CN115266883B - Biosensor based on TFET device and manufacturing method thereof - Google Patents
Biosensor based on TFET device and manufacturing method thereof Download PDFInfo
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- CN115266883B CN115266883B CN202210710429.4A CN202210710429A CN115266883B CN 115266883 B CN115266883 B CN 115266883B CN 202210710429 A CN202210710429 A CN 202210710429A CN 115266883 B CN115266883 B CN 115266883B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/403—Cells and electrode assemblies
- G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
- G01N27/4145—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
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- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
- H05K3/00—Apparatus or processes for manufacturing printed circuits
- H05K3/30—Assembling printed circuits with electric components, e.g. with resistor
- H05K3/32—Assembling printed circuits with electric components, e.g. with resistor electrically connecting electric components or wires to printed circuits
- H05K3/34—Assembling printed circuits with electric components, e.g. with resistor electrically connecting electric components or wires to printed circuits by soldering
- H05K3/341—Surface mounted components
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- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
- H05K3/00—Apparatus or processes for manufacturing printed circuits
- H05K3/30—Assembling printed circuits with electric components, e.g. with resistor
- H05K3/32—Assembling printed circuits with electric components, e.g. with resistor electrically connecting electric components or wires to printed circuits
- H05K3/34—Assembling printed circuits with electric components, e.g. with resistor electrically connecting electric components or wires to printed circuits by soldering
- H05K3/3489—Composition of fluxes; Methods of application thereof; Other methods of activating the contact surfaces
Abstract
The invention belongs to the technical field of biosensors, in particular to a biosensor based on a TFET device and a manufacturing method thereof. The invention is based on TFET device to manufacture the biological sensor for biological entity or biological molecule, to realize the interaction and reaction detection between reactant and biological entity/biological molecule; the pin of the device can be impregnated with rosin liquid in the preparation process of the biosensor, the pin can be firmly welded on a circuit board for bearing in the welding process, the connection firmness degree of the biosensor is improved, the quality of the biosensor is improved, and the stability of the quality of the biosensor is ensured.
Description
Technical Field
The invention relates to the technical field of biosensors, in particular to a biosensor based on a TFET device and a manufacturing method thereof.
Background
Biosensors are devices for sensing and detecting biomolecules and operate based on electronic, electrochemical, optical and mechanical detection principles. Biosensors that include transistors are sensors that sense the charge, photon and mechanical properties of a biological entity or a biological molecule. The detection may be performed by detecting the biological entity or the biological molecule itself, or by interactions and reactions between specific reactants and biological entities/biological molecules. Such a biosensor can be manufactured using a semiconductor process, can rapidly convert an electrical signal, and can be easily applied to an Integrated Circuit (IC) and a microelectromechanical system (MEMS);
the biosensor system package described in application number CN2021101298179 and a method for manufacturing the same, including the biosensor system package, includes: a transistor structure in the semiconductor layer having a front side and a back side, the transistor structure including a channel region; a Buried Oxide (BOX) layer on a back side of the semiconductor layer, wherein the buried oxide layer has an opening on the back side of the channel region and the interfacial layer covers the back side over the channel region; a multilayer interconnect (MLI) structure on a front side of the semiconductor layer, the transistor structure electrically connected to the MLI structure; and a cover structure attached to the buried oxide layer, the cover structure including microneedles. Embodiments of the present application also relate to methods of manufacturing a biosensor system package; the biosensor prepared by the scheme can be manufactured by using a semiconductor process, can rapidly convert electric signals, and can be easily applied to Integrated Circuits (ICs) and micro-electromechanical systems (MEMS), but pins on devices in the biosensor, especially pins on two sides of the bottom of a TFET device, are required to be welded with a circuit board for bearing in the actual production and processing process, the existing welding mode is easy to generate unstable connection, and the unstable quality of the sensor occurs, so that the biosensor based on the TFET device is required and a manufacturing method thereof.
Disclosure of Invention
The biosensor based on the TFET device and the manufacturing method thereof solve the problems in the prior art.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
a biosensor based on TFET device and its preparation method, including the biological sensor system, the said biological sensor includes the bearing plate used for bearing, biological sensor unit, control sensor unit, temperature sensor unit, amplifier, power regulator, analog-to-digital converter, digital control module and wireless transceiver set up on bearing plate;
the preparation steps are as follows:
s1, preparing a device according to a biosensor composition;
s2, welding the prepared device on a preset position of a bearing plate by using a welding device;
and S3, packaging the bearing plate after welding.
Preferably, the welding device comprises a base, a bracket arranged at the top of the base, a welding component fixedly connected to one side of the bracket, a conveying component fixedly connected to the top of the bracket, a sucking and dyeing component fixedly connected to the bottom of the conveying component and a positioning component fixedly connected to the top of the base; the sucking and dip-dyeing assembly comprises a sucking mechanism connected with the output end of the bottom of the conveying assembly, dip-dyeing mechanisms arranged on two sides of the sucking mechanism and an air supply mechanism arranged on one side of the sucking mechanism.
Preferably, the suction mechanism comprises a supporting tube with a strip-shaped structure fixedly connected with the output end of the bottom of the conveying assembly, a driving screw rod arranged inside the supporting tube, a lifting tube sleeved on the outer ring of the bottom of the driving screw rod in a threaded manner, a sucking disc fixedly connected at the bottom of the lifting tube, a fixed push plate fixedly connected on two sides of the lifting tube and an adsorption block inlaid at the top of the fixed push plate, wherein two groups of the fixed push plates are respectively provided with a stretching channel penetrating through the strip-shaped structure of the supporting tube on one side far away from each other, sliding grooves arranged along the length direction of the two groups of the stretching channels are respectively formed in the inner side walls of the stretching channels, racks meshed with the dip dyeing mechanism are fixedly connected on one side of one end of the stretching channels stretching into the supporting tube, locking plates connected with the dip dyeing mechanism in a clamping manner are arranged on the other side, far away from the adjacent racks, of the locking plates, and telescopic units fixedly connected with the inner side walls of the supporting tube.
Preferably, the dip dyeing mechanism comprises a fixed sleeve which is connected with the extending channel in a sliding manner, a sliding plate which is fixedly sleeved on the outer ring of the fixed sleeve and is connected with the sliding groove in a sliding manner, a rotating shaft which is movably sleeved on the inner ring of the fixed sleeve, a gear which is fixedly arranged on the rotating shaft and extends into the outer ring of one end of the supporting tube, a pushing screw which is slidably sleeved on the other end of the rotating shaft, a thread sleeve which is pushed by the pushing screw, a movable sleeve which is movably sleeved on one end of the pushing screw extending out of the fixed sleeve and is connected with the outer ring of the fixed sleeve, a connecting rod is fixedly connected with one end of the movable sleeve, which is far away from the supporting tube, a dip dyeing box is fixedly connected with the bottom of the connecting rod, a dip dyeing hole is formed in one end, close to the supporting tube, of the dip dyeing box, and an adsorbing ring is fixedly sleeved on the outer ring at one end, close to the lifting tube, of the gear.
Preferably, the air supply mechanism comprises an air inlet pipe fixedly connected with the suction mechanism and a connecting pipe sleeved on the inner ring at the bottom of the air inlet pipe in a sliding manner.
Preferably, the conveying assembly comprises a first pushing unit fixedly connected with the support, a second pushing unit vertically arranged at the bottom output end of the first pushing unit is fixedly connected with the first pushing unit, and the second pushing unit is fixedly connected with the top of the support tube.
Preferably, the welding assembly comprises a pushing unit III fixedly connected with the side edge of the bracket, a pushing unit IV fixedly connected with the output end of the bottom of the pushing unit III, a pushing unit V fixedly connected with the output end of the pushing unit IV, a substrate fixedly connected with the bottom of the output end of the bottom of the pushing unit V, a supporting plate of an L-shaped structure fixedly connected with the bottom of the substrate and a welding gun fixedly connected on the supporting plate.
Preferably, the locating component comprises a placing plate fixedly connected with the top of the base, an adsorption cavity formed in the top of the placing plate, an adsorption plate fixedly connected to the opening of the adsorption cavity, two groups of transverse extrusion plates which are arranged in parallel and are connected to the bottom of the adsorption plate in a sliding mode, and two groups of longitudinal extrusion plates arranged between the two groups of transverse extrusion plates, wherein two sides of the two groups of longitudinal extrusion plates are respectively provided with an inwards concave groove, an extension plate connected with the transverse extrusion plates in a sliding mode is sleeved in the grooves in a sliding mode, one end of the extension plate extending into the grooves is fixedly connected with a spring fixedly connected with the inner side wall of the end portion of the groove, two sides of the two groups of transverse extrusion plates far away from each other and two groups of longitudinal extrusion plates far away from each other are respectively provided with a mounting groove located above the placing plate, a push rod I sleeved in a sliding mode is arranged in the mounting groove, one end of the push rod I extends into the adsorption cavity and is fixedly connected with the adjacent transverse extrusion plate or the longitudinal extrusion plate, one end of the push rod I extends into one end of the mounting groove to the push plate with an L-shaped structure, one end of the top of the placing plate is fixedly connected with a clamping plate, and the bottom of the push plate is connected with a clamping driving mechanism.
In the present invention,
the biosensor for the biological entity or the biological molecule itself is manufactured based on the TFET device by the aid of the arranged bearing plate, the biosensor unit arranged on the bearing plate, the control sensor unit, the temperature sensor unit, the amplifier, the power regulator, the analog-to-digital converter, the digital control module and the wireless transceiver, so that interaction and reaction detection between reactants and the biological entity/biological molecule are realized;
through the base, the support, conveying assembly, absorb dip subassembly, welding set spare, positioning assembly, suction mechanism, air feed mechanism, dip mechanism, place the board, adsorb the chamber, adsorb the board, the lateral extrusion board, vertical extrusion board, the extension board, the mounting groove, push rod one, the push pedal, splint, clamping driving mechanism, the stay tube, drive screw, the lifter, the sucking disc, fixed push pedal, the adsorption block, stretch into passageway, the spout, the rack, the locking board, flexible unit, fixed sleeve, the slide, the rotation axis, the gear, promote the screw, movable sleeve, the connecting rod, dip case, dip hole and absorption ring, can be to the pin dip rosin liquid of device in the preparation process of biosensor, make the pin can firmly weld on the circuit board that is used for bearing in the welding process, improve biosensor quality, ensure biosensor quality stability.
Drawings
Fig. 1 is a schematic structural diagram of a biosensor based on a TFET device and a manufacturing method thereof, and a welding device;
fig. 2 is a cross-sectional view of a biosensor based on TFET devices and a manufacturing method thereof according to the present invention, wherein a welding device absorbs a dip-dye component;
fig. 3 is a partial enlargement of a biosensor based on TFET device and a manufacturing method thereof, and a welding device;
fig. 4 is a schematic structural diagram of a suction dip-dyeing assembly of a biosensor based on a TFET device and a manufacturing method thereof according to the present invention;
fig. 5 is a top view of a suction dip-dyeing assembly of a TFET device-based biosensor and a method for manufacturing the same according to the present invention;
fig. 6 is a schematic structural diagram of a positioning component of a biosensor based on TFET device and a manufacturing method thereof, which is provided by the invention;
fig. 7 is a top view of a positioning component of a TFET device-based biosensor and a manufacturing method thereof according to the present invention.
In the figure: 1 base, 2 support, 3 conveying component, 4 absorbing dip dyeing component, 5 welding component, 6 positioning component, 7 absorbing mechanism, 8 air supply mechanism, 9 dip dyeing mechanism, 61 placing plate, 62 absorbing cavity, 63 absorbing plate, 64 horizontal extruding plate, 65 vertical extruding plate, 66 extending plate, 67 installing groove, 68 push rod one, 69 push plate, 610 clamping plate, 611 clamping driving mechanism, 71 supporting tube, 72 driving screw, 73 lifting tube, 74 sucking disc, 75 fixed push plate, 76 absorbing block, 714 extending channel, 715 sliding groove, 716 rack, 717 locking plate, 718 telescopic unit, 91 fixed sleeve, 92 sliding plate, 93 rotating shaft, 94 gear, 95 pushing screw, 96 movable sleeve, 97 connecting rod, 98 dip dyeing box, 99 dip dyeing hole, 910 absorbing ring.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments.
Referring to fig. 1-7, a biosensor based on a TFET device and a method of fabricating the same, including a biosensor system, the biosensor including a carrier plate for carrying, a biosensor unit disposed on the carrier plate, a control sensor unit, a temperature sensor unit, an amplifier, a power regulator, an analog-to-digital converter, a digital control module, and a wireless transceiver;
the preparation steps are as follows:
s1, preparing a device according to a biosensor composition;
s2, welding the prepared device on a preset position of a bearing plate by using a welding device;
and S3, packaging the bearing plate after welding.
Further, the welding device comprises a base 1, a bracket 2 arranged at the top of the base 1, a welding component 5 fixedly connected to one side of the bracket 2, a conveying component 3 fixedly connected to the top of the bracket 2, a sucking and dyeing component 4 fixedly connected to the bottom of the conveying component 3 and a positioning component 6 fixedly connected to the top of the base 1; the suction dip dyeing assembly 4 comprises a suction mechanism 7 connected with the output end of the bottom of the conveying assembly 3, dip dyeing mechanisms 9 arranged on two sides of the suction mechanism 7 and an air supply mechanism 8 arranged on one side of the suction mechanism 7.
Specifically, the suction mechanism 7 includes a supporting tube 71 with a strip structure fixedly connected with the output end at the bottom of the conveying assembly 3, a driving screw 72 disposed inside the supporting tube 71, a lifting tube 73 screwed on the outer ring at the bottom of the driving screw 72, a suction cup 74 fixedly connected at the bottom of the lifting tube 73, fixing push plates 75 fixedly connected at two sides of the lifting tube 73, and an adsorption block 76 inlaid at the top of the fixing push plates 75, one side, far away from each other, of the two groups of fixing push plates 75 is provided with a stretching channel 714 penetrating through the strip structure of the supporting tube 71, the inner side walls of the two groups of stretching channels 714 are provided with sliding grooves 715 disposed along the length direction of the sliding grooves, one side, extending into one end of the supporting tube 71, of the two groups of stretching channels 714 is fixedly connected with racks 716 meshed with the dip dyeing mechanism 9, the other side, extending into one end of the supporting tube 71, of the two groups of stretching channels 714 is provided with locking plates 717, and the inner side, far away from the adjacent racks 716, of the locking plates 717 are fixedly connected with telescopic units 718 fixedly connected with the inner side walls of the supporting tube 71.
In particular, the dip dyeing mechanism 9 comprises a fixed sleeve 91 slidably connected with the extending channel 714, a sliding plate 92 fixedly sleeved on the outer ring of the fixed sleeve 91 and slidably connected with a sliding groove 715, a rotating shaft 93 movably sleeved on the inner ring of the fixed sleeve 91, a gear 94 fixed on the outer ring of one end of the rotating shaft 93 and extending into the supporting tube 71, and a pushing screw 95 slidably sleeved on the other end of the rotating shaft 93, wherein the pushing screw 95 is in threaded sleeve connection with the fixed sleeve 91, one end of the pushing screw 95 extending out of the fixed sleeve 91 is movably sleeved with a movable sleeve 96 slidably connected with the outer ring of the fixed sleeve 91, one end of the movable sleeve 96, far away from the supporting tube 714, is fixedly connected with a connecting rod 97, the bottom of the connecting rod 97 is fixedly connected with a dip dyeing box 98, one end of the dip dyeing box 98, close to the supporting tube 71, is provided with a dip dyeing hole 99, one end outer ring of the gear 94, close to the lifting tube 73, is fixedly sleeved with an adsorption ring 910, the inside of the dip dyeing box 98 is filled with adsorption sponge, and the adsorption sponge is filled with dip dyeing liquid.
It is worth to describe that the air supply mechanism 8 comprises an air inlet pipe fixedly connected with the suction mechanism 7, and a connecting pipe sleeved on the inner ring at the bottom of the air inlet pipe in a sliding manner, and the bottom of the connecting pipe is communicated with the suction disc 74.
In addition, the conveying assembly 3 comprises a first pushing unit fixedly connected with the bracket 2, a second pushing unit vertically arranged at the bottom output end of the first pushing unit is fixedly connected with the bottom output unit of the second pushing unit, and the top of the supporting tube 71 is fixedly connected with the bottom output unit of the second pushing unit.
In addition, the welding assembly 5 comprises a pushing unit III fixedly connected with the side edge of the bracket 2, a pushing unit IV fixedly connected with the output end of the bottom of the pushing unit III, a pushing unit V fixedly connected with the output end of the pushing unit IV, a substrate fixedly connected with the bottom of the output end of the pushing unit V, a supporting plate of an L-shaped structure fixedly connected with the bottom of the substrate and a welding gun fixedly connected on the supporting plate.
Further, the positioning assembly 6 includes a placement plate 61 fixedly connected with the top of the base 1, an adsorption cavity 62 formed at the top of the placement plate 61, an adsorption plate 63 fixedly connected at the opening of the adsorption cavity 62, two sets of parallel-arranged transverse extrusion plates 64 slidably connected at the bottom of the adsorption plate 63, and two sets of longitudinal extrusion plates 65 arranged between the two sets of transverse extrusion plates 64, both sides of the two sets of longitudinal extrusion plates 65 are respectively provided with an inward concave groove, an extension plate 66 slidably connected with the transverse extrusion plates 64 is slidably sleeved in the grooves, one end of the extension plate 66 extending into the grooves is fixedly connected with a spring fixedly connected with the inner side wall of the end of the grooves, both sides of the two sets of transverse extrusion plates 64 away from each other and both sides of the two sets of longitudinal extrusion plates 65 away from each other are respectively provided with a mounting groove 67 positioned above the placement plate 61, a push rod 68 slidably sleeved in the mounting groove 67, one end of the push rod 68 extending into the adsorption cavity 62 is fixedly connected with the adjacent transverse extrusion plates 64 or the longitudinal extrusion plates 65, one end of the push rod 68 is fixedly connected with a push plate 69 with an L-shaped structure, one end of the push plate 69 extending into the mounting groove 69 is fixedly connected with a clamping mechanism of the push plate 61, and the bottom of the clamping mechanism is fixedly connected with the clamping mechanism 610, and the clamping mechanism is fixedly connected with the bottom of the clamping mechanism is connected with the bottom 610;
embodiment one:
the adsorption ring 910 and the adsorption block 76 are made of magnetic materials, and the adsorption ring 910 and the adsorption block 76 are magnetically adsorbed.
Embodiment two:
the clamping driving mechanism 611 comprises a screw rod in threaded sleeve joint with the push plate 69, one end of the screw rod is fixedly connected with a motor I fixedly connected with the mounting groove 67, and the adsorption plate 63 is penetrated with adsorption holes distributed in an array.
Embodiment III:
the top of the driving screw 72 is fixedly connected with a second motor fixedly connected with the inner side wall of the supporting tube 71, and the outer side of the top of the lifting tube 73 is fixedly connected with a first sliding block which is in sliding connection with the inside of the supporting tube 71.
Embodiment four:
the telescopic unit 718 comprises a movable rod fixedly connected with the locking plate 717, a guide pipe fixedly connected with the inner side wall of the supporting pipe 71 is sleeved at the other end of the movable rod in a sliding manner, a spring II fixedly connected with the inner side wall of the supporting pipe 71 is fixedly connected at one end of the movable rod extending into the guide pipe, a latch arranged along the length direction of the locking plate 717 is fixedly connected at one side of the locking plate 717 close to the gear 94, and a slope surface arranged obliquely is arranged at the top of one side of the fixed push plate 75 close to the locking plate 717.
Fifth embodiment:
one end of the rotating shaft 93 far away from the lifting pipe 73 is provided with a second sliding groove arranged along the length direction of the rotating shaft 93, and a third sliding block fixedly connected with the end part of the pushing screw 95 is connected inside the second sliding groove in a sliding manner.
Example six:
the pushing unit I, the pushing unit II and the pushing unit III adopt linear modules, and the pushing unit IV and the pushing unit V adopt push rod motors.
Working principle: when the biosensor is manufactured, the prepared bearing plate is placed above the adsorption plate 63 on the top of the placement plate 61, at this time, a motor I on the clamping driving mechanism 611 is started, a screw rod rotates, under the action of threads, a push plate 69 moves along the length direction of a push rod I68 so as to drive a base plate 610 and the push rod I68 to move together, at this time, the clamping plate 610 clamps and positions the bearing plate, the transverse extrusion plate 64 and the longitudinal extrusion plate 65 connected with the push rod I68 move together with the adjacent clamping plate 610 above the clamping and positioning process, the two groups of transverse extrusion plates 64, the two groups of longitudinal extrusion plates 65 and the vertical plate 66 form a rectangular isolating cavity positioned at the bottom of the adsorption plate 63, at this time, the size of the isolating cavity is adaptively adjusted along with the movement of the clamping plate 610, after the clamping and positioning of the bearing plate, the size of the isolating cavity formed by the four groups of clamping plates 610 is adaptively adjusted along with the size of the bearing plate, the clamping plate is suitable for the adsorption of the bearing plates with different sizes, then the inner side of the isolating cavity is in a negative pressure state, the isolating cavity is in the air pumping-out, the inner side of the isolating cavity is positioned on the adjacent clamping plate and the clamping plate, the two groups of the transverse extrusion plates 64 and the longitudinal extrusion plates are positioned on the adsorption plate 63, and the adsorption plate is adsorbed on the adsorption plate, and the adsorption plate 63, and the bearing plate is prevented from being loose in the process;
when the biosensor unit and the control sensor unit are welded on the bearing plate, a tray for placing devices is placed on one side of the top of the base 1, the biosensor unit and the control sensor unit are placed in the tray, the conveying component 3 conveys the sucker 74 to the upper part of the tray, then the sucker 74 on the suction mechanism 7 sucks the devices, and then the conveying component 3 is conveyed to the upper part of the bearing plate to wait for welding;
before welding operation, the sucked biological sensor unit or the control sensor unit is required to be impregnated with the pins at the two sides of the bottom, and the pins are impregnated with rosin liquid which is convenient for welding;
when the dip dyeing is performed, a motor II positioned on the driving screw 72 is started, then the driving screw 72 rotates, the lifting pipe 73 moves upwards under the action of threads, in the upward moving process, the fixed push plate 75 on the outer ring of the pipe 73 moves upwards, when approaching the dip dyeing mechanism 9, the slope surface on the fixed push plate 75 pushes the locking plate 717 from the bottom to the side far away from the rack 716, at the moment, the locking plate 717 is not clamped with the gear 94, the adsorption block 76 on the fixed push plate 75 is magnetically adsorbed with the adsorption ring 910 on the rotating shaft 93, then the fixed push plate 75 is abutted against the bottom of the rotating shaft 93 when moving upwards and pushes the rotating shaft 93 upwards, when pushing the rotating shaft 93 upwards, the dip dyeing box 98 positioned on the connecting rod 97 keeps consistent with the sucker 74 in the vertical distance, and then the device on the sucker 74 moves upwards together with the dip dyeing mechanism 9;
when the dip dyeing mechanism 9 moves upwards, the gear 94 moves relative to the rack 716, under the meshing action of the gear 94 and the rack 716, the gear 94 rotates, then the rotating shaft 93 rotates, when the rotating shaft 93 rotates, the sliding block III which is connected with the rotating shaft in a sliding way rotates along with the rotating shaft 93, then the pushing screw 95 rotates simultaneously with the rotating shaft 93, under the action of the threads on the fixed sleeve 91, the pushing screw 95 moves relative to the length direction of the fixed sleeve 91, so that the movable sleeve 96 which is movably connected with the pushing screw 95 is driven to move along the length direction of the movable sleeve 96, at the moment, the movable sleeve 96 moves towards the suction disc 74, then the dip dyeing box 98 moves towards the suction disc 74, so that pins of devices absorbed at the bottom of the suction disc 74 extend into the dip dyeing box 98 from dip dyeing holes 99 on the dip dyeing box 98 to adhere rosin liquid, when the pins enter the dip-dyeing box 98 and then the motor II on the driving screw 72 is turned over, and then the opposite steps are installed, so that the pins extend out of the dip-dyeing box 98, when the fixing push plate 75 moves downwards, the rotating shaft 93 moves downwards due to magnetic adsorption, until the fixing sleeve 91 moves to the lowest part of the extending channel 714, then the adsorption block 76 is separated from the adsorption ring 910, simultaneously the locking plate 717 is clamped with the gear 94 again under the action of a spring, then the device immersed with rosin liquid moves downwards along with the rotation of the motor II, then the device is conveyed to the designated position of the bearing plate by the conveying assembly 3, and then the welding assembly 5 starts to weld the pins of the device on the designated position of the bearing plate; the design is based on TFET devices to manufacture a biosensor for a biological entity or a biological molecule, so that the interaction and reaction between reactants and the biological entity/biological molecule are detected; the pin of the device can be impregnated with rosin liquid in the preparation process of the biosensor, the pin can be firmly welded on a circuit board for bearing in the welding process, the connection firmness degree of the biosensor is improved, the quality of the biosensor is improved, and the stability of the quality of the biosensor is ensured.
In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings are merely for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the apparatus or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present invention.
Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more such feature. In the description of the present invention, the meaning of "a plurality" is two or more, unless explicitly defined otherwise.
The foregoing is only a preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art, who is within the scope of the present invention, should make equivalent substitutions or modifications according to the technical scheme of the present invention and the inventive concept thereof, and should be covered by the scope of the present invention.
Claims (5)
1. The biosensor welding device based on the TFET device is characterized by comprising a base (1), a support (2) arranged at the top of the base (1), a welding component (5) fixedly connected to one side of the support (2), a conveying component (3) fixedly connected to the top of the support (2), a sucking dip-dyeing component (4) fixedly connected to the bottom of the conveying component (3) and a positioning component (6) fixedly connected to the top of the base (1); the suction dip dyeing assembly (4) comprises a suction mechanism (7) connected with the output end at the bottom of the conveying assembly (3), dip dyeing mechanisms (9) arranged at two sides of the suction mechanism (7) and an air supply mechanism (8) arranged at one side of the suction mechanism (7);
the suction mechanism (7) comprises a supporting tube (71) of a strip-shaped structure fixedly connected with the bottom output end of the conveying assembly (3), a driving screw (72) arranged inside the supporting tube (71), a lifting tube (73) sleeved on the outer ring of the bottom of the driving screw (72) in a threaded manner, a sucking disc (74) fixedly connected to the bottom of the lifting tube (73), a fixed push plate (75) fixedly connected to two sides of the lifting tube (73) and a suction block (76) inlaid on the top of the fixed push plate (75), wherein one side, far away from each other, of the two groups of the fixed push plates (75) is provided with a stretching-in channel (714) penetrating the long-shaped structure of the supporting tube (71), the inner side wall of the two groups of the stretching-in channel (714) is provided with a sliding groove (715) arranged along the length direction of the sliding groove, one side, which stretches into one end of the supporting tube (71), of the two groups of the stretching-in channel (714) is fixedly connected with a rack (716) meshed with a dip dyeing mechanism (9), the other side, which stretches into one end of the supporting tube (71), of the other group of the stretching-in channel (714) is provided with a locking plate (717) clamped with the dip dyeing mechanism (9), and the locking plate (717) which is fixedly connected with the inner side of the inner side wall (717) which is far away from the sliding unit (717, and is fixedly connected with the inner side of the inner side wall (717;
the dip dyeing mechanism (9) comprises a fixed sleeve (91) which is in sliding connection with a stretching-in channel (714), a sliding plate (92) which is fixedly sleeved on the outer ring of the fixed sleeve (91) and is in sliding connection with a sliding groove (715), a rotating shaft (93) which is movably sleeved on the inner ring of the fixed sleeve (91), a gear (94) which is fixedly sleeved on the rotating shaft (93) and stretches into the outer ring of one end of the supporting tube (71), a pushing screw (95) which is slidably sleeved on the other end of the rotating shaft (93), the pushing screw (95) is in threaded sleeve connection with the fixed sleeve (91), a movable sleeve (96) which is in sliding connection with the outer ring of the fixed sleeve (91) is movably sleeved on one end of the pushing screw (95) which stretches out of the fixed sleeve (91), a connecting rod (97) is fixedly connected with one end of the movable sleeve (96) which is far away from the supporting tube (71), a dip dyeing box (98) is fixedly connected with the bottom of the connecting rod (97), one end of the dip dyeing box (98) which is close to the supporting tube (71) is provided with a dip dyeing hole (99), and one end of the gear (94) which is close to the lifting tube (73) is fixedly sleeved with an adsorption ring (910).
The positioning component (6) comprises a placing plate (61) fixedly connected with the top of the base (1), an adsorption cavity (62) formed in the top of the placing plate (61), an adsorption plate (63) fixedly connected at the opening of the adsorption cavity (62), two groups of parallel-arranged transverse extrusion plates (64) slidingly connected with the bottom of the adsorption plate (63) and two groups of longitudinal extrusion plates (65) arranged between the two groups of transverse extrusion plates (64), grooves inwards concave inwards are formed in two sides of the two groups of longitudinal extrusion plates (65), extension plates (66) slidingly sleeved in the grooves and slidingly connected with the transverse extrusion plates (64), springs fixedly connected with the inner side walls of the end parts of the grooves are fixedly connected at one ends of the extension plates (66), two groups of transverse extrusion plates (64) are mutually far away, two groups of longitudinal extrusion plates (65) are respectively provided with a mounting groove (67) positioned above the placing plate (61), a push rod (68) slidingly sleeved with the placing plate (61) is installed in the interior of the mounting groove (67), one push rod (68) is fixedly connected with one end of the adjacent push rod (64) extending into the adsorption cavity (62) and one end of the push rod (69) is fixedly connected with one end of the push rod (69), one end of the push plate (69) extending to the top of the placing plate (61) is fixedly connected with a clamping plate (610), and the bottom of the push plate (69) is connected with a clamping driving mechanism (611).
2. The biosensor welding device based on the TFET device according to claim 1, wherein the air supply mechanism (8) comprises an air inlet pipe fixedly connected with the suction mechanism (7) and a connecting pipe sleeved at the inner ring at the bottom of the air inlet pipe in a sliding manner.
3. The biosensor welding device based on the TFET device according to claim 1, wherein the conveying assembly (3) comprises a pushing unit I fixedly connected with the support (2), a pushing unit II which is vertically arranged at the bottom output end of the pushing unit I is fixedly connected with the pushing unit II, and the bottom output unit of the pushing unit II is fixedly connected with the top of the supporting tube (71).
4. The biosensor welding device based on the TFET device according to claim 1, wherein the welding component (5) comprises a pushing unit three fixedly connected with the side edge of the bracket (2), a pushing unit four fixedly connected with the output end of the bottom of the pushing unit three, a pushing unit five fixedly connected with the output end of the pushing unit four, a substrate fixedly connected with the bottom of the output end of the pushing unit five, a supporting plate with an L-shaped structure fixedly connected with the bottom of the substrate, and a welding gun fixedly connected with the supporting plate.
5. A method for manufacturing a biosensor based on a TFET device using the biosensor soldering device of any of claims 1-4, comprising a biosensor system, characterized in that the biosensor system comprises a carrier plate for carrying, a biosensor unit disposed on the carrier plate, a control sensor unit, a temperature sensor unit, an amplifier, a power regulator, an analog-to-digital converter, a digital control module, and a wireless transceiver; the preparation steps are as follows:
s1, preparing a device according to a biosensor composition;
s2, welding the prepared device on a preset position of a bearing plate by using a welding device;
and S3, packaging the bearing plate after welding.
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