CN115299458A - Silver ion long-acting antibacterial agent and preparation method thereof - Google Patents

Abstract

The invention belongs to the technical field of antibacterial agents, and particularly relates to a silver ion long-acting antibacterial agent and a preparation method thereof. A long-acting antibacterial agent of silver ion is prepared from the following raw materials: silver ion water, plant extract, and emulsifier. The antibacterial agent prepared by the invention ensures that the antibacterial agent has higher bacterial inactivation rate under the synergistic action of the silver ion water, the plant extract, the emulsifier, the regulator and the like, and can effectively coat the active ingredients under the action of the emulsifiers with different HLB values, so that the antibacterial active ingredients can be slowly released, and the antibacterial agent has continuous and lasting antibacterial capability, can avoid the damage to human bodies and the environment no matter the antibacterial agent is used in the human bodies or the environment, and has strong safety and good antibacterial effect.

Description

Silver ion long-acting antibacterial agent and preparation method thereof

Technical Field

The invention belongs to the technical field of A01N antibacterial agents, and particularly relates to a silver ion long-acting antibacterial agent and a preparation method thereof.

Background

With the development of antibacterial agents, the development of antibacterial agents has undergone continuous innovation and progress. With the increase of safety consciousness of people, more and more safe and environment-friendly antibacterial disinfectants appear, wherein more plant extracts are used.

The plant extract is widely applied to the fields of medicines, health-care foods, cosmetics and the like because the plant extract does not contain organic chemical components and is harmless to human bodies and the environment. However, in the development of antibacterial agents, the inhibitory effect and inactivation rate of a single or several plant extracts on bacteria, viruses and the like are low.

For example, chinese invention patent No. CN201610709030.9 discloses a bactericidal repairing detergent, a preparation method and an application thereof, wherein a better bactericidal effect is expected to be achieved by using a plant extract and a silver ion antibacterial agent in the disclosed patent, but the concentration of the silver ion solution used in the disclosed patent is relatively low, and it is necessary to increase the amount of the plant extract to obtain the better bactericidal effect, but the increase of the amount of the plant extract correspondingly increases the amount of a surfactant or other auxiliary agents, which may cause the occurrence of an unstable storage phenomenon in a specific use process.

In the face of the current requirements of safety and high bacterial inactivation rate of the antibacterial agent, the research and development of a product which is highly safe to human bodies and has high bacterial and viral inactivation rate is an important research task for researchers.

Disclosure of Invention

In order to solve the above technical problems, a first aspect of the present invention provides a long-acting antibacterial agent for silver ions, which is prepared from the following raw materials: silver ion water, plant extract, emulsifier and auxiliary materials;

the emulsifier is selected from at least one of polyoxyethylene fatty alcohol ether, polyoxyethylene-polyoxypropylene copolymer, polyoxyethylene sorbitan fatty acid ester and sorbitan fatty acid.

In some preferred embodiments, the plant extract is selected from one or more of honeysuckle extract, dandelion extract, garlic extract, forsythia extract, aloe extract and green tea extract.

In some preferred embodiments, the plant extract is a honeysuckle extract and a green tea extract.

Honeysuckle extract, INCI: honeyysuckle Flower Extract;

green tea extract, INCI: green Tea Extract;

in some preferred embodiments, the weight ratio of the honeysuckle extract to the green tea extract is 1: (1-3).

Further preferably, the weight ratio of the honeysuckle extract to the green tea extract is 1:2.

in some preferred embodiments, the silver ion water has a mass concentration of 20 to 60ppm.

In some preferred embodiments, the silver ion water has a mass concentration of 30 to 50ppm.

In some preferred embodiments, the silver ion water has a mass concentration of 40ppm.

In some preferred embodiments, the emulsifier has an HLB value of 12 to 18.

In some preferred embodiments, the emulsifier has an HLB value of from 14 to 16.

In some preferred embodiments, the emulsifier is a polyoxyethylene fatty alcohol ether and/or a polyoxyethylene polyoxypropylene ether block copolymer.

In some preferred embodiments, the polyoxyethylene fatty alcohol ether is castor oil polyoxyethylene ether.

In some preferred embodiments, the weight ratio of the castor oil polyoxyethylene ether poly and the polyoxyethylene polyoxypropylene ether block copolymer is 1: (0.1-0.5).

Further preferably, the weight ratio of the castor oil polyoxyethylene ether block copolymer to the polyoxyethylene polyoxypropylene ether block copolymer is 1:0.3.

after a great deal of inventive experimental research, the applicant found that an emulsifier with HLB value of 14-16 was selected for the preparation of antibacterial agent, in a synergistic weight ratio of 1: the honeysuckle extract and the green tea extract in the formula (1-3) enable the antibacterial effect of the antibacterial agent prepared by the formula to be greatly improved, the bacteria inactivation rate reaches 99.99%, the applicant conjectures that when the HLB value of the emulsifier is 14-16, the emulsifier can stably coat the plant extract and silver ions in a system, and the dispersibility of the substance such as chlorogenic acid contained in the honeysuckle extract and the interaction force such as hydrogen bonds and van der waals among active groups in the emulsifier in the system is greatly improved, so that not only is the reaction basis provided for the specific combination between the silver ions and thalli, but also the synergistic effect of the honeysuckle extract, the green tea extract, the castor oil polyoxyethylene ether poly and the polyoxyethylene polyoxypropylene ether block copolymer is improved, and the antibacterial effect is improved.

Applicants have found that when the HLB value of the emulsifier is selected to be too great, this results in a significant reduction in the shelf life of the antimicrobial; when the proportion or the types of the two selected emulsifiers are different, the effect of the effective components of the antibacterial agent is inhibited, and the inactivation rate of bacteria is influenced. In addition, the applicant finds that the excessive content of the added polyoxyethylene polyoxypropylene ether block copolymer in the system influences the contact probability between free particles in the system, further influences the mutual synergistic effect between substances and influences the bacteriostatic effect.

Meanwhile, the block copolymer of castor oil polyoxyethylene ether and polyoxyethylene polyoxypropylene ether selectively added in the application also influences the stability of the system.

In some preferred embodiments, the adjuvant comprises at least one of a conditioning agent, a compatibilizing agent, a stabilizing agent, an anti-freezing agent, and an antioxidant.

Further preferably, the auxiliary material comprises a conditioner.

In some preferred embodiments, the preparation raw materials comprise, by weight: the preparation raw materials comprise the following components in parts by weight: 20-50 parts of silver ion water, 8-12 parts of plant extract, 0.1-1 part of emulsifier and 5-10 parts of conditioner.

The second aspect of the invention provides a preparation method of a silver ion long-acting antibacterial agent, which comprises the following steps:

1) Adding silver ion water, plant extract, emulsifier and conditioner into a reaction kettle, controlling the stirring speed to be 800-1000rpm, and mixing to obtain a mixture A;

2) And (5) stirring the mixture A to be transparent, and filtering to obtain the product.

Has the advantages that: the antibacterial agent prepared by the invention ensures that the antibacterial agent has higher bacterial inactivation rate under the synergistic action of the silver ion water, the plant extract, the emulsifier, the regulator and the like, and can effectively coat active ingredients under the action of the emulsifiers with different HLB values, so that the antibacterial active ingredients can be slowly released, and the antibacterial agent has continuous and lasting antibacterial capability.

Detailed Description

Examples

Example 1

The long-acting antibacterial agent for silver ions comprises the following preparation raw materials in parts by weight: 40 parts of silver ion water, 10 parts of plant extract, 0.8 part of emulsifier and 8 parts of conditioner.

The silver ion water has a mass concentration of 40ppm and is purchased from Japan oasis corporation.

The plant extract is selected from honeysuckle extract and green tea extract, and the weight ratio of the honeysuckle extract to the green tea extract is 1:2.

the emulsifier is a block copolymer of castor oil polyoxyethylene ether and polyoxyethylene polyoxypropylene ether, and the weight ratio of the block copolymer is 1:0.3;

castor oil polyoxyethylene ether with HLB value of 14-16 and model number EL-10, purchased from Haian petrochemical plant of Jiangsu province;

the polyoxyethylene polyoxypropylene ether block copolymer has HLB value of 14-16, and is available from Gnaphaline Biotech, inc. of Wuhan Hua.

The conditioner is sodium alginate.

Honeysuckle extract, purchased from denying sincerity biotechnology limited; green tea extract, savo biotechnology limited, shaanxi.

A preparation method of a silver ion long-acting antibacterial agent comprises the following steps:

1) Adding silver ion water, plant extract, emulsifier and conditioner into a reaction kettle, controlling the stirring speed to be 900rpm, and mixing to obtain a mixture A;

2) And (5) stirring the mixture A to be transparent, and filtering to obtain the product.

Example 2

A long-acting antibacterial agent of silver ions comprises the following raw materials in parts by weight: 40 parts of silver ion water, 10 parts of plant extract, 0.8 part of emulsifier and 8 parts of conditioner.

The silver ion water has a mass concentration of 40ppm and is purchased from Japan oasis corporation.

The plant extract is selected from honeysuckle extract and green tea extract, and the weight ratio of the honeysuckle extract to the green tea extract is 1:2.

the emulsifier is castor oil polyoxyethylene ether;

castor oil polyoxyethylene ether with HLB value of 14-16 and model number EL-10, purchased from Haian petrochemical plant of Jiangsu province;

the conditioner is sodium alginate.

Honeysuckle extract, purchased from denying sincerity biotechnology limited; green tea extract, savo biotechnology limited, shaanxi.

A preparation method of a silver ion long-acting antibacterial agent comprises the following steps:

1) Adding silver ion water, plant extract, emulsifier and conditioner into a reaction kettle, controlling the stirring speed to be 900rpm, and mixing to obtain a mixture A;

2) And (4) stirring the mixture A to be transparent, and filtering to obtain the product.

Example 3

A long-acting antibacterial agent of silver ions comprises the following raw materials in parts by weight: 40 parts of silver ion water, 10 parts of plant extract, 0.8 part of emulsifier and 8 parts of conditioner.

The silver ion water has a mass concentration of 40ppm and is purchased from Japan oasis.

The plant extract is selected from honeysuckle extract and green tea extract, and the weight ratio of the honeysuckle extract to the green tea extract is 1:2.

the emulsifier is a block copolymer of castor oil polyoxyethylene ether and polyoxyethylene polyoxypropylene ether, and the weight ratio of the block copolymer is 1:1;

castor oil polyoxyethylene ether with HLB value of 14-16 and type EL-10, purchased from Haian petrochemical plant of Jiangsu province;

the polyoxyethylene polyoxypropylene ether block copolymer has HLB value of 14-16, and is available from Gnaphaline Biotech, inc. of Wuhan Hua.

The conditioner is sodium alginate.

Honeysuckle extract, purchased from sinceri biotechnology limited of denying; green tea extract, savo biotechnology limited, shaanxi.

A preparation method of a silver ion long-acting antibacterial agent comprises the following steps:

1) Adding silver ion water, plant extract, emulsifier and conditioner into a reaction kettle, controlling the stirring speed to be 900rpm, and mixing to obtain a mixture A;

2) And (5) stirring the mixture A to be transparent, and filtering to obtain the product.

Example 4

A long-acting antibacterial agent of silver ions comprises the following raw materials in parts by weight: 40 parts of silver ion water, 10 parts of plant extract, 0.8 part of emulsifier and 8 parts of conditioner.

The silver ion water has a mass concentration of 40ppm and is purchased from Japan oasis corporation.

The plant extract is selected from honeysuckle extract.

The emulsifier is a block copolymer of castor oil polyoxyethylene ether and polyoxyethylene polyoxypropylene ether, and the weight ratio of the block copolymer is 1:0.3;

castor oil polyoxyethylene ether with HLB value of 14-16 and model number EL-10, purchased from Haian petrochemical plant of Jiangsu province;

the polyoxyethylene polyoxypropylene ether block copolymer has HLB value of 14-16, and is available from Gnaphaline Biotech, inc. of Wuhan Hua.

The conditioner is sodium alginate.

Honeysuckle extract, purchased from sinceri biotechnology limited, denying, jeans.

A preparation method of a silver ion long-acting antibacterial agent comprises the following steps:

1) Adding silver ion water, plant extract, emulsifier and conditioner into a reaction kettle, controlling the stirring speed to be 900rpm, and mixing to obtain a mixture A;

2) And (5) stirring the mixture A to be transparent, and filtering to obtain the product.

Example 5

A long-acting antibacterial agent of silver ions comprises the following raw materials in parts by weight: 40 parts of silver ion water, 10 parts of plant extract, 0.8 part of emulsifier and 8 parts of conditioner.

The silver ion water has a mass concentration of 40ppm and is purchased from Japan oasis corporation.

The plant extract is green tea extract.

The emulsifier is a block copolymer of castor oil polyoxyethylene ether and polyoxyethylene polyoxypropylene ether, and the weight ratio of the block copolymer is 1:0.3;

castor oil polyoxyethylene ether with HLB value of 14-16 and type EL-10, purchased from Haian petrochemical plant of Jiangsu province;

the polyoxyethylene polyoxypropylene ether block copolymer has HLB value of 14-16, and is available from Gnaphaline Biotech, inc. of Wuhan Hua.

The conditioner is sodium alginate.

Green tea extract, shanxi ruivo biotechnology limited.

A preparation method of a silver ion long-acting antibacterial agent comprises the following steps:

1) Adding silver ion water, plant extract, emulsifier and conditioner into a reaction kettle, controlling the stirring speed to be 900rpm, and mixing to obtain a mixture A;

2) And (5) stirring the mixture A to be transparent, and filtering to obtain the product.

And (4) performance testing:

1. and (3) testing the bacterial inactivation rate: the silver ion long-acting antibacterial agents prepared in examples 1 to 5 were used for the bacterial inactivation rate test, the test strains were escherichia coli and staphylococcus aureus, and the bacterial inactivation rates were counted in table 1 below.

Table 1:

2. and (3) effectiveness accelerated test: the silver ion long-acting antibacterial agents prepared in examples 1 to 5 were used for accelerated effectiveness tests, the test methods were accelerated according to "Disinfection technical Specification 2002 edition", and when the test time was 90 days under the conditions of constant temperature and humidity at 37 ℃, the decrease of the inactivation rate of bacteria was judged,

when the inactivation rate of the bacteria is reduced by less than or equal to 5 percent, the validity period is determined to be more than 2 years, and the validity is determined to be excellent; when the bacteria inactivation rate is reduced to 5-8%, the validity period is determined to be between 2 years and 1 year, and the validity is determined to be good; when the inactivation rate of the bacteria is reduced by more than or equal to 10 percent, the validity period is determined to be within 1 year, and the validity is determined to be poor; and the results are tabulated in table 1.

Experiment of	Effectiveness of
		Example 1	Superior food
Example 2	Difference (D)
		Example 3	Good wine
Example 4	Superior food
		Example 5	Superior food

Claims (10)

1. The long-acting antibacterial agent for silver ions is characterized by comprising the following preparation raw materials: silver ion water, plant extract, emulsifier and auxiliary materials;

the emulsifier is selected from at least one of polyoxyethylene fatty alcohol ether, polyoxyethylene-polyoxypropylene copolymer, polyoxyethylene sorbitan fatty acid ester and fatty acid sorbitan.

2. The long-acting antibacterial agent for silver ions according to claim 1, wherein the plant extract is one or more selected from the group consisting of honeysuckle extract, dandelion extract, garlic extract, forsythia extract, aloe extract, and green tea extract.

3. The long-acting silver ion antibacterial agent according to claim 1, wherein the silver ion water has a mass concentration of 30 to 50ppm; preferably, the mass concentration of the silver ion water is 40ppm.

4. The long-acting silver ion antibacterial agent according to claim 1, wherein said emulsifier has an HLB value of 12 to 18.

5. The long-acting silver ion antibacterial agent of claim 4, wherein the emulsifier is a polyoxyethylene fatty alcohol ether and/or a polyoxyethylene polyoxypropylene ether block copolymer.

6. The long-acting silver ion antibacterial agent according to claim 1 or 5, wherein the polyoxyethylene fatty alcohol ether is castor oil polyoxyethylene ether.

7. The long-acting silver ion antibacterial agent of claim 1, wherein the adjuvant comprises at least one of a conditioner, a compatibilizer, a stabilizer, an antifreeze, and an antioxidant.

8. The long-acting silver ion antibacterial agent of claim 1, wherein the adjuvant comprises a conditioning agent.

9. The long-acting silver ion antibacterial agent according to claim 8, wherein the preparation raw materials comprise, by weight: 20-50 parts of silver ion water, 8-12 parts of plant extract, 0.1-1 part of emulsifier and 5-10 parts of conditioner.

10. A method of preparing a long-acting silver ion antibacterial agent according to claim 8 or 9, comprising the steps of:

1) Adding silver ion water, plant extract, emulsifier and conditioner into a reaction kettle, controlling the stirring speed to be 800-1000rpm, and mixing to obtain a mixture A;

2) And (4) stirring the mixture A to be transparent, and filtering to obtain the product.