CN115335396A - 靶向cd33的嵌合抗原受体 - Google Patents

靶向cd33的嵌合抗原受体 Download PDF

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Publication number
CN115335396A
CN115335396A CN202180025378.5A CN202180025378A CN115335396A CN 115335396 A CN115335396 A CN 115335396A CN 202180025378 A CN202180025378 A CN 202180025378A CN 115335396 A CN115335396 A CN 115335396A
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cell
cells
seq
car
domain
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Chinese (zh)
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C·J·图尔特勒
R·B·沃尔特
G·S·拉斯洛
S·弗洛伦扎
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Fred Hutchinson Cancer Center
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Fred Hutchinson Cancer Center
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001111—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
    • A61K2039/55527—Interleukins
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K2039/55522—Cytokines; Lymphokines; Interferons
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
    • A61K2239/23—On/off switch
    • A61K2239/25—Suicide switch
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/20—Cytokines; Chemokines
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  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN202180025378.5A 2020-03-31 2021-03-31 靶向cd33的嵌合抗原受体 Pending CN115335396A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063003213P 2020-03-31 2020-03-31
US63/003,213 2020-03-31
PCT/US2021/025248 WO2021202793A2 (en) 2020-03-31 2021-03-31 Chimeric antigen receptors targeting cd33

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CN115335396A true CN115335396A (zh) 2022-11-11

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US (1) US20230151094A1 (enExample)
EP (1) EP4126925A4 (enExample)
JP (1) JP7859985B2 (enExample)
CN (1) CN115335396A (enExample)
CA (1) CA3173210A1 (enExample)
WO (1) WO2021202793A2 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7840865B2 (ja) 2020-03-31 2026-04-06 フレッド ハッチンソン キャンサー センター キメラ抗原受容体ターゲティングｃｄ３３
WO2024037461A1 (zh) * 2022-08-16 2024-02-22 赛斯尔擎生物技术（上海）有限公司 工程化免疫细胞及其制备方法
WO2025059062A1 (en) * 2023-09-11 2025-03-20 The Trustees Of The University Of Pennsylvania Genetic engineering of human hematopoietic stem/progenitor cells (hspcs) for locus-specific expression of therapeutic proteins
CN120177299B (zh) * 2024-12-03 2026-06-12 江苏省人民医院（南京医科大学第一附属医院） 利用流式细胞仪识别慢性粒单核细胞免疫分型的抗体组合物及方法

Citations (5)

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Publication number Priority date Publication date Assignee Title
US20170145094A1 (en) * 2014-04-03 2017-05-25 Cellectis Cd33 specific chimeric antigen receptors for cancer immunotherapy
WO2018218207A1 (en) * 2017-05-26 2018-11-29 Fred Hutchinson Cancer Research Center Anti-cd33 antibodies and uses thereof
US20190016820A1 (en) * 2015-08-20 2019-01-17 Autolus Limited Chimeric cytokine receptor
CN109970862A (zh) * 2017-12-27 2019-07-05 亘喜生物科技（上海）有限公司 一种携带Beacon标签的嵌合抗原受体T细胞改造技术
WO2019178382A1 (en) * 2018-03-14 2019-09-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-cd33 chimeric antigen receptors and their uses

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GB201518136D0 (en) * 2015-10-14 2015-11-25 Glaxosmithkline Ip Dev Ltd Novel chimeric antigen receptors
JP7189019B2 (ja) * 2016-02-05 2022-12-13 シティ・オブ・ホープ 中枢神経系の癌の治療のための操作されたｔ細胞の投与
US20190233534A1 (en) * 2016-07-14 2019-08-01 Fred Hutchinson Cancer Research Center Multiple bi-specific binding domain constructs with different epitope binding to treat cancer
WO2019084234A1 (en) * 2017-10-26 2019-05-02 St. Jude Childen's Research Hospital, Inc. METHODS AND COMPOSITIONS FOR TREATING CD33 + CANCERS AND IMPROVING IN VIVO PERSISTENCE OF CHIMERIC ANTIGEN RECEPTOR T CELLS
JOP20190116A1 (ar) * 2018-05-24 2019-11-24 Janssen Biotech Inc الأجسام المضادة لتكتل التمايز 33 (cd33)، والأجسام المضادة ثنائية النوعية لتكتل التمايز 33 (cd33)/تكتل التمايز 3 (cd3) واستخداماتها
WO2019246593A2 (en) * 2018-06-22 2019-12-26 Fred Hutchinson Cancer Research Center Compositions and methods to target cll-1 and cd123 for the treatment of acute myeloid leukemia and related disorders

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170145094A1 (en) * 2014-04-03 2017-05-25 Cellectis Cd33 specific chimeric antigen receptors for cancer immunotherapy
US20190016820A1 (en) * 2015-08-20 2019-01-17 Autolus Limited Chimeric cytokine receptor
WO2018218207A1 (en) * 2017-05-26 2018-11-29 Fred Hutchinson Cancer Research Center Anti-cd33 antibodies and uses thereof
CN109970862A (zh) * 2017-12-27 2019-07-05 亘喜生物科技（上海）有限公司 一种携带Beacon标签的嵌合抗原受体T细胞改造技术
WO2019178382A1 (en) * 2018-03-14 2019-09-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-cd33 chimeric antigen receptors and their uses

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SAISAI LI PHD等: "Incorporation of 4-1BB Endowed the Potent CD33 Specific Chimeric Antigen Receptor T Cells with Anti-Exhaustion Capacity and Increased Central Memory Compartment", BLOOD, vol. 130, 8 December 2017 (2017-12-08), pages 2636 *
王谦等: "抗CD33单抗联合化疗药物治疗复发或难治性急性髓系白血病的疗效观察", 苏州大学学报(医学版), vol. 31, no. 2, 25 March 2011 (2011-03-25), pages 317 - 320 *

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JP7859985B2 (ja) 2026-05-15
EP4126925A4 (en) 2024-07-24
JP2023520410A (ja) 2023-05-17
WO2021202793A3 (en) 2021-11-11
EP4126925A2 (en) 2023-02-08
CA3173210A1 (en) 2021-10-07
US20230151094A1 (en) 2023-05-18
WO2021202793A2 (en) 2021-10-07

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