CN115361974A - 小檗碱类似物与jak抑制剂在胃肠道炎症性疾病治疗中的用途 - Google Patents

小檗碱类似物与jak抑制剂在胃肠道炎症性疾病治疗中的用途 Download PDF

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CN115361974A
CN115361974A CN202180024709.3A CN202180024709A CN115361974A CN 115361974 A CN115361974 A CN 115361974A CN 202180024709 A CN202180024709 A CN 202180024709A CN 115361974 A CN115361974 A CN 115361974A
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berberine
substituted
composition
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CN115361974B (zh
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寿建勇
江磊
金贤
刘胜洋
毛旭东
张建华
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Yinuo Zhejiang Pharmaceutical Co ltd
Shanghai Ennovabio Pharmaceuticals Co Ltd
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Yinuo Zhejiang Pharmaceutical Co ltd
Shanghai Ennovabio Pharmaceuticals Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Pain & Pain Management (AREA)
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Abstract

本发明涉及一种小檗碱类似物与JAK抑制剂联合治疗胃肠道炎症性疾病的策略，具体地，本发明提供了含有小檗碱类似物与JAK抑制剂的药物组合物，及其在胃肠道炎症性疾病治疗中的用途。所述的组合物可以表现出比小檗碱或JAK抑制剂单独使用情况下改善的效果。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN202180024709.3A 2020-03-26 2021-03-26 小檗碱类似物与jak抑制剂在胃肠道炎症性疾病治疗中的用途 Active CN115361974B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202010225184.7A CN113440613A (zh) 2020-03-26 2020-03-26 小檗碱类似物与jak抑制剂在胃肠道炎症性疾病治疗中的用途
CN2020102251847 2020-03-26
PCT/CN2021/083421 WO2021190647A1 (zh) 2020-03-26 2021-03-26 小檗碱类似物与jak抑制剂在胃肠道炎症性疾病治疗中的用途

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CN115361974A true CN115361974A (zh) 2022-11-18
CN115361974B CN115361974B (zh) 2024-04-16

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CN202180024709.3A Active CN115361974B (zh) 2020-03-26 2021-03-26 小檗碱类似物与jak抑制剂在胃肠道炎症性疾病治疗中的用途

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CN (2) CN113440613A (zh)
WO (1) WO2021190647A1 (zh)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118043051A (zh) * 2021-08-12 2024-05-14 江苏恒瑞医药股份有限公司 用于治疗或预防抗宿主病的吡咯并六元杂芳物
CN114177173B (zh) * 2021-12-02 2023-11-07 哈尔滨医科大学 四氢小檗红碱在制备预防或治疗肠粘连疾病药物中的应用
CN114736202A (zh) * 2022-04-20 2022-07-12 四川大学 具有ido1/tdo抑制活性的小檗碱衍生物的制备及用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108272802A (zh) * 2018-03-09 2018-07-13 华南理工大学 一种治疗溃疡性结肠炎的联合用药物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108272802A (zh) * 2018-03-09 2018-07-13 华南理工大学 一种治疗溃疡性结肠炎的联合用药物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
XIU-TING YU等: "Berberrubine attenuates mucosal lesions and inflammation in dextran sodium sulfateinduced colitis in mice", PLOS ONE *

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CN115361974B (zh) 2024-04-16
CN113440613A (zh) 2021-09-28
US20230293503A1 (en) 2023-09-21
WO2021190647A1 (zh) 2021-09-30

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