CN115317562A - 一种治疗牙髓炎的中药组合物及其制备方法 - Google Patents
一种治疗牙髓炎的中药组合物及其制备方法 Download PDFInfo
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- CN115317562A CN115317562A CN202211155445.8A CN202211155445A CN115317562A CN 115317562 A CN115317562 A CN 115317562A CN 202211155445 A CN202211155445 A CN 202211155445A CN 115317562 A CN115317562 A CN 115317562A
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Abstract
本发明属于中药领域,具体涉及一种具有牙髓炎中药组合物及其制备方法与用途.本发明具有杀菌消炎止疼的中药组合物,充分考虑各中药的药理及性能,并选择各中药相互之间的配比,使各中药的配伍关系相互配合,共同作用,从而发挥牙髓炎治疗作用.包括以下重要成份原料:冰片5‑10重量份,石膏20‑60重量份,樟脑5‑20重量份,川牛膝10‑40重量份,知母10‑40重量份,牡丹皮10‑40重量份,细辛10‑30重量份,酒黄连20‑60重量份,酒大黄20‑40重量份,升麻10‑30重量份,防风5‑30重量份,酒黄芩10‑40重量份,酒黄柏20‑40重量份,花椒5‑30重量份。本发明配方独特,精工制备,各原料协同起效,具有清热泻火、凉血解毒、消肿止痛、逐瘀通经的功效,作为辅助治疗牙髓炎起效快.效果好。
Description
技术领域
本发明涉及一种牙髓炎辅助治疗的中药组合物及其制备方法。
背景技术
牙髓炎,是一种常见疾病,大多因牙龈炎和牙周炎、龋齿、蛀牙或折裂牙而导致牙髓、牙神经感染而引起。牙髓炎主要表现为疼痛,疼痛的性质有冷热刺激痛,自发性疼痛、阵发性加剧、呈间歇性发作等。
牙髓炎一旦发作疼痛难忍,严重者影响患者日常生活和工作,目前,除了杀死牙神经的方法外,很少有快速消除牙神经疼痛的药物或方法,患者只能服用抗生素药物缓解牙髓炎症状或者一直忍受牙疼直至杀死牙神经,但口服药物的疗效慢,止痛作用不是很明显。中医认为牙髓炎是由于外感风邪、胃肠火炽盛、肾虚火旺、虫蚀牙齿等原因所致,只有从根源出手才能彻底消除牙髓炎的病因.
发明内容
本发明的目的是提供一种牙髓炎辅助治疗的中药组合物,该药物能快速止痛,辅助治愈牙髓炎.
本发明的另一目的是提供该中药组合物的制备方法,该方法能有效的提取药物的有效成分,减少用药量,使药物吸收更好,能更快发挥治疗效果。
本发明是通过以下技术方案实现的:
一种牙髓炎治疗的中药组合物,其特征是包括以下重量份的原料:石膏 15-20份,川牛膝10-15 份,知母5-15 份,蒲公英5-15 份,牡丹皮5-15 份,酒黄连5-10 份,酒大黄 5-20 份,冰片10份。
优选的,(1)中药组合物包括以下重量份的原料:石膏 18 份,川牛膝 12份,知母9 份,蒲公英 9 份,牡丹皮 9 份,酒黄连 6 份,酒大黄 6 份,樟脑12份。(2)石膏20重量份,川牛膝 15重量份,知母 10重量份,牡丹皮15重量份,蜂房30重量份,荜拨10重量份,金银花30重量份,板蓝根40重量份,赤芍20重量份,榉树皮20重量份,
进一步的,上述中药组合物可以为水剂,凝胶,颗粒剂,剂型为胶囊剂、片剂,内服或外用。
上述治疗牙髓炎辅助治疗的中药组合物的制备方法包括以下步骤:
(1)将牡丹皮和荷叶用水蒸馏法提取 2 次,收集挥发油,合并备用;
(2)将步骤(1)的药渣与剩余的原料混合,用水煎煮 2 次,合并水煎液;
(3)将水煎液低温浓缩至 1:1(g/ml),然后加乙醇至醇含量为 60 体积 %,静置过夜,过滤,将滤液回收乙醇,剩余的滤液浓缩成浸膏,干燥得干浸膏;
(4)将干浸膏粉碎,加入步骤(1)的挥发油,混合,加入辅料适量,制成所需剂型。
上述步骤(2)中,水的用量为药渣和剩余原料总质量的 6-10 倍,优选 8 倍,每次提取 2h。
上述步骤(3)中,乙醇的浓度为 95%。
本发明根据牙髓炎的病机病因,筛选出治疗效果好的配方,配方中石膏清热泻火为君药,知母清热泻火,滋阴润燥;黄连、大黄、蒲公英清热解毒;牡丹皮清热凉血,活血散瘀;樟脑杀虫止痒,消肿止痛热;地黄清热泻火,凉血解毒共为臣药;川牛膝逐瘀通经,引火下行;甘草缓急止痛,清热解毒为佐使药;诸药共用达到清热泻火、凉血解毒、消肿止痛、逐瘀通经的功效,各原料功效如下:
石膏:硫酸盐类矿物硬石膏族石膏,主要化学成分是含水硫酸钙(CaSO4·2H2O)。药性:辛、甘,大寒,归肺、胃经。功效:生石膏清热泻火,除烦止渴,肺热咳喘,胃火头痛、牙痛,热毒壅盛,口舌生疮等。
川牛膝:苋科植物川牛膝的干燥根。药性:甘、微苦,平,归肝、肾经。功效:逐瘀通经,通利关节,利尿通淋,引火下行。用于齿痛、口舌生疮等。
知母:百合科植物知母 的干燥根茎。药性:苦、甘,寒,归肺、胃、肾经。功效:清热泻火,滋阴润燥。用于外感热病,高热烦渴,肺热燥咳,骨蒸潮热,内热消渴,肠燥便秘等。
蒲公英:菊科植物蒲公英、碱地蒲公英. 或同属数种植物的干燥全草。药性:苦、甘,寒,归肝、胃经。功效:清热解毒,消痈散结。可用于热毒壅结于肌肉所致的痈肿疮毒,乳痈内痈;热毒证,尤善清肝、胃经热,治疗肝热目赤肿痛,胃火牙痛,及热淋涩痛,湿热黄疸等。
牡丹皮:毛茛科植物牡丹 的干燥根皮。药性:味苦、辛,微寒,归心、肝、肾经。功效:清热凉血,活血散瘀。用于血滞经闭、痛经、痈肿疮毒、跌扑伤痛、风湿热痹;温热病热入血分发斑,吐衄等。
樟脑:为樟科樟属植物樟树的根、干、枝、叶经蒸馏精制而成的颗粒状物。药性:味辛,性温,入心、脾经。通关窍,利滞气,辟秽浊,杀虫止痒,消肿止痛热病神昏,中恶猝倒,痧胀吐泻腹痛,寒湿脚气,疥疮顽癣,秃疮,冻疮,臁疮,水火烫伤,跌打伤痛,牙痛,风火赤眼
黄连:毛茛科植物黄连、三角叶黄连 或云连 的干燥根茎。以上三种分别习称“味连”、“雅连”、“云连”。药性:苦,寒,归心、脾、胃、胆、大肠经。功效:清热燥湿,泻火解毒。用于湿热痞满,呕吐吞酸,湿热泻痢,黄疸,高热神昏,心火亢盛,消渴,心烦不寐,血热吐衄,目赤,牙痛,痈肿疔疮等。
大黄:蓼科植物掌叶大黄 .唐古特大黄或药用大黄 的干燥根及根茎。药性:苦,寒,归脾、胃、大肠、肝、心包经。功效:泻下攻积,清热泻火,凉血解毒,逐瘀通经。用于热结胸痞,湿热泻痢,黄疸,淋病,水肿腹满,小便不利,目赤,咽肿,口舌生疮,胃热呕吐等。酒制大黄擅活血,且善清上焦血分之热。 冰片: 菊科植物艾纳香Blumea balsamifera.性寒,味辛、苦。归心经、脾经、肺经.开窍醒神、清热止痛。属开窍药。.《纲目》:"疗喉痹,脑痛,鼻息,齿痛,伤寒舌出,小儿痘陷。通诸窍,散郁火''. 蜂房: 惊痫螈,寒热邪气,癫疾,鬼精蛊毒,肠痔。火熬之良(《本经》)。荜茇 :胡椒科植物荜茇.的近成熟或成熟果穗。味辛,性热。归胃 经、大肠经。温中散寒、下气止痛。属温里药
榉树皮: 榆科植物榉树的树皮 . 清热解毒,止血,利水,安胎。感冒发热,血痢,便血,水肿,妊娠腹痛,目赤肿痛,烫伤,疮疡肿痛。进一步的,在配方中还可以加入花椒、地骨皮成分,花椒散寒燥湿、温中止痛、杀虫止痒,地骨皮凉血降火,可进一步增加治疗效果,加入花椒、地骨皮形成的药物配方为(重量份):石膏 15-20 份,川牛膝 10-15 份,知母 5-15份,蒲公英 5-15 份,牡丹皮 5-15 份,冰片5-15 份,酒黄连5-10 份,酒大黄 5-10 份,花椒 1-6 份,地骨皮 1-5 份。优选为(重量份):石膏 30 份,川牛膝 15份,知母 10 份,蒲公英 10 份,牡丹皮 10份,榉树皮 9 份,酒黄连10 份,酒大黄 5 份,花椒 10,地骨皮 5 份。
加入花椒和地骨皮后,药物的制备方法为:
(1)将牡丹皮、花椒和榉树皮用水蒸馏法提取 2 次,收集挥发油,合并备用;
(2)将步骤(1)的药渣与剩余的原料混合,用水煎煮 2 次,水的用量为药渣和剩余原料总质量的 6-10 倍,每次提取 2h,合并水煎液;
(3)将水煎液低温浓缩至 1:1(g/ml),然后加乙醇至醇含量为 60 体积 %,静置过夜,过滤,将滤液回收乙醇,剩余的滤液浓缩成浸膏,干燥得干浸膏;
(4)将干浸膏粉碎,加入步骤(1)的挥发油,混合,加入辅料适量,制成所需剂型。
上述步骤(3)中,乙醇的浓度为 95%。
本发明配方独特,精工制备,各原料协同起效,具有清热泻火、凉血解毒、消肿止痛、逐瘀通经的功效,治疗牙髓炎起效快,提高治愈率30%。
具体实施方式
下面通过具体实施例对本发明进行进一步阐述,应该明白的是,下述说明仅是为了解释本发明,并不对其内容进行限制。如无特别说明,下述实施例中药物原料均为重量份。
取石膏 20 份,川牛膝15 份,知母 10 份,蒲公英 10 份,牡丹皮 10 份,樟脑10份,酒黄连15 份,酒大黄 6 份,按照下面的方法制备药物组合物:
1、将牡丹皮,樟脑用水蒸留法提取 2 次,收集挥发油,合并备用;
2、将牡丹皮和樟脑的药渣与剩余的原料混合,用水煎煮 2 次,水用量为药渣和剩余原料总质量的 8 倍,每次 2h,合并水煎液;
3、将水煎液低温浓缩至 1:1(g/ml),然后缓缓加 95wt% 乙醇至醇含量为 60%(ml/ml),静置 24h 过夜,过滤取滤液,将滤液回收乙醇,余液浓缩成浸膏,干燥得干浸膏;
4、将干浸膏粉碎过六号筛,加入步骤(1)的挥发油,混合,制得本发明中药组合物。根据需要可以将此中药组合物粉末按照常规工艺制成胶囊、片剂、颗粒剂等。
实施例 2
取石膏 15 份,川牛膝 10 份,知母 5 份,蒲公英 5 份,牡丹皮 5 份,冰片 15份,酒黄连 10 份,酒大黄 10 份,按照下面的方法制备药物组合物:
1、将牡丹皮和荷叶用水蒸留法提取 2 次,收集挥发油,合并备用;
2、将牡丹皮等的药渣与剩余的原料混合,用水煎煮 2 次,水用量为药渣和剩余原料质量的 6 倍,每次 2h,合并水煎液;
3、将水煎液低温浓缩至 1:1(g/ml),然后缓缓加 95wt% 乙醇至醇含量为 60%(ml/ ml),静置 24h 过夜,过滤取滤液,将滤液回收乙醇,余液浓缩成浸膏,干燥得干浸膏;
4、将干浸膏粉碎过六号筛,加入步骤(1)的挥发油,混合,制得本发明中药组合物。根据需要可以将此中药组合物粉末按照常规工艺制成水剂,颗粒,膏剂,消毒棉球等。
实施例 3
石膏20重量份,川牛膝 15重量份,知母 10重量份,牡丹皮15重量份,蜂房30重量份,荜拨10重量份,金银花30重量份,板蓝根40重量份,赤芍20重量份,榉树皮20重量份,白芷10重量份,按照下面的方法制备药物组合物:
1、将牡丹皮和榉树皮用水蒸留法提取 2 次,收集挥发油,合并备用;
2、将牡丹皮等的药渣与剩余的原料混合,用水煎煮 2 次,水用量为药渣和原料质量的 10 倍,每次 2h,合并水煎液;
3、将水煎液低温浓缩至 1:1(g/ml),然后缓缓加 95wt% 乙醇至醇含量为 60%(ml/ml),静置 24h 过夜,过滤取滤液,将滤液回收乙醇,余液浓缩成浸膏,干燥得干浸膏;
4、将干浸膏粉碎过六号筛,加入步骤(1)的挥发油,混合,制得本发明中药组合物。
根据需要可以将此中药组合物粉末按照常规工艺制成水剂,颗粒,膏剂,消毒棉球等。
实施例 4
取石膏 18 份,川牛膝 12 份,知母 9 份,蒲公英 9 份,牡丹皮 9 份,樟脑 9份,酒黄连 6 份,酒大黄 6 份,花椒 5 份,地骨皮 2 份,按照下面的方法制备药物组合物:
1、将牡丹皮、花椒和荷叶用水蒸留法提取 2 次,收为 60%(ml/集挥发油,合并备用;
2、将牡丹皮、花椒和荷叶的药渣与剩余的原料混合,用水煎煮 2 次,水用量为药渣和剩余原料总质量的 8 倍,每次 2h,合并水煎液;
3、将水煎液低温浓缩至 1:1(g/ml),然后缓缓加 95wt% 乙醇至醇含量为 60%(ml/ ml),静置 24h 过夜,过滤取滤液,将滤液回收乙醇,余液浓缩成浸膏,干燥得干浸膏;
4、将干浸膏粉碎过六号筛,加入步骤(1)的挥发油,混合,制得本发明中药组合物。
根据需要可以将此中药组合物粉末按照常规工艺制成水剂,颗粒,膏剂,等。
实施例 5
取石膏 15 份,川牛膝 10 份,知母 5 份,蒲公英 5 份,牡丹皮 5 份,冰片 15份,酒黄连 10 份,酒大黄 10 份,花椒 6 份,地骨皮 1份,按照实施例 4 的方法制备药物组合物。
临床资料
选择门诊牙髓炎患者 260 例,男 135例,女125 例,年龄 15 ~ 60 岁,平均年龄40.7 岁,患者牙髓炎表现为:自发疼,冷热疼,夜间疼,胀痛、间歇式、连续式疼痛中的一种或多种,患者牙痛时间最短一天,最长2年,平均 30天。将所有患者平均分为5 组,各组患者无统计学差异。
上述四组患者分别外用本发明实施例 1、2、3 ,4、5 的中药组合物,每次 1g,每周一次或10天一次换药,可根据病情的具体情况而定. 2月为一疗程。
疗效标准: 痊 愈 显效:临床症状消失,遇冷热刺激、嚼硬物无酸胀疼痛感;
有效:牙痛发作次数以及发作时疼痛的程度比治疗前减轻. 无效:治疗前后症状无明显变化或加重。
各组患者用药物后病情情况见下表:
痊愈 | 显效 | 有效 | 无效 | 总有效率 | |
第一组 | 46 | 5 | 1 | 0 | 100% |
第二组 | 43 | 6 | 1 | 2 | 96..1% |
第三组 | 36 | 9 | 4 | 3 | 94.3% |
第四组 | 30 | 18 | 3 | 1 | 98% |
第五组 | 28 | 20 | 2 | 1 | 98% |
Claims (9)
1.一种牙髓炎辅助治疗的中药组合物,其特征是由以下重量份的原料组成:石膏 15-20 份,川牛膝 10-15 份,知母 5-15 份,蒲公英 5-15 份,牡丹皮 5-15 份,荷叶 5-15份,酒黄连 5-10 份,酒大黄 5-10 份,地黄 5-10 份,樟脑5-20重量份。
2.根据权利要求 1 所述的中药组合物,其特征是由以下重量份的原料组成:石膏 18份,川牛膝 12 份,知母 9 份,蒲公英 9 份,牡丹皮 9 份,冰片5-10重量份,酒黄连 6 份,酒大黄 6 份,地黄 6 份,甘草 6 份。
3.一种牙髓炎辅助治疗的中药组合物,其特征是由以下重量份的原料组成:石膏 15-20 份,川牛膝 10-15 份,知母 5-15 份,蒲公英 5-15 份,牡丹皮 5-15 份,荷叶 5-15份,酒黄连 5-10 份,酒大黄 5-10 份,地黄 5-10 份,甘草 5-10 份,花椒 1-6 份,地骨皮1-5 份。
4.根据权利要求 3 所述的中药组合物,其特征是由以下重量份的原料组成:石膏 18份,川牛膝 12 份,知母 9 份,蒲公英 9 份,牡丹皮 9 份,荷叶 9 份,酒黄连 6 份,酒大黄 6 份,地黄 6 份,甘草 6 份,花椒 5 份,地骨皮 2 份。
5.根据权利要求 1 或 2 所述的中药组合物,其特征是:剂型为水剂,凝胶,膏剂,颗粒均外用。
6. 一种牙髓炎辅助治疗的中药组合物的制备方法,其特征是:原料按重量份计为:石膏18份,川牛膝 12 份,知母 9 份,蒲公英 9 份,牡丹皮 9 份,樟脑18份,酒黄连 6 份,酒大黄 6 份,地黄 6 份,甘草 6 份;包括以下步骤:(1)将牡丹皮和荷叶用水蒸馏法提取 2次,收集挥发油,合并备用;(2)将步骤(1)的药渣与剩余的原料混合,用水煎煮 2 次,合并水煎液;(3)将水煎液低温浓缩至浓度为 1g/ml,然后加乙醇至醇含量为 60 体积 %,静置过夜,过滤,将滤液回收乙醇,剩余的滤液浓缩成浸膏,干燥得干浸膏;(4)将干浸膏粉碎,加入步骤(1)的挥发油,混合,加入辅料适量,制成所需剂型。
7.根据权利要求 6 所述的制备方法,其特征是:步骤(2)中,水的用量为药渣和剩余原料总质量的 6-10 倍,每次提取 2h。
8.根据权利要求 7 所述的制备方法,其特征是:步骤(2)中,水的用量为药渣和剩余原料总质量的 8 倍。
9.根据权利要求 6 所述的制备方法,其特征是:步骤(3)中,乙醇的浓度为 95 体积%。
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