CN115266883A - Biosensor based on TFET device and manufacturing method thereof - Google Patents
Biosensor based on TFET device and manufacturing method thereof Download PDFInfo
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- CN115266883A CN115266883A CN202210710429.4A CN202210710429A CN115266883A CN 115266883 A CN115266883 A CN 115266883A CN 202210710429 A CN202210710429 A CN 202210710429A CN 115266883 A CN115266883 A CN 115266883A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/403—Cells and electrode assemblies
- G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
- G01N27/4145—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
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- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
- H05K3/00—Apparatus or processes for manufacturing printed circuits
- H05K3/30—Assembling printed circuits with electric components, e.g. with resistor
- H05K3/32—Assembling printed circuits with electric components, e.g. with resistor electrically connecting electric components or wires to printed circuits
- H05K3/34—Assembling printed circuits with electric components, e.g. with resistor electrically connecting electric components or wires to printed circuits by soldering
- H05K3/341—Surface mounted components
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- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
- H05K3/00—Apparatus or processes for manufacturing printed circuits
- H05K3/30—Assembling printed circuits with electric components, e.g. with resistor
- H05K3/32—Assembling printed circuits with electric components, e.g. with resistor electrically connecting electric components or wires to printed circuits
- H05K3/34—Assembling printed circuits with electric components, e.g. with resistor electrically connecting electric components or wires to printed circuits by soldering
- H05K3/3489—Composition of fluxes; Methods of application thereof; Other methods of activating the contact surfaces
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Abstract
The invention belongs to the technical field of biosensors, and particularly relates to a biosensor based on a TFET device and a manufacturing method thereof. The invention is based on TFET device to produce the biosensor for biological entity or biological molecule, to realize the interaction and reaction detection between reactant and biological entity/biological molecule; the pins of the device can be impregnated with rosin liquid in the preparation process of the biosensor, and the pins can be firmly welded on a circuit board for bearing in the welding process, so that the connection firmness of the biosensor is improved, the quality of the biosensor is improved, and the stable quality of the biosensor is ensured.
Description
Technical Field
The invention relates to the technical field of biosensors, in particular to a biosensor based on a TFET device and a manufacturing method thereof.
Background
Biosensors are devices for sensing and detecting biomolecules and operate on the basis of electronic, electrochemical, optical and mechanical detection principles. Biosensors comprising a transistor are sensors that electrically sense charge, photon and mechanical properties of a biological entity or biomolecule. Detection may be carried out by detecting the biological entity or biomolecule itself, or by interaction and reaction between a specific reactant and the biological entity/biomolecule. Such biosensors can be manufactured using a semiconductor process, can rapidly convert an electrical signal, and can be easily applied to Integrated Circuits (ICs) and Micro Electro Mechanical Systems (MEMS);
a biosensor system package and a method for manufacturing the same described in CN2021101298179, which includes a biosensor system package comprising: a transistor structure in a semiconductor layer having a front side and a back side, the transistor structure including a channel region; a Buried Oxide (BOX) layer on a backside of the semiconductor layer, wherein the buried oxide layer has an opening on the backside of the channel region and an interfacial layer covers the backside over the channel region; a multilayer interconnect (MLI) structure on a front side of the semiconductor layer, the transistor structure being electrically connected to the MLI structure; and a cover structure attached to the buried oxide layer, the cover structure comprising microneedles. Embodiments of the present application also relate to methods of manufacturing biosensor system packages; the biosensor prepared by the scheme can be manufactured by using a semiconductor process, can quickly convert an electric signal, and can be easily applied to an Integrated Circuit (IC) and a micro-electro-mechanical system (MEMS), but pins on a device in the biosensor, especially pins on two sides of the bottom of a TFET device, need to be welded with a circuit board for bearing in an actual production and processing process, the existing welding mode is easy to cause the conditions of weak connection and unstable sensor quality, and therefore, the biosensor based on the TFET device and the manufacturing method thereof are needed.
Disclosure of Invention
The biosensor based on the TFET device and the manufacturing method thereof solve the problems in the prior art.
In order to achieve the purpose, the invention adopts the following technical scheme:
a biosensor based on a TFET device and a manufacturing method thereof comprise a biosensor system, wherein the biosensor comprises a bearing plate for bearing, a biosensor unit arranged on the bearing plate, a control sensor unit, a temperature sensor unit, an amplifier, a power regulator, an analog-to-digital converter, a digital control module and a wireless transceiver;
the manufacturing steps are as follows:
s1, preparing a device according to the composition of the biosensor;
s2, welding the prepared device on a preset position of the bearing plate by using a welding device;
and S3, packaging the bearing plate after welding is completed.
Preferably, the welding device comprises a base, a support arranged at the top of the base, a welding assembly fixedly connected to one side of the support, a conveying assembly fixedly connected to the top of the support, a suction dip-dyeing assembly fixedly connected to the bottom of the conveying assembly, and a positioning assembly fixedly connected to the top of the base; the suction dip-dyeing component comprises a suction mechanism connected with the output end of the bottom of the conveying component, dip-dyeing mechanisms arranged on two sides of the suction mechanism and an air supply mechanism arranged on one side of the suction mechanism.
Preferably, the suction means includes with the stay tube of the long bar-shaped structure of conveyor components bottom output end rigid coupling, set up at the inside drive screw of stay tube, screw cup joint the fall way in drive screw bottom outer lane, rigid coupling sucking disc, rigid coupling in the fall way bottom the fixed push pedal of fall way both sides and inlay the absorption piece at fixed push pedal top, it is two sets of the passageway that stretches into of the long bar-shaped structure that runs through the stay tube is all seted up to one side that fixed push pedal kept away from each other is two sets of stretch into the spout that sets up along its length direction all to stretch into the inside wall that stretches into the passageway, and is two sets of it has the rack with dip-dye mechanism meshing to stretch into the passageway and stretch into the locking board that the opposite side that stretches into stay tube one end was provided with and dip-dye mechanism joint, and locking board and stay tube inside wall sliding connection, one side rigid coupling that adjacent rack was kept away from to the locking board has the flexible unit with stay tube inside wall rigid coupling.
Preferably, dip-dye mechanism include with stretch into passageway sliding connection's fixed sleeve, fixed cup joint at fixed sleeve outer lane and spout sliding connection's slide, activity cup joint at the rotation axis of fixed sleeve inner circle, fix the rotation axis and stretch into to stay tube one end outer lane survey gear, slide and cup joint the promotion screw rod at the rotation axis other end, promote screw rod and fixed sleeve thread cup joint, the one end activity that the promotion screw rod stretches out fixed sleeve has cup jointed the movable sleeve with fixed sleeve outer lane sliding connection, the one end rigid coupling that the stay tube was kept away from to the movable sleeve has the connecting rod, and the bottom rigid coupling of connecting rod has the dip-dye case, the one end that the dip-dye case is close to the stay tube has seted up the dip-dye hole, and the one end outer lane fixed cup joint that the gear is close to the fall pipe has adsorbed the ring.
Preferably, the air supply mechanism comprises an air inlet pipe fixedly connected with the suction mechanism and a connecting pipe sleeved on an inner ring at the bottom of the air inlet pipe in a sliding manner.
Preferably, the conveying assembly comprises a first pushing unit fixedly connected with the support, a second pushing unit vertically arranged is fixedly connected with the bottom output end of the first pushing unit, and the bottom output unit of the second pushing unit is fixedly connected with the top of the supporting pipe.
Preferably, the welding assembly comprises a third pushing unit fixedly connected with the side edge of the support, a fourth pushing unit fixedly connected with the output end of the bottom of the third pushing unit, a fifth pushing unit fixedly connected with the output end of the fourth pushing unit, a substrate fixedly connected with the bottom of the output end of the bottom of the fifth pushing unit, a supporting plate of an L-shaped structure fixedly connected with the bottom of the substrate and a welding gun fixedly connected with the supporting plate.
Preferably, the locating component includes with the board of placing of bottom plate top rigid coupling, set up the absorption chamber of placing the board top, the rigid coupling is at the adsorption plate that adsorbs the chamber opening part, sliding connection is at the horizontal stripper plate of two sets of parallel arrangement's of adsorption plate bottom and set up two sets of vertical stripper plates between two sets of horizontal stripper plates, inwards sunken recess has all been seted up to two sets of vertical stripper plate's both sides, the inside slip of recess cup joints the extension board with horizontal stripper plate sliding connection, the extension board stretches into the one end rigid coupling to the recess has the spring with the rigid coupling of recess tip inside wall, the mounting groove that is located the board top is all seted up to the both sides that two sets of horizontal stripper plates kept away from each other and two sets of vertical stripper plates each other, the internally mounted of mounting groove has with place the push rod that board slip cup jointed one, one end and adjacent horizontal stripper plate or vertical stripper plate rigid coupling that the push rod stretched into to the absorption chamber, one end rigid coupling that the push rod stretched into to the mounting groove has the push pedal of L type structure, the push pedal extends to the one end rigid coupling of placing the board top has splint, the bottom of push pedal is connected with centre gripping actuating mechanism.
In the present invention,
through the arranged bearing plate, the biosensor unit arranged on the bearing plate, the control sensor unit, the temperature sensor unit, the amplifier, the power regulator, the analog-digital converter, the digital control module and the wireless transceiver, the biosensor used for the biological entity or the biological molecule is manufactured on the basis of the TFET device, and the interaction and the reaction detection between reactants and the biological entity/biological molecule are realized;
through the base that sets up, a support, conveying component, absorb the dip-dyeing subassembly, the welding subassembly, locating component, suction means, air feed mechanism, the dip-dyeing mechanism, place the board, the absorption chamber, the adsorption plate, horizontal stripper plate, vertical stripper plate, the extension board, the mounting groove, push rod one, the push pedal, splint, centre gripping actuating mechanism, the stay tube, driving screw, the fall way, the sucking disc, fixed push pedal, the adsorption block, stretch into the passageway, the spout, the rack, the locking plate, flexible unit, the fixed sleeve, the slide, the rotation axis, the gear, push screw, the movable sleeve, the connecting rod, the dip-dyeing case, dip-dyeing hole and absorption ring, can dip-dye rosin liquid to the pin of device carrying out biosensor preparation process, make the pin can firmly weld on the circuit board that is used for bearing in welding process, improve the firm degree that the biosensor is connected, improve the biosensor quality, ensure the biosensor stable in quality.
Drawings
Fig. 1 is a schematic structural diagram of a biosensor based on a TFET device and a welding device for manufacturing the biosensor according to the present invention;
fig. 2 is a cross-sectional view of a TFET device-based biosensor and a manufacturing method thereof, wherein a welding device sucks a dip-dyeing component;
FIG. 3 is a partial enlargement of a welding device of a biosensor based on a TFET device and a manufacturing method thereof according to the present invention;
FIG. 4 is a schematic structural diagram of a sucking dip-dyeing component of a welding device of a biosensor based on a TFET device and a manufacturing method thereof according to the present invention;
FIG. 5 is a top view of a sucking and dipping assembly of a welding device of a biosensor based on a TFET device and a manufacturing method thereof according to the present invention;
fig. 6 is a schematic structural diagram of a positioning assembly of a welding device of a biosensor based on a TFET device and a manufacturing method thereof according to the present invention;
fig. 7 is a top view of a positioning assembly of a soldering apparatus for a biosensor based on a TFET device and a method for fabricating the same according to the present invention.
In the figure: the device comprises a base 1, a support 2, a conveying assembly 3, a suction dyeing assembly 4, a welding assembly 5, a positioning assembly 6, a suction mechanism 7, an air supply mechanism 8, a dip dyeing mechanism 9, a placing plate 61, an adsorption cavity 62, an adsorption plate 63, a transverse extrusion plate 64, a longitudinal extrusion plate 65, an extension plate 66, a mounting groove 67, a first push rod 68, a push plate 69, a clamping plate 610, a 611 clamping and driving mechanism, a supporting tube 71, a driving screw 72, a lifting tube 73, a suction cup 74, a fixed push plate 75, an adsorption block 76, an extension channel 714, a 715 sliding chute, a rack 716, a 717 locking plate, a 718 telescopic unit, a fixed sleeve 91, a sliding plate 92, a 93 rotating shaft, a 94 gear, a 95 pushing screw, a 96 movable sleeve, a 97 connecting rod, a 98 dip dyeing box 99 dip dyeing hole and a 910 suction ring.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
Referring to fig. 1-7, a biosensor based on a TFET device and a method for manufacturing the same includes a biosensor system, the biosensor includes a bearing plate for bearing, a biosensor unit disposed on the bearing plate, a control sensor unit, a temperature sensor unit, an amplifier, a power regulator, an analog-to-digital converter, a digital control module, and a wireless transceiver;
the manufacturing steps are as follows:
s1, preparing a device according to the composition of the biosensor;
s2, welding the prepared device on a preset position of the bearing plate by using a welding device;
and S3, packaging the bearing plate after welding is completed.
Further, the welding device comprises a base 1, a support 2 arranged at the top of the base 1, a welding component 5 fixedly connected to one side of the support 2, a conveying component 3 fixedly connected to the top of the support 2, a suction dip-dyeing component 4 fixedly connected to the bottom of the conveying component 3, and a positioning component 6 fixedly connected to the top of the base 1; the suction dip-dyeing component 4 comprises a suction mechanism 7 connected with the output end at the bottom of the conveying component 3, dip-dyeing mechanisms 9 arranged at two sides of the suction mechanism 7 and an air supply mechanism 8 arranged at one side of the suction mechanism 7.
Specifically, the suction mechanism 7 includes a support tube 71 of a long strip structure fixedly connected to the bottom output end of the conveying assembly 3, a driving screw 72 disposed inside the support tube 71, a lifting tube 73 threadedly sleeved on the outer ring of the bottom of the driving screw 72, a suction cup 74 fixedly connected to the bottom of the lifting tube 73, fixed push plates 75 fixedly connected to both sides of the lifting tube 73, and an adsorption block 76 embedded at the top of the fixed push plates 75, an extending channel 714 penetrating through the long strip structure of the support tube 71 is formed on one side of each of the two groups of fixed push plates 75, sliding grooves 715 disposed along the length direction of each of the two groups of extending channels 714 are formed on the inner side walls of the two groups of extending channels 714, a rack 716 engaged with the dip-dyeing mechanism 9 is fixedly connected to one side of each of the two groups of extending channels 714 extending to one end of the support tube 71, a locking plate 717 engaged with the dip-dyeing mechanism 9 is disposed on the other side of each of the two groups of extending channels 714 extending to one end of the support tube 71, the locking plate 717 is slidably connected to the inner side wall of the support tube 71, and a telescopic unit 718 is fixedly connected to the inner side wall of the support tube 71, and a telescopic unit 718 fixedly connected to the side of the locking plate 717 of the inner side of the adjacent rack 716.
In particular, the dip dyeing mechanism 9 includes a fixed sleeve 91 slidably connected to the extending passage 714, a sliding plate 92 fixedly sleeved on an outer ring of the fixed sleeve 91 and slidably connected to the sliding groove 715, a rotating shaft 93 movably sleeved on an inner ring of the fixed sleeve 91, a measuring gear 94 fixed on an outer ring of one end of the rotating shaft 93 extending to the support tube 71, and a pushing screw 95 slidably sleeved on the other end of the rotating shaft 93, wherein the pushing screw 95 is in threaded sleeve connection with the fixed sleeve 91, a movable sleeve 96 slidably connected to an outer ring of the fixed sleeve 91 is movably sleeved on one end of the pushing screw 95 extending out of the fixed sleeve 91, a connecting rod 97 is fixedly connected to one end of the movable sleeve 96 far from the support tube 714, a dip dyeing box 98 is fixedly connected to the bottom of the connecting rod 97, a dip dyeing hole 99 is formed in one end of the dip dyeing box 98 close to the support tube 71, an adsorption ring 910 is fixedly sleeved on an outer ring of one end of the gear 94 close to the lifting tube 73, an adsorption sponge is filled in the dip dyeing box 98, and the adsorption sponge is filled with a dip dyeing liquid.
It should be noted that the air supply mechanism 8 includes an air inlet pipe fixedly connected with the suction mechanism 7, and a connecting pipe slidably sleeved on an inner ring at the bottom of the air inlet pipe, and the bottom of the connecting pipe is communicated with the suction cup 74.
In addition, the conveying component 3 comprises a first pushing unit fixedly connected with the bracket 2, a second pushing unit vertically arranged is fixedly connected with the bottom output end of the first pushing unit, and the bottom output unit of the second pushing unit is fixedly connected with the top of the supporting pipe 71.
In addition, the welding assembly 5 comprises a third pushing unit fixedly connected with the side edge of the support 2, a fourth pushing unit fixedly connected with the output end of the bottom of the third pushing unit, a fifth pushing unit fixedly connected with the output end of the fourth pushing unit, a substrate fixedly connected with the bottom of the output end of the bottom of the fifth pushing unit, a supporting plate of an L-shaped structure fixedly connected with the bottom of the substrate and a welding gun fixedly connected with the supporting plate.
Furthermore, the positioning assembly 6 includes a placing plate 61 fixedly connected to the top of the bottom plate 1, an adsorption cavity 62 formed at the top of the placing plate 61, an adsorption plate 63 fixedly connected to an opening of the adsorption cavity 62, two sets of parallel lateral extrusion plates 64 slidably connected to the bottom of the adsorption plate 63, and two sets of longitudinal extrusion plates 65 disposed between the two sets of lateral extrusion plates 64, two sides of each of the two sets of longitudinal extrusion plates 63 are respectively provided with an inwardly recessed groove, an extension plate 66 slidably connected to the lateral extrusion plates 64 is slidably sleeved inside the groove, one end of the extension plate 66 extending into the groove is fixedly connected to a spring fixedly connected to the inner side wall of the groove, two sides of each of the two sets of lateral extrusion plates 64 and two sides of each of the two sets of longitudinal extrusion plates 65 are respectively provided with an installation groove 67 located above the placing plate 61, a push rod 68 slidably sleeved with the placing plate 61 is installed inside the installation groove 67, one end of the push rod 68 extending into the adsorption cavity 62 is fixedly connected to the adjacent lateral extrusion plate 64 or the longitudinal extrusion plate 65, one end of the push rod 68 extending into the installation groove 67 is fixedly connected to a push plate 69 with an L-shaped push plate 69, one end of the push plate extending into the top of the placing plate 61 is connected to a clamping mechanism 611, and a clamping tube of the clamping plate is connected to the bottom of the clamping plate 610 fixedly connected to a clamping mechanism of the clamping plate 69;
the first embodiment is as follows:
the adsorption ring 910 and the adsorption block 76 are both made of magnetic materials, and the adsorption ring 910 and the adsorption block 76 are magnetically adsorbed.
The second embodiment:
the clamping driving mechanism 611 comprises a screw rod in threaded sleeve connection with the push plate 69, one end of the screw rod is fixedly connected with a first motor fixedly connected with the mounting groove 67, and the adsorption plate 63 is provided with adsorption holes distributed in an array manner in a penetrating manner.
Example three:
the top of the driving screw 72 is fixedly connected with a second motor fixedly connected with the inner side wall of the supporting pipe 71, and the outer side of the top of the lifting pipe 73 is fixedly connected with a first sliding block slidably connected with the inside of the supporting pipe 71.
Example four:
the telescopic unit 718 includes a movable rod fixedly connected to the locking plate 717, a guide tube fixedly connected to the inner side wall of the support tube 71 is slidably sleeved at the other end of the movable rod, a second spring fixedly connected to the inner side wall of the support tube 71 is fixedly connected to one end of the movable rod extending into the guide tube, a latch fixedly connected to one side of the locking plate 717 close to the gear 94 along the length direction of the locking plate 717 is fixedly connected to one side of the locking plate 717 close to the gear 94, and a slope surface obliquely arranged is formed at the top of one side of the fixed push plate 75 close to the locking plate 717.
Example five:
one end of the rotating shaft 93, which is far away from the lifting pipe 73, is provided with a second sliding groove which is arranged along the length direction of the rotating shaft 93, and a third sliding block which is fixedly connected with the end part of the pushing screw 95 is connected inside the second sliding groove in a sliding manner.
Example six:
the first pushing unit, the second pushing unit and the third pushing unit adopt linear modules, and the fourth pushing unit and the fifth pushing unit adopt push rod motors.
The working principle is as follows: when the biosensor is manufactured, the prepared bearing plate is placed above the adsorption plate 63 on the top of the placing plate 61, at this time, a motor on the clamping driving mechanism 611 is started, the screw rod rotates, under the action of the screw thread, the push plate 69 moves along the length direction of the first push rod 68, so that the base plate 610 and the first push rod 68 are driven to move together, at this time, the clamping plate 610 clamps and positions the bearing plate, the transverse extrusion plate 64 and the longitudinal extrusion plate 65 which are connected with the first push rod 68 move together with the adjacent clamping plate 610 above the transverse extrusion plate in the clamping and positioning process, an isolation cavity of a rectangular structure positioned at the bottom of the adsorption plate 63 is formed between the two groups of transverse extrusion plates 64 and the two groups of longitudinal extrusion plates 65 and between the vertical plates 66, at this time, the size of the isolation cavity is adaptively adjusted along with the movement of the clamping plate 610, so that after the four groups of clamping plates 610 clamp and position the bearing plate, the isolation cavity formed by the four groups of clamping plates 610 is adaptively adjusted along with the size of the bearing plate, the bearing plate is suitable for adsorption of the bearing plate, then, the bearing plate is sucked by the air suction pipe, and the bearing plate is prevented from loosening in the welding process;
when the biosensor unit and the control sensor unit are welded on the bearing plate, a material tray for placing devices is placed on one side of the top of the base 1, the biosensor unit and the control sensor unit are placed in the material tray, the conveying assembly 3 conveys the suction disc 74 to the position above the material tray, then the suction disc 74 on the suction mechanism 7 sucks the devices, and then the devices are conveyed to the position above the bearing plate by the conveying assembly 3 to wait for welding;
before welding operation, pins on two sides of the bottom of the absorbed biosensor unit or the absorbed control sensor unit need to be dip-dyed, and rosin liquid convenient for welding is dip-dyed on the pins;
during dip dyeing, a second motor on the driving screw 72 is started, then the driving screw 72 rotates, the lifting pipe 73 moves upwards under the action of threads, in the process of upward movement, the fixed push plate 75 on the outer ring of the pipe 73 moves upwards, when the fixed push plate is close to the dip dyeing mechanism 9, the slope surface on the fixed push plate 75 pushes the locking plate 717 to the side far away from the rack 716 from the bottom, at the moment, the locking plate 717 is not clamped with the gear 94, the adsorption block 76 on the fixed push plate 75 is magnetically adsorbed with the adsorption ring 910 on the rotating shaft 93, then the fixed push plate 75 is abutted against the bottom of the rotating shaft 93 and pushes the rotating shaft 93 upwards during upward movement, when the rotating shaft 93 is pushed upwards, the dip dyeing box 98 on the connecting rod 97 keeps consistent vertical distance with the sucker 74, and then the device on the sucker 74 moves upwards together with the dip dyeing mechanism 9;
when the dip dyeing mechanism 9 moves upwards, the gear 94 moves relative to the rack 716, the gear 94 rotates under the meshing action of the gear 94 and the rack 716, then the rotating shaft 93 rotates, when the rotating shaft 93 rotates, the sliding block III connected with the rotating shaft 93 in a sliding way rotates along with the rotating shaft, then the pushing screw 95 rotates along with the rotating shaft 93 at the same time, under the action of the screw thread on the fixed sleeve 91, the pushing screw 95 moves along the length direction relative to the fixed sleeve 91, so that the movable sleeve 96 movably connected with the rotating shaft is driven to move along the length direction, at the moment, the movable sleeve 96 moves towards the suction disc 74, then the dip dyeing box 98 moves towards the suction disc 74, so that the pins of the device adsorbed at the bottom of the suction disc 74 extend into the dip dyeing box 98 from the dip dyeing hole 99 on the dip dyeing box 98 to adhere rosin liquid, when the pins enter the dip dyeing box 98 and then drive the motor II on the screw 72 to turn over, then the reverse steps are installed, the pins extend out of the dip dyeing box 98, when the fixed sleeve 91 moves downwards, the fixed sleeve 91 moves to the lowest position of the fixed sleeve 716, the fixed sleeve reaches the lowest position of the suction channel 714, then the suction ring 76 of the suction ring is separated from the dip dyeing box 98, the designated device conveying plate 910, and the designated device conveying assembly is welded on the designated plate, and the designated plate 5, and the designated device conveying plate 75 is locked by the designated plate by the motor 717 and then the conveying assembly, and the pin is welded on the conveying assembly, and the conveying plate by the conveying assembly, and the pin is started; the design is based on a TFET device to manufacture a biosensor for a biological entity or a biological molecule, and realizes the detection of the interaction and reaction between a reactant and the biological entity/the biological molecule; the pins of the device can be impregnated with rosin liquid in the preparation process of the biosensor, and the pins can be firmly welded on a circuit board for bearing in the welding process, so that the connection firmness of the biosensor is improved, the quality of the biosensor is improved, and the stable quality of the biosensor is ensured.
In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", and the like, indicate orientations and positional relationships based on those shown in the drawings, and are used only for convenience of description and simplicity of description, and do not indicate or imply that the equipment or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be considered as limiting the present invention.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered as the technical solutions and the inventive concepts of the present invention within the technical scope of the present invention.
Claims (8)
1. A biosensor based on a TFET device and a manufacturing method thereof comprise a biosensor system, and are characterized in that the biosensor comprises a bearing plate for bearing, a biosensor unit arranged on the bearing plate, a control sensor unit, a temperature sensor unit, an amplifier, a power regulator, an analog-to-digital converter, a digital control module and a wireless transceiver;
the manufacturing steps are as follows:
s1, preparing a device according to the composition of the biosensor;
s2, welding the prepared device on a preset position of the bearing plate by using a welding device;
and S3, packaging the bearing plate after welding is completed.
2. The biosensor based on the TFET device and the manufacturing method thereof according to claim 1, wherein the welding device comprises a base (1), a support (2) arranged on the top of the base (1), a welding component (5) fixedly connected to one side of the support (2), a conveying component (3) fixedly connected to the top of the support (2), a suction and dip-dyeing component (4) fixedly connected to the bottom of the conveying component (3), and a positioning component (6) fixedly connected to the top of the base (1); the suction dip-dyeing component (4) comprises a suction mechanism (7) connected with the output end of the bottom of the conveying component (3), dip-dyeing mechanisms (9) arranged on two sides of the suction mechanism (7) and an air supply mechanism (8) arranged on one side of the suction mechanism (7).
3. The biosensor based on TFET device and its manufacturing method according to claim 2, it is characterized in that the suction mechanism (7) comprises a support tube (71) which is fixedly connected with the bottom output end of the conveying component (3) and has a long strip-shaped structure, a driving screw (72) which is arranged in the support tube (71), a lifting tube (73) which is in threaded sleeve joint with the outer ring of the bottom of the driving screw (72), a sucker (74) which is fixedly connected with the bottom of the lifting tube (73), fixed push plates (75) which are fixedly connected with the two sides of the lifting tube (73) and an adsorption block (76) which is embedded at the top of the fixed push plates (75), extending channels (714) which penetrate through the long strip-shaped structure of the support tube (71) are arranged on one sides of the two groups of fixed push plates (75) which are far away from each other, sliding grooves (715) which are arranged along the length direction of the inner side walls of the two groups of the extending channels (714), racks (716) which are engaged with the dip dyeing mechanism (9) are arranged on one side of the one end of the support tube (71) into which the two groups of the extending channels (714), and locking plates (717) which are fixedly connected with the dip dyeing mechanism (9) are arranged on the other side of one end of the support tube (71) which the extending channels (714) which is fixedly connected with the dip dyeing mechanism (717), and the locking plate (717) is connected with the inner side wall of the supporting pipe (71) in a sliding way, and one side of the locking plate (717) far away from the adjacent rack (716) is fixedly connected with a telescopic unit (718) fixedly connected with the inner side wall of the supporting pipe (71).
4. The biosensor based on the TFET device and the manufacturing method thereof as claimed in claim 3, wherein the dip-dyeing mechanism (9) comprises a fixed sleeve (91) slidably connected with the stretching channel (714), a sliding plate (92) fixedly sleeved on the outer ring of the fixed sleeve (91) and slidably connected with the sliding groove (715), a rotating shaft (93) movably sleeved on the inner ring of the fixed sleeve (91), a measuring gear (94) fixed on the outer ring of one end of the rotating shaft (93) stretching into the supporting tube (71), and a pushing screw (95) slidably sleeved on the other end of the rotating shaft (93), wherein the pushing screw (95) is in threaded sleeve connection with the fixed sleeve (91), a movable sleeve (96) slidably connected with the outer ring of the fixed sleeve (91) is movably sleeved on one end of the pushing screw (95) stretching out of the fixed sleeve (91), a connecting rod (97) is fixedly connected to one end of the movable sleeve (96) far away from the supporting tube (714), a dip-dyeing box (98) is fixedly connected to the bottom of the connecting rod (97), a dip-dyeing box (98) is provided with a dip-dyeing hole (99) at one end close to the supporting tube (71), and an absorption ring (910) is connected to one end of the outer ring (94) close to the lifting tube (73).
5. The biosensor based on the TFET device and the manufacturing method thereof according to claim 2, wherein the air supply mechanism (8) comprises an air inlet pipe fixedly connected with the suction mechanism (7) and a connecting pipe sleeved at the inner ring at the bottom of the air inlet pipe in a sliding manner.
6. The biosensor based on the TFET device and the manufacturing method thereof according to claim 2, wherein the conveying assembly (3) comprises a first pushing unit fixedly connected with the support (2), a second pushing unit vertically arranged is fixedly connected with the bottom output end of the first pushing unit, and the bottom output unit of the second pushing unit is fixedly connected with the top of the support tube (71).
7. The biosensor based on TFET device and the manufacturing method thereof according to claim 2, wherein the welding assembly (5) comprises a third pushing unit fixedly connected to the side of the support (2), a fourth pushing unit fixedly connected to the bottom output end of the third pushing unit, a fifth pushing unit fixedly connected to the four output end of the fourth pushing unit, a base plate fixedly connected to the bottom output end of the fifth pushing unit, a L-shaped support plate fixedly connected to the bottom of the base plate, and a welding gun fixedly connected to the support plate.
8. The biosensor based on the TFET device and the manufacturing method thereof according to claim 2, wherein the positioning assembly (6) comprises a placing plate (61) fixedly connected with the top of the bottom plate (1), an adsorption cavity (62) formed at the top of the placing plate (61), an adsorption plate (63) fixedly connected at the opening of the adsorption cavity (62), two groups of parallel transverse extrusion plates (64) slidably connected to the bottom of the adsorption plate (63), and two groups of longitudinal extrusion plates (65) arranged between the two groups of transverse extrusion plates (64), wherein two sides of the two groups of longitudinal extrusion plates (63) are respectively provided with an inward concave groove, an extension plate (66) slidably connected with the transverse extrusion plates (64) is slidably sleeved inside the groove, one end of the extension plate (66) extending into the groove is fixedly connected with a spring fixedly connected with the inner side wall of the groove, two sides of the two groups of transverse extrusion plates (64) far away from each other and two sides of the two groups of longitudinal extrusion plates (65) far away from each other are respectively provided with an extension plate (67) positioned above the placing plate (61), a mounting groove (67) is internally provided with a mounting groove (68) sleeved with the push rod (68), one end of the push rod (68) extending into the groove (64) or one end of the extrusion plate (64) fixedly connected with a push rod (69), one end of the push plate (69) extending to the top of the placing plate (61) is fixedly connected with a clamping plate (610), and the bottom of the push plate (69) is connected with a clamping driving mechanism (611).
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| CN202210710429.4A CN115266883B (en) | 2022-06-22 | 2022-06-22 | Biosensor based on TFET device and manufacturing method thereof |
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| CN115266883B (en) | 2023-05-12 |
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