CN115252947B - A alveolar lavage device for disease animal model - Google Patents
A alveolar lavage device for disease animal model Download PDFInfo
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- CN115252947B CN115252947B CN202211177789.9A CN202211177789A CN115252947B CN 115252947 B CN115252947 B CN 115252947B CN 202211177789 A CN202211177789 A CN 202211177789A CN 115252947 B CN115252947 B CN 115252947B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M3/00—Medical syringes, e.g. enemata; Irrigators
- A61M3/02—Enemata; Irrigators
- A61M3/0233—Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs
- A61M3/0254—Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs the liquid being pumped
- A61M3/0258—Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs the liquid being pumped by means of electric pumps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
- A61D2003/006—Appliances for supporting or fettering animals for operative purposes with leg or foot restraining means
Abstract
The present invention relates to an alveolar lavage device for animal models of disease, comprising an injection base; an injection structure is arranged on the injection base; the injection structure includes: a control structure for controlling the injection frequency, and a push structure for realizing the injection function; the pushing structure is internally provided with a clamping structure capable of clamping syringes with different sizes, and a control structure controls the pushing structure to complete the pumping operation; a placing plate for placing the experimental animal is additionally arranged; the placing plate is provided with an extension structure for adjusting the placing area; the placing plate is provided with a lifting structure for adjusting the height of the placing table; the placing plate is connected with the injection base through a lifting structure; the placing plate is provided with a fixing assembly for fixing the experimental animal.
Description
Technical Field
The invention belongs to the technical field of medical instruments, and particularly relates to an alveolar lavage device for a disease animal model.
Background
At present, alveolar lavage of an animal model of a disease is generally manually completed by experimental operators, the angle, speed and lavage quantity during alveolar lavage are not accurate enough, and errors can be caused by the difference of operation of different experimenters, for example, the alveolar wall of a lung is broken due to too fast operation during alveolar lavage, so that subsequent pathological observation of the lung and measurement of cytokines in alveolar lavage liquid and the like are influenced. In addition, under the condition of needing a large amount of lavages and a plurality of lavages, the alveolar lavages take too long time, and the experiment progress is influenced by the occupied manpower and time; in addition, there are many types of modeling animals commonly used at present, and when alveolar perfusion is performed, the animal model cannot be well fixed, and flexible adjustment and fixation cannot be performed on animal models of different types and different body types.
The present invention addresses the above-mentioned problems by providing an alveolar lavage device for animal models of disease.
Disclosure of Invention
To overcome the problems noted in the background, the present invention provides an alveolar lavage apparatus for animal models of disease.
An alveolar lavage device for animal models of disease comprising an injection base; an injection structure is arranged on the injection base; the injection structure includes: a control structure for controlling the injection frequency, and a push structure for realizing the injection function; the pushing structure is internally provided with a clamping structure capable of clamping syringes with different sizes, and a control structure controls the pushing structure to complete the pumping operation; a placing plate for placing the experimental animal is additionally arranged; the placing plate is provided with an extension structure for adjusting the placing area; the placing plate is provided with a lifting structure for adjusting the height of the placing table; the placing plate is connected with the injection base through a lifting structure; the placing plate is provided with a fixing component for fixing the experimental animal.
Further, a placing groove is formed in the top of the injection base, a first end of the placing groove is provided with an injector placing table, and a fixing structure for fixing the injector is arranged on the placing table; the second end of the placing groove is provided with a connecting table; a first limiting rod for limiting the pushing structure is arranged in the placing groove; this setting guarantees that the pushing structure has sufficient promotion space to through setting up gag lever post one messenger pushing structure steadily carry out the displacement.
Further, the pushing structure includes: the device comprises a ball screw, a pushing assembly and a motor; the ball screw is arranged in the placing groove, the pushing assembly is connected with the ball screw through a first connecting hole, and a first connecting hole connected with the limiting rod is further formed in the pushing assembly; the output end of the motor is connected with the first end of the ball screw, and the ball screw is driven by the motor to rotate so as to realize the forward and backward movement of the pushing assembly.
Further, the motor sets up in the motor cavity that the platform was placed to the syringe, and ball screw stretches into to the motor cavity through setting up the through-hole one at the first terminal surface in motor cavity to be connected with the output of motor.
Furthermore, the second end of ball is provided with the bearing, reduces the frictional force when ball is rotatory.
Further, the pushing assembly includes: a clamping structure and a pushing block; the pushing block is internally provided with a first limiting groove for fixing and limiting the clamping structure and a second limiting groove for placing the injector, the first limiting groove is communicated with the second limiting groove by arranging an open groove between the first limiting groove and the second limiting groove, the clamping structure is arranged in the first limiting groove, and the clamping part of the clamping structure extends out of the second limiting groove and is used for clamping the injector.
Furthermore, the top of the second limiting groove is open, and a placing opening for placing an injector push rod is formed in the outer wall of the second limiting groove.
Further, the placing opening is an elastic opening structure, which comprises: the first reset spring and the baffle plate; spring grooves are formed in two side walls of the placing opening, a first end of the return spring is fixedly arranged in the spring grooves, and a second end of the return spring I is integrally connected with the baffle; the baffle includes: the first baffle plate and the second baffle plate are same in size and shape and are arranged in a mirror image manner; the size of opening and closing of the placing opening is flexibly adjusted according to the diameter of the syringe push rod through the arrangement.
Furthermore, the top of the baffle plate I is provided with an inclined surface I, the top of the baffle plate II is provided with an inclined surface II, and the inclined surface I and the inclined surface II are arranged in a mirror image manner; when the tail end of the syringe push rod is placed in the second limiting groove, the first baffle plate and the second baffle plate are squeezed to move towards two sides, so that flexible size adjustment is realized according to the diameter of the syringe push rod.
Further, the clamping structure includes: the adjusting rotating wheel, the threaded rod I and the sliding block are arranged; the adjusting rotating wheel is arranged in a connecting groove communicated with the first limiting groove; the first threaded rod is arranged in the first limiting groove; the first threaded rod is provided with a threaded section with the opposite rotating direction; the slider includes: a first sliding block and a second sliding block; the first end faces of the first sliding block and the second sliding block are respectively provided with a first rack matched with the threaded section, and the second end faces of the first sliding block and the second sliding block are provided with annular protrusions for clamping the injector; the first sliding block and the second sliding block can slide along the open slot; through the arrangement, the clamping of the first sliding block and the second sliding block to the tail sections of the push rods of the syringes with different diameters is realized.
Further, it is provided with the tooth one to adjust the runner, threaded rod one is provided with the interlude, just be provided with tooth two on the interlude, adjust the rotation that the runner drove threaded rod one through rotating to realize that sliding block one carries out the removal of mirror image with sliding block two.
Furthermore, two short side faces of the first limiting groove are provided with second through holes, and the first end and the second end of the first threaded rod are connected and limited through the second through holes respectively.
Further, place the fixed knot that is provided with fixed syringe main part on the platform and construct, fixed knot constructs including: the threaded rod II, the limiting rod II, the fixing unit, the limiting unit and the locking unit; the second threaded rod is perpendicular to the end face of the top of the placing table and is tangent to the end face of the short edge of the placing table; the first end of the second limiting rod is connected with the injection base, and the second end of the second limiting rod and the second highest point of the threaded rod are positioned on the same transverse plane; the second threaded rod is connected with the second limiting rod through a connector; the locking unit is connected with the first end of the second threaded rod, the fixing unit is connected with the second threaded rod and the second limiting rod, the fixing unit moves up and down along the second threaded rod and the second limiting rod, and the limiting unit is fixedly arranged on the top end face of the placing table; realize the fixed to the syringe main part through this setting, can prevent to advance the slip that the in-process of injection appears the syringe main part to the laboratory animal, this setting can be fixed the syringe main part of not unidimensional diameter moreover.
Further, the limiting unit comprises: the first limiting unit and the second limiting unit are arranged in a mirror image mode by taking the central line of the placing opening as an axis.
Furthermore, a lifting groove is formed in the first end face of the injection base, and a lifting shaft is arranged in the injection base; the bottom of the placing plate is provided with a lifting structure and is connected with a lifting shaft through the lifting structure; the height adjustment of the placing plate is realized by arranging the lifting groove and the lifting shaft.
Furthermore, a second rack is arranged on the lifting shaft and is integrally connected with the lifting shaft, and the second rack is parallel to the lifting groove and is opposite to the lifting groove.
Further, the elevation structure includes: the lifting assembly, a worm wheel, a worm and a transmission handle; the lifting assembly is sleeved on the lifting shaft, the turbine is arranged in the lifting assembly, and a fixed shaft is arranged in the lifting assembly for positioning and fixing; the worm is arranged above the worm wheel, and the transversal lines of the worm wheel and the worm are positioned in the same plane and are parallel to each other; the transmission handle sets up in the first end of worm, realizes through rotating the transmission handle that the worm drives the worm wheel and rotates to realize that elevation structure reciprocates along the lift axle, reach this and place the regulation of board height.
Further, the lifting assembly comprises: the lantern ring that cup joints with the lift axle, baffle one and baffle two of being connected with the lantern ring, leave the space between baffle one and the baffle two, the space width is the same with the worm wheel width, guarantees through this setting that the rack that worm wheel and lift epaxial set up contacts.
Furthermore, a first fixing block and a second fixing block are arranged on the tops of the first partition plate and the second partition plate, a first through hole is formed in the first fixing block, a second through hole is formed in the second fixing block, and the distance between the first fixing block and the second fixing block is the same as the length of the thread section of the worm.
Furthermore, a first protruding shaft is arranged at the first end of the worm, a second protruding shaft is arranged at the second end of the worm, the first protruding shaft is connected with the first through hole, and the second protruding shaft is connected with the second through hole; the limit of the worm is realized through the structure.
Furthermore, the first extension shaft is provided with an extension section, and the transmission handle is connected with the extension end; the rotation of the worm is driven by the transmission handle through the arrangement.
Furthermore, a support frame is arranged at the top of the first partition plate and the top of the second partition plate, a slide rail is arranged on the support frame, and a sliding platform is arranged to be connected with the slide rail; the sliding frame is arranged at the bottom of the placing plate and connected with the sliding platform; and realize carrying out the translation along the slide rail through sliding platform to this lateral shifting who places the board is realized, through this setting be convenient for the experimenter to carry out operations such as trachea cannula, alveolar lavage and anatomy to the experimental animal.
Furthermore, a first connecting shaft is arranged on the sliding platform, and the inside of the first connecting shaft is hollow; the bottom of the sliding frame is provided with a second connecting shaft, and the first connecting shaft is sleeved with the second connecting shaft; the placing plate rotates by the circle centers of the connecting shaft I and the connecting shaft II; the experimental animal experiment device is convenient for experimental personnel to carry out various experimental operations on experimental animals.
Furthermore, locking bolts are arranged on two sides of the sliding rail, and the placing plate is fixed in position after moving transversely through the locking bolts.
Further, the placing board includes: the auxiliary placing plate comprises a main placing plate, an auxiliary placing plate I and an auxiliary placing plate II; the main board bottom of placing is provided with extension structure, and vice placing board one and vice placing board two realize placing the combination of board with the main through extension structure to realize placing the adjustment of board area size through extension structure.
Further, the extension structure includes: the device comprises a threaded rod III, a rocker I, a rocker II, an extension assembly, a stroke rod I and a stroke rod II; the third threaded rod is connected with the sliding frame; the extension assembly is connected with the third threaded rod and moves along the third threaded rod; the first ends of the first rocking rods and the second rocking rods are hinged with the two sides of the extension assembly respectively, the second ends of the first rocking rods are hinged with the first stroke blocks at the bottom of the first auxiliary placing plate, and the second ends of the second rocking rods are hinged with the second stroke blocks at the bottom of the second auxiliary placing plate; the first auxiliary placing plate is in sliding connection with the first stroke rod through the first stroke block, and the second auxiliary placing plate is in sliding connection with the second stroke rod through the second stroke block; when the third threaded rod rotates, the extension assembly moves forwards or backwards along the third threaded rod, and when the extension assembly moves, the first auxiliary placing plate and the second auxiliary placing plate are driven by the first rocker and the second rocker to slide along the first stroke rod and the second stroke rod.
Furthermore, the first stroke rod and the second stroke rod are respectively arranged on the left side and the right side of the third threaded rod, and the first ends of the first stroke rod and the second stroke rod are integrally connected with the first end of the third threaded rod; an included angle of 35-65 degrees is formed between the first stroke rod and the third stroke rod and between the second stroke rod and the third threaded rod; through this setting, realize that vice placing plate one and vice placing plate two can be steady extend along stroke pole one with the stroke pole is outside.
Further, the fixing assembly includes: the fixing device comprises a first fixing component, a second fixing component and a third fixing component, wherein the first fixing component is arranged on the main placing plate, the second fixing component is arranged on the first auxiliary placing plate, and the third fixing component is arranged on the second auxiliary placing plate; the first fixing component, the second fixing component and the third fixing component form the same structure; the first fixing component is used for fixing forelimbs of the experimental animal, and the second fixing component and the third fixing component are used for fixing hind limbs of the experimental animal; the fixing of experimental animals of different types and different body types is realized through the setting.
Furthermore, the main placing plate is further provided with an elastic fixing belt for fixing the trunk part of the experimental animal.
Furthermore, two sliding grooves are arranged on the main placing plate in a mirror image mode, and a first fixing component is arranged in each sliding groove; the first fixing component and the second fixing component can both perform translational motion along the sliding groove; through this setting can be nimble adjust the interval between two fixed subassemblies one to the realization is fixed to different types and different size experimental animals forelimbs.
Further, the second fixing component is fixedly arranged on the first auxiliary placing plate, the third fixing component is fixedly arranged on the second auxiliary placing plate, and the distance between the second fixing component and the third fixing component is adjusted by extending the first auxiliary placing plate and the second auxiliary placing plate.
Further, the first fixing component comprises: the device comprises a fixed claw, a rectangular body, a rocker III and a return spring II; an operation cavity is arranged in the fixed component; the rectangular body is arranged in the operation cavity in a sliding mode; the second reset spring is arranged at the bottom of the rectangular body, and the fixed claw is fixedly connected to the first end face of the rectangular body; the outer wall of the rectangular body is provided with a stroke groove; the first end of the rocker III is connected with a protruding shaft in the operation cavity, and the second end of the rocker III is provided with a connecting protrusion; the connecting bulge moves along the stroke groove; when the fixed claw is pressed down, the rectangular body slides downwards, and meanwhile, the second reset spring is pressed tightly, so that the fixed claw is clamped; when the fixed claw is pressed down again, the second reset spring returns, and the fixed claw releases clamping.
Further, the fixed claw is made of elastic materials, and the maximum diameter of the fixed claw is larger than that of the operation cavity; when the fixed claw enters the operation cavity, the fixed claw is blocked by the operation cavity to clamp the forelimb of the experimental animal.
Further, the stroke groove is provided with a first concave point and a second concave point, the fixed claw is in a release state when the connecting protrusion is located at the first concave point, and the fixed claw is in a clamping state when the connecting protrusion is located at the second concave point.
Further, the control structure is disposed within the injection base, the control structure comprising: the device comprises an operation panel, a central control module and a frequency conversion module; the central control module is used for receiving input signals and controlling the stroke distance of the pushing assembly in pushing and withdrawing; the operation panel is connected with the central control module and used for inputting operation instructions, the frequency conversion module is connected with the central control module and is connected with the motor circuit; the output power of the motor is controlled through the frequency conversion module, and the forward and reverse rotation of the motor is controlled through the central control module, so that the injector is driven to inject and withdraw.
Further, the operation panel includes: a display screen and operation keys; the operation key includes: a power key, a number key, a motor speed reduction key, a motor speed increase key, a pause key and a push injection mode setting key; the push injection and withdrawal speed and the push injection and withdrawal times are accurately regulated and controlled through the setting; meanwhile, the display screen can display the input information, so that experimenters can read the information conveniently.
Further, still be provided with power supply unit in the injection base, injection base outer wall is provided with the power wiring, realizes supplying power to control structure through this setting.
When the anesthesia fixing device is used, firstly, the anesthetized experimental animal is fixed on the main placing plate through the elastic fixing belt, and the four limbs of the experimental animal are fixed through the fixing component I, the fixing component II and the fixing component III; adjusting the position of the experimental animal to a proper position for alveolar lavage by using the lifting structure; the injector is fixed through a fixing structure, and the tail section of the push rod of the injector is fixed in the pushing assembly through a clamping structure; after the preparation is finished, the advancing speed and the withdrawing speed are set through the control structure, and the stroke length of the pushing assembly is set through the control structure; in addition, the number of times of pushing and withdrawing can be set by the control structure.
The invention has the beneficial effects that: (1) By arranging the control structure and the pushing assembly, the speed and the lavage amount during alveolar lavage can be accurately controlled, and errors caused by operation differences are reduced; (2) The experimental animals of different types and different body types can be fixed by arranging the lifting structure and the placing plate with the fixing component, and the height of the experimental animals can be adjusted during injection according to the body types of the experimental animals; (3) The time and labor for alveolar lavage operation are reduced, and the progress of the experiment is accelerated.
Drawings
FIG. 1 is a schematic view of the overall structure of the present invention;
FIG. 2 is a front view of the present invention;
FIG. 3 is a schematic left side view of the present invention;
FIG. 4 is an internal cross-sectional view of the present invention;
FIG. 5 is a schematic view of a pushing assembly according to the present invention;
FIG. 6 is a schematic cross-sectional view of a pushing assembly of the present invention;
FIG. 7 is a top cross-sectional view of the pushing assembly of the present invention;
FIG. 8 is a schematic view of a fastening structure of the present invention;
FIG. 9 is a schematic view of the placement table of the present invention;
FIG. 10 is a schematic cross-sectional view of the lift structure of the present invention;
FIG. 11 is a cross-sectional schematic view of the lift assembly of the present invention;
FIG. 12 is a schematic view of a slide rail according to the present invention;
FIG. 13 is a schematic top view of the subject holding station;
FIG. 14 is a bottom view of the park bench of the present invention;
FIG. 15 is a schematic view of a securing assembly of the present invention;
FIG. 16 is an internal cross-sectional view of the fixing assembly of the present invention;
in the figure, 1, an injection base; 11. a placement groove; 111. a placing table; 1111. a motor cavity; 112. a connecting table; 113. a first limiting rod; 12. a ball screw; 13. a pushing assembly; 131. a pushing block; 132. a first limiting groove; 133. a second limiting groove; 134. a placement port; 135. adjusting the rotating wheel; 136. a first threaded rod; 137. a first sliding block; 138. a second sliding block; 139. an annular projection; 14. an electric motor; 15. a second threaded rod; 151. a second limiting rod; 152. a fixing unit; 153. a first limiting unit; 1531. a second limiting unit; 154. a locking unit; 155. a linker; 2. a lifting groove; 21. a lifting shaft; 22. a second rack; 23. a lifting assembly; 24. a worm gear; 25. a worm; 26. a drive handle; 27. a fixed shaft; 28. a first fixed block; 29. a second fixed block; 291. a first clapboard; 292. a second clapboard; 3. a support frame; 31. a slide rail; 311. locking the bolt; 32. a carriage; 33. a sliding platform; 34. connecting a shaft I; 4. a main placement board; 41. the auxiliary placing plate I; 42. a second auxiliary placing plate; 43. a third threaded rod; 44. a first rocker; 45. a rocker II; 46. an extension assembly; 47. a first stroke rod; 48. a second stroke rod; 5. a first fixing component; 51. a fixed jaw; 511. a rectangular body; 512. a rocker III; 513. a second return spring; 52. a second fixing component; 53. a third fixing component; 54. an elastic fixing band; 56. a sliding groove; 561. a first pit; 562. a second pit; 6. a display screen; 61. an operation key; 62. a central control module; 63. a frequency conversion module; 64. a power supply device; 65. and power supply wiring.
Detailed Description
The technical solutions in the embodiments of the present invention are clearly and completely described below by specific embodiments, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, rather than all embodiments, and other advantages and effects of the present invention can be easily understood by those skilled in the art from the disclosure of the present specification. The present invention can be implemented or applied by other different specific embodiments, and the features in the following embodiments and examples can be combined with each other without conflict, and all other embodiments obtained by a person of ordinary skill in the art without making creative efforts based on the embodiments in the present invention shall fall within the protection scope of the present invention.
Example 1
Referring to fig. 1-4, an alveolar lavage device for animal models of disease includes an injection base 1; an injection structure is arranged on the injection base 1; the injection structure includes: a control structure for controlling the injection frequency, and a push structure for implementing the injection function; the pushing structure is internally provided with a clamping structure capable of clamping syringes with different sizes, and a control structure controls the pushing structure to complete pumping operation; a placing plate for placing the experimental animal is additionally arranged; the placing plate is provided with an extension structure for adjusting the placing area; the placing plate is provided with a lifting structure for adjusting the height of the placing table 111; the placing plate is connected with the injection base 1 through a lifting structure; the placing plate is provided with a fixing component for fixing the experimental animal.
A control structure is provided within the injection base 1, the control structure comprising: an operation panel, a central control module 62 and a frequency conversion module 63; the central control module 62 is used for receiving an input signal and controlling the stroke distance of the pushing component 13 for pushing and withdrawing; the operation panel is connected with the central control module 62 and used for inputting operation instructions, the frequency conversion module 63 is connected with the central control module 62, and the frequency conversion module 63 is connected with the motor 14 through a circuit; the output power of the motor 14 is controlled by the frequency conversion module 63, and the forward and reverse rotation of the motor 14 is controlled by the central control module 62, so that the injector is driven to inject and withdraw.
The operation panel includes: a display screen 6 and operation keys 61; the operation key 61 includes: a power key, a number key, a motor 14 speed reduction key, a motor 14 speed increase key, a pause key and a push injection mode setting key; the push injection and withdrawal speed and the push injection and withdrawal times are accurately regulated and controlled through the setting; meanwhile, the display screen 6 can display the input information, so that the experimenter can read the information conveniently.
Still be provided with power supply unit 64 in the injection base 1, injection base 1 outer wall is provided with power connection 65, realizes supplying power to control structure through this setting.
Example 2
Referring to fig. 1-4, the injection base 1 and the pushing structure are arranged on the basis of embodiment 1, a placing groove 11 is arranged on the top of the injection base 1, a first end of the placing groove 11 is arranged as a syringe placing table 111, and a second end of the placing groove 11 is arranged as a connecting table 112; a first limiting rod 113 for limiting the pushing structure is arranged in the placing groove 11; this setting guarantees that the pushing structure has sufficient promotion space to make the steady displacement that carries on of pushing structure through setting up gag lever post one 113.
The pushing structure includes: a ball screw 12, a pushing assembly 13 and a motor 14; the ball screw 12 is arranged in the placing groove 11, the pushing assembly 13 is connected with the ball screw 12 through a first connecting hole, and the pushing assembly 13 is further provided with a first connecting hole connected with a first limiting rod 113; the output end of the motor 14 is connected with the first end of the ball screw, and the motor 14 drives the ball screw 12 to rotate so as to realize the forward and backward movement of the pushing assembly 13.
The motor 14 is arranged in a motor cavity 1111 of the injector placing table 111, and the ball screw extends into the motor cavity 1111 through a first through hole arranged on a first end surface of the motor cavity 1111 and is connected with an output end of the motor 14.
The second end of the ball screw 12 is provided with a bearing to reduce friction when the ball screw 12 rotates.
Example 3
Referring to fig. 1 to 7, a pushing assembly 13 is provided on the basis of embodiment 2, the pushing assembly 13 includes: a clamping structure, a pusher block 131; the pushing block 131 is internally provided with a first limiting groove 132 for fixing and limiting the clamping structure and a second limiting groove 133 for placing the injector, the first limiting groove 132 is communicated with the second limiting groove 133 through an open groove between the first limiting groove 132 and the second limiting groove 133, the clamping structure is arranged in the first limiting groove 132, and a clamping part of the clamping structure extends into the second limiting groove 133 for clamping the injector.
The top of the second limiting groove 133 is open, and a placing opening 134 for placing the syringe push rod is arranged on the outer wall of the second limiting groove 133.
The placement port 134 is a resilient open structure that includes: the first reset spring and the baffle plate; spring grooves are formed in two side walls of the placing opening 134, a first end of the return spring is fixedly arranged in the spring grooves, and a second end of the first return spring is integrally connected with the baffle; the baffle includes: the first baffle plate and the second baffle plate are same in size and shape and are arranged in a mirror image manner; the opening and closing size of the placing opening 134 can be flexibly adjusted according to the diameter of the syringe push rod through the arrangement.
The top of the baffle plate I is provided with an inclined plane I, the top of the baffle plate II is provided with an inclined plane II, and the inclined plane I and the inclined plane II are also arranged in a mirror image manner; when the tail end of the syringe push rod is placed in the second limiting groove 133, the first baffle plate and the second baffle plate are extruded to move towards two sides, so that flexible size adjustment is achieved according to the diameter of the syringe push rod.
The clamping structure includes: the adjusting rotating wheel 135, the first threaded rod 136 and the sliding block; the adjusting rotating wheel 135 is arranged in a connecting groove communicated with the first limiting groove 132; the first threaded rod 136 is arranged in the first limiting groove 132; the first threaded rod 136 is provided with threaded sections with opposite rotating directions; the slider includes: a first slider 137 and a second slider 138; the first end faces of the first sliding block 137 and the second sliding block 138 are respectively provided with a first rack matched with the threaded section, and the second end faces of the first sliding block 137 and the second sliding block 138 are provided with an annular protrusion 139 used for clamping the syringe; the first sliding block 137 and the second sliding block 138 can slide along the opening groove; through the arrangement, the first sliding block 137 and the second sliding block 138 clamp the tail sections of the push rods of the injectors with different diameters.
Adjusting wheel 135 is provided with the rodent one, threaded rod one 136 is provided with the interlude, just be provided with rodent two on the interlude, through rotating adjusting wheel 135 and driving the rotation of threaded rod one 136 to realize that sliding block one 137 and two sliding blocks 138 carry out the removal of mirror image.
And two short side surfaces of the first limit groove 132 are provided with a second through hole, and the first end and the second end of the first threaded rod 136 are connected and limited through the second through hole respectively.
Example 4
Referring to fig. 8, a fixing structure is provided on the basis of embodiment 1, and a fixing structure for fixing a syringe body is provided on the placing table 111, and the fixing structure includes: the second threaded rod 15, the second limiting rod 151, the fixing unit 152, the limiting unit and the locking unit 154; the second threaded rod 15 is perpendicular to the top end face of the placing table 111 and is tangent to the end face of the short side of the placing table 111; the first end of the second limiting rod 151 is connected with the injection base 1, and the second end of the second limiting rod 151 and the highest point of the second threaded rod 15 are located on the same transverse plane; the second threaded rod 15 is connected with the second limiting rod 151 through a connecting body 155; the locking unit 154 is connected with the first end of the second threaded rod 15, the fixing unit 152 is connected with the second threaded rod 15 and the second limiting rod 151, the fixing unit 152 moves up and down along the second threaded rod 15 and the second limiting rod 151, and the limiting unit is fixedly arranged on the top end face of the placing table 111; realize the fixed to the syringe main part through this setting, can prevent to advance the slip that the in-process of injection appears the syringe main part to experimental animals, this setting can be fixed the syringe main part of not unidimensional diameter moreover.
The spacing unit includes: the first limiting unit 153 and the second limiting unit 1531 are arranged in a mirror image mode by taking the central line of the placing opening 134 as an axis.
Example 5
Referring to fig. 9-12, a lifting structure is provided on the basis of embodiment 1, a lifting groove 2 is provided on a first end face of an injection base 1, and a lifting shaft 21 is provided inside the injection base 1; the bottom of the placing plate is provided with a lifting structure and is connected with a lifting shaft 21 through the lifting structure; the height adjustment of the placing plate is realized by arranging the lifting groove 2 and the lifting shaft 21.
The second rack 22 is arranged on the lifting shaft 21, the second rack 22 is integrally connected with the lifting shaft 21, the second rack 22 is parallel to the lifting groove 2, and the second rack 22 is opposite to the lifting groove 2.
Elevation structure includes: the lifting component 23, the worm wheel 24, the worm 25 and the transmission handle 26; the lifting assembly 23 is sleeved on the lifting shaft 21, the turbine is arranged in the lifting assembly 23, and a fixed shaft 27 is arranged in the lifting assembly 23 for positioning and fixing; the worm 25 is arranged above the worm wheel 24, and cross sectional lines of the worm wheel 24 and the worm 25 are in the same plane and are parallel to each other; the transmission handle 26 is arranged at the first end of the worm 25, and the worm 25 drives the worm wheel 24 to rotate by rotating the transmission handle 26, so that the lifting structure moves up and down along the lifting shaft 21, and the height of the placing plate is adjusted.
The elevating assembly 23 includes: the lantern ring that cup joints with lift axle 21, the baffle 291 and the baffle 292 that are connected with the lantern ring, leave the space between the baffle 291 and the baffle 292, the space width is the same with worm wheel 24 width, guarantees through this setting that worm wheel 24 contacts with the rack that sets up on the lift axle 21.
The first fixing block 28 and the second fixing block 29 are arranged on the tops of the first partition plate 291 and the second partition plate 292, a first through hole is formed in the first fixing block 28, a second through hole is formed in the second fixing block 29, and the distance between the first fixing block 28 and the second fixing block 29 is the same as the length of the thread section of the worm 25.
A first extending shaft is arranged at the first end of the worm 25, a second extending shaft is arranged at the second end of the worm 25, the first extending shaft is connected with the first through hole, and the second extending shaft is connected with the second through hole; the limit of the worm 25 is realized by this structure.
The first extension shaft is provided with an extension section, and the transmission handle 26 is connected with the extension end; the rotation of the drive shaft 26 with the worm 25 is achieved by this arrangement.
The top parts of the first partition plate 291 and the second partition plate 292 are provided with a support frame 3, the support frame 3 is provided with a slide rail 31, and a sliding platform 33 is arranged to be connected with the slide rail 31; a sliding frame 32 is arranged at the bottom of the placing plate, and the sliding frame 32 is connected with a sliding platform 33; and realize carrying out the translation along slide rail 31 through sliding platform 33 to this lateral shifting who places the board that realizes, through this setting be convenient for the experimenter to carry out operations such as trachea cannula, alveolar lavage and anatomy to the experimental animal.
The experimental animal sliding platform 33 is provided with a first connecting shaft 34, and the inside of the first connecting shaft 34 is hollow; the bottom of the sliding frame 32 is provided with a second connecting shaft, and the first connecting shaft 34 is sleeved with the second connecting shaft; the placing plate rotates by the circle centers of the first connecting shaft 34 and the second connecting shaft; the experimental operation of experimenters on experimental animals is facilitated.
The slide rail 31 is provided with a locking bolt 311, and the position of the placing plate after the transverse movement is fixed through the locking bolt 311.
Example 6
Referring to fig. 13 to 14, the setting of the placing plate on the basis of embodiment 5 includes: a main placing plate 4, a first auxiliary placing plate 41 and a second auxiliary placing plate 42; the board 4 bottom of mainly placing is provided with extending structure, and vice board 41 of placing realizes and the combination of main board 4 of placing through extending structure with vice board two 42 of placing to realize placing the adjustment of board area size through extending structure.
The extension structure includes: a third threaded rod 43, a first rocker 44, a second rocker 45, an extension assembly 46, a first travel rod 47 and a second travel rod 48; the third threaded rod 43 is connected with the sliding frame 32; the extension component 46 is connected with the third threaded rod 43, and the extension component 46 moves along the third threaded rod 43; the first ends of the rocker I44 and the rocker II 45 are respectively hinged with two sides of the extension assembly 46, the second end of the rocker I44 is hinged with the first stroke block at the bottom of the auxiliary placing plate I41, and the second end of the rocker II 45 is hinged with the second stroke block at the bottom of the auxiliary placing plate II 42; the first auxiliary placing plate 41 is connected with the first stroke rod 47 in a sliding mode through the first stroke block, and the second auxiliary placing plate 42 is connected with the second stroke rod 48 in a sliding mode through the second stroke block; when the third threaded rod 43 rotates, the extension assembly moves forwards or backwards along the third threaded rod 43, and the first secondary placement plate 41 and the second secondary placement plate 42 are driven by the first rocker 44 and the second rocker 45 to slide along the first stroke rod 47 and the second stroke rod 48 while the extension assembly moves.
The first travel rod 47 and the second travel rod 48 are respectively arranged on the left side and the right side of the third threaded rod 43, and the first ends of the first travel rod 47 and the second travel rod 48 are integrally connected with the first end of the third threaded rod 43; an included angle of 35-65 degrees is formed between the first stroke rod 47, the second stroke rod 48 and the third threaded rod 43; through the arrangement, the first auxiliary placing plate 41 and the second auxiliary placing plate 42 can smoothly extend outwards along the first stroke rod 47 and the second stroke rod 48.
Example 7
Referring to fig. 13 to 16, a fixing assembly is provided on the basis of embodiment 6, the fixing assembly including: the first fixing component 5 is arranged on the main placing plate 4, the second fixing component 52 is arranged on the first auxiliary placing plate 41, and the third fixing component 53 is arranged on the second auxiliary placing plate 42; the first fixing component 5, the second fixing component 52 and the third fixing component 53 have the same structure; the first fixing component 5 is used for fixing forelimbs of the experimental animal, and the second fixing component 52 and the third fixing component 53 are used for fixing hindlimbs of the experimental animal; the fixing of experimental animals of different varieties and different body types is realized through the arrangement.
The main placing plate 4 is further provided with an elastic fixing belt 54 for fixing the trunk part of the experimental animal.
Two sliding grooves 56 are arranged on the main placing plate 4 in a mirror image mode, and a first fixing component 5 is arranged in each sliding groove 56; both the first fixing assemblies 5 can perform translational motion along the sliding groove 56; through the arrangement, the distance between the two first fixing assemblies 5 can be flexibly adjusted, so that the forelimbs of different types and different experimental animals can be fixed.
The second fixing element 52 is fixedly arranged on the first auxiliary placing plate 41, the third fixing element 53 is fixedly arranged on the second auxiliary placing plate 42, and the distance between the second fixing element 52 and the third fixing element 53 is adjusted by the extending operation of the first auxiliary placing plate 41 and the second auxiliary placing plate 42.
The first fixing member 5 includes: the fixed claw 51, the rectangular body 511, the rocker III 512 and the return spring II 513; an operation cavity is arranged in the fixed component; the rectangular body 511 is arranged in the operation cavity in a sliding mode; the second return spring 513 is arranged at the bottom of the rectangular body 511, and the fixed claw 51 is fixedly connected to the first end face of the rectangular body 511; the outer wall of the rectangular body 511 is provided with a stroke groove; the first end of the third rocker 512 is connected with a protruding shaft in the operation cavity, and the second end of the third rocker 512 is provided with a connecting protrusion; the connecting bulge moves along the stroke groove; when the fixed claw 51 is pressed downwards, the rectangular body 511 slides downwards and presses the second return spring 513, so that the fixed claw 51 is clamped; when the fixed claw 51 is pressed down again, the second reset spring 513 returns, and the fixed claw 51 releases the clamping.
The fixed claw 51 is made of elastic material, and the maximum diameter of the fixed claw 51 is larger than that of the operation cavity; when the fixed claw 51 enters the operation cavity, the fixed claw 51 is blocked by the operation cavity to clamp the forelimb of the experimental animal.
The stroke groove is provided with a first depression 561 and a second depression 562, the stationary pawl 51 being in a released state when the connecting projection is located at the first depression 561, and the stationary pawl 51 being in a clamped state when the connecting projection is located at the second depression 562.
The above description of the embodiments is only intended for the understanding of the present invention. It should be noted that modifications could be made to the invention without departing from the principle of the invention, which would also fall within the scope of the claims of the invention.
Claims (8)
1. An alveolar lavage device for animal models of disease comprising, an injection base; the injection device is characterized in that an injection structure is arranged on the injection base; the injection structure includes: a control structure for controlling the injection frequency, and a push structure for realizing the injection function; the pushing structure is internally provided with a clamping structure capable of clamping syringes with different sizes, and a control structure controls the pushing structure to complete the pumping operation; a placing plate for placing the experimental animal is additionally arranged; the placing plate is provided with an extension structure for adjusting the placing area; the placing plate is provided with a lifting structure for adjusting the height of the placing table; the placing plate is connected with the injection base through a lifting structure; the placing plate is provided with a fixing component for fixing the experimental animal; the pushing structure includes: the device comprises a ball screw, a pushing assembly and a motor; the push assembly includes: a pushing block; the pushing block is internally provided with a first limiting groove for fixing and limiting the clamping structure and a second limiting groove for placing the syringe, an open groove is arranged between the first limiting groove and the second limiting groove to enable the first limiting groove to be communicated with the second limiting groove, the clamping structure is arranged in the first limiting groove, and the clamping part of the clamping structure extends into the second limiting groove and is used for clamping the syringe; the top of the second limiting groove is open, and a placing opening for placing a push rod of the injector is formed in the outer wall of the second limiting groove; the clamping structure includes: the adjusting rotating wheel, the first threaded rod and the sliding block are arranged; the adjusting rotating wheel is arranged in a connecting groove communicated with the limiting groove I; the first threaded rod is arranged in the first limiting groove; the first threaded rod is provided with threaded sections with opposite rotation directions; the slider includes: a first sliding block and a second sliding block; the first end faces of the first sliding block and the second sliding block are respectively provided with a first rack matched with the threaded section, and the second end faces of the first sliding block and the second sliding block are provided with annular protrusions for clamping the injector; the first sliding block and the second sliding block can slide along the open slot; the adjusting rotating wheel is provided with a first rodent tooth, the first threaded rod is provided with a middle section, and the middle section is provided with a second rodent tooth; and two short side surfaces of the first limiting groove are provided with second through holes, and the first end and the second end of the first threaded rod are connected and limited through the second through holes respectively.
2. The alveolar lavage device for animal disease models according to claim 1, wherein the injection base is provided with a placement groove at the top, the first end of the placement groove is provided with an injector placement platform, and a fixing structure for fixing the injector is arranged on the placement platform; the second end of the placing groove is provided with a connecting table; be provided with in the standing groove and carry out spacing gag lever post one to pushing away the structure.
3. The alveolar lavage device for animal models with diseases of claim 2, wherein the ball screw is arranged in the placement groove, the pushing assembly is connected with the ball screw by arranging a first connecting hole, and the pushing assembly is further provided with a first connecting hole connected with a first limiting rod; the output end of the motor is connected with the first end of the ball screw.
4. The alveolar lavage device for animal models with diseases according to claim 1, wherein the first end surface of the injection base is provided with a lifting groove, and the inside of the injection base is provided with a lifting shaft; the bottom of the placing plate is provided with a lifting structure and is connected with a lifting shaft through the lifting structure; the lifting shaft is provided with a second rack, the second rack is integrally connected with the lifting shaft, and the second rack is parallel to the lifting groove and opposite to the lifting groove.
5. The alveolar lavage device for an animal model with disease according to claim 4, wherein the elevating structure comprises: the lifting assembly, a worm wheel, a worm and a transmission handle; the lifting assembly is sleeved on the lifting shaft, the worm gear is arranged in the lifting assembly, and a fixed shaft is arranged in the lifting assembly for positioning and fixing; the worm is arranged above the worm wheel, and the cross sectional lines of the worm wheel and the worm are in the same plane and are parallel to each other; the transmission handle is arranged at the first end of the worm; the lifting assembly comprises: the device comprises a lantern ring sleeved with a lifting shaft, a first partition plate and a second partition plate, wherein the first partition plate and the second partition plate are connected with the lantern ring, a space is reserved between the first partition plate and the second partition plate, and the width of the space is the same as that of a worm gear; a first fixing block and a second fixing block are arranged at the tops of the first partition plate and the second partition plate, a first through hole is formed in the first fixing block, a second through hole is formed in the second fixing block, and the distance between the first fixing block and the second fixing block is the same as the length of the thread section of the worm; the first end of the worm is provided with a first extending shaft, the second end of the worm is provided with a second extending shaft, the first extending shaft is connected with the first through hole, and the second extending shaft is connected with the second through hole.
6. The alveolar lavage device for an animal model with disease according to claim 1, wherein the placement plate comprises: the main placing plate, the auxiliary placing plate I and the auxiliary placing plate II; the bottom of the main placing plate is provided with an extension structure; the extension structure includes: the device comprises a threaded rod III, a rocker I, a rocker II, an extension assembly, a stroke rod I and a stroke rod II; the third threaded rod is connected with the sliding frame; the extension assembly is connected with the third threaded rod and moves along the third threaded rod; the first end of the rocker I and the first end of the rocker II are respectively hinged with two sides of the extension assembly, the second end of the rocker I is hinged with the first stroke block at the bottom of the auxiliary placing plate I, and the second end of the rocker II is hinged with the second stroke block at the bottom of the auxiliary placing plate II; the first auxiliary placing plate is in sliding connection with the first stroke rod through the first stroke block, and the second auxiliary placing plate is in sliding connection with the second stroke rod through the second stroke block; the first stroke rod and the second stroke rod are respectively arranged on the left side and the right side of the third threaded rod, and the first ends of the first stroke rod and the second stroke rod are integrally connected with the first end of the third threaded rod; and an included angle of 35-65 degrees is formed between the first stroke rod and the third stroke rod and between the second stroke rod and the third threaded rod.
7. The alveolar lavage device for an animal model of disease according to claim 1, wherein the fixing assembly comprises: the fixing device comprises a first fixing component, a second fixing component and a third fixing component, wherein the first fixing component is arranged on the main placing plate, the second fixing component is arranged on the first auxiliary placing plate, and the third fixing component is arranged on the second auxiliary placing plate; the first fixing component, the second fixing component and the third fixing component form the same structure; the first fixing component comprises: the device comprises a fixed claw, a rectangular body, a rocker III and a return spring II; an operation cavity is arranged in the fixed component; the rectangular body is arranged in the operation cavity in a sliding mode; the second reset spring is arranged at the bottom of the rectangular body, and the fixed claw is fixedly connected to the first end face of the rectangular body; a stroke groove is formed in the outer wall of the rectangular body; the first end of the rocker III is connected with a protruding shaft in the operation cavity, and the second end of the rocker III is provided with a connecting protrusion; the connecting bulge moves along the stroke groove; the fixed claw is made of elastic materials, and the maximum diameter of the fixed claw is larger than that of the operation cavity.
8. The alveolar lavage device for an animal model with a disease according to any one of claims 1 to 7, wherein the control structure is provided within an injection base, the control structure comprising: the device comprises an operation panel, a central control module and a frequency conversion module; the operation panel includes: a display screen and operation keys; the operation key includes: a power key, a number key, a motor speed-down key, a motor speed-up key, a pause key and a push injection mode setting key; still be provided with power supply unit in the injection base, injection base outer wall is provided with the power wiring.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202211177789.9A CN115252947B (en) | 2022-09-27 | 2022-09-27 | A alveolar lavage device for disease animal model |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202211177789.9A CN115252947B (en) | 2022-09-27 | 2022-09-27 | A alveolar lavage device for disease animal model |
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| CN115252947B true CN115252947B (en) | 2023-01-17 |
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| CA2269005A1 (en) * | 1998-04-15 | 1999-10-15 | Thomas Randall Inkpen | Needle injection-facilitating device |
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| CN212089836U (en) * | 2019-12-31 | 2020-12-08 | 黎安良 | Auxiliary device for animal anesthesia |
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| GB1178738A (en) * | 1966-07-25 | 1970-01-21 | Sweden Freezer Mfg Company | Drive Mechanism for a Syringe |
| CN109998729B (en) * | 2019-05-08 | 2019-12-03 | 南京秦淮紫云创益企业服务有限公司 | A kind of livestock-raising medical injection apparatus |
| CN210582746U (en) * | 2019-06-26 | 2020-05-22 | 周华 | Novel anesthesia breathing device |
| CN111685910A (en) * | 2020-05-27 | 2020-09-22 | 杭州电子科技大学 | Automatic injection device of fish bacterin |
| CN112315619A (en) * | 2020-11-03 | 2021-02-05 | 王秀艳 | Automatic injection device of anesthetic |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2269005A1 (en) * | 1998-04-15 | 1999-10-15 | Thomas Randall Inkpen | Needle injection-facilitating device |
| AT505749A4 (en) * | 2008-03-17 | 2009-04-15 | Hans-Peter Dr Steiner | Flushing device for e.g. dual lumen puncturing device, for puncturing follicle for sterility treatment of patient, has rinsing agent container fixed in holding device that is connected with drive device for dosed delivery of rinsing agent |
| CA2724317A1 (en) * | 2009-09-29 | 2011-03-29 | Marc J. Salzman | Syringe-attached topical anesthetic dispenser |
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| CN115252947A (en) | 2022-11-01 |
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