in particular the moisture in step 2) is controlled to 30% -40%.

Further, the drying temperature in step 4) is 15-30 ℃, preferably the drying temperature in step 4) is 18-25 ℃, in particular the drying temperature in step 4) is 18-20 ℃.

Further, the drying time in step 4) is 4 to 24 hours, preferably 8 to 20 hours in step 4), and in particular 8 to 16 hours in step 4).

Further, the concentration of the ozone gas is 30-40 mg/L.

Further, the soft capsule specification in step 4) is 0.1g to 1.0 g/granule, preferably the soft capsule specification in step 4) is 0.15g to 0.85 g/granule, and in particular, the soft capsule specification in step 4) is 0.5g to 1.0 g/granule.

Compared with the prior art, the technical scheme provided by the application has the following beneficial effects:

(1) According to the application, sea buckthorn seed oil, grape seed oil, pomegranate seed oil and camellia seed oil are used as raw materials, and the special performances of the raw materials are fully utilized by optimizing the proportion according to the Chinese medicine theory of monarch, minister, assistant and guide, so that the effects of beautifying, losing weight and enhancing the immunity of organisms are provided;

(2) By adding the perilla seed oil and the evening primrose oil, the sea buckthorn seed oil, the grape seed oil, the pomegranate seed oil and the camellia seed oil are promoted to be blended, the immunity enhancing function of all special components of various raw materials is fully exerted, and the health care effect of the application is improved;

(3) The application takes edible gelatin, edible glycerol, polyethylene glycol and titanium dioxide as raw materials to prepare the glue solution, ensures that the glue solution is safe and nontoxic, has better mechanical strength and toughness, and is easy to disintegrate and be absorbed under the action of gastric juice after entering human bodies;

(4) The application has scientific compatibility of raw materials, simple preparation process, low production cost and convenient administration, and is suitable for long-term administration.

Detailed Description

The present application will be further described in detail with reference to the following embodiments, in order to make the objects, technical solutions and advantages of the present application more apparent. It should be understood that the description is only illustrative and is not intended to limit the scope of the application. In addition, in the following description, descriptions of well-known structures and techniques are omitted so as not to unnecessarily obscure the present application.

Example 1

The vegetable oil compound soft capsule with the health care effect is prepared from the following raw materials in parts by weight: 30 parts of sea buckthorn seed oil, 30 parts of grape seed oil, 30 parts of pomegranate seed oil, 180 parts of camellia seed oil, 15 parts of perilla seed oil, 15 parts of evening primrose oil, 200 parts of edible gelatin, 200 parts of edible glycerol, 100 parts of polyethylene glycol, 30 parts of titanium dioxide and 500 parts of water.

A preparation method of a compound vegetable oil soft capsule with health care effect comprises the following steps:

1) Measuring sea buckthorn seed oil, grape seed oil, pomegranate seed oil, camellia seed oil, perilla seed oil and evening primrose oil, controlling the temperature between 20 ℃ and 25 ℃, pouring the mixture into a reaction kettle, introducing ozone with the concentration of 35mg/L for sterilization and disinfection, and vacuumizing and defoaming after uniform stirring to obtain capsule contents;

2) Weighing a certain amount of edible gelatin, edible glycerol, purified water, polyethylene glycol and titanium dioxide, putting into a reaction kettle, uniformly stirring, heating to 50 ℃, preserving heat for 2.0 hours, vacuumizing, and controlling the water content to be 20% -50%, thus obtaining a glue solution;

4) And (3) drying the soft capsule primary product prepared in the step (3) in a roller dryer, washing, drying, bottling and packaging to obtain a vegetable oil compound soft capsule finished product, wherein the total water content is less than or equal to 0.5%.

Example 2

The vegetable oil compound soft capsule with the health care effect is prepared from the following raw materials in parts by weight: 10 parts of sea buckthorn seed oil, 50 parts of grape seed oil, 10 parts of pomegranate seed oil, 200 parts of camellia seed oil, 10 parts of perilla seed oil, 50 parts of evening primrose oil, 100 parts of edible gelatin, 300 parts of edible glycerol, 50 parts of polyethylene glycol, 100 parts of titanium dioxide and 500 parts of water.

1) Measuring sea buckthorn seed oil, grape seed oil, pomegranate seed oil, camellia seed oil, perilla seed oil and evening primrose oil, controlling the temperature between 20 ℃ and 25 ℃, pouring the mixture into a reaction kettle, introducing ozone with the concentration of 30mg/L for sterilization and disinfection, and vacuumizing and defoaming after uniform stirring to obtain capsule contents;

2) Weighing edible gelatin, edible glycerol, purified water, polyethylene glycol and titanium dioxide, putting into a reaction kettle, stirring uniformly, heating to 80 ℃, preserving heat for 0.5 hour, vacuumizing, and controlling the water content to 20% -50% to obtain a glue solution;

Example 3

The vegetable oil compound soft capsule with the health care effect is prepared from the following raw materials in parts by weight: 50 parts of sea buckthorn seed oil, 10 parts of grape seed oil, 50 parts of pomegranate seed oil, 100 parts of camellia seed oil, 50 parts of perilla seed oil, 10 parts of evening primrose oil, 300 parts of edible gelatin, 100 parts of edible glycerol, 200 parts of polyethylene glycol, 10 parts of titanium dioxide and 500 parts of water.

1) Measuring sea buckthorn seed oil, grape seed oil, pomegranate seed oil, camellia seed oil, perilla seed oil and evening primrose oil, controlling the temperature between 20 ℃ and 25 ℃, pouring the mixture into a reaction kettle, introducing ozone with the concentration of 40mg/L for sterilization and disinfection, and vacuumizing and defoaming after uniform stirring to obtain capsule contents;

2) Weighing edible gelatin, edible glycerol, purified water, polyethylene glycol and titanium dioxide, putting into a reaction kettle, stirring uniformly, heating at 40 ℃ for 3.0 hours, vacuumizing, and controlling the water content to be 20% -50%, thus obtaining a glue solution;

Comparative example

The same weight part of seabuckthorn seed oil was added without adding grape seed oil, and a soft capsule was prepared as described in example 1 as comparative example 1;

the soft capsule was prepared as comparative example 2 by the method described in example 2 without adding the pomegranate seed oil, adding the same weight parts of seabuckthorn seed oil;

the same weight part of seabuckthorn seed oil was added without adding camellia seed oil, and a soft capsule was prepared as described in example 3 as comparative example 3;

a soft capsule was prepared as comparative example 4 by the method described in example 1, without adding perilla seed oil and evening primrose oil, with the same weight parts of seabuckthorn seed oil added.

Example 4

Selecting male mice, wherein the weight of the male mice is 20-25g, and the male mice are divided into 8 groups, 10 soft capsule finished products prepared according to the embodiment 3 are respectively fed into a high-dose group, a medium-dose group and a low-dose group, and the high-dose group, the medium-dose group and the low-dose group are respectively 1.0g/kg.BW, 400mg/kg.BW and 200mg/kg.BW; feeding the soft capsule product prepared in the comparative example, wherein the dosage is 400 mg/kg/BW; the normal diet group was fed normal feed for comparison. Mice were continuously fed for 8 weeks and tested for health indicators. Body weight was measured twice weekly and the results are shown in table 1.

TABLE 1

As shown in Table 1, the vegetable oil compound soft capsule prepared by feeding the application can make mice obtain obvious weight-losing effect.

After 8 weeks of feeding, the immune index was measured by antibody-producing cell detection (Jerne modified slide method), and the data was analyzed by SPSS, and the analysis results are shown in table 2.

TABLE 2

As shown in Table 2, the high dose group, the medium dose group and the low dose group of the finished product of the vegetable oil compound soft capsule prepared by the application can obviously improve the antibody-producing cell number of mice, P is less than 0.05, and the difference is obvious, while the comparison example and the normal diet group P is more than 0.05, and the difference is not obvious, thus the application has the effect of enhancing the immune function of organisms.

The above description of the specific embodiments of the present application is given by way of example only, and the present application is not equivalent to the above-described specific embodiments. Any equivalent modifications and substitutions for the present application will occur to those skilled in the art, and are also within the scope of the present application. Accordingly, equivalent changes and modifications to the disclosed embodiments are intended to be included within the scope of the present application.

Claims

1. The vegetable oil compound soft capsule is characterized by being prepared from the following raw materials in parts by weight: 50 parts of sea buckthorn seed oil, 10 parts of grape seed oil, 50 parts of pomegranate seed oil, 100 parts of camellia seed oil, 50 parts of perilla seed oil, 10 parts of evening primrose oil, 300 parts of edible gelatin, 100 parts of edible glycerol, 200 parts of polyethylene glycol, 10 parts of titanium dioxide and 500 parts of water; the preparation method of the compound soft capsule comprises the following steps:

2. The compound vegetable oil soft capsule according to claim 1, wherein the content in the soft capsule has a specification of 0.5g-1.0 g/granule.