CN115252504A - Soothing composition and application thereof - Google Patents
Soothing composition and application thereof Download PDFInfo
- Publication number
- CN115252504A CN115252504A CN202211069413.6A CN202211069413A CN115252504A CN 115252504 A CN115252504 A CN 115252504A CN 202211069413 A CN202211069413 A CN 202211069413A CN 115252504 A CN115252504 A CN 115252504A
- Authority
- CN
- China
- Prior art keywords
- parts
- extract
- soothing composition
- malachite
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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Abstract
The invention discloses a soothing composition and application thereof, wherein the composition comprises the following components in parts by weight: 0.5-10 parts of peony flower extract, 0.2-5 parts of malachite extract and 0.1-4 parts of tetrahydro-methyl pyrimidine carboxylic acid; also included are the use of the soothing composition in cosmetics. The invention has the characteristic of promoting the synergy of three active ingredients with different sources to achieve the effect of relieving.
Description
Technical Field
The invention relates to the field of cosmetics, in particular to a soothing composition and application thereof.
Background
In recent years, because of environmental pollution, working pressure, bad living habits and people receiving new media such as internet to protect skin blindly, relieving skin sensitivity symptoms becomes one of the most urgent skin care requirements. Sensitive muscles are characterized by strong and poorly tolerated skin sensation, invisible phenomena (tingling, burning, tightness) and visible signs (red blood streaks, desquamation, dryness, etc.). The main causes of the skin comprise the damage of the barrier function of the skin and the inflammation state of the epidermis, and the causes mutually promote and affect at the same time, so that the sensitive skin is caused to enter poor circulation and is not easy to be converted into normal skin.
Although a plurality of relieving products with different formulations exist in the market at present, most of the relieving products are mainly compounded by plant extract raw materials of relieving types, the relieving effect is general, in order to ensure that the effect is better, the proportion of the added raw materials is relatively higher, the cost is higher, great challenge is brought to the shelf-life stability of the product, and meanwhile, certain sensitization risk is brought by complex components due to the mixed use of a plurality of plant extracts. Therefore, the prior art has the problems of general relieving effect, poor product stability and certain sensitization risk.
Disclosure of Invention
The invention aims to provide a soothing composition and application thereof. The invention has the characteristics of effectively relieving the effect, improving the stability of the product and effectively reducing the sensitization risk.
The technical scheme of the invention is as follows: a soothing composition comprises the following components in parts by weight: 0.5-10 parts of peony flower extract, 0.2-5 parts of malachite extract and 0.1-4 parts of tetrahydro-methyl pyrimidine carboxylic acid.
In the above soothing composition, the peony flower extract is a substance extracted from peony flower by ultrasonic extraction; the extraction process comprises the following steps: freeze drying, pulverizing, sieving, mixing with 50% ethanol solution at a ratio of 1 to 40, and performing ultrasonic extraction at 40 deg.C for 3 times each for 10min; the ultrasonic power is 110-118W, and the frequency is 82-90kHz.
In the above soothing composition, the extraction method of the malachite extract comprises: grinding malachite into powder, adding water, stirring, and oxidizing refractory ore powder by thiobacillus oxydans to obtain leachate; adding chelating agent into the leachate, stabilizing, filtering, and sterilizing and filtering to obtain malachite extract.
Use of a soothing composition in cosmetics, said soothing composition employing the soothing composition as described above.
A cosmetic comprises the above soothing composition, and also comprises humectant, thickener, pH regulator and antiseptic.
The cosmetic comprises the following components in parts by weight: 0.5-25 parts of humectant, 0.05-2 parts of thickener, 0-2 parts of pH regulator, 0.5-2 parts of preservative and relieving composition; the soothing composition comprises 0.5-10 parts of peony flower extract, 0.2-5 parts of malachite extract and 0.1-4 parts of tetrahydro-methyl pyrimidine carboxylic acid.
In the cosmetic, the humectant is one or a combination of more than two of glycerin, propylene glycol, dipropylene glycol, polyethylene glycols, methyl glucitol polyether-10, glyceryl polyether-26, 1, 3-butanediol, trehalose, xylitol, betaine, beta-glucan, erythrose, biogum-1, oat beta-glucan, acetyl chitosamine, water-soluble oil and fat, water-soluble silicone oil and sodium hyaluronate.
In the cosmetic, the thickener is one or a combination of more than two of carbomer, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, xanthan gum, sclerotium rolfsii gum, hydroxyethyl cellulose and sodium polyacrylate.
In the cosmetic, the pH adjuster is one or a combination of two or more of triethanolamine, aminomethyl propanol, arginine, potassium hydroxide, and sodium hydroxide.
In the cosmetic, the preservative is one or a combination of more than two of p-hydroxyacetophenone, 1, 2-hexanediol, phenoxyethanol and ethylhexyl glycerin.
Compared with the prior art, the invention adopts a certain proportion of the peony flower extract, the malachite extract and the tetrahydro-methylpyrimidine carboxylic acid as the soothing composition, and solves the problem of skin sensitivity from different ways.
Aiming at the inflammatory factors causing skin sensitivity, the peony flower extract and the malachite extract are cooperated to comprehensively reduce the expression of the inflammatory factors and effectively relieve the skin inflammation problem.
Malachite extract reacts against external stress and free radicals produced by the skin itself by increasing the activity of glutathione reductase, an important cellular antioxidant. Glutathione reductase is an important enzyme for eliminating H202 and a plurality of organic hydroperoxides in vivo, and reduces toxic H202 and lipid peroxides into nontoxic hydroxyl compounds by catalyzing glutathione, thereby protecting the structure and function of cell membranes from being damaged and interfered by peroxides and preventing skin from being induced to generate related inflammatory factors. On the other hand, the malachite extract contains trace elements which can perform double protection on skin cells by directly acting on cell protection and activating the regeneration of a natural defense system of the cells, so that the skin is indirectly prevented from being stimulated by the outside to generate inflammation.
Peony, as a traditional Chinese medicine with high medicinal value, contains various bioactive substances including terpenoids, flavonoids, steroids, glycosides, phenols, tannins, volatile oil and the like. The flos Paeoniae extract extracted by ultrasonic low temperature low pressure extraction technology contains higher content of penoniflorin, and can significantly reduce multiple inflammation parameters including TNF-alpha, IL-6 level and proinflammatory mediator level (MCP-1, COX-2, IFN-gamma, TNF-alpha, IL-6 and IL-17). Meanwhile, the composition has the function of inhibiting harmful bacteria of the skin to a certain extent, thereby blocking inflammatory signal transmission caused by skin microecological imbalance.
In the aspect of skin barrier damage, the tetrahydro-methyl pyrimidine carboxylic acid is a cyclic amino acid derivative generated by an extreme organism to ensure survival in an extreme environment. In aqueous systems, water complexes are formed, which protect and stabilize biomolecules by surrounding cells, enzymes, proteins and other biomolecules by forming a water shell around them. Skin epithelial cells, including extracellular matrix, are exposed to damage stressors (e.g., radiation, particulate matter, cold and heat, etc.), which tend to cause damage to the cell membrane, loss of water and release of stress mediators. The tetrahydro-methyl pyrimidine carboxylic acid protects and stabilizes cell membranes, reduces oxidative stress and damage, and simultaneously reduces intracellular inflammatory gene expression. On the other hand, the self-defense and repair mechanism is improved by increasing the fluidity of the cell membrane; and by increasing hydration, the skin barrier effect is improved. Clinical trials have shown that after 7 days of treatment with skin care products containing tetrahydro-methyl pyrimidine carboxylic acid, 1% of tetrahydro-methyl pyrimidine carboxylic acid reduces TEWL by 28% and redness of the skin by 45% due to its anti-inflammatory and reparative properties, corresponding to the therapeutic results for hydrocortisone.
In addition, the tetrahydro-methyl pyrimidine carboxylic acid has a certain effect of promoting the stability of active ingredients of the peony extract, the three ingredients are respectively from plant extraction, mineral elements and extreme biological fermentation, and compared with the combination of the three plant extracts, the ingredients are relatively simple and are not simple superposition use of similar core ingredients; the combination of the three active substances in a certain proportion can not only improve the original single value of each component, but also achieve the effects of supplementing each other and promoting each other synergistically.
In conclusion, the invention has the characteristics of effectively relieving the effect, improving the product stability and effectively reducing the sensitization risk.
Detailed Description
The present invention is further illustrated by the following examples, which are not to be construed as limiting the invention.
Examples are given. A soothing composition comprises the following components in parts by weight: 0.5-8 parts of peony flower extract, 0.2-5 parts of malachite extract and 0.1-4 parts of tetrahydro-methyl pyrimidine carboxylic acid.
Preferably, the composition comprises the following components in parts by weight: 1-6 parts of peony flower extract, 0.3-3 parts of malachite extract and 0.3-2 parts of tetrahydro-methyl pyrimidine carboxylic acid.
Most preferably, the peony flower extract: malachite extract: the weight ratio of the tetrahydro-methyl-pyrimidine-carboxylic acid is 4.5.
The peony flower extract is extracted by an ultrasonic low-pressure extraction technology, and extraction process parameters are optimized to ensure that the content of a component paeoniflorin with the highest anti-inflammatory activity is highest.
The peony flower extract is a substance extracted from peony flowers in an ultrasonic extraction mode; the extraction process comprises the following steps: freeze drying, pulverizing, sieving, mixing with 50% ethanol solution at a ratio of 1 to 40, and performing ultrasonic extraction at 40 deg.C for 3 times each for 10min; the ultrasonic power is 110-118W, and the frequency is 82-90kHz.
Preferably, the ultrasonic power is 115W, and the frequency is 85KHz.
The malachite extract is derived from ore enriched in certain traces of the original minerals, and is ground into a powder. The extraction of any latent active ingredient from ore fines without the use of any organic solvents or chemicals, the extraction process being based on the research of ore chemical processes. The trace elements are rendered soluble and bioavailable by sequestration using a stabilization process. The extraction method comprises the following steps: grinding malachite into powder, adding water, stirring, and oxidizing refractory ore powder by thiobacillus oxydans to obtain leachate; adding chelating agent into the leachate for stabilization, filtering, and sterilizing and filtering to obtain malachite extract.
The dropping process of the chelating agent comprises the following steps: directly dripping organic chelating agent containing DMTDA as active ingredient, adding 5-10mg/L at pH4-8, and stirring for 10-15min.
Said tetrahydro-methyl-pyrimidine-carboxylic acid is produced by culturing a specific, non-transgenic halophile, the purification process comprising micro/ultrafiltration, electrodialysis, chromatography, drying and crystallization; tetrahydrophylpyrimidine carboxylic acids may be provided as Ectoin natural by bitop.
The invention also discloses an application of the soothing composition in cosmetics.
The invention also discloses a cosmetic which comprises the soothing composition, and also comprises a humectant, a thickening agent, a pH regulator and a preservative.
Preferably, the humectant is 0.5 to 25 parts, and comprises one or more of glycerol, propylene glycol, dipropylene glycol, polyethylene glycols, methyl glucitol polyether-10, glyceryl polyether-26, 1, 3-butanediol, trehalose, xylitol, betaine, beta-glucan, erythrose, biogum-1, oat beta-glucan, acetyl chitosamine, water-soluble oil and fat, water-soluble silicone oil and sodium hyaluronate.
Preferably, the thickening agent is 0.05-2 parts, and comprises one or the combination of more than two of carbomer, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, xanthan gum, sclerotium rolfsii gum, hydroxyethyl cellulose and sodium polyacrylate.
Preferably, the pH regulator is 0-2 parts, and comprises one or more of triethanolamine, aminomethyl propanol, arginine, potassium hydroxide and sodium hydroxide.
Preferably, the preservative is 0.5-2 parts and comprises one or the combination of more than two of p-hydroxyacetophenone, 1, 2-hexanediol, phenoxyethanol and ethylhexyl glycerin.
Most preferably, the humectant comprises glycerin and dipropylene glycol, and the weight ratio of glycerin to dipropylene glycol is (2-7): (2-5); the thickening agent comprises hydroxyethyl cellulose and carbomer, wherein the weight ratio of the hydroxyethyl cellulose to the carbomer is (0.02-0.12): (0.04-0.2); the pH regulator comprises arginine, and the using amount of the arginine is 0.04-0.2%; the preservative comprises p-hydroxyacetophenone and 1, 2-hexanediol, and the ratio of the p-hydroxyacetophenone to the 1, 2-hexanediol is (0.2-0.8): (0.2-0.8).
Also included is the use of a soothing composition in a base mask fluid.
Example 1:
the mask liquid comprises an A phase and a B phase, wherein the A phase comprises the following components in percentage by weight: 5% of glycerol, 3% of dipropylene glycol, 0.05% of hydroxyethyl cellulose, 0.15% of carbomer, 0.5% of p-hydroxyacetophenone and deionized water; the phase B comprises the following components in percentage by weight: 1.5% Paeonia lactiflora flower extract, 0.5% malachite extract, 0.5% tetrahydromethylpyrimidine carboxylic acid, 0.5% 1, 2-hexanediol.
The preparation method of the facial mask liquid comprises the following preparation steps:
s1, taking other components except the hydroxyacetophenone in the phase A, uniformly mixing and heating to 80 ℃, preserving heat for 20min to form a solution I, adding the hydroxyacetophenone in the phase A into the solution I when the temperature is reduced to 65 ℃, and cooling while stirring;
and S2, adding the phase B into the phase A when the temperature is reduced to 45 ℃, and stirring and mixing uniformly to obtain a finished product.
Example 2:
the mask liquid comprises an A phase and a B phase, wherein the A phase comprises the following components in percentage by weight: 5% of glycerol, 3% of dipropylene glycol, 0.05% of hydroxyethyl cellulose, 0.15% of carbomer, 0.5% of p-hydroxyacetophenone and deionized water; the phase B comprises the following components in percentage by weight: 3% of peony flower extract, 1.2% of malachite extract, 1% of tetrahydro-methyl pyrimidine carboxylic acid and 0.5% of 1, 2-hexanediol.
Example 3:
the mask liquid comprises an A phase and a B phase, wherein the A phase comprises the following components in percentage by weight: 5% of glycerol, 3% of dipropylene glycol, 0.05% of hydroxyethyl cellulose, 0.15% of carbomer, 0.5% of p-hydroxyacetophenone and deionized water; the phase B comprises the following components in percentage by weight: 4.5% of peony flower extract, 2% of malachite extract, 1.5% of tetrahydro-methyl pyrimidine carboxylic acid and 0.5% of 1, 2-hexanediol.
Example 4:
the mask liquid comprises an A phase and a B phase, wherein the A phase comprises the following components in percentage by weight: 5% of glycerol, 3% of dipropylene glycol, 0.05% of hydroxyethyl cellulose, 0.15% of carbomer, 0.5% of p-hydroxyacetophenone and deionized water; the phase B comprises the following components in percentage by weight: 6% of peony flower extract, 2.5% of malachite extract, 2% of tetrahydromethylpyrimidine carboxylic acid, and 0.5% of 1, 2-hexanediol.
Comparative example 1:
a facial mask solution, different from example 1, without a soothing composition, the remaining ingredients being in accordance with example 1.
Comparative example 2:
a mask liquid, different from example 1, not containing malachite extract, tetrahydro-methyl pyrimidine carboxylic acid, the rest being identical to example 1.
Comparative example 3:
a facial mask solution, which is different from example 1, does not contain peony flower extract and tetrahydro-methyl pyrimidine carboxylic acid, and the rest is the same as the ingredient of example 1.
Comparative example 4:
a mask liquid, which is different from example 1 in that it does not contain an extract of peony flower and an extract of malachite, and the rest is the same as the composition of example 1.
Comparative example 5:
a facial mask solution, which is different from the facial mask solution of example 1 in that no tetrahydro-methyl pyrimidine carboxylic acid is contained, and the rest is the same as the ingredient of example 1.
Comparative example 5:
a mask liquid, which is different from example 1 in that it does not contain malachite extract, and the rest is the same as the ingredient of example 1.
Comparative example 7:
a facial mask solution, different from example 1, does not contain peony flower extract, and the rest is the same as the ingredient of example 1.
The specific components of examples 1-4 and comparative examples 1-7 are shown in Table 1 below. The preparation method of example 1 was followed to obtain the final product.
Table 1 formulation table of the examples
Table 2 comparative example formulation table
385 volunteers meeting the test conditions were selected by a dermatologist and evenly divided into 11 groups, in this order, examples 1-4 and comparative examples 1-7.
The using method comprises the following steps: the samples were applied to the face after rinsing every morning and evening for 4 weeks. The volunteers were tested for return visits at 0 day, 1 week, 2 weeks, 3 weeks, 4 weeks at the time of use, respectively.
The test results were as follows:
table 3 test results using 1 week time:
table 4 results of 2 week testing using
TABLE 5 use of 3 week test results
Table 6 using 4 week test results
Through the test results of four different cycles of comparative example 1 to example 4, it was found that as the concentration of the peony flower extract, malachite extract and the addition of the tetrahydro-methylpyrimidine carboxylic acid increases, the absolute values of the decrease in TEWL value and hemoglobin become larger, indicating that the soothing effect on the skin is enhanced as the three components in the composition increase. However, it was found that the TEWL values and the absolute reduced hemoglobin values of examples 3 to 4 were not as great as those of examples 1 to 3, indicating that the concentrations of the components have a certain threshold value for the skin effect within a certain range, and that too high or too low values may have an effect on the effect.
By comparing example 1 with comparative examples 1-4, it was found that the absolute value of the reduction in TEWL value for a single equivalent amount of ingredient was lower than for the three ingredient composition, except for comparative example 4. The composition is shown to maintain the skin barrier more effectively than the single herb flower extract, malachite extract. The barrier effect of a considerable amount of single tetrahydromethylpyrimidine carboxylic acid is better than that of the composition, but the price cost is far higher than that of the composition. Meanwhile, the absolute value of the reduction of hemoglobin of comparative examples 1 to 4 is lower than that of example 1, which shows that a considerable amount of the composition is more effective in reducing skin inflammation than the single component.
By comparing example 1 and comparative example 5, the soothing effect of the equivalent amount of the peony flower extract and the malachite extract was weaker than the composition. Comparative example 1 and comparative examples 6-7 found that the absolute value of TEWL reduction was somewhat improved over equivalent compositions when the absolute value of heme reduction was combined with one of the two components, the peony flower extract and the malachite extract, but the absolute value of heme reduction was not as high as for equivalent compositions and the cost was much higher than for equivalent compositions.
Stability test, stability tests were performed on the facial masks prepared in examples 1-4 and comparative examples 2-7 of the present invention.
Cold resistance test: taking a proper amount of the product, placing the product in a sample bottle, sealing the sample bottle, placing the sample bottle in a refrigerator at the temperature of-16 ℃, sampling every 7 days, continuously inspecting for 3 months, and observing appearance change.
Heat resistance test: and taking a proper amount of product, placing the product in a sample bottle, sealing the sample bottle, placing the sample bottle in a 50 ℃ oven, sampling and observing every 7 days, continuously inspecting for 3 months, and observing appearance change.
And (3) illumination test: and taking a proper amount of product, placing the product in a sample bottle, sealing the sample bottle, placing the sample bottle in an ultraviolet illumination box, sampling and observing every 7 days, continuously inspecting for 3 months, and observing appearance change.
The detection results show that the products prepared in examples 1-4 and comparative examples 1-7 have no change in appearance after high-temperature and low-temperature tests, which shows that the active combination of the cosmetic is reasonably selected, and the compositions with different concentrations can be in a stable state in a matrix system.
Claims (10)
1. The soothing composition is characterized by comprising the following components in parts by weight: 0.5-10 parts of peony flower extract, 0.2-5 parts of malachite extract and 0.1-4 parts of tetrahydro-methyl pyrimidine carboxylic acid.
2. A soothing composition according to claim 1 wherein: the peony flower extract is a substance extracted from peony flowers in an ultrasonic extraction mode; the extraction process comprises the following steps: freeze drying, pulverizing, sieving, mixing with 50% ethanol solution at a ratio of material to liquid of 1; the ultrasonic power is 110-118W, and the frequency is 82-90kHz.
3. A soothing composition as claimed in claim 1 wherein the malachite extract is extracted by a method comprising: grinding malachite into powder, adding water, stirring, and oxidizing refractory ore powder by thiobacillus oxydans to obtain leachate; adding chelating agent into the leachate for stabilization, filtering, and sterilizing and filtering to obtain malachite extract.
4. Use of a soothing composition in cosmetics, characterized in that: the soothing composition employs a soothing composition as claimed in any one of claims 1 to 3.
5. A cosmetic characterized by: a soothing composition comprising any one of claims 1 to 3, further comprising a humectant, a thickener, a pH adjuster, and a preservative.
6. The cosmetic according to claim 5, comprising the following components in parts by weight: 0.5 to 25 portions of humectant, 0.05 to 2 portions of thickener, 0 to 2 portions of pH regulator, 0.5 to 2 portions of preservative and soothing composition; the soothing composition comprises 0.5-10 parts of peony flower extract, 0.2-5 parts of malachite extract and 0.1-4 parts of tetrahydro-methyl pyrimidine carboxylic acid.
7. The cosmetic according to claim 5 or 6, characterized in that: the humectant is one or a combination of more than two of glycerol, propylene glycol, dipropylene glycol, polyethylene glycols, methyl glucitol polyether-10, glyceryl polyether-26, 1, 3-butanediol, trehalose, xylitol, betaine, beta-glucan, erythrose, biogum-1, oat beta-glucan, acetyl chitosamine, water-soluble grease, water-soluble silicone oil and sodium hyaluronate.
8. The cosmetic according to claim 5 or 6, characterized in that: the thickening agent is one or the combination of more than two of carbomer, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, xanthan gum, sclerotium rolfsii gum, hydroxyethyl cellulose and sodium polyacrylate.
9. The cosmetic according to claim 5 or 6, characterized in that: the pH regulator is one or the combination of more than two of triethanolamine, aminomethyl propanol, arginine, potassium hydroxide and sodium hydroxide.
10. The cosmetic according to claim 5 or 6, characterized in that: the antiseptic is one or more of p-hydroxyacetophenone, 1, 2-hexanediol, phenoxyethanol and ethylhexyl glycerin.
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