CN115299609A - Composition with function of improving sleep and preparation method thereof - Google Patents
Composition with function of improving sleep and preparation method thereof Download PDFInfo
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- CN115299609A CN115299609A CN202210275867.2A CN202210275867A CN115299609A CN 115299609 A CN115299609 A CN 115299609A CN 202210275867 A CN202210275867 A CN 202210275867A CN 115299609 A CN115299609 A CN 115299609A
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/745—Bifidobacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/529—Infantis
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Abstract
The invention discloses a composition with a function of improving sleep, which comprises the following components (1) and (2) in parts by weight: (1) 2-5 parts of lycium ruthenicum extract and/or 2-5 parts of spina date seed extract and/or 2-5 parts of Chinese yam extract and/or 1-5 parts of rose petal extract; (2) 0.05-0.5 part of infant bifidobacterium dry powder. The invention is based on the overall concept of traditional Chinese medicine, scientific compatibility is carried out, the sleep quality can be effectively improved, and the effective components can play a synergistic interaction role, so that the composition formula with the function of improving the sleep is obtained. In the composition, the medlar has the functions of clearing liver, improving vision, tonifying kidney and aiding sleep; semen Ziziphi Spinosae has effects in nourishing heart, tranquilizing mind, and improving sleep; the yam has the effects of nourishing blood, tonifying brain and tonifying kidney; the rose helps to soothe the nerves, and the combination of the medicines can fully play the integral adjustment advantage of the compound preparation, has better sleep improvement effect and exact curative effect.
Description
Technical Field
The invention belongs to the technical field of special medical food, and particularly relates to a composition with a sleep improving function and a preparation method thereof.
Background
Sleep is critical to the normal functioning of the brain. However, in recent years, sleep disorders have occurred more frequently. Poor sleep quality causes withered and yellow face, slow response and hypomnesis, which not only affects life and work, but also causes various chronic diseases such as diabetes, cardiovascular and cerebrovascular diseases and the like. The hypnotic and melatonin-dependent therapy is not different from drinking \40489andthirst quenching, the side effect of the drug cannot be ignored, the drug can also generate dependence on the body, and the normal synthesis and secretion of the melatonin of the body can be directly inhibited, so that the sleep disorder is caused. Although many traditional Chinese medicine extracts for improving sleep quality are found, no widely accepted dietary supplement and medicinal supplement scheme aiming at improving sleep quality exists at present due to various reasons such as toxic and side effects.
Disclosure of Invention
In order to solve the defects in the prior art, the invention aims to provide a composition with a function of improving sleep and a preparation method thereof. Probiotics is a kind of active microorganisms beneficial to a host, and is a general term for active beneficial microorganisms which are planted in the intestinal tract and the reproductive system of a human body and can generate definite health efficacy so as to improve the micro-ecological balance of the host and play beneficial roles. Wherein, the infant bifidobacterium has obvious effects of resisting aging and oxidation, reviving the immune function of the organism, adjusting internal secretion and the like. The invention discovers that the combination of the bifidobacterium infantis with the lycium ruthenicum, the spina date seed, the Chinese yam and the rose petal has the obvious effect of improving the sleep quality. The specific technical scheme is as follows:
the invention provides a composition with a function of improving sleep, which comprises the following components (1) and (2) in parts by weight:
(1) 2-5 parts of lycium ruthenicum extract and/or 2-5 parts of spina date seed extract and/or 2-5 parts of Chinese yam extract and/or 1-5 parts of rose petal extract;
(2) 0.05-0.5 part of infant bifidobacterium dry powder.
Preferably, the composition comprises the following components in parts by weight:
2 to 5 parts of lycium ruthenicum extract, 2 to 5 parts of spina date seed extract, 2 to 5 parts of Chinese yam extract, 1 to 5 parts of rose petal extract and 0.05 to 0.5 part of infant bifidobacterium dry powder.
Further, the number of viable bacteria in the infant bifidobacterium dry powder is 1 multiplied by 10 9 -10 10 CFU/g。
Furthermore, the composition also comprises 0.1-4 parts of auxiliary materials.
Further, the auxiliary materials comprise 0-30% of fruit powder, 0-30% of edible essence, 0-30% of sweetening agent, 0-30% of sour agent, 0-30% of filling agent, 0-30% of lubricating agent, 0-30% of preservative, 0-30% of suspending agent, 0-30% of edible pigment, 0-30% of diluent and 0-30% of plasticizer.
Further, the lycium ruthenicum extract, the spina date seed extract, the Chinese yam extract and the rose petal extract are powder obtained by carrying out water extraction, decoction and drying on lycium ruthenicum, the spina date seed, the Chinese yam and the rose petals.
Further, the preparation method of the lycium ruthenicum extract, the spina date seed extract, the Chinese yam extract or the rose petal extract comprises the following steps: soaking fructus Lycii, semen Ziziphi Spinosae, rhizoma Dioscoreae or flos Rosae Rugosae in water for 0.5-1 hr, extracting with boiling water at normal pressure for 2-3 times, each for 1-2 hr, evaporating under reduced pressure, concentrating to obtain extract, and freeze drying to obtain fructus Lycii extract, semen Ziziphi Spinosae extract, rhizoma Dioscoreae extract or flos Rosae Rugosae extract;
preferably, the mass volume ratio of the lycium ruthenicum murr, the spina date seed, the Chinese yam or the rose petal to the water is 1.
Further, the dosage form of the composition is oral;
preferably, the oral preparation includes powder, granule, tablet, hard capsule, soft capsule, oral liquid and soft candy.
The second aspect of the invention provides a preparation method of the composition with the function of improving sleep, which comprises the steps of mixing 1-5 parts of lycium ruthenicum extract and/or 2-5 parts of spina date seed extract and/or 2-5 parts of Chinese yam extract and/or 1-5 parts of rose petal extract with 0.05-0.5 part of bifidobacterium infantis, adding auxiliary materials, and preparing the oral preparation.
Further, the oral preparation includes powder, granules, tablets, hard capsules, soft capsules, oral liquid and soft sweets.
The invention has the beneficial effects that:
the invention is based on the overall concept of traditional Chinese medicine, scientific compatibility is carried out, and the composition with the function of improving sleep is provided, wherein the composition is formed by combining the infant bifidobacterium with the lycium ruthenicum murr, the spina date seeds, the Chinese yam, the rose petals and the like, and the active ingredients can play a synergistic interaction role, wherein the lycium ruthenicum murr has the effects of clearing liver, improving eyesight, tonifying kidney and aiding sleep; semen Ziziphi Spinosae has effects in nourishing heart, tranquilizing mind, and improving sleep; chinese yam has the effects of nourishing blood, tonifying brain and tonifying kidney; the rose helps to soothe the nerves, and the combination of the medicines can fully play the integral adjustment advantage of the compound preparation, has better sleep improvement effect and exact curative effect. Meanwhile, the bifidobacterium infantis is probiotics, and the lycium ruthenicum murr, the spina date seed, the Chinese yam and the rose petal are food materials with dual purposes of medicine and food.
Detailed Description
In order that the invention may be more clearly understood, it will now be further described with reference to the following examples. The examples are for illustration only and do not limit the invention in any way. In the examples, each raw reagent material is commercially available, and the experimental method not specifying the specific conditions is a conventional method and a conventional condition well known in the art, or a condition recommended by an instrument manufacturer.
In the embodiment, the lycium ruthenicum extract, the spina date seed extract, the Chinese yam extract and the rose petal extract are powder obtained by carrying out water extraction, decoction and drying on lycium ruthenicum, the spina date seed, the Chinese yam and the rose petals.
Specifically, the preparation method of the lycium ruthenicum extract, the spina date seed extract, the Chinese yam extract or the rose petal extract comprises the following steps: adding water (w/v, 1.
The grouping and feeding conditions of the mice in the embodiment of the invention are as follows:
the experiments were performed after one week of adaptation of C57BL/6J mice (22-25 g) to the experimental environment. Each 12 mice was randomly assigned to one group. Feeding conditions are as follows: animal experimental facilities continue to maintain barrier environmental standards. Control range of main environmental indicators: the temperature was 23.1. + -. 0.9 ℃. The relative humidity is 52.8 +/-3 g. Ventilation times are 10-20 times/hour, and light illumination is performed: dark =12h: and (4) 12h. And carrying out feeding management by the personnel obtaining qualification certification. Changing the sterilized padding and cages 2 times a week, and keeping the environment in the box clean and dry; feed and drinking water are added every day to keep animals free to eat and eat.
For each example/comparative example, 36 mice were divided into 3 experimental groups (1 group was subjected to a direct sleep experiment, a sleep time extension experiment with sodium pentobarbital; 1 group was subjected to a lower dose hypnotic experiment with sodium pentobarbital; 1 group was subjected to a sleep latency experiment with sodium barbital), and 12 mice were each group.
The test method of the mouse sleep experiment in the embodiment of the invention is as follows:
direct sleep experiments: after the last gastric lavage, the patient is observed whether sleep occurs. The disappearance of the righting reflex is used as an index for sleeping. When the mouse was placed in the dorsal decubitus position. The body can be turned right immediately, if the body cannot be turned right for more than 60s, the turning-right reflex is considered to disappear, and the user enters sleep. The recovery of the turning reflection is the awakening of the animal, the time from disappearance of the turning reflection to recovery is the sleeping time of the animal, and the number of sleeping animals and the sleeping time of the control group and each dosage group are recorded.
Experiment for prolonging sleep time of sodium pentobarbital: after the last intragastric administration for 15min, 50 mg/kg-1 BW pentobarbital sodium is injected into the abdominal cavity of each group of animals, the injection amount is 0.2mL/20g BW, the disappearance of righting reflex is taken as a sleep-falling judgment standard, and whether the test sample prolongs the sleep time of the pentobarbital sodium is observed.
Barbiturate sodium sleep latency experiments: injecting 280 mg/kg intraperitoneal injection into each group of animals 15min after last intragastric administration - 1 BW barbital sodium with the injection amount of 0.2mL/20g BW, and the influence of the tested sample on the sleep latency of the barbital sodium is observed by taking the disappearance of the righting reflex as an index.
Example 1
This example provides a probiotic for improving sleep quality, bifidobacterium infantis 5X 10 9 CFU (0.25 g) plus distilled waterRedissolving, diluting to 0.08 × 10 9 -10 10 CFU/mL, the gavage amount of each mouse is 10mL/kg, namely the equivalent dose of the human body is fed to the mouse, and the gavage is carried out for 1 time every day.
Example 2
The present embodiment provides a composition for improving sleep quality, comprising: infant Bifidobacterium 5X 10 9 CFU (0.25 g), lycium ruthenicum Murr extract 3g; the rest of the procedure was carried out in the same manner as in example 1 to obtain a composition.
Example 3
The present embodiment provides a composition for improving sleep quality, comprising: bifidobacterium infantis 5X 10 9 CFU (0.25 g), semen Ziziphi Spinosae extract 3g; the rest of the procedure was carried out in the same manner as in example 1 to obtain a composition.
Example 4
The present embodiments provide a composition for improving sleep quality, comprising: infant Bifidobacterium 5X 10 9 CFU (0.25 g), rhizoma Dioscoreae extract 3g; the rest of the procedure was carried out in the same manner as in example 1 to obtain a composition.
Example 5
The present embodiment provides a composition for improving sleep quality, comprising: infant Bifidobacterium 5X 10 9 CFU (0.25 g), rose Pedal extract 3g; the rest of the procedure was carried out in the same manner as in example 1 to obtain a composition.
Example 6
The present embodiment provides a composition for improving sleep quality, comprising: bifidobacterium infantis 5X 10 9 CFU (0.25 g), lycium ruthenicum Murr extract 3g, semen Ziziphi Spinosae extract 3g, rhizoma Dioscoreae extract 3g, and flos Rosae Rugosae petal extract 3g; the rest of the procedure was carried out in the same manner as in example 1 to obtain a composition.
Comparative example 1
This comparative example was conducted in an animal experiment using the same amount of distilled water as that used in example 1.
Comparative example 2
This comparative example carried out an animal experiment using the same amount of gamma-aminobutyric acid (GABA) as that used in example 1.
Comparative example 3
This comparative example was conducted using the same amount of lycium ruthenicum extract as the composition of example 2.
Comparative example 4
The bifidobacterium infantis in example 2 was modified to gamma-aminobutyric acid (GABA), and an animal experiment was conducted using a composition comprising 0.25g of GABA and 3g of lycium ruthenicum extract.
The compositions of examples 1-6 and comparative examples 1-4 were subjected to the mouse sleep test method. The results are shown in Table 1.
TABLE 1 test results of examples 1-6 and comparative examples 1-4
As can be seen from the above table, the sleeping time of mice of the group of bifidobacterium infantis (example 1) was significantly prolonged, the proportion of mice falling asleep was more, i.e. the incidence of sleep was higher, and the sleep latency was shorter, compared to the blank group (comparative example 1). Bifidobacterium infantis (example 1) had a comparable level of effect in improving sleep quality compared to GABA (comparative example 2). Compared with the single infant bifidobacterium (example 1), the combination of the bifidobacterium infantis and the medicinal and edible plant extracts of lycium ruthenicum murr, spina date seeds, chinese yam and rose petals can play a remarkable synergistic effect of improving the sleep quality, greatly improve the sleep time and the sleep incidence of mice and shorten the sleep latency; the synergistic effect of the lycium ruthenicum extract single component (comparative example 3) and the lycium ruthenicum extract combined with the gamma-aminobutyric acid composition (comparative example 4) is not obvious, and the results show that the bifidobacterium infantis and plants which are homologous in medicine and food can exert a special synergistic effect of improving the sleep quality. The combination of bifidobacterium infantis with lycium ruthenicum murr, spina date seeds, chinese yam and rose petals is a medicine and food homologous plant (example 6), although the sleeping time of a mouse is not obviously prolonged, the sleeping occurrence rate is obviously improved, and the sleeping latency rate is obviously reduced, which indicates that the composition can be used for regulating the balance of circadian rhythm in a targeted manner and avoiding insomnia and excessive somnolence at night.
It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. This need not be, nor should it be exhaustive of all embodiments. And obvious variations or modifications therefrom are within the scope of the invention.
Claims (10)
1. The composition with the function of improving sleep is characterized by comprising the following components (1) and (2) in parts by weight:
(1) 2-5 parts of lycium ruthenicum extract and/or 2-5 parts of spina date seed extract and/or 2-5 parts of Chinese yam extract and/or 1-5 parts of rose petal extract;
(2) 0.05-0.5 part of infant bifidobacterium dry powder.
2. The composition according to claim 1, characterized in that it comprises the following components in parts by weight:
2 to 5 parts of lycium ruthenicum extract, 2 to 5 parts of spina date seed extract, 2 to 5 parts of Chinese yam extract, 1 to 5 parts of rose petal extract and 0.05 to 0.5 part of infant bifidobacterium dry powder.
3. The composition according to claim 1 or 2, wherein the viable count of the Bifidobacterium infantis is 1 x 10 9 -10 10 CFU/g。
4. The composition according to claim 1 or 2, wherein the composition further comprises 0.1-4 parts of an auxiliary material.
5. The composition as claimed in claim 4, wherein the auxiliary materials comprise 0-30% of fruit powder, 0-30% of edible essence, 0-30% of sweetening agent, 0-30% of sour agent, 0-30% of filling agent, 0-30% of lubricating agent, 0-30% of preservative, 0-30% of suspending agent, 0-30% of edible pigment, 0-30% of diluting agent and 0-30% of plasticizer.
6. The composition of claim 1 or 2, wherein the lycium ruthenicum extract, the spina date seed extract, the Chinese yam extract and the rose petal extract are powder of lycium ruthenicum, spina date seed, chinese yam and rose petal which are subjected to water extraction, decoction and drying.
7. The composition of claim 1 or 2, wherein the lycium ruthenicum extract, the spina date seed extract, the yam extract or the rose petal extract is prepared by a method comprising the following steps of: soaking fructus Lycii, semen Ziziphi Spinosae, rhizoma Dioscoreae or flos Rosae Rugosae in water for 0.5-1 hr, extracting with boiling water at normal pressure for 2-3 times, each for 1-2 hr, evaporating under reduced pressure, concentrating to obtain extract, and freeze drying to obtain fructus Lycii extract, semen Ziziphi Spinosae extract, rhizoma Dioscoreae extract or flos Rosae Rugosae extract;
preferably, the mass volume ratio of the lycium ruthenicum murr, the spina date seed, the Chinese yam or the rose petal to the water is 1.
8. The composition according to claim 1 or 2, wherein the composition is in the form of an oral dosage form;
preferably, the oral preparation includes powder, granule, tablet, hard capsule, soft capsule, oral liquid and soft candy.
9. A preparation method of the composition of claim 1, wherein 1-5 parts of Lycium ruthenicum Murr extract and/or 2-5 parts of spina date seed extract and/or 2-5 parts of Chinese yam extract and/or 1-5 parts of rose petal extract are mixed with 0.05-0.5 part of Bifidobacterium infantis, and auxiliary materials are added to prepare the oral preparation.
10. The method of claim 9, wherein the oral preparation comprises powders, granules, tablets, hard capsules, soft capsules, oral liquids, and soft sweets.
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| CN102960447A (en) * | 2008-11-03 | 2013-03-13 | 雀巢产品技术援助有限公司 | A nutritional composition comprising probiotics and improving sleep patterns |
| CN103784611A (en) * | 2014-01-23 | 2014-05-14 | 云南白药天颐茶品有限公司 | Composition capable of improving sleep and relieving pressure and application thereof |
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| CN108671135A (en) * | 2018-08-01 | 2018-10-19 | 泰安大凡神农生物有限公司 | A kind of Traditional Chinese medicine probiotic compound of conditioning insomnia and depression |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102960447A (en) * | 2008-11-03 | 2013-03-13 | 雀巢产品技术援助有限公司 | A nutritional composition comprising probiotics and improving sleep patterns |
| CN103784611A (en) * | 2014-01-23 | 2014-05-14 | 云南白药天颐茶品有限公司 | Composition capable of improving sleep and relieving pressure and application thereof |
| CN104187613A (en) * | 2014-07-29 | 2014-12-10 | 胡安然 | Total-nutrient formulated food for patients with insomnia |
| CN108671135A (en) * | 2018-08-01 | 2018-10-19 | 泰安大凡神农生物有限公司 | A kind of Traditional Chinese medicine probiotic compound of conditioning insomnia and depression |
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