CN115381129A - Buccal tobacco product containing betel nut extract and preparation method thereof - Google Patents
Buccal tobacco product containing betel nut extract and preparation method thereof Download PDFInfo
- Publication number
- CN115381129A CN115381129A CN202211017492.6A CN202211017492A CN115381129A CN 115381129 A CN115381129 A CN 115381129A CN 202211017492 A CN202211017492 A CN 202211017492A CN 115381129 A CN115381129 A CN 115381129A
- Authority
- CN
- China
- Prior art keywords
- parts
- extract
- buccal
- betel nut
- nicotine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 244000080767 Areca catechu Species 0.000 title claims abstract description 68
- 235000006226 Areca catechu Nutrition 0.000 title claims abstract description 54
- 235000019505 tobacco product Nutrition 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 238000000605 extraction Methods 0.000 title claims description 16
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims abstract description 25
- 239000000843 powder Substances 0.000 claims abstract description 23
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims abstract description 22
- 229960002715 nicotine Drugs 0.000 claims abstract description 22
- 238000003756 stirring Methods 0.000 claims abstract description 18
- 239000000945 filler Substances 0.000 claims abstract description 13
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 13
- 239000003906 humectant Substances 0.000 claims abstract description 13
- 238000002156 mixing Methods 0.000 claims abstract description 13
- 239000003755 preservative agent Substances 0.000 claims abstract description 13
- 230000002335 preservative effect Effects 0.000 claims abstract description 13
- 239000003765 sweetening agent Substances 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000007788 liquid Substances 0.000 claims abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 30
- 239000000706 filtrate Substances 0.000 claims description 18
- 210000000582 semen Anatomy 0.000 claims description 17
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 15
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 15
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 10
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Substances [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 10
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 9
- 230000002195 synergetic effect Effects 0.000 claims description 9
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 8
- 239000000835 fiber Substances 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- 239000002245 particle Substances 0.000 claims description 7
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 6
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 6
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 6
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 6
- 235000017550 sodium carbonate Nutrition 0.000 claims description 6
- 238000009777 vacuum freeze-drying Methods 0.000 claims description 6
- NFDMMMYNZBKUOW-UHFFFAOYSA-N 2,3-dihydroxybutanedioic acid;3-(1-methylpyrrolidin-2-yl)pyridine;dihydrate Chemical compound O.O.OC(=O)C(O)C(O)C(O)=O.CN1CCCC1C1=CC=CN=C1 NFDMMMYNZBKUOW-UHFFFAOYSA-N 0.000 claims description 5
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 5
- 239000004386 Erythritol Substances 0.000 claims description 5
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 5
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 5
- 229930195725 Mannitol Natural products 0.000 claims description 5
- 235000010582 Pisum sativum Nutrition 0.000 claims description 5
- 239000002202 Polyethylene glycol Substances 0.000 claims description 5
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 5
- VAUQRLHPXWYZRZ-PPHPATTJSA-N benzoic acid 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine Chemical compound OC(=O)c1ccccc1.CN1CCC[C@H]1c1cccnc1 VAUQRLHPXWYZRZ-PPHPATTJSA-N 0.000 claims description 5
- 235000019414 erythritol Nutrition 0.000 claims description 5
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 5
- 229940009714 erythritol Drugs 0.000 claims description 5
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 5
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 5
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 5
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 5
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 5
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 5
- 239000000905 isomalt Substances 0.000 claims description 5
- 235000010439 isomalt Nutrition 0.000 claims description 5
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 claims description 5
- 239000000395 magnesium oxide Substances 0.000 claims description 5
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims description 5
- 235000012245 magnesium oxide Nutrition 0.000 claims description 5
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims description 5
- 235000010449 maltitol Nutrition 0.000 claims description 5
- 239000000845 maltitol Substances 0.000 claims description 5
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims description 5
- 229940035436 maltitol Drugs 0.000 claims description 5
- 239000000594 mannitol Substances 0.000 claims description 5
- 235000010355 mannitol Nutrition 0.000 claims description 5
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 5
- 239000001814 pectin Substances 0.000 claims description 5
- 235000010987 pectin Nutrition 0.000 claims description 5
- 229920001277 pectin Polymers 0.000 claims description 5
- 229920001223 polyethylene glycol Polymers 0.000 claims description 5
- 239000011736 potassium bicarbonate Substances 0.000 claims description 5
- 235000015497 potassium bicarbonate Nutrition 0.000 claims description 5
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims description 5
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 5
- 235000011181 potassium carbonates Nutrition 0.000 claims description 5
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims description 5
- 239000000047 product Substances 0.000 claims description 5
- 235000013772 propylene glycol Nutrition 0.000 claims description 5
- 239000000230 xanthan gum Substances 0.000 claims description 5
- 235000010493 xanthan gum Nutrition 0.000 claims description 5
- 229920001285 xanthan gum Polymers 0.000 claims description 5
- 229940082509 xanthan gum Drugs 0.000 claims description 5
- 239000000811 xylitol Substances 0.000 claims description 5
- 235000010447 xylitol Nutrition 0.000 claims description 5
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 5
- 229960002675 xylitol Drugs 0.000 claims description 5
- 239000005711 Benzoic acid Substances 0.000 claims description 4
- 235000010233 benzoic acid Nutrition 0.000 claims description 4
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 4
- 235000010199 sorbic acid Nutrition 0.000 claims description 4
- 239000004334 sorbic acid Substances 0.000 claims description 4
- 229940075582 sorbic acid Drugs 0.000 claims description 4
- AIBWPBUAKCMKNS-PPHPATTJSA-N 2-hydroxybenzoic acid;3-[(2s)-1-methylpyrrolidin-2-yl]pyridine Chemical compound OC(=O)C1=CC=CC=C1O.CN1CCC[C@H]1C1=CC=CN=C1 AIBWPBUAKCMKNS-PPHPATTJSA-N 0.000 claims description 3
- MQWJVKLIBZWVEL-XRIOVQLTSA-N 3-[(2s)-1-methylpyrrolidin-2-yl]pyridine;dihydrochloride Chemical compound Cl.Cl.CN1CCC[C@H]1C1=CC=CN=C1 MQWJVKLIBZWVEL-XRIOVQLTSA-N 0.000 claims description 3
- HDJBTCAJIMNXEW-PPHPATTJSA-N 3-[(2s)-1-methylpyrrolidin-2-yl]pyridine;hydrochloride Chemical compound Cl.CN1CCC[C@H]1C1=CC=CN=C1 HDJBTCAJIMNXEW-PPHPATTJSA-N 0.000 claims description 3
- YHBIGBYIUMCLJS-UHFFFAOYSA-N 5-fluoro-1,3-benzothiazol-2-amine Chemical compound FC1=CC=C2SC(N)=NC2=C1 YHBIGBYIUMCLJS-UHFFFAOYSA-N 0.000 claims description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 3
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 3
- 235000011118 potassium hydroxide Nutrition 0.000 claims description 3
- 238000010298 pulverizing process Methods 0.000 claims description 3
- 235000010356 sorbitol Nutrition 0.000 claims description 3
- 239000000600 sorbitol Substances 0.000 claims description 3
- FGAFEHZTRRYNDF-UHFFFAOYSA-L zinc;3-(1-methylpyrrolidin-2-yl)pyridine;dichloride Chemical compound [Cl-].[Cl-].[Zn+2].CN1CCCC1C1=CC=CN=C1 FGAFEHZTRRYNDF-UHFFFAOYSA-L 0.000 claims description 3
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 claims description 2
- 230000000391 smoking effect Effects 0.000 claims 5
- 235000019504 cigarettes Nutrition 0.000 abstract description 13
- 240000008154 Piper betle Species 0.000 abstract description 4
- 235000008180 Piper betle Nutrition 0.000 abstract description 4
- 239000002994 raw material Substances 0.000 abstract description 2
- -1 pH regulator Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 32
- HJJPJSXJAXAIPN-UHFFFAOYSA-N arecoline Chemical compound COC(=O)C1=CCCN(C)C1 HJJPJSXJAXAIPN-UHFFFAOYSA-N 0.000 description 10
- 230000000052 comparative effect Effects 0.000 description 6
- 241000208125 Nicotiana Species 0.000 description 5
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 5
- 229940095523 buccal product Drugs 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 210000000214 mouth Anatomy 0.000 description 5
- 230000006378 damage Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000003760 magnetic stirring Methods 0.000 description 4
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 3
- SERLAGPUMNYUCK-YJOKQAJESA-N 6-O-alpha-D-glucopyranosyl-D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-YJOKQAJESA-N 0.000 description 3
- 206010006784 Burning sensation Diseases 0.000 description 3
- 239000004283 Sodium sorbate Substances 0.000 description 3
- 239000004745 nonwoven fabric Substances 0.000 description 3
- 235000010241 potassium sorbate Nutrition 0.000 description 3
- 239000004302 potassium sorbate Substances 0.000 description 3
- 229940069338 potassium sorbate Drugs 0.000 description 3
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical group [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 3
- 235000010234 sodium benzoate Nutrition 0.000 description 3
- 239000004299 sodium benzoate Substances 0.000 description 3
- LROWVYNUWKVTCU-STWYSWDKSA-M sodium sorbate Chemical compound [Na+].C\C=C\C=C\C([O-])=O LROWVYNUWKVTCU-STWYSWDKSA-M 0.000 description 3
- 235000019250 sodium sorbate Nutrition 0.000 description 3
- 240000000560 Citrus x paradisi Species 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- 235000004936 Bromus mango Nutrition 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 206010018275 Gingival atrophy Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 240000007228 Mangifera indica Species 0.000 description 1
- 235000014826 Mangifera indica Nutrition 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
- 208000003445 Mouth Neoplasms Diseases 0.000 description 1
- 208000004179 Oral Leukoplakia Diseases 0.000 description 1
- 235000009184 Spondias indica Nutrition 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000001785 acacia senegal l. willd gum Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 235000010237 calcium benzoate Nutrition 0.000 description 1
- 239000004301 calcium benzoate Substances 0.000 description 1
- MCFVRESNTICQSJ-RJNTXXOISA-L calcium sorbate Chemical compound [Ca+2].C\C=C\C=C\C([O-])=O.C\C=C\C=C\C([O-])=O MCFVRESNTICQSJ-RJNTXXOISA-L 0.000 description 1
- 235000010244 calcium sorbate Nutrition 0.000 description 1
- 239000004303 calcium sorbate Substances 0.000 description 1
- HZQXCUSDXIKLGS-UHFFFAOYSA-L calcium;dibenzoate;trihydrate Chemical compound O.O.O.[Ca+2].[O-]C(=O)C1=CC=CC=C1.[O-]C(=O)C1=CC=CC=C1 HZQXCUSDXIKLGS-UHFFFAOYSA-L 0.000 description 1
- 229940095710 chewable product Drugs 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 201000005562 gingival recession Diseases 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 229940071676 hydroxypropylcellulose Drugs 0.000 description 1
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 description 1
- 229960000869 magnesium oxide Drugs 0.000 description 1
- 201000008557 oral mucosa leukoplakia Diseases 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 235000010235 potassium benzoate Nutrition 0.000 description 1
- 239000004300 potassium benzoate Substances 0.000 description 1
- 229940103091 potassium benzoate Drugs 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 230000005586 smoking cessation Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229940001593 sodium carbonate Drugs 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 210000004876 tela submucosa Anatomy 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B13/00—Tobacco for pipes, for cigars, e.g. cigar inserts, or for cigarettes; Chewing tobacco; Snuff
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/12—Chemical features of tobacco products or tobacco substitutes of reconstituted tobacco
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B3/00—Preparing tobacco in the factory
- A24B3/14—Forming reconstituted tobacco products, e.g. wrapper materials, sheets, imitation leaves, rods, cakes; Forms of such products
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Manufacture Of Tobacco Products (AREA)
Abstract
A buccal cigarette product containing areca catechu extract and a preparation method thereof relate to the technical field of buccal cigarettes. The buccal tobacco product comprises the following components: areca extract, nicotine source, filler, pH regulator, sweetener, humectant and preservative. The preparation method comprises the following steps: s11: mixing 5-30 parts of filler, 0.01-15 parts of areca extract, 0.01-15 parts of pH regulator, 10-30 parts of sweetener and 0.05-0.5 part of preservative, adding water, and mixing the following raw materials in parts by weight, S12: adding 0.5-2 parts of nicotine source to 0.5-5 parts of humectant, S13: and (4) adding the liquid obtained in the step (S12) into the powder obtained in the step (S11), stirring in a stirrer for 20-60min, and standing for 12-24h to obtain the buccal tobacco product containing the betel nut extract. By adopting the technical scheme, the device has the advantage of helping a user get rid of dependence on the traditional cigarettes and the betel nuts.
Description
Technical Field
The invention relates to the technical field of buccal cigarettes, in particular to a buccal cigarette product containing an areca catechu extract and a preparation method thereof.
Background
Betel nut is native to malaysia, and china is mainly distributed in tropical areas such as Yunnan, hainan and Taiwan. The tropical region of Asia is cultivated widely. Betel nut is an important Chinese medicinal material, and fruits are also used as a chewable product in some minority people in south.
The damage of betel nut refers to the damage of chewing betel nut, which can cause oral cancer besides periodontal disease, oral submucosa fibrosis and oral leukoplakia caused by tooth blackening, abrasion, shaking and gingival atrophy.
Buccal tobacco is a tobacco product containing nicotine. The buccal cigarette is prepared by high temperature sterilization (without fermentation), and nicotine is inhaled by sucking. As such, many people consider moist mouth tobacco to be a healthier choice than cigarettes.
However, the smoking cessation effect of the buccal cigarette is only effective for the novice smokers because the mouth feel and the taste brought by tar are not good.
A new product is urgently needed to be researched and developed, so that the requirements of smokers on cigarettes are met, the smokers are attracted, and the situation that the smokers turn to traditional tobacco with higher harm is reduced; but also meets the requirement of betel nut enthusiasts on betel nuts, attracts the betel nut enthusiasts and has little damage to oral cavities.
Disclosure of Invention
The invention aims to overcome the defects and shortcomings of the prior art, and provides a buccal tobacco product containing betel nut extract and a preparation method thereof, which have the advantage of helping a user get rid of dependence on traditional cigarettes and betel nuts.
In order to achieve the purpose, the invention adopts the technical scheme that: a buccal tobacco product containing areca extract comprises the following components: areca catechu extract, a nicotine source, a filler, a pH regulator, a sweetener, a humectant and a preservative.
The invention further provides the following components in parts by weight: 0.01-15 parts of areca extract, 0.5-2 parts of nicotine source, 5-30 parts of filler, 0.01-15 parts of pH regulator, 10-30 parts of sweetener, 0.5-5 parts of humectant and 0.05-0.5 part of preservative.
The invention further provides that the filler is: microcrystalline cellulose, hydroxypropyl methylcellulose, hydroxypropyl cellulose, pea fiber, and a-fiber.
The invention further provides that the nicotine source is: one or more of nicotine hydrochloride, nicotine dihydrochloride, nicotine tartrate dihydrate, nicotine sulfate, nicotine zinc chloride, nicotine salicylate, and nicotine benzoate.
The invention further provides that the pH regulator is one or more of sodium carbonate, sodium bicarbonate, magnesium oxide, potassium hydroxide, potassium carbonate and potassium bicarbonate.
The invention further provides that the sweetener is: one or more of xylitol, maltitol, erythritol, isomalt, mannitol and sorbitol.
The invention further provides that the humectant is: propylene glycol, glycerol, polyethylene glycol, xanthan gum and pectin.
According to a further aspect of the invention, the preservative is: sorbic acid and its salts or benzoic acid and its salts.
The invention also provides another technical scheme: a method for preparing buccal tobacco product containing Arecae semen extract comprises the following steps:
s11: mixing 5-30 parts of filler, 0.01-15 parts of areca extract, 0.01-15 parts of pH regulator, 10-30 parts of sweetener and 0.05-0.5 part of preservative, adding water,
s12: adding 0.5-2 parts of nicotine source into 0.5-5 parts of humectant,
s13: and (4) adding the liquid obtained in the step (S12) into the powder obtained in the step (S11), stirring in a stirrer for 20-60min, and standing for 12-24h to obtain the buccal tobacco product containing the betel nut extract.
The invention further provides a preparation method of the betel nut extract, which comprises the following steps:
s21: pulverizing Arecae semen to obtain powder with particle size of 40-120 um;
s22: putting the powder and 75-95 wt% of ethanol solution into a cavity of ultrasonic-microwave synergistic extraction equipment for extraction for 2-4 times to obtain an extracting solution, and cooling;
s23: filtering the extractive solution with mesh screen to obtain filtrate;
s24: vacuum concentrating the filtrate under reduced pressure, removing ethanol from the filtrate, and centrifuging to obtain concentrated solution;
s25: vacuum freeze drying the concentrated solution to obtain Arecae semen extract.
After the technical scheme is adopted, the invention has the beneficial effects that: the betel nut extract and the nicotine source are added into the buccal product simultaneously, and the recognizable burning sensation can be obtained by utilizing the physiological synergistic enhancement effect of the nicotine and the arecoline, so that the tobacco experience is better simulated, the dependence of a user on the traditional cigarette and the betel nut is helped to be eliminated, the burning of tar is not needed, the direct contact with the oral cavity is reduced, and the buccal product is healthier.
Detailed Description
The present invention will be described in further detail below.
The specific embodiments are only for explaining the present invention, and the present invention is not limited thereto, and those skilled in the art can make modifications to the embodiments as necessary without making a contribution to the art after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present invention.
The embodiment relates to a buccal cigarette product containing betel nut extract, which comprises the following specific components in parts by weight: 0.01-15 parts of areca extract, 0.5-2 parts of nicotine source, 5-30 parts of filler, 0.01-15 parts of pH regulator, 10-30 parts of sweetener, 0.5-5 parts of humectant and 0.05-0.5 part of preservative.
Wherein, the filler is: microcrystalline cellulose, hydroxypropyl methylcellulose, hydroxypropyl cellulose, pea fiber, and a-fiber. The nicotine source is: one or more of nicotine hydrochloride, nicotine dihydrochloride, nicotine tartrate dihydrate, nicotine sulfate, nicotine zinc chloride, nicotine salicylate, and nicotine benzoate. The pH regulator is one or more of sodium carbonate, sodium bicarbonate, magnesium oxide, potassium hydroxide, potassium carbonate and potassium bicarbonate. The sweetening agent is: one or more of xylitol, maltitol, erythritol, isomalt, mannitol and sorbitol. The humectant is as follows: propylene glycol, glycerol, polyethylene glycol, xanthan gum, and pectin. The preservative is as follows: sorbic acid and its salts or benzoic acid and its salts.
Wherein, the sorbic acid and the salt thereof are sodium sorbate, potassium sorbate or calcium sorbate; the benzoic acid and its salt is sodium benzoate, potassium benzoate or calcium benzoate.
The invention also provides a preparation method of the buccal tobacco product containing the betel nut extract, which comprises the following steps:
s11: adding 0-10 parts of water into 5-30 parts of filler, mixing for 10-30min, standing and absorbing for 1-5h;
s12: stirring and mixing 10-30 parts of sweetening agent, 0.5-5 parts of humectant, 0.5-2 parts of nicotine source, 0.01-15 parts of areca extract, 0.01-15 parts of pH regulator and 0.05-0.5 part of preservative for 5-30min, and stirring on a magnetic stirring instrument for 1-5h;
s13: and (4) adding the liquid obtained in the step (S12) into the substance obtained in the step (S11), stirring in a stirrer for 20-60min, and standing for 12-24h to obtain the buccal tobacco product containing the betel nut extract.
The preparation method of the betel nut extract comprises the following steps:
s21: pulverizing Arecae semen to obtain powder with particle size of 40-120 um;
s22: putting the powder and 75-95 wt% of ethanol solution into a cavity of ultrasonic-microwave synergistic extraction equipment for extraction for 2-4 times to obtain an extracting solution, and cooling;
s23: filtering the extractive solution with 150-200 mesh sieve to obtain filtrate;
s24: vacuum concentrating the filtrate under reduced pressure, removing ethanol from the filtrate, and centrifuging to obtain concentrated solution;
s25: vacuum freeze drying the concentrated solution to obtain Arecae semen extract.
In S21, the betel nut material may be betel nut kernel, betel nut shell, betel nut pedicle, or a mixture thereof.
The invention is further illustrated by the following examples:
the first embodiment is as follows: a buccal tobacco product containing areca extract comprises the following components: areca catechu extract, nicotine tartrate, microcrystalline cellulose, sodium carbonate, xylitol, propylene glycol, sodium sorbate and grapefruit essence.
The weight parts of each component are as shown in the following table 1:
TABLE 1
A method for preparing a buccal tobacco product containing betel nut extract comprises the following steps:
taking the sample 1 as an example, the method,
s11: mixing microcrystalline cellulose 20 parts, arecae semen extract 0.01 part, sodium carbonate and sodium bicarbonate 15 parts, xylitol 15 parts, and sodium sorbate 0.1 part, adding water,
s12: adding 0.5 part of nicotine tartrate and 0.8 part of grapefruit essence into 0.5 part of propylene glycol and glycerol,
s13: and (4) adding the liquid obtained in the step (S12) into the powder obtained in the step (S11), stirring in a stirrer for 40min, and standing for 18h to obtain the buccal tobacco product containing the betel nut extract.
Finally, the buccal tobacco products can be packaged by using high-quality edible heat-sealing filter paper or edible heat-sealing non-woven fabrics according to the specification of 0.1-1g per bag.
The same applies to samples 2-5, wherein in step S11, the selection range of water is 0-10 parts, the mixture is mixed for 10-30min, and the mixture is kept stand to absorb for 1-5h; in the step S12, stirring and mixing for 5-30min, and stirring for 1-5h on a magnetic stirring instrument; in step S13, stirring in a stirrer for 20-60min, and standing for 12-24h.
Example two: a buccal tobacco product containing areca extract comprises the following components: areca catechu extract, nicotine benzoate, hydroxypropylmethyl cellulose, hydroxypropyl cellulose, magnesium oxide, maltitol, erythritol, polyethylene glycol, and potassium sorbate.
The weight parts of the components are shown in the following table 2:
TABLE 2
A method for preparing buccal tobacco product containing Arecae semen extract comprises the following steps:
taking the sample 7 as an example,
s11: mixing hydroxypropyl methylcellulose 15 parts, hydroxypropyl cellulose 2 parts, arecae semen extract 1 part, magnesium oxide 25 parts, maltitol and erythritol, and potassium sorbate 0.2 part, adding water,
s12: adding 2 parts of nicotine benzoate and 1 part of lemon essence into 1 part of polyethylene glycol,
s13: and (4) adding the liquid obtained in the step (S12) into the powder obtained in the step (S11), stirring in a stirrer for 40min, and standing for 18h to obtain the buccal tobacco product containing the betel nut extract.
Finally, the buccal tobacco product can be packaged by high-quality edible heat-seal filter paper or edible heat-seal non-woven fabric according to the specification of 0.1-1 g/bag.
The same applies to the samples 6, 8-10, wherein in the step S11, the selection range of water is 0-10 parts, the mixture is mixed for 10-30min, and the mixture is kept stand and absorbed for 1-5h; in the step S12, stirring and mixing for 5-30min, and stirring for 1-5h on a magnetic stirring instrument; in step S13, stirring in a stirrer for 20-60min, and standing for 12-24h.
Example three: a buccal tobacco product containing areca extract comprises the following components: areca extract, nicotine tartrate dihydrate, pea fiber, potassium carbonate, potassium bicarbonate, isomalt, mannitol, xanthan gum, pectin, and sodium benzoate.
The weight ratio of each component is shown in Table 3:
TABLE 3
A method for preparing a buccal tobacco product containing betel nut extract comprises the following steps:
taking the sample 13 as an example, the method,
s11: mixing 10 parts of pea fiber, 5 parts of betel nut extract, 5 parts of potassium carbonate and potassium bicarbonate, 10 parts of isomalt and mannitol and 0.05 part of sodium benzoate, adding water,
s12: adding 1.5 parts of nicotine tartrate and nicotine tartrate dihydrate and 1.5 parts of mango essence into 5 parts of xanthan gum and pectin,
s13: and (4) adding the liquid obtained in the step (S12) into the powder obtained in the step (S11), stirring in a stirrer for 40min, and standing for 18h to obtain the buccal tobacco product containing the betel nut extract.
Finally, the buccal tobacco product can be packaged by high-quality edible heat-seal filter paper or edible heat-seal non-woven fabric according to the specification of 0.1-1 g/bag.
Sample 11, sample 12, sample 14 and sample 15 are the same, wherein in step S11, the selection range of water is 0-10 parts, mixing is carried out for 10-30min, and standing absorption is carried out for 1-5h; in the step S12, stirring and mixing for 5-30min, and stirring for 1-5h on a magnetic stirring instrument; in step S13, stirring in a stirrer for 20-60min, and standing for 12-24h.
Comparative example one: 5363 portions of microcrystalline cellulose 86.149 portions, 0.001 portion of sodium sweet, 0.5 portion of sodium chloride, 0.45 portion of sodium carbonate, 3 portions of Arabic gum, 1 portion of sodium alginate, 1.2 portions of peppermint essential oil, 1.7 portions of nicotine, 6 portions of glycerol and 50 portions of distilled water.
TABLE 4-1 comparison of samples 1 to 5
TABLE 4-2 comparison of sample 6 to sample 10
TABLE 4-3 comparison of samples 11 to 15 and comparative example one
As can be seen from tables 4-1, 4-2 and 4-3, in samples 1-15, compared to comparative example one, the betel nut extract and nicotine source were added to the buccal product at the same time, and a recognizable burning sensation was obtained by utilizing the physiological synergistic enhancement effect of nicotine in combination with arecoline.
In the following examples, the betel nut raw material is betel nut kernels in betel nuts produced in Hainan:
example four: a method for preparing Arecae semen extract comprises:
s21: crushing the areca nut kernels to obtain powder with the crushing particle size of 80 um;
s22: putting the powder and 85wt% ethanol solution into ultrasonic-microwave synergistic extraction equipment cavity for extraction for 3 times to obtain extractive solution, and cooling; wherein the mass of the ethanol solution is 9 times of that of the powder;
s23: filtering the extract with a screen to obtain a filtrate;
s24: vacuum concentrating the filtrate under reduced pressure, removing ethanol from the filtrate, and centrifuging to obtain concentrated solution;
s25: vacuum freeze drying the concentrated solution at-50 deg.C under vacuum degree of 6pa to obtain Arecae semen extract.
Example five: a method for preparing Arecae semen extract comprises:
s21: crushing areca nut kernels to obtain powder with the crushing particle size of 40 um;
s22: putting the powder and 75wt% ethanol solution into a cavity of ultrasonic-microwave synergistic extraction equipment for extraction for 2 times to obtain an extracting solution, and cooling; wherein the mass of the ethanol solution is 8 times of that of the powder;
s23: filtering the extract with a screen to obtain a filtrate;
s24: vacuum concentrating the filtrate under reduced pressure, removing ethanol from the filtrate, and centrifuging to obtain concentrated solution;
s25: vacuum freeze drying the concentrated solution at-40 deg.C under vacuum degree of 6pa to obtain Arecae semen extract.
Example six: a method for preparing Arecae semen extract comprises:
s21: crushing areca nut kernels to obtain powder with the crushing particle size of 120 um;
s22: putting the powder and 95wt% ethanol solution into a cavity of ultrasonic-microwave synergistic extraction equipment for extraction for 4 times to obtain an extracting solution, and cooling; wherein the mass of the ethanol solution is 10 times of that of the powder;
s23: filtering the extract with a screen to obtain a filtrate;
s24: vacuum concentrating the filtrate under reduced pressure, removing ethanol from the filtrate, and centrifuging to obtain concentrated solution;
s25: vacuum freeze drying the concentrated solution at-60 deg.C under vacuum degree of 6pa to obtain Arecae semen extract.
Comparative example two:
crushing the areca nut kernels to obtain powder with the crushing particle size of 80 um;
adding the powder into activated complex enzyme preparation buffer solution for enzymolysis to obtain enzymolysis solution, specifically performing enzymolysis for 15h in water bath at 60 deg.C,
adjusting the enzymolysis solution to be alkaline, and then extracting by using an organic solvent;
carrying out centrifugal concentration on the extract liquor to obtain a concentrated solution;
drying the concentrated solution to obtain Arecae semen extract.
TABLE 5 comparison of example four to example six with comparative example two
By comparison, after detecting the arecoline extraction, the arecoline extraction amount of the examples four to six is much higher than that of the comparative example two.
The working principle of the invention is roughly as follows: the betel nut extract and the nicotine source are added into the buccal product simultaneously, and the recognizable burning sensation can be obtained by utilizing the physiological synergistic enhancement effect of the nicotine and the arecoline, so that the tobacco experience is better simulated, the dependence of a user on the traditional cigarette and the betel nut is helped to be eliminated, the burning of tar is not needed, the direct contact with the oral cavity is reduced, and the buccal product is healthier.
The above description is only for the purpose of illustrating the technical solutions of the present invention and not for the purpose of limiting the same, and other modifications or equivalent substitutions made by those skilled in the art to the technical solutions of the present invention should be covered by the claims of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. A buccal tobacco product containing areca extract is characterized by comprising the following components: areca catechu extract, a nicotine source, a filler, a pH regulator, a sweetener, a humectant and a preservative.
2. The buccal tobacco product containing the betel nut extract as claimed in claim 1, is characterized in that the weight ratio of each component is as follows: 0.01-15 parts of areca extract, 0.5-2 parts of nicotine source, 5-30 parts of filler, 0.01-15 parts of pH regulator, 10-30 parts of sweetener, 0.5-5 parts of humectant and 0.05-0.5 part of preservative.
3. The buccal smoking article containing betel nut extract as claimed in claim 1, wherein the filler is: microcrystalline cellulose, hydroxypropyl methylcellulose, hydroxypropyl cellulose, pea fiber, and a-fiber.
4. The buccal smoking article with areca catechu extract of claim 1, wherein said nicotine source is: one or more of nicotine hydrochloride, nicotine dihydrochloride, nicotine tartrate dihydrate, nicotine sulfate, nicotine zinc chloride, nicotine salicylate, and nicotine benzoate.
5. The buccal smoking article containing betel nut extract as claimed in claim 1, wherein the pH regulator is one or more of sodium carbonate, sodium bicarbonate, magnesium oxide, potassium hydroxide, potassium carbonate and potassium bicarbonate.
6. The buccal tobacco product containing betel nut extract as claimed in claim 1, wherein the sweetener is: one or more of xylitol, maltitol, erythritol, isomalt, mannitol and sorbitol.
7. The buccal smoking product containing betel nut extract as claimed in claim 1, wherein the humectant is: propylene glycol, glycerol, polyethylene glycol, xanthan gum and pectin.
8. The buccal smoking product containing betel nut extract as claimed in claim 1, wherein the preservative is: sorbic acid and its salts or benzoic acid and its salts.
9. A preparation method of a buccal tobacco product containing betel nut extract is characterized by comprising the following steps:
s11: mixing 5-30 parts of filler, 0.01-15 parts of areca extract, 0.01-15 parts of pH regulator, 10-30 parts of sweetener and 0.05-0.5 part of preservative, adding water,
s12: adding 0.5-2 parts of nicotine source into 0.5-5 parts of humectant,
s13: and (4) adding the liquid obtained in the step (S12) into the powder obtained in the step (S11), stirring in a stirrer for 20-60min, and standing for 12-24h to obtain the buccal tobacco product containing the betel nut extract.
10. The method for preparing buccal tobacco product containing betel nut extract as claimed in claim 9, wherein,
the preparation method of the betel nut extract comprises the following steps:
s21: pulverizing Arecae semen to obtain powder with particle size of 40-120 um;
s22: putting the powder and 75-95 wt% of ethanol solution into an ultrasonic-microwave synergistic extraction equipment cavity for extraction for 2-4 times to obtain an extracting solution, and cooling;
s23: filtering the extract with a screen to obtain a filtrate;
s24: vacuum concentrating the filtrate under reduced pressure, removing ethanol from the filtrate, and centrifuging to obtain concentrated solution;
s25: vacuum freeze drying the concentrated solution to obtain Arecae semen extract.
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