JPH11313637A - New food using coleus forskohlii root - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a new food containing Coleus forskohlii having a hypotensive action, etc., by mixing the dry root powder of the Coleus forskohlii with black vinegar brew residues (unrefined black vinegar), etc., and subsequently compressing the mixture into tablets, etc. SOLUTION: This new food is obtained by mixing the dry root powder of Coleus forskohlii with black vinegar brew residues (unrefined black vinegar), acetic acid-containing powder, the powder of an edible lower aliphatic acid such as citric acid or malic acid, and, if necessary, crystalline cellulose, a polysaccharide or a sucrose fatty acid ester, and subsequently compressing the mixture into tablets, granulating the mixture into granules or filling the mixture into capsules.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a novel food product using Coleus forskoli root containing forskolin, which has various pharmacological actions such as blood pressure lowering action.

[0002]

2. Description of the Related Art Coleus forskoli ( Coleus) , a plant belonging to the Labiatae family native to the Indian region of Nepal.
forskohlii ) is known to have many pharmacological effects, but recently it has been found that forskolin, one of the diterpenes contained in its roots, is a trace and powerful activator. Numerous studies have been carried out, and Mr. Sano has organized and reported the research report on this forskolin (“Forskolin and adenylate cyclase”: “Protein Nucleic Acid Enzyme” Vol 28, No. 7, p943-p950).
(1983)).

This report clarifies the structure and pharmacological action of forskolin, a comparison of forskolin and adenylate cyclase activator, the action and tissue specificity of forskolin, and the effect of forskolin on living cells. .

In this report, Coleus Forskoli ( C
oleus forskohlii ). It is described that the desired forskolin can be obtained by separating a methanol extract of potatoes (roots accumulating nutrients: hereinafter referred to as “roots”) by silica gel column chromatography and purifying diterpenes. And studies on the pharmacological effects of forskolin. Therefore, it is conceivable to actually apply this to medicines and the like. In addition, the above-mentioned Coleus
It is said that forskolin extracted and purified from Forskoli does not have good absorbability when taken orally, and a derivative for the purpose of improvement has been proposed (Japanese Patent Laid-Open No. 63-10 / 1988).
No. 783, JP-A-64-9986, etc.).

[0005] By the way, Coleus forskoli roots containing forskolin are described in ancient Hindu medical books as having an effect on heart disease and the like, and there are some parts of India where they are cultivated and used for food. This is explained in the introduction to the report.

[0006]

Therefore, it is conceivable to provide a food in which the effect of forskolin can be widely obtained in Japan by using the method of eating Coleus forskoli roots in India. .

[0007] However, when the present inventor conducted a tasting test of a plurality of panelists on foods using Coleus forskoli roots produced by the method carried out in India as described above, it was found that the flavor, texture, and post-meal texture were low. All of these were unpopular, and it was clear that they did not fit into Japanese eating habits. In other words, the texture generally responds as "the unique smell is intense and does not feel like food" and "remains in the mouth as if eating a tree root". The smell remained, and my appetite declined. " The details of the tasting test are as follows. In other words, in accordance with the above-mentioned method in India,
Soak the dried Coleus forskoli roots in water for two nights,
After washing thoroughly with water, immerse in commercial vinegar,
(〜20 ° C.) in a dark place for 7 days, and then taken out and made into a pickle having a diameter of about 1 cm and a length of about 5 cm.

As can be seen from the results of the above tasting test,
Although Coleus forskoli roots contain forskolin, which has excellent pharmacological actions, it is difficult to use a well-known method to eat it without difficulty from a dietary habit. However, at present, an appropriate food form that solves this has not been known.

In view of the above-mentioned current situation, the present inventors have conducted intensive studies for the purpose of providing new foods using Coleus forskoli roots as a raw material, and have accomplished the present invention.

[0010]

Means for Solving the Problems To achieve the above object, the invention of a novel food using Coleus forskoli root according to claim 1 of the present invention is to provide a dried powder of Coleus forskoli root, a vinegar residue of black vinegar (Moromi black vinegar) And, if necessary, add and mix microcrystalline cellulose, polysaccharides, and sucrose fatty acid esters, and then tablet them into tablets, granulate into granules, or fill in capsules. Characterized as capsules.

[0011] The invention of claim 2 is to provide a dry powder of Coleus forskoli root, a powder containing acetic acid, a powder of edible lower fatty acid such as citric acid or malic acid, and if necessary, crystalline cellulose, polysaccharide, sucrose. The fatty acid ester is added and mixed, and the mixture is compressed into tablets, granulated into granules, or filled into capsules to form capsules.

[0012]

DESCRIPTION OF THE PREFERRED EMBODIMENTS In each of the above-mentioned inventions, it is important to powder the Coleus forskoli roots, and as a result, as a novel food in the form of a tablet or the like that can be taken orally without chewing. Because it can be provided. The powder of the Coleus forskoli root (hereinafter abbreviated as “Coleus powder”) is obtained by thoroughly washing the Coleus forskoli root, drying it, and using an appropriate crusher, crusher, or the like, to obtain 40 to 200 mesh, preferably A powder of 60 to 100 mesh is used.

[0013] The black vinegar moromi used by mixing with the coleus powder is a powder of a natural brewed vinegar extraction residue that forms a brown color.
It is conventionally well known that usually contains 5 to 6% of water and 0.1 to 0.5% of acetic acid.

The blending ratio of Coleus powder and Moromi black vinegar is as follows:
Although not limited, generally, the mixing ratio of (Coleus powder) :( Moromi black vinegar) is about 10: 1 to 1: 1, preferably about 3: 1 to 2: 1. .
If the blending ratio of the Coleus powder is less than 1: 1, the pharmacological effect is undesirably reduced.

[0015] Coleus powder may be mixed with crystalline cellulose, polysaccharide,
Sucrose fatty acid esters can be added. These optional components may be added in an amount of not more than 20 parts by weight, preferably not more than 10 parts by weight, based on 100 parts by weight of Coleus powder and Moromi black vinegar. If the amount of these additives is too large, the amount of the Coleus forskoli root containing the active ingredient forskolin will be too small.

According to the present invention, the food prepared from the Coleus forskoli root can be taken orally without inducing repellency, and forskolin extracted and purified from the Coleus forskoli root is administered to the living body. Biochemical findings, such as those reported by Metzger and Linder, show that when forskolin is administered to rabbits, it stimulates protein phosphorylation (Metzger, H., Li
ndoner, E: Drug Reserch , 31 , 1248 (1981)) and its causal relationship with the action of enhancing lipid metabolism are not always clear, but as can be seen from the examples described below, a diet effect can be obtained. I understand.

The invention of claim 2 uses an acetic acid-containing powder or a powder of an edible lower fatty acid such as citric acid or malic acid instead of the above-mentioned moromi black vinegar. It is effective to mix acetic acid into tablets to be ingested, and if acetic acid is contained,
It has been clarified that the material to be mixed with the Coleus powder is not necessarily limited to black vinegar moromi, and that it can be used without particular limitation as long as it has the same effect and action. That is, the important configuration in the present invention is to use the powdered Coleus forskoli root and mix it with acetic acid-containing powder or granules to provide the above-mentioned tablet or other dosage form. Is essential. Any substance containing acetic acid suitable for the purpose and capable of forming a dosage form such as a tablet can be used without any particular limitation.

Tableting (triangular, circular, elliptical, etc.) for forming each dosage form, granulation, and filling in capsules (hard capsules, soft capsules) are performed by a conventionally known method. Can be done.

[0019]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below with reference to embodiments and reference examples.

Example 1 Coleus forskoli roots were thoroughly washed, pulverized, and the powder under the sieve was collected using a sieve to obtain Coleus powder.

Using this as a main raw material, Coleus powder 75 m
g, black vinegar Moromi 50 mg, crystalline cellulose (Avicel F
D101: manufactured by Asahi Kasei Corporation) 50 mg, sorbitol 7
5 mg was weighed, and 250 mg in total was agitated (high speed mixer agitator: 200 rpm).
m) and a chopper (Fukae Kogyo Co., Ltd .: 3000 rpm)
m) for 3 minutes.

Next, 2 wt% of sucrose fatty acid ester (DK Ester 20W, manufactured by Daiichi Kogyo Seiyaku Co., Ltd.) was added to the mixture.
In addition, after further mixing for 5 minutes, a tableting machine (manufactured by Kikusui Seisakusho Co., Ltd., RIBLA36) was used to produce triangular tablets (250 mg / 1 tablet) 8.2 mm on a side.

Reference Example 1 (Method of Ingestion) The tablet containing the coleus powder prepared in Example 1 was used for a total of 10 tablets of 4 adult males and 6 adult females.
A field test was performed using the name as a monitor.

In this test, each monitor was orally ingested 3 to 6 tablets at a time with a full glass of water three times a day before meals (30 to 10 minutes before).
It was performed for four consecutive days.

(Status of intake during test) During the 14-day intake period, no one repelled the intake due to stomach pain or the like.

This is a big difference compared to the above-mentioned intake test of the sample in which the Coleus forskoli root was pickled in vinegar, as compared with the fact that there were always those who avoided the intake due to stomach pain and the like.

(Confirmation of Diet Effect) The effect of the diet on each monitor before and after the field test was evaluated by measuring the waist (before, during the week during, and after), body weight (once daily, daily: before breakfast), body Fat percentage (once a day daily:
Before breakfast), it was determined by the change.

Table 1 below shows the individual data of each monitor before the field test was performed, Table 2 shows the changes of the above three items before and after the test, and Tables 3 and 4 show the total of the changes of these three items. Indicated.

[0029]

[Table 1]

[0030]

[Table 2]

[0031]

[Table 3]

[0032]

[Table 4]

As can be seen from the results of these tables, the waist was reduced in 9 monitors, and the remaining example was “no change”. This is because in the field test of ordinary diet foods etc., hearing after the test tends to relax more than eating on a regular basis because of the sense of security that “I am eating diet foods”. The fact that the numerical values of the measurement items are increasing seems to be something that should be noted.

The relationship between the body fat percentage and the increase / decrease in the body fat percentage of the top two persons (monitor Nos. 1 and 4) having a large decrease in waist size was not observed. Top two people who declined (Monitor No2,
8) The waist sizes were 2 cm and 1 cm, respectively, and were in the average range. Although it is necessary to accumulate more data, these results indicate that the body fat percentage of the present invention and the waist size are not necessarily in direct proportion, based on the results of field tests using the tablets produced in Example 1. Not
This suggests that it is possible to expect a reduction in waist size even if there is little change in weight or body fat percentage.

[0035]

According to the present invention, a novel food having a diet effect by oral ingestion is provided by using Coleus forskoli root as a raw material, and it can be ingested as a tablet or the like without chewing. The effect of not inviting is produced.

Claims (2)

[Claims] 1. To a dry powder of Coleus forskoli root, black vinegar brewing residue (black vinegar moromi) and, if necessary, microcrystalline cellulose, polysaccharides and sucrose fatty acid ester are added, mixed and compressed. A new food product using Coleus forskoli root, wherein the food is a tablet, granulated into granules, or filled into a capsule to form a capsule. 2. Dry powder of Coleus forskoli root is mixed with acetic acid-containing powder, powder of edible lower fatty acid such as citric acid or malic acid, and, if necessary, crystalline cellulose, polysaccharide, and sucrose fatty acid ester. A novel food product using Coleus forskoli root, which is obtained by tableting, granulating into granules, or filling in capsules to form capsules.