CN115364020A - Whitening and moisturizing composition, body lotion and preparation method thereof - Google Patents

Whitening and moisturizing composition, body lotion and preparation method thereof Download PDF

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CN115364020A
CN115364020A CN202111208858.3A CN202111208858A CN115364020A CN 115364020 A CN115364020 A CN 115364020A CN 202111208858 A CN202111208858 A CN 202111208858A CN 115364020 A CN115364020 A CN 115364020A
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whitening
moisturizing
component
paeonol
parts
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程瑶
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35Ketones, e.g. benzophenone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63Steroids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/673Vitamin B group
    • A61K8/675Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/732Starch; Amylose; Amylopectin; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728Fungi, e.g. yeasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/48Thickener, Thickening system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52Stabilizers
    • A61K2800/524Preservatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74Biological properties of particular ingredients
    • A61K2800/78Enzyme modulators, e.g. Enzyme agonists
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74Biological properties of particular ingredients
    • A61K2800/78Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782Enzyme inhibitors; Enzyme antagonists
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/85Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine

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  • Cosmetics (AREA)

Abstract

A whitening and moisturizing composition, body lotion and a preparation method thereof relate to the technical field of cosmetics; the composition comprises the following components in parts by mass: 0.02-0.3 part of lily extract component and 0.05-0.4 part of yeast fermentation product extract component; 0.05-0.3 part of nicotinamide and 0.01-0.2 part of paeonol component; the invention combines the lily extract component, the yeast fermentation product extract component, the nicotinamide and the paeonol, and can promote active substances to be absorbed by skin, thereby achieving the synergistic effect on deep moisturizing, whitening and anti-aging. The preparation method is simple, the process is stable, and the prepared body lotion has good moisturizing and whitening effects.

Description

Whitening and moisturizing composition, body lotion and preparation method thereof
Technical Field
The invention relates to the field of cosmetics, and particularly relates to a whitening and moisturizing composition, body lotion and a preparation method thereof.
Background
With seasonal changes, the intensity of sunlight and the humidity of air can change obviously, which can affect the health of human skin. If the strong light in the south and the dry air in the north cause the epidermis layer of the skin to lack enough water, the skin is dry, the skin shows redness and fine cracks, scales or desquamation can be generated if the dry condition is continued seriously, the cracks can even crack the skin, the depth reaches the dermis layer, infection is caused, and the skin is damaged.
In order to effectively avoid the problem of skin dryness, besides supplementing body water, some mild and non-irritant skin care products can be properly selected, so that the direct contact of the skin and the air is reduced, the evaporation speed of water is reduced, and the drying speed of the skin is reduced. Therefore, most of the existing skin care agents play a certain role in moisturizing the skin surface only by reducing the contact between the skin and the air, cannot reach the deep layer of the skin, and radically solve the problem of water shortage. Although skin care agents may be added with absorption-promoting agents, the effect is not ideal.
Disclosure of Invention
In order to overcome the disadvantages of the prior art, the first object of the present invention is to provide a whitening and moisturizing composition containing multiple skin conditioning agents. The composition can moisten skin, reduce water loss, and be easily absorbed by skin, and can be used for deep care of skin.
The second object of the invention is to provide a body lotion containing the whitening and moisturizing composition.
The third purpose of the invention is to provide a preparation method of the whitening and moisturizing body lotion.
The first purpose of the invention can be achieved by adopting the following technical scheme:
the whitening and moisturizing composition is characterized by comprising the following components in parts by weight: 0.02-0.3 part of lilium candidum extract component and 0.05-0.4 part of yeast fermentation product extract component; 0.05-0.3 part of nicotinamide and 0.01-0.2 part of paeonol component;
the components of the lilium candidum extract are obtained by uniformly mixing and dissolving water, butanediol, the lilium candidum extract and phenoxyethanol according to the weight ratio of 10-30;
the yeast fermentation product extract component is prepared by uniformly mixing and dissolving a yeast fermentation product extract, 1,2-hexanediol and p-hydroxyacetophenone according to the weight ratio of 3-8:5-10;
the paeonol component is prepared by uniformly mixing paeonol, dipotassium glycyrrhizinate and amylopectin according to the weight ratio of 1-3:1-2:2-5.
Further, the paint comprises the following components in parts by weight: 0.08-0.15 part of lilium candidum extract component and 0.1-0.2 part of yeast fermentation product extract component; 0.08-0.2 part of nicotinamide and 0.05-0.1 part of paeonol component.
The second purpose of the invention can be achieved by adopting the following technical scheme:
a whitening and moisturizing body lotion comprises the whitening and moisturizing composition.
Further, the coating also comprises the following components in parts by weight:
5.01 to 15.05 portions of humectant, 0.9 to 2.3 portions of emollient, 0.3 to 0.8 portion of colorant, 0.48 to 1.15 portions of thickener, 0.06 to 0.15 portion of pH regulator and 78 to 88 portions of water.
Further, the humectant comprises the following components in parts by weight: 5-15 parts of water and/or glycerol; 0.01-0.05 part of sodium hyaluronate;
the emollient includes: 0.6-1.5 parts of ethylhexyl palmitate, and 0.3-0.8 part of cyclopentadimethicone and/or cyclohexasiloxane;
the colorant is one or a composition of more than two of titanium dioxide, perfluorooctyl triethoxysilane and polydimethylsiloxane;
the thickener comprises: 0.3-0.8 part of acrylate copolymer sodium and/or lecithin, 0.1-0.2 part of xanthan gum and 0.08-0.15 part of carbomer;
the pH regulator is triethanolamine.
Further, the coating also comprises the following components in parts by mass: 0.31-0.65 part of preservative and 0.03-0.1 part of essence.
Further, the preservative comprises the following components in parts by mass: 0.1-0.2 part of methyl hydroxybenzoate, 0.06-0.15 part of propyl hydroxybenzoate and 0.15-0.3 part of bis (hydroxymethyl) imidazolidinyl urea.
The third purpose of the invention is realized by adopting the following technical scheme:
a preparation method of the moisturizing and whitening body lotion comprises the following steps:
s1, uniformly stirring water, a humectant, a thickening agent and nicotinamide at 75-85 ℃ to obtain a water phase mixture;
s2, uniformly stirring the coloring agent, the emollient, methyl hydroxybenzoate and propyl hydroxybenzoate at 75-85 ℃ to obtain an oil phase mixture;
s3, stirring the water phase mixture, adding the water phase mixture into the oil phase mixture, homogenizing at 80-85 ℃, adding a pH regulator, stirring in vacuum for homogenizing, and stirring at a constant temperature to obtain an emulsified mixture;
and S4, cooling the emulsified mixture to 45-50 ℃, adding bis (hydroxymethyl) imidazolidinyl urea, the lilium candidum extract component, the yeast fermentation product extract component, the paeonol component and the essence, uniformly stirring, and discharging to obtain the moisturizing skin care product.
Further, in the step S4, the components of the lilium candidum extract are uniformly mixed and dissolved according to the weight ratio of water, butanediol, lilium candidum extract and phenoxyethanol of 10-30 to 2-5:3-8;
uniformly mixing and dissolving the components of the yeast fermentation product extract according to the proportion of 1,2-hexanediol and p-hydroxyacetophenone of 3-8:5-10;
the paeonol components are uniformly mixed according to the proportion that the weight of paeonol, dipotassium glycyrrhizinate and amylopectin is 1-3:1-2:2-5.
Further, in the step S1 and the step S2, the stirring speed is 15-25 rpm;
the step S3 specifically includes: stirring the oil phase mixture at 25-35 r/min under-0.04-0.08 MPa, adding the water phase mixture while stirring, homogenizing at 80-85 ℃ for 8-12min after the water phase mixture is completely added, then adding the pH regulator, stirring in vacuum for homogenizing for 3-5min, and stirring at the constant temperature for 25-30min to obtain an emulsified mixture.
In the step S4, the stirring speed is 15-20 rpm.
The formulation design principle of the invention is as follows:
the lilium candidum extract contains a large amount of organic acids, flavonoids, glycosides and other substances, has the proliferation effect on fibroblasts, has the promotion effect on the activity of cathepsin, has the anti-aging effect, has the promotion effect on the activity of luciferase and has the anti-inflammatory effect. The contained aspartic acid has an anti-oxidation effect, the ophiopogon polysaccharide is a natural humectant, and veratramine has a strong inhibition effect on tyrosinase and can whiten and remove freckles. Therefore, the lilium candidum extract is an excellent active substance for whitening, moisturizing and resisting aging.
The yeast fermentation product extract not only contains skin beneficial components such as monosaccharide, polysaccharide, mineral substances, vitamins and the like which are products of yeast fermentation, but also contains active components such as amino acid, nucleotide and the like which are obtained by degrading proteins, nucleic acid and the like in yeast cells. After fermentation or degradation, the formed substances with small molecular weight have stronger permeability and are easier to enter the deep layer of the skin and be absorbed. Free amino acids are important components of natural skin moisturizing factors, amino acids, polypeptides have good effect on inhibiting the formation of tyrosinase melanin, abundant vitamins, polysaccharides have antioxidant, anti-inflammatory and anti-aging effects, minerals can promote the generation of body cells, and organic acids can remove cutin mildly; thus making the skin smooth and tender.
Paeonol is an effective component extracted from dried root bark of Paeonia suffruticosa Andr of Ranunculaceae. At a concentration that is devoid of the effect of a killer cell, paeonol is effective in inhibiting tyrosinase activity of melanoma cells and human epidermal melanocytes, thereby effectively inhibiting melanin synthesis. On the other hand, paeonol inhibits intracellular O 2- The generation of free radicals slows down the fibrosis of protein cells, so that the skin loses elasticity and wrinkles are generated; slowing down the peroxidation of adipocytes leading to skin becomingDull and colored. Therefore, the paeonol has the functions of whitening the skin and reducing and fading deposited pigments in the skin. In addition, the paeonol also has good anti-inflammatory effect.
The dipotassium glycyrrhizinate can activate corticosteroid compounds, indirectly enhance the effect of the corticosteroid compounds, effectively prevent sensitive inflammation phenomenon when skin is stimulated, has anti-inflammatory and sedative effects on inflammation, can be used together with paeonol, has synergistic anti-inflammatory effect, and is used for resisting allergy and repairing skin tissues.
Amylopectin has high branching property, the structure is favorable for being combined with water molecules through hydrogen bonds, the amylopectin is easily dispersed into viscous colloidal solution, and the three-dimensional reticular space distribution hinders the formation of the hydrogen bonds of the microcrystalline bundles, so that the amylopectin is very stable, basically cannot be aged, is easily adhered to the surface layer of skin, can carry and control active substances such as paeonol, dipotassium glycyrrhizinate and the like to be slowly released through the three-dimensional spatial structure, and realizes the long-time repair of the skin.
Phenoxyethanol is a substance with extremely strong killing effect on pseudomonas aeruginosa, p-hydroxyacetophenone is also an excellent preservative, and can be respectively mixed with lily extract and yeast fermentation product extract for use, so that the growth of microorganisms can be effectively inhibited, and the activity of the extract can be maintained.
The bis (hydroxymethyl) imidazolidinyl urea is a preservative, plays a role in sterilization and bacteriostasis by releasing formaldehyde, particularly has an antifungal effect, and can greatly improve the preservative property when being used together with methyl hydroxybenzoate and propyl hydroxybenzoate.
The xanthan gum is one of biological gums with excellent performance, and integrates the functions of thickening property, water locking property, suspension property, emulsifying property and the like. Has good intersolubility with other thickeners, can improve the viscosity of the product by compounding, and simultaneously locks water.
Nicotinamide is non-acidic and non-irritating, is a highly absorptive water-soluble substance, and can reduce the transfer of melanosomes from melanocytes to keratinocytes, block the transfer of melanin, reduce the amount of melanin transferred to epidermal cells, and achieve whitening effect. And niacinamide can increase the levels of free fatty acids and ceramides in the skin, enhance keratin synthesis, and thus help the skin retain water. The most important thing is that niacinamide can inhibit sugar aging and indirectly resist aging, excessive sugar is absorbed and cannot be completely metabolized by the body, sugar can be attached to protein in the dermis layer, collagen loses elasticity and turns brown, and elastic fiber is broken due to saccharification. Nicotinamide can stimulate collagen production and slow down the sugar aging process.
Compared with the prior art, the invention has the beneficial effects that:
the invention provides a whitening and moisturizing composition which comprises the following components: a lily lilium extract component, a yeast fermentation product extract component; nicotinamide, paeonol component. The lilium candidum extract contains a large amount of organic acids, flavonoids, glycosides and other substances, and is an excellent active substance for whitening, moisturizing and resisting aging. The yeast fermentation product extract contains skin beneficial components such as monosaccharide, polysaccharide, mineral, vitamins, etc. after fermentation of yeast, and also contains amino acids, nucleotides, etc. after degradation of protein, nucleic acid, etc. in yeast cell. The permeability is stronger, the skin can be absorbed more easily in the deep layer of the skin, and the moisturizing, whitening and anti-aging effects are effectively improved. Paeonol and nicotinamide are also active substances with good skin adsorbability, whitening, moisturizing and anti-aging. The invention combines the lily extract component, the yeast fermentation product extract component, the nicotinamide and the paeonol, and can promote active substances to be absorbed by skin, thereby achieving the synergistic effect on deep moisturizing, whitening and anti-aging.
The body lotion comprises a lily liliflora extract component, a yeast fermentation product extract component; the nicotinamide and the paeonol have obvious effects of repairing skin injury and moistening skin.
The preparation method of the moisturizing skin care product is simple and stable in process, and the prepared body lotion is good in moisturizing and whitening effects.
Detailed Description
The present invention is further described below with reference to specific embodiments, and it should be noted that, without conflict, any combination between the embodiments or technical features described below may form a new embodiment. The following are specific examples of the present invention, and raw materials, equipments and the like used in the following examples can be obtained by purchasing them unless otherwise specified.
Example 1:
the whitening and moisturizing composition comprises the following components in parts by weight: 0.02 part of lily extract component and 0.4 part of yeast fermentation product extract component; 0.3 part of nicotinamide and 0.01 part of paeonol component;
the components of the lilium candidum extract are obtained by uniformly mixing and dissolving water, butanediol, the lilium candidum extract and phenoxyethanol according to the weight ratio of 30;
the yeast fermentation product extract component is prepared by uniformly mixing and dissolving a yeast fermentation product extract, 1,2-hexanediol and p-hydroxyacetophenone according to the weight ratio of 3;
the paeonol component is prepared by uniformly mixing paeonol, dipotassium glycyrrhizinate and amylopectin according to the weight ratio of 3.
The preparation method comprises the following steps: at the temperature of 45 ℃, preparing lily bulb extract components, yeast fermentation product extract components and paeonol components according to a proportion respectively, mixing the lily bulb extract components and the yeast fermentation product extract components according to the formula amount to obtain a mixed solution, adding nicotinamide and the paeonol components according to the formula amount into the mixed solution, and uniformly mixing to obtain the whitening and moisturizing composition.
Example 2:
the whitening and moisturizing composition comprises the following components in parts by weight: 0.08 part of lily extract component and 0.2 part of yeast fermentation product extract component; 0.05 part of nicotinamide and 0.2 part of paeonol component;
the components of the lilium candidum extract are obtained by uniformly mixing and dissolving water, butanediol, the lilium candidum extract and phenoxyethanol according to the weight ratio of 20;
the yeast fermentation product extract component is prepared by uniformly mixing and dissolving a yeast fermentation product extract, 1,2-hexanediol and p-hydroxyacetophenone according to the weight ratio of 8;
the paeonol component is prepared by uniformly mixing paeonol, dipotassium glycyrrhizinate and amylopectin according to the weight ratio of 2.
The preparation method comprises the following steps: respectively preparing the lilium album extract component, the yeast fermentation product extract component and the paeonol component in proportion at 50 ℃, mixing the lilium album extract component and the yeast fermentation product extract component in a formula amount to obtain a mixed solution, adding the nicotinamide and the paeonol component in a formula amount into the mixed solution, and uniformly mixing to obtain the whitening and moisturizing composition.
Example 3:
the whitening and moisturizing composition comprises the following components in parts by weight: 0.15 part of lilium candidum extract component and 0.1 part of yeast fermentation product extract component; 0.2 part of nicotinamide and 0.1 part of paeonol component;
the components of the lilium candidum extract are obtained by uniformly mixing and dissolving water, butanediol, the lilium candidum extract and phenoxyethanol according to the weight ratio of 10;
the yeast fermentation product extract component is prepared by uniformly mixing and dissolving yeast fermentation product extract, 1,2-hexanediol and p-hydroxyacetophenone according to the weight ratio of 5.5;
the paeonol component is prepared by uniformly mixing paeonol, dipotassium glycyrrhizinate and amylopectin according to the weight ratio of 1.5.
The preparation method comprises the following steps: at 47 ℃, preparing lily bulb extract components, yeast fermentation product extract components and paeonol components in proportion respectively, mixing the lily bulb extract components and the yeast fermentation product extract components in formula amount to obtain a mixed solution, adding nicotinamide and the paeonol components in formula amount to the mixed solution, and uniformly mixing to obtain the whitening and moisturizing composition.
Example 4:
the whitening and moisturizing composition comprises the following components in parts by weight: 0.3 part of lilium candidum extract component and 0.05 part of yeast fermentation product extract component; 0.08 part of nicotinamide and 0.05 part of paeonol component;
the lilium candidum extract is prepared by uniformly mixing and dissolving water, butanediol, lilium candidum extract and phenoxyethanol according to the weight ratio of 25;
the yeast fermentation product extract component is prepared by uniformly mixing and dissolving a yeast fermentation product extract, 1,2-hexanediol and p-hydroxyacetophenone according to the weight ratio of 5;
the paeonol component is prepared by uniformly mixing paeonol, dipotassium glycyrrhizinate and amylopectin according to the weight ratio of 3.
The preparation method comprises the following steps: at 49 ℃, respectively preparing the lily flower extract component, the yeast fermentation product extract component and the paeonol component in proportion, mixing the lily flower extract component and the yeast fermentation product extract component in a formula amount to obtain a mixed solution, adding the nicotinamide and the paeonol component in a formula amount into the mixed solution, and uniformly mixing to obtain the whitening and moisturizing composition.
Example 5
The whitening and moisturizing body lotion comprises the whitening and moisturizing composition of example 1, and further comprises the following components in parts by weight:
5.01 parts of humectant, 0.9 part of emollient, 0.3 part of colorant, 0.48 part of thickener, 0.06 part of triethanolamine, 0.03 part of essence and 78 parts of water.
The humectant includes: 5 parts of water and glycerol; 0.01 part of sodium hyaluronate;
the emollient includes: 0.6 part of ethylhexyl palmitate, 0.3 part of cyclopentadimethylsiloxane and cyclohexasiloxane;
the colorant is one or more than two of titanium dioxide, perfluorooctyl triethoxysilane and polydimethylsiloxane 0.3 part of composition
The thickener comprises: 0.3 part of acrylate copolymer sodium and lecithin, 0.1 part of xanthan gum and 0.08 part of carbomer;
the preservative comprises: 0.1 part of methyl hydroxybenzoate, 0.06 part of propyl hydroxybenzoate and 0.15 part of bis (hydroxymethyl) imidazolidinyl urea.
A preparation method of the whitening and moisturizing body lotion comprises the following steps:
s1, uniformly stirring water, a humectant, a thickening agent and nicotinamide at 75 ℃ to obtain a water-phase mixture;
s2, uniformly stirring the coloring agent, the emollient, methyl hydroxybenzoate and propyl hydroxybenzoate at 75 ℃ to obtain an oil phase mixture;
s3, stirring the water phase mixture, adding the water phase mixture into the oil phase mixture, homogenizing at 80 ℃, adding a pH regulator, stirring in vacuum, homogenizing, and stirring at a constant temperature to obtain an emulsified mixture;
and S4, cooling the emulsified mixture to 45 ℃, adding bis (hydroxymethyl) imidazolidinyl urea, the lilium candidum extract component, the yeast fermentation product extract component, the paeonol component and the essence, uniformly stirring, and discharging to obtain the whitening and moisturizing body lotion.
Example 6
The whitening and moisturizing body lotion comprises the whitening and moisturizing composition of example 2, and further comprises the following components in parts by weight:
15.05 parts of humectant, 2.3 parts of emollient, 0.8 part of colorant, 1.15 parts of thickener, 0.15 part of triethanolamine, 0.1 part of essence and 88 parts of water.
The humectant comprises: water and 15 parts of glycerol; 0.05 part of sodium hyaluronate;
the emollient includes: 1.5 parts of ethylhexyl palmitate, 0.8 part of cyclopentadimethylsiloxane and cyclohexasiloxane;
the colorant is one or more than two of titanium dioxide, perfluorooctyl triethoxysilane and polydimethylsiloxane 0.8 part of composition
The thickening agent comprises: 0.8 part of acrylate copolymer sodium and lecithin, 0.2 part of xanthan gum and 0.15 part of carbomer;
the preservative comprises: 0.2 part of methyl hydroxybenzoate, 0.15 part of propyl hydroxybenzoate and 0.3 part of bis (hydroxymethyl) imidazolidinyl urea.
A preparation method of the whitening and moisturizing body lotion comprises the following steps:
s1, uniformly stirring water, a humectant, a thickening agent and nicotinamide at 85 ℃ to obtain a water-phase mixture;
s2, uniformly stirring the coloring agent, the emollient, methyl hydroxybenzoate and propyl hydroxybenzoate at 85 ℃ to obtain an oil phase mixture;
s3, stirring the water phase mixture, adding the water phase mixture into the oil phase mixture, homogenizing at 85 ℃, adding a pH regulator, stirring in vacuum, homogenizing, and stirring at a constant temperature to obtain an emulsified mixture;
and S4, cooling the emulsified mixture to 50 ℃, adding bis (hydroxymethyl) imidazolidinyl urea, the lilium candidum extract component, the yeast fermentation product extract component, the paeonol component and the essence, uniformly stirring, and discharging to obtain the whitening and moisturizing body lotion.
Example 7
The whitening and moisturizing body lotion comprises the whitening and moisturizing composition of example 4, and further comprises the following components in parts by weight:
10.03 parts of humectant, 1.6 parts of emollient, 0.55 part of colorant, 0.82 part of thickener, 0.1 part of triethanolamine, 0.065 part of essence and 83 parts of water.
The humectant includes: 10 parts of water and glycerol; 0.03 part of sodium hyaluronate;
the emollient includes: 1.1 parts of ethylhexyl palmitate, 0.5 parts of cyclopentadimethylsiloxane and cyclohexasiloxane;
the colorant is one or more than two of titanium dioxide, perfluorooctyl triethoxysilane and polydimethylsiloxane 0.55 part of composition
The thickener comprises: 0.55 part of acrylate copolymer sodium and lecithin, 0.15 part of xanthan gum and 0.12 part of carbomer;
the preservative comprises: 0.15 part of methyl hydroxybenzoate, 0.1 part of propyl hydroxybenzoate and 0.23 part of bis (hydroxymethyl) imidazolidinyl urea.
A preparation method of the whitening and moisturizing body lotion comprises the following steps:
s1, uniformly stirring water, a humectant, a thickening agent and nicotinamide at 80 ℃ to obtain a water-phase mixture;
s2, uniformly stirring the coloring agent, the emollient, methyl hydroxybenzoate and propyl hydroxybenzoate at 80 ℃ to obtain an oil phase mixture;
s3, stirring the water phase mixture, adding the water phase mixture into the oil phase mixture, homogenizing at 82.5 ℃, adding a pH regulator, stirring in vacuum, homogenizing, and stirring at a constant temperature to obtain an emulsified mixture;
and S4, cooling the emulsified mixture to 47.5 ℃, adding bis (hydroxymethyl) imidazolidinyl urea, the lilium candidum extract component, the yeast fermentation product extract component, the paeonol component and the essence, uniformly stirring, and discharging to obtain the whitening and moisturizing body lotion.
Comparative example 1
Comparative example 1 differs from example 7 in that the raw material does not contain lily extract;
comparative example 2
Comparative example 2 differs from example 7 in that the starting material does not contain yeast fermentation product extract;
comparative example 3
Comparative example 3 differs from example 7 in that the starting material does not contain yeast fermentation product extract;
comparative example 4
Comparative example 4 is different from example 7 in that the lily alba extract component, the yeast fermentation product extract component, and the paeonol component in the raw materials are not separately mixed in advance;
the whitening and moisturizing body lotion comprises the following components in parts by weight:
0.15 part of yeast fermentation product extract component, 0.3 part of lily extract component, 0.08 part of nicotinamide and 0.05 part of paeonol component; 10.03 parts of humectant, 1.6 parts of emollient, 0.55 part of colorant, 0.82 part of thickener, 0.1 part of triethanolamine, 0.065 part of essence and 83 parts of water.
The lily flower extract component contains water, butanediol, lily flower extract and phenoxyethanol according to the weight ratio of 25;
the yeast fermentation product extract component comprises a yeast fermentation product extract, 1,2-hexanediol, p-hydroxyacetophenone, in a weight ratio of 5;
the paeonol component comprises paeonol, dipotassium glycyrrhizinate and amylopectin according to the weight ratio of 3.
The humectant includes: 10 parts of water and glycerol; 0.03 part of sodium hyaluronate;
the emollient includes: 1.1 parts of ethylhexyl palmitate, 0.5 parts of cyclopentadimethylsiloxane and cyclohexasiloxane;
the colorant is one or more than two of titanium dioxide, perfluorooctyl triethoxysilane and polydimethylsiloxane 0.55 part of composition
The thickener comprises: 0.55 part of acrylate copolymer sodium and lecithin, 0.15 part of xanthan gum and 0.12 part of carbomer;
the preservative comprises: 0.15 part of methyl hydroxybenzoate, 0.1 part of propyl hydroxybenzoate and 0.23 part of bis (hydroxymethyl) imidazolidinyl urea.
A preparation method of the whitening and moisturizing body lotion comprises the following steps:
s1, uniformly stirring water, a humectant, a thickening agent and nicotinamide at 80 ℃ to obtain a water-phase mixture;
s2, uniformly stirring the coloring agent, the emollient, methyl hydroxybenzoate and propyl hydroxybenzoate at 80 ℃ to obtain an oil phase mixture;
s3, stirring the water phase mixture, adding the water phase mixture into the oil phase mixture, homogenizing at 82.5 ℃, adding a pH regulator, stirring in vacuum, homogenizing, and stirring at a constant temperature to obtain an emulsified mixture;
s4, cooling the emulsified mixture to 47.5 ℃, adding bis (hydroxymethyl) imidazolidinyl urea, adding the lily extract component, the yeast fermentation product extract component and the raw materials contained in the paeonol component into a reactor, adding essence, stirring uniformly, and discharging to obtain the whitening and moisturizing body lotion.
Quality detection
Detecting metal ions in the whitening and moisturizing body milk of the embodiments 5-7 according to a mercury, lead, arsenic and cadmium detection method in a detection requirement detection method of technical Specification for safety of cosmetics 2015 edition; the results are shown in Table 1;
detecting the flora in the whitening and moisturizing body milk of the examples 5-7 according to a detection method of total bacterial colony, total mould and saccharomycetes, heat-resistant escherichia coli, staphylococcus aureus and pseudomonas aeruginosa in a detection requirement detection method of technical Specification for safety of cosmetics 2015 edition; the results are shown in Table 2;
TABLE 1 whitening and moisturizing body milk metal ions
Detecting items The result of the detection Standard requirements (mg/kg)
Mercury Not detected out ≤1
Lead (II) Undetected ≤10
Arsenic (As) Not detected out ≤2
Cadmium (Cd) Not detected out ≤5
TABLE 2 detection of bacteria in body milk for whitening and moisturizing
Figure BDA0003308070920000151
Figure BDA0003308070920000161
Performance testing
Test 1: moisture retention test:
the whitening and moisturizing body milk of the examples 5 to 7 and the comparative examples 1 to 4 was subjected to the moisturizing test, and the specific operation method was: selecting a glass dish with a proper size, weighing a certain amount of the moisturizing skin care product, dropwise adding the moisturizing skin care product on the glass dish, putting the glass dish into a dryer for 24 hours, then weighing, and calculating the water loss rate, wherein the results are shown in table 3.
Table 3 body lotion loss test results for whitening and moisturizing
Example 5 Example 6 Example 7 Comparative example 1 Comparative example 2 Comparative example 3 Comparative example 4
The water loss rate% 8.5 8.1 8.4 12.1 11.5 11.3 11.5
As shown in table 1, the whitening and moisturizing body lotions of examples 5 to 7 have a water loss rate of less than 9% and a good moisturizing effect; in the comparative examples 1-3, the water loss rate is higher and the moisture retention performance is poorer because the lily lilium candidum extract component, the yeast fermentation product extract component and the paeonol component are lacked; therefore, the lily extract component, the yeast fermentation product extract component, the paeonol component and other components are combined, and the moisture retention effect of the composition achieves the synergistic effect. And it can be seen from comparative example 4 that, although the same ingredients as in example 7 were used, since the lily bulbs extract component, the yeast fermentation product extract component and the paeonol component were not separately premixed and the ingredients in the respective components were mixed, but the lily bulbs extract component, the yeast fermentation product extract component and the paeonol component were separately added at the same time for reaction and mixing in the preparation of the body lotion, the moisturizing effect was slightly inferior to that of the body lotion prepared by premixing, which is not only a synergistic effect of the respective components but also a certain correlation with the order of mixing the components.
And (3) testing 2: tyrosinase inhibition assay:
dissolving tyrosinase in PBS buffer with pH =6.8 to prepare 120U/mL tyrosinase solution; dissolving L-tyrosine in PBS buffer solution with pH =6.8 to prepare 1.6 mol/L-tyrosine solution; dissolving a sample to be detected in PBS (phosphate buffer solution) with pH =6.8 to prepare a sample solution to be detected of 0.5 mg/mL; taking 0.5mL of sample solution to be tested, adding 0.5mL of tyrosinase solution and 1.5mL of PBS buffer solution with the pH value of 6.8, preheating for 10min at 35 ℃, adding 0.5mL of L-tyrosine solution, reacting for 15min at 35 ℃, measuring the light absorption value at 475nm, testing 3 groups according to the same formula, and taking the average value.
Tyrosinase inhibition (%) = [1- (A1-A2)/(A3-A4) ] × 100
Wherein, A1: l-tyrosine, the light absorption value of the sample to be detected and the tyrosinase system; a2: the light absorption value of the sample to be detected, tyrosinase and PBS buffer solution system; a3: the light absorption values of the L-tyrosine and tyrosinase systems and the PBS buffer solution; a4: and (3) the light absorption value of a tyrosinase and PBS buffer solution system.
TABLE 4 tyrosinase inhibition rate test table
Figure BDA0003308070920000171
The whitening and moisturizing body lotion prepared by the invention has good whitening effect; comparing examples 5-7 with comparative examples 1-3, it can be seen that the whitening humectant is obtained by compounding the lily lilium candidum extract, the yeast fermentation product extract and the paeonol component, and has synergistic effect, so that the whitening effect is further improved; according to the invention, the lily extract, the yeast fermentation product extract and the paeonol component with specific contents are added, so that the lily extract, the yeast fermentation product extract and the paeonol component interact with other active ingredients in the formula in a coordinated manner to nourish the skin together; the lily extract and the yeast fermentation product extract are mutually complemented with different whitening and moisturizing active ingredients of paeonol, so that the inhibition on the catalytic activity of tyrosinase is further enhanced, and simultaneously, more whitening active ingredients act on the tyrosinase, the formation of melanin is effectively inhibited, and the skin whitening effect is better.
Therefore, the combination of the lily extract component, the yeast fermentation product extract component, the nicotinamide and the paeonol can promote active substances to be absorbed by skin, so that the synergistic effect on deep moisturizing, whitening and anti-aging is achieved.
The above embodiments are only preferred embodiments of the present invention, and the protection scope of the present invention is not limited thereby, and any insubstantial changes and substitutions made by those skilled in the art based on the present invention are within the protection scope of the present invention.

Claims (10)

1. The whitening and moisturizing composition is characterized by comprising the following components in parts by weight: 0.02-0.3 part of lily extract component and 0.05-0.4 part of yeast fermentation product extract component; 0.05-0.3 part of nicotinamide and 0.01-0.2 part of paeonol component;
the components of the lilium candidum extract are obtained by dissolving and uniformly mixing water, butanediol, the lilium candidum extract and phenoxyethanol according to the weight ratio of 10-30;
the yeast fermentation product extract component is obtained by dissolving and uniformly mixing yeast fermentation product extract, 1,2-hexanediol and p-hydroxyacetophenone according to the weight ratio of 3-8:5-10;
the paeonol component is prepared by uniformly mixing paeonol, dipotassium glycyrrhizinate and amylopectin according to the weight ratio of 1-3:1-2:2-5.
2. The whitening and moisturizing composition as claimed in claim 1, comprising the following components in parts by mass: 0.08-0.15 part of lily extract component and 0.1-0.2 part of yeast fermentation product extract component; 0.08-0.2 part of nicotinamide and 0.05-0.1 part of paeonol component.
3. A whitening and moisturizing body lotion, characterized by comprising the whitening and moisturizing composition of any one of claims 1-2.
4. The whitening and moisturizing body lotion according to claim 3, further comprising the following components in parts by mass: 5.01 to 15.05 parts of humectant, 0.9 to 2.3 parts of emollient, 0.3 to 0.8 part of colorant, 0.48 to 1.15 parts of thickener, 0.06 to 0.15 part of pH regulator and 78 to 88 parts of water.
5. The whitening and moisturizing body lotion according to claim 4, wherein the moisturizing agent comprises the following components in parts by weight: 5-15 parts of water and/or glycerol; 0.01-0.05 part of sodium hyaluronate;
the emollient includes: 0.6-1.5 parts of ethylhexyl palmitate, and 0.3-0.8 part of cyclopentasiloxane and/or cyclohexasiloxane;
the colorant is one or a composition of more than two of titanium dioxide, perfluorooctyl triethoxysilane and polydimethylsiloxane;
the thickener comprises: 0.3-0.8 part of acrylate copolymer sodium and/or lecithin, 0.1-0.2 part of xanthan gum and 0.08-0.15 part of carbomer;
the pH regulator is triethanolamine.
6. The whitening and moisturizing body lotion according to claim 3, further comprising the following components in parts by weight: 0.31-0.65 part of preservative and 0.03-0.1 part of essence;
the preservative comprises: 0.1-0.2 part of methyl hydroxybenzoate, 0.06-0.15 part of propyl hydroxybenzoate and 0.15-0.3 part of bis (hydroxymethyl) imidazolidinyl urea.
7. The preparation method of the moisturizing and whitening body lotion is characterized by comprising the following steps:
s1, uniformly stirring water, a humectant, a thickening agent and nicotinamide at 75-85 ℃ to obtain a water phase mixture;
s2, uniformly stirring the coloring agent, the emollient, methyl hydroxybenzoate and propyl hydroxybenzoate at 75-85 ℃ to obtain an oil phase mixture;
s3, stirring the water phase mixture, adding the water phase mixture into the oil phase mixture, homogenizing at 80-85 ℃, adding a pH regulator, stirring in vacuum, homogenizing, and stirring at a constant temperature to obtain an emulsified mixture;
and S4, cooling the emulsified mixture to 45-50 ℃, adding bis (hydroxymethyl) imidazolidinyl urea, the lilium candidum extract component, the yeast fermentation product extract component, the paeonol component and the essence, uniformly stirring, and discharging to obtain the moisturizing skin care product.
8. The preparation method of the moisturizing and whitening body lotion according to claim 7, wherein in the step S4, the components of the lilium candidum extract are dissolved and mixed uniformly according to the weight ratio of water, butanediol, the lilium candidum extract and phenoxyethanol of 10-30;
dissolving and uniformly mixing the components of the yeast fermentation product extract according to the weight ratio of the yeast fermentation product extract, 1,2-hexanediol and p-hydroxyacetophenone of 3-8:5-10;
uniformly mixing the paeonol component according to the weight ratio of paeonol, dipotassium glycyrrhizinate and amylopectin of 1-3:1-2:2-5.
9. The preparation method of the moisturizing and whitening body lotion according to claim 7, wherein in the step S1 and the step S2, the stirring speed is 15-25 rpm, and in the step S4, the stirring speed is 15-20 rpm.
10. The preparation method of the moisturizing and whitening body lotion according to claim 7, wherein the step S3 is specifically as follows: stirring the oil phase mixture at 25-35 r/min under-0.04-0.08 MPa, adding the water phase mixture while stirring, homogenizing at 80-85 deg.C for 8-12min, adding pH regulator, vacuum stirring and homogenizing for 3-5min, and stirring at constant temperature for 25-30min to obtain emulsified mixture.
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115919716A (en) * 2022-12-30 2023-04-07 北京植物医生生物科技有限公司 Low-irritation, whitening and skin-care facial mask and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115919716A (en) * 2022-12-30 2023-04-07 北京植物医生生物科技有限公司 Low-irritation, whitening and skin-care facial mask and preparation method thereof

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