CN115397436B - 用于抑制PNPLA3表达的RNAi剂、其药物组合物和使用方法 - Google Patents

用于抑制PNPLA3表达的RNAi剂、其药物组合物和使用方法 Download PDF

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CN115397436B
CN115397436B CN202180024737.5A CN202180024737A CN115397436B CN 115397436 B CN115397436 B CN 115397436B CN 202180024737 A CN202180024737 A CN 202180024737A CN 115397436 B CN115397436 B CN 115397436B
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pnpla
rnai agent
modified base
phosphate
modified
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CN115397436A (zh
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A·尼古拉斯
裴涛
徐昭
C·席恩贝克
丁志鸣
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Arrowhead Pharmaceuticals Inc
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Arrowhead Pharmaceuticals Inc
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CN202180024737.5A 2020-03-26 2021-03-26 用于抑制PNPLA3表达的RNAi剂、其药物组合物和使用方法 Active CN115397436B (zh)

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US202063000137P 2020-03-26 2020-03-26
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PCT/US2021/024299 WO2021195467A2 (en) 2020-03-26 2021-03-26 RNAi AGENTS FOR INHIBITING EXPRESSION OF PNPLA3, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE

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CA3065523A1 (en) 2017-06-02 2018-12-06 Wave Life Sciences Ltd. Oligonucleotide compositions and methods of use thereof
SG11202009877XA (en) 2018-04-12 2020-11-27 Wave Life Sciences Ltd Oligonucleotide compositions and methods of use thereof
US12391942B2 (en) 2018-05-11 2025-08-19 Wave Life Sciences Ltd. Oligonucleotide compositions and methods of use thereof
EP4347823A1 (en) * 2021-06-02 2024-04-10 Alnylam Pharmaceuticals, Inc. Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
WO2023196941A1 (en) * 2022-04-08 2023-10-12 Arrowhead Pharmaceuticals, Inc. Treatment of a non-alcoholic fatty liver disease
WO2025223315A1 (zh) * 2024-04-25 2025-10-30 苏州时安生物技术有限公司 一种用于肝脏特异性递送的多靶标双链rna偶联物及药物组合物

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