CN115337016A - Method and device for evaluating myocardial ischemia based on current density vector diagram - Google Patents

Method and device for evaluating myocardial ischemia based on current density vector diagram Download PDF

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CN115337016A
CN115337016A CN202210914815.5A CN202210914815A CN115337016A CN 115337016 A CN115337016 A CN 115337016A CN 202210914815 A CN202210914815 A CN 202210914815A CN 115337016 A CN115337016 A CN 115337016A
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许琳
封燮
王睿奇
汤苏晋
陈铭远
赵凯明
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Suzhou Kadi Merck Medical Instrument Ltd
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    • A61B5/242Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents
    • A61B5/243Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetocardiographic [MCG] signals
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Abstract

The invention discloses a method and a device for evaluating myocardial ischemia based on a current density vector diagram, wherein the method comprises the following steps: acquiring a magnetic field map recorded by a magnetocardiogram instrument; inverting the magnetic field diagram recorded by the magnetocardiograph, and converting the magnetic field diagram into a current density vector diagram; six parameters of the current density vector diagram were calculated: vortex value-symmetry degree, R wave and T wave area ratio, angle deviation value, normal current total ratio, abnormal current number-transmembrane action potential uniformity and maximum active current area; controlling the final number range of the six parameters in the range of 0-1 through transformation, wherein the larger the number is, the more the number is prone to abnormity; and calculating the average value of the finally obtained six parameters, and then comparing the average value with contrast data to judge the positivity/negativity. The invention can help doctors to diagnose more quickly and better by automatically judging the result through the computer, thereby judging the coronary heart disease without invasive examination.

Description

Method and device for evaluating myocardial ischemia based on current density vector diagram
Technical Field
The invention relates to the technical field of data analysis, in particular to a method and a device for evaluating myocardial ischemia based on a current density vector diagram.
Background
Magnetocardiographs are used to measure and analyze the magnetic field formed by cardiac currents. The ionic activity inside and outside the cardiomyocytes produces a potential difference across the body surface, which can be recorded by a common Electrocardiogram (ECG). The electrical activity of the heart also produces corresponding changes in the magnetic field. Magnetocardiography (MCG) is a recording means and technique for generating electromagnetic field changes (i.e. time function of magnetic field strength or magnetic induction) to the heart. In contrast, the magnetocardiograph is capable of very sensitive detection of tangential and eddy current signals to which the electrocardiograph is not sensitive; the electromagnetic signals generated by the heart are not influenced by peripheral organs of the heart, so that the magnetocardiograph can reflect the real electrophysiological conditions of specific positions of the heart. MCG is a product of combining superconducting weak magnetic detection technology and computer technology, and is one of the latest and most advanced technologies in the field of heart noninvasive examination. The MCG improves the sensitivity and the accuracy of heart noninvasive examination, has complementary effect on the current noninvasive examination of ECG and the like, and has outstanding advantages and application prospects in aspects of heart disease risk classification, general survey, interventional diagnosis and treatment effect evaluation and the like.
Heart disease, particularly coronary heart disease, often affects the spread of myocardial electrical current. Sensitive magnetocardiographs can recalculate potential abnormal currents by detecting weak changes in the cardiac magnetic field. The magnetocardiogram instrument has very high sensitivity and can sense the complete dynamic process of myocardial current change in a cardiac cycle. Unlike other imaging procedures, magnetocardiographs are capable of directly displaying the function of heart activity, and are functional imaging techniques (rather than morphology).
Magnetocardiography has the advantage of being non-invasive and does not radiate energy during diagnostic procedures, e.g., without the need for X-ray, ultrasound, or Magnetic Resonance Imaging (MRI). Only the physiological magnetic field above the thorax needs to be measured. Thus, the inspection is absolutely risk-free and can be repeated as often as necessary. At present, MCG can be clinically used for early diagnosis of acute and chronic myocardial ischemia, detection of survival cardiac muscle in an infarcted area after myocardial infarction, evaluation of the risk degree of malignant arrhythmia, and follow-up of treatment (including drug treatment, coronary stent and coronary bypass) of patients with coronary heart disease.
The advantage of the magnetocardiograph is that coronary artery disease is identified early (from existing clinical data), with higher sensitivity and specificity compared to Electrocardiogram (ECG), the measured values are not distorted, there is no interference of the measurement (due to the tissue interface), there is no potentially harmful radiation or other energy, no use of chemical contrast agents, or aids, no contact with the patient, short examination time, no dressing change, and the measurement can be performed in a normal room (no shielding).
The magnetocardiograph can accurately record the cardiac magnetic signals, but how to interpret the signals is also a big difficulty. At present, the heart diseases generally still need to be diagnosed by using an invasive developer, and a technical means which can diagnose the heart diseases wrapped in the chest cavity noninvasively at an early stage is lacked. The magnetocardiogram detection can just make up for the technical barrier, so that the real noninvasive developer-free passive heart disease diagnosis is realized, the detection accuracy is up to 90 percent, a plurality of blank diagnosis areas of heart disease diagnosis in the current medical field are fundamentally filled, and revolutionary changes are brought to the whole diagnosis process of the current cardiology department and the global heart disease prevention and treatment.
Disclosure of Invention
The invention aims to: the method comprises the steps of inverting a magnetic field map recorded by a magnetocardiogram instrument to be converted into a current density vector map, calculating six parameters of the current density vector map to obtain an average value, and automatically judging a result through a computer. The automated diagnostic procedure can help physicians diagnose coronary heart disease faster and better, thereby eliminating the need for invasive examination.
The technical scheme of the invention is as follows:
a method for assessing myocardial ischemia based on a current density vector map, comprising:
s1, obtaining a magnetic field map recorded by a magnetocardiogram instrument;
s2, inverting the magnetic field diagram recorded by the magnetocardiogram instrument and converting the magnetic field diagram into a current density vector diagram;
s3, calculating six parameters of the current density vector diagram:
a. vortex value-degree of symmetry;
b. area ratio of R wave to T wave;
c. an angle deviation value;
d. the total normal current accounts for;
e. number of abnormal currents-transmembrane action potential homogeneity;
f. maximum active current area;
s4, controlling the final number range of the six parameters in the range of 0-1 through transformation, wherein the larger the number is, the more the number tends to be abnormal;
and S5, calculating the Mean value Mean = (a + b + c + d + e + f)/6 of the finally obtained six parameters, comparing the Mean value with contrast data, and judging the positivity/negativity.
Preferably, the method for calculating the swirl value-symmetry degree in S3 is as follows:
it is best if there are two symmetric vortices representing cardiac conditions, better if there are two asymmetric vortices, and severe if there are three or more vortices; the range of the vortex value is 60-100, and the smaller the value is, the more the value is normal.
Preferably, the method for calculating the area ratio of the R wave to the T wave in S3 is as follows:
and comparing the ratio of the area under the R wave to the area under the T wave, wherein the value range is 0.1-1.2, and the larger the value is, the more the value is normal.
Preferably, the method for calculating the angle deviation value in S3 is as follows:
the angular deviation refers to the maximum vector and the angular deviation thereof compared with the 45-degree direction of the lower right corner, the value range is 0-150 degrees, and the smaller the numerical value is, the more the numerical value is, the normal the numerical value is.
Preferably, the calculation method of the ratio of the total number of the normal currents in S3 is as follows:
the normal current is the ratio of the normal vector value to the total vector in the residual vectors after the tiny vectors are removed, the value range is 0-1, and the larger the value is, the more the value tends to be normal.
Preferably, the method for calculating the number of abnormal currents-transmembrane action potential uniformity in S3 comprises:
the abnormal current number refers to the number of blocks of the residual vector after the tiny vector is removed, the value range is 2-6, and the smaller the value is, the more the value is normal.
Preferably, in S5, each magnetocardiogram test patient is automatically assigned a Mean value by the system, and the Mean value is compared with the contrast data to define positive groups with stenosis greater than 80 and negative groups.
An apparatus for assessing myocardial ischemia based on current density vectorial maps, comprising:
the acquisition module acquires a magnetic field map of the myocardium through the magnetocardiogram instrument;
the conversion module is used for inverting the magnetic field diagram recorded by the magnetocardiograph and converting the magnetic field diagram into a current density vector diagram;
the evaluation module calculates six parameters of the current density vector diagram:
a. vortex value-degree of symmetry;
b. the area ratio of the R wave to the T wave;
c. an angle deviation value;
d. the total normal current accounts for;
e. number of abnormal currents-transmembrane action potential homogeneity;
f. maximum active current area;
the final number range of the six parameters is controlled within the range of 0-1 through transformation, and the larger the numerical value is, the more abnormal the numerical value is;
calculating the Mean value Mean = (a + b + c + d + e + f)/6 of the finally obtained six parameters, and then comparing the Mean value with contrast data to judge the positivity/negativity.
Preferably, the method for calculating six parameters of the current density vector diagram by the evaluation module comprises the following steps:
a. swirl value-degree of symmetry:
it is best if there are two symmetric vortices representing cardiac conditions, better if there are two asymmetric vortices, and severe if there are three or more vortices; the value range of the vortex value is 60-100, and the smaller the value is, the more the value tends to be normal;
b. r wave, T wave:
comparing the ratio of the area under the R wave to the area under the T wave, wherein the value range is 0.1-1.2, and the larger the value is, the more the value is normal;
c. angle deviation value:
the angle deviation refers to the maximum vector and the angle deviation thereof compared with the 45-degree direction of the lower right corner, the value range is 0-150 degrees, and the smaller the numerical value is, the more the numerical value is normal;
d. normal current sum ratio:
the normal current is the ratio of the normal vector value to the total vector in the residual vectors after the micro vectors are removed, the value range is 0-1, and the larger the value is, the more the value is normal;
e. number of abnormal currents-transmembrane action potential homogeneity:
the abnormal current number refers to the number of blocks of the residual vector after the tiny vector is removed, the value range is 2-6, and the smaller the value is, the more the value is normal.
Preferably, each magnetocardiogram test patient is automatically assigned a Mean value by the system, and the Mean value is compared to the contrast data to define positive groups with stenosis greater than 80 and negative groups.
The invention has the advantages that:
1. according to the method and the device for evaluating myocardial ischemia based on the current density vector diagram, the magnetic field diagram recorded by the magnetocardiogram instrument is inverted and converted into the current density vector diagram, six parameters of the current density vector diagram are calculated, an average value is obtained, and the result is automatically judged by a computer. The automated diagnostic procedure can help doctors diagnose more quickly and better, so that invasive examination is not needed to judge coronary heart disease.
2. The method and the device for evaluating myocardial ischemia based on the current density vector diagram have higher sensitivity and positive prejudgment value for the diagnosis of the magnetocardiogram instrument. Along with the test, the expansion of the sample data can obtain more comprehensive data information and more persuasive comparison results.
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The invention is further described below with reference to the following figures and examples:
FIG. 1 is a schematic diagram of the detection signals of the magnetocardiograph in the embodiment;
FIG. 2 is a graph of swirl value versus degree of symmetry;
FIG. 3 is a diagram illustrating the ratio of the areas under R wave and T wave;
FIG. 4 is a schematic view of an angle deviation value;
FIG. 5 is a graph of normal current ratio;
FIG. 6 is a schematic diagram of the number of abnormal currents vs. the uniformity of the action potential across the membrane;
FIG. 7 is a detailed interpretation flowchart;
FIG. 8 shows the area under the curve, p-value, cut-off point, sensitivity and specificity by SPSS software.
Detailed Description
The invention provides a method for evaluating myocardial ischemia based on a current density vector diagram, which comprises the following steps of:
s1, acquiring a magnetic field map recorded by a magnetocardiogram instrument by an acquisition module. The magnetocardiograph is checked for a detected signal and if the signal diagram is as shown in fig. 1, it is a normal signal. If the signal appears in many uneven places, representing noise interference, pre-processing or re-testing is required.
And S2, inverting the magnetic field diagram recorded by the magnetocardiogram instrument by the conversion module, and converting the magnetic field diagram into a current density vector diagram.
S3, an evaluation module calculates six parameters of the current density vector diagram:
a. vortex value-degree of symmetry:
as shown in fig. 2, it is best if there are two symmetric vortices representing the cardiac condition, better if there are two asymmetric vortices, and severe if there are three or more vortices; the value range of the vortex value is 60-100, and the smaller the value is, the more the value is normal;
b. the following area ratio of R wave to T wave:
as shown in fig. 3, the ratio of the area under the R wave to the area under the T wave is compared, the range of the values is 0.1-1.2, and the larger the value is, the more the value is normal;
c. angle deviation value:
as shown in fig. 4, the angular deviation refers to the maximum vector and its angular deviation compared with the 45-degree direction of the lower right corner, and the value range is 0-150 degrees, and the smaller the value is, the more the value is normal;
d. normal current sum ratio:
as shown in fig. 5, the normal current refers to the ratio of the normal vector value to the total vector in the residual vectors after the minute vector is removed, the numeric value ranges from 0 to 1, and the larger the numeric value is, the more the numeric value tends to be normal;
e. number of abnormal currents-transmembrane action potential homogeneity:
as shown in fig. 6, the number of abnormal currents refers to the number of blocks of residual vectors after removing the small vectors, and the value range is 2-6, and the smaller the value, the more the value is normal.
f. Maximum active current area.
S4, the evaluation module controls the final number range of the six parameters in the range of 0-1 through transformation, and the larger the numerical value is, the more the numerical value tends to be abnormal;
s5, the evaluation module calculates the Mean value Mean = (a + b + c + d + e + f)/6 of the finally obtained six parameters, each magnetocardiogram test patient automatically obtains a Mean value through the system, then the Mean value is compared with contrast data, and the patient with the stenosis larger than 80 is defined as a positive group, and the rest are negative groups. Fig. 7 shows a specific interpretation flowchart.
As shown in FIG. 8, the area under the curve, p-value, cut-off point, sensitivity and specificity were also obtained by SPSS software.
In clinical application of a magnetocardiogram instrument, the specific embodiment of the invention is designed as follows:
patients with magnetocardiogram testing, with patient 389 patients with contrast data, were enrolled since 11 months 2021. The patients who were finally enrolled after exclusion of the corresponding patients according to the exclusion conditions were 267, and the positive group in which the contrast showed a degree of coronary stenosis of more than 80% was 109. The imaging showed that the degree of coronary stenosis was less than 80% or 158 persons were voluntarily enrolled in total, and the healthy persons were confirmed to be normal by clinical examination (resting electrocardiogram, loaded electrocardiogram, echocardiogram).
Exclusion criteria were as follows:
(1) Patients with severe hypertension (> 180/1l0 mmHg);
(2) Complex arrhythmias, such as frequent atrial premature beats, ventricular premature beats, atrial fibrillation, atrial flutter, complete bundle branch block;
(3) Severe lung disease and chest deformity or operator;
(4) Echocardiography confirmed as a patient with ventricular hypertrophy or dilated cardiomyopathy;
(5) Heart valvular disease, congenital heart disease, installation of cardiac pacemaker and implantation of drug pump;
(6) Left trunk lesion, coronary spasm, and lesion or microangiopathy with blood vessel diameter of criminal less than or equal to 2.5 mm;
(7) Cardiac insufficiency, NYHA classification, grade III or higher;
(8) The subject who needs coronary angiography examination does not meet the examination-related requirements;
(9) Pregnant, intention pregnant, lactating women;
(10) Other clinical trials were attended within 3 months;
(11) Other researchers believe the reasons for this unsuitability.
The conditions of the tested persons are as follows:
Figure DEST_PATH_IMAGE002
those with a stenosis greater than 80 were defined as positive groups, and the rest as negative groups. Meanwhile, the Mean value of each member is obtained by magnetocardiogram software, the area under the curve is 0.751, and the p value is 0.00 by SPSS software analysis. The result of statistical analysis by a magnetocardiogram instrument can obtain a Cut-off point of 0.52, a sensitivity of 0.831 and a specificity of 0.60.
The test results show that the diagnosis of the magnetocardiogram instrument has higher sensitivity and positive prediction value. As the test progresses and the sample data expands, more comprehensive data information and more persuasive comparison results can be obtained.
The above embodiments are merely illustrative of the technical ideas and features of the present invention, and the purpose of the embodiments is to enable those skilled in the art to understand the contents of the present invention and implement the present invention, and not to limit the protection scope of the present invention. All modifications made in accordance with the spirit of the main technical scheme of the invention are intended to be covered by the scope of the invention.

Claims (10)

1. A method for assessing myocardial ischemia based on a current density vector map, comprising:
s1, acquiring a magnetic field map recorded by a magnetocardiogram instrument;
s2, inverting the magnetic field diagram recorded by the magnetocardiogram instrument and converting the magnetic field diagram into a current density vector diagram;
s3, calculating six parameters of a current density vector diagram:
a. vortex value-degree of symmetry;
b. the area ratio of the R wave to the T wave;
c. an angle deviation value;
d. the total normal current accounts for a ratio;
e. abnormal current number-transmembrane action potential homogeneity;
f. maximum active current area;
s4, controlling the final number range of the six parameters in the range of 0-1 through transformation, wherein the larger the number is, the more the number tends to be abnormal;
and S5, calculating the Mean value Mean = (a + b + c + d + e + f)/6 of the finally obtained six parameters, comparing the Mean value with contrast data, and judging the positivity/negativity.
2. The method for myocardial ischemia assessment based on current density vector graphics of claim 1, wherein the method for calculating the swirl value-degree of symmetry in S3 is:
it is best if there are two symmetric vortices representing cardiac conditions, better if there are two asymmetric vortices, and severe if there are three or more vortices; the range of the vortex value is 60-100, and the smaller the value is, the more the value is normal.
3. The method for myocardial ischemia assessment based on current density vector graphics of claim 1, wherein the calculation method of the area ratio of R-wave to T-wave in S3 is:
and comparing the ratio of the area under the R wave to the area under the T wave, wherein the value range is 0.1-1.2, and the larger the value is, the more the value is normal.
4. The method for myocardial ischemia based on current density vector graphics of claim 1, wherein the calculation of the angular deviation value in S3 is:
the angle deviation refers to the maximum vector and the angle deviation thereof compared with the 45-degree direction of the lower right corner, the value range is 0-150 degrees, and the smaller the value is, the more the value is normal.
5. The method for myocardial ischemia assessment based on current density vector graphics of claim 1, wherein the calculation method of the ratio of the total number of normal currents in S3 is:
the normal current is the ratio of the normal vector value in the residual vector to the total vector after the tiny vector is removed, the value range is 0-1, and the larger the value is, the more the normal is.
6. The method for myocardial ischemia assessment based on current density vector graphics of claim 1, wherein the method for calculating the homogeneity of the number of abnormal currents-transmembrane action potential in S3 is:
the abnormal current number refers to the number of blocks of the residual vector after the tiny vector is removed, the value range is 2-6, and the smaller the value is, the more the value is normal.
7. The method of claim 1, wherein in step S5, each magnetocardiogram test patient automatically obtains a Mean value, and then compares the Mean value with the contrast data, and defines the stenosis greater than 80 as a positive group and the remaining as a negative group.
8. An apparatus for assessing myocardial ischemia based on a current density vector map, comprising:
the acquisition module acquires a magnetic field map of the myocardium through a magnetocardiogram instrument;
the conversion module is used for inverting the magnetic field diagram recorded by the magnetocardiograph and converting the magnetic field diagram into a current density vector diagram;
the evaluation module calculates six parameters of the current density vector diagram:
a. vortex value-degree of symmetry;
b. area ratio of R wave to T wave;
c. an angle deviation value;
d. the total normal current accounts for;
e. number of abnormal currents-transmembrane action potential homogeneity;
f. maximum active current area;
the final number range of the six parameters is controlled in the range of 0-1 through transformation, and the larger the numerical value is, the more abnormal the numerical value is;
calculating the Mean value Mean = (a + b + c + d + e + f)/6 of the six finally obtained parameters, and then comparing the Mean value with contrast data to judge positivity/negativity.
9. The apparatus for current density vector diagram based myocardial ischemia assessment according to claim 8, wherein said means for evaluating calculates six parameters of current density vector diagram comprises:
a. vortex value-degree of symmetry:
it is best if there are two symmetric vortices representing cardiac conditions, better if there are two asymmetric vortices, and severe if there are three or more vortices; the value range of the vortex value is 60-100, and the smaller the value is, the more the value is normal;
b. r wave, T wave:
comparing the ratio of the area under the R wave to the area under the T wave, wherein the value range is 0.1-1.2, and the larger the value is, the more the value is normal;
c. angle deviation value:
the angle deviation refers to the maximum vector and the angle deviation thereof compared with the 45-degree direction of the lower right corner, the value range is 0-150 degrees, and the smaller the numerical value is, the more the numerical value is normal;
d. normal current sum ratio:
the normal current is the ratio of normal vector values in residual vectors to total vectors after micro vectors are removed, the value range is 0-1, and the larger the value is, the more the normal vector value tends to be normal;
e. number of abnormal currents-transmembrane action potential homogeneity:
the abnormal current number refers to the number of blocks of residual vectors after the tiny vectors are removed, the value range is 2-6, and the smaller the value is, the more the value is normal.
10. The apparatus of claim 8, wherein each magnetocardiogram test patient is automatically assigned a Mean value by the system, and the Mean value is compared with the contrast data to define positive groups with stenosis greater than 80 and negative groups with the rest.
CN202210914815.5A 2022-08-01 2022-08-01 Method and device for evaluating myocardial ischemia based on current density vector diagram Pending CN115337016A (en)

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Cited By (3)

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CN116965822A (en) * 2023-09-25 2023-10-31 合肥工业大学 Magnetocardiogram color space circle diagram generation and wave band time identification method and storage medium
CN117100276A (en) * 2023-10-23 2023-11-24 山东大学齐鲁医院 Cardiac function detection system, computer storage medium and terminal
CN117137492A (en) * 2023-11-01 2023-12-01 山东大学齐鲁医院 Coronary artery blood flow abnormality detection system, storage medium, and terminal

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116965822A (en) * 2023-09-25 2023-10-31 合肥工业大学 Magnetocardiogram color space circle diagram generation and wave band time identification method and storage medium
CN116965822B (en) * 2023-09-25 2023-12-29 合肥工业大学 Magnetocardiogram color space circle diagram generation and wave band time identification method and storage medium
CN117100276A (en) * 2023-10-23 2023-11-24 山东大学齐鲁医院 Cardiac function detection system, computer storage medium and terminal
CN117100276B (en) * 2023-10-23 2024-01-12 山东大学齐鲁医院 Cardiac function detection system, computer storage medium and terminal
CN117137492A (en) * 2023-11-01 2023-12-01 山东大学齐鲁医院 Coronary artery blood flow abnormality detection system, storage medium, and terminal
CN117137492B (en) * 2023-11-01 2024-02-09 山东大学齐鲁医院 Coronary artery blood flow abnormality detection system, storage medium, and terminal

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