CN115335405B - 全人源抗人cd22的嵌合抗原受体及其应用 - Google Patents
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Abstract
Description
克隆编号 | IgG KD(M)Avid | kon(1/Ms) | koff(1/s) | Response(nm) |
17 | 1.6E-09 | 1.3E+05 | 2.0E-04 | 0.62 |
28 | 9.7E-10 | 2.1E+05 | 2.0E-04 | 0.81 |
80 | 8.2E-10 | 2.4E+05 | 2.0E-04 | 0.93 |
克隆编号 | Fab KD(M)Monovalent | kon(1/Ms) | koff(1/s) | Response(nm) |
17 | 8.1E-09 | 2.1E+05 | 1.7E-03 | 0.19 |
28 | 9.4E-10 | 2.8E+05 | 2.7E-04 | 0.25 |
80 | 1.3E-08 | 3.6E+05 | 4.6E-03 | 0.24 |
Claims (26)
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GB0210121D0 (en) * | 2002-05-02 | 2002-06-12 | Celltech R&D Ltd | Biological products |
BRPI0717902A2 (pt) * | 2006-12-01 | 2013-10-29 | Medarex Inc | "anticorpo monoclonal humano isolado, composição, conjugado anticorpo-molécula parceria, imunoconjugado, molécula de ácido nucléico isolada, vetor de expressão, célula hospedeira, método para prepar um anticorpo anti-cd22, método para inibir o desenvolvimento de uma célula tumoral que expressa cd22 e método para tratar uma doença inflamatória ou autoimuneem um indivíduo" |
EP2768863B1 (en) * | 2011-10-20 | 2017-09-27 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Anti-cd22 chimeric antigen receptors |
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AU2019245285A1 (en) * | 2018-03-30 | 2020-11-12 | Eureka Therapeutics, Inc. | Constructs targeting CD22 and uses thereof |
US11939377B2 (en) * | 2018-07-12 | 2024-03-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Affinity matured CD22-specific monoclonal antibody and uses thereof |
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