CN115381855A - 用于治疗创伤性脑损伤和用于调节神经原性细胞迁移的方法和组合物 - Google Patents

用于治疗创伤性脑损伤和用于调节神经原性细胞迁移的方法和组合物 Download PDF

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Publication number
CN115381855A
CN115381855A CN202211044392.2A CN202211044392A CN115381855A CN 115381855 A CN115381855 A CN 115381855A CN 202211044392 A CN202211044392 A CN 202211044392A CN 115381855 A CN115381855 A CN 115381855A
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cells
cell
brain injury
neurogenic
tbi
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Chinese (zh)
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C·V·博兰干
C·C·凯斯
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Sanbio Inc
University of South Florida St Petersburg
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Sanbio Inc
University of South Florida St Petersburg
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/42—Notch; Delta; Jagged; Serrate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1353—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24035—Gelatinase B (3.4.24.35), i.e. matrix metalloprotease 9 or MMP9

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  • General Health & Medical Sciences (AREA)
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  • Biotechnology (AREA)
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  • Wood Science & Technology (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Developmental Biology & Embryology (AREA)
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  • General Engineering & Computer Science (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202211044392.2A 2012-05-16 2013-03-13 用于治疗创伤性脑损伤和用于调节神经原性细胞迁移的方法和组合物 Pending CN115381855A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261647893P 2012-05-16 2012-05-16
US61/647,893 2012-05-16
CN201380025599.8A CN104519891B (zh) 2012-05-16 2013-03-13 用于治疗创伤性脑损伤和用于调节神经原性细胞迁移的方法和组合物
PCT/US2013/030895 WO2013172944A1 (en) 2012-05-16 2013-03-13 Methods and compositions for treatment of traumatic brain injury and for modulation of migration of neurogenic cells

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CN201380025599.8A Active CN104519891B (zh) 2012-05-16 2013-03-13 用于治疗创伤性脑损伤和用于调节神经原性细胞迁移的方法和组合物
CN201910165600.6A Active CN109718250B (zh) 2012-05-16 2013-03-13 用于治疗创伤性脑损伤和用于调节神经原性细胞迁移的方法和组合物

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CN201910165600.6A Active CN109718250B (zh) 2012-05-16 2013-03-13 用于治疗创伤性脑损伤和用于调节神经原性细胞迁移的方法和组合物

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US (4) US9828593B2 (enExample)
EP (1) EP2849766B1 (enExample)
JP (6) JP6134783B2 (enExample)
CN (3) CN115381855A (enExample)
AU (2) AU2013263417B2 (enExample)
CA (1) CA2872188C (enExample)
WO (1) WO2013172944A1 (enExample)

Families Citing this family (7)

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EP2849766B1 (en) * 2012-05-16 2019-03-06 SanBio, Inc. Cells for use in the treatment of brain injury
CA2885414C (en) 2012-10-09 2018-05-01 Sanbio, Inc. Methods and compositions for treatment of retinal degeneration
WO2015120388A1 (en) * 2014-02-10 2015-08-13 Cytori Therapeutics, Inc. Regenerative cell therapy for central nervous system (cns) disorders and ptsd
ES2890123T3 (es) 2015-04-01 2022-01-17 Sanbio Inc Métodos y composiciones para la estimulación de la proliferación celular y el suministro de mezclas biológicamente activas de isoformas FGF2
KR101986366B1 (ko) * 2016-02-26 2019-06-07 주식회사 이노퓨틱스 Ｎｕｒｒ１과 Ｆｏｘａ２의 교질세포 기능 조절에 의한 염증성 신경질환 치료
WO2017152035A1 (en) * 2016-03-03 2017-09-08 Henry Ford Health System 3-d collagen scaffold-generated exosomes and uses thereof
CN110382020A (zh) 2016-12-28 2019-10-25 桑比欧公司 细胞递送系统及操作细胞递送系统的方法

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CN1639335A (zh) * 2002-02-06 2005-07-13 桑比欧公司 通过导入notch基因将骨髓基质细胞诱导分化为神经细胞或骨骼肌细胞的方法
CN101801396A (zh) * 2007-08-15 2010-08-11 桑比欧公司 治疗神经变性的方法和组合物
CN104519891A (zh) * 2012-05-16 2015-04-15 桑比欧公司 用于治疗创伤性脑损伤和用于调节神经原性细胞迁移的方法和组合物

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US20030003090A1 (en) 2001-05-31 2003-01-02 Prockop Darwin J. Directed in vitro differentiation of marrow stromal cells into neural cell progenitors
JP3886346B2 (ja) 2001-06-22 2007-02-28 サンバイオ，インコーポレイティド 骨髄間質細胞由来Ｓｃｈｗａｎｎ細胞を含む神経再生用医薬組成物
US20050032827A1 (en) 2003-06-12 2005-02-10 Donna Oksenberg Sigma ligands for neuronal regeneration and functional recovery
JP2007532112A (ja) 2004-04-12 2007-11-15 サンバイオ，インコーポレイティド ニューロン始原細胞特性を示す細胞
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ES2551356T3 (es) 2007-12-03 2015-11-18 Sanbio, Inc. Métodos y composiciones para modular la diferenciación de células pluripotenciales
PL2274430T3 (pl) 2008-04-30 2017-09-29 Sanbio Inc Komórki regenerujące nerwy ze zmianami w metylacji DNA
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JP6023218B2 (ja) 2012-01-27 2016-11-09 サンバイオ，インコーポレイティド 血管新生及び血管発生を調節するための方法及び組成物

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CN1639335A (zh) * 2002-02-06 2005-07-13 桑比欧公司 通过导入notch基因将骨髓基质细胞诱导分化为神经细胞或骨骼肌细胞的方法
CN101584869A (zh) * 2002-02-06 2009-11-25 桑比欧公司 通过导入notch基因将骨髓基质细胞诱导分化为神经细胞或骨骼肌细胞的方法
CN101801396A (zh) * 2007-08-15 2010-08-11 桑比欧公司 治疗神经变性的方法和组合物
CN104519891A (zh) * 2012-05-16 2015-04-15 桑比欧公司 用于治疗创伤性脑损伤和用于调节神经原性细胞迁移的方法和组合物
CN109718250A (zh) * 2012-05-16 2019-05-07 桑比欧公司 用于治疗创伤性脑损伤和用于调节神经原性细胞迁移的方法和组合物

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Publication number Publication date
CN104519891B (zh) 2019-03-22
US20190185839A1 (en) 2019-06-20
CA2872188C (en) 2018-08-14
EP2849766A1 (en) 2015-03-25
JP2016220694A (ja) 2016-12-28
JP2021098738A (ja) 2021-07-01
JP2025098021A (ja) 2025-07-01
WO2013172944A1 (en) 2013-11-21
AU2013263417B2 (en) 2016-05-26
AU2013263417A1 (en) 2014-11-20
JP2023099213A (ja) 2023-07-11
US20200354709A1 (en) 2020-11-12
CN104519891A (zh) 2015-04-15
CN109718250B (zh) 2022-08-30
CA2872188A1 (en) 2013-11-21
AU2016204910A1 (en) 2016-08-04
US20140186316A1 (en) 2014-07-03
EP2849766B1 (en) 2019-03-06
HK1206631A1 (en) 2016-01-15
US9828593B2 (en) 2017-11-28
CN109718250A (zh) 2019-05-07
JP2015517520A (ja) 2015-06-22
JP6134783B2 (ja) 2017-05-24
AU2016204910B2 (en) 2017-07-20
US10626389B2 (en) 2020-04-21
US20150197741A1 (en) 2015-07-16
JP2018111733A (ja) 2018-07-19

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