CN115252481B - Repairing and whitening essential oil composition and preparation method thereof - Google Patents
Repairing and whitening essential oil composition and preparation method thereof Download PDFInfo
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- CN115252481B CN115252481B CN202210979033.XA CN202210979033A CN115252481B CN 115252481 B CN115252481 B CN 115252481B CN 202210979033 A CN202210979033 A CN 202210979033A CN 115252481 B CN115252481 B CN 115252481B
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- 239000000341 volatile oil Substances 0.000 title claims abstract description 114
- 239000000203 mixture Substances 0.000 title claims abstract description 54
- 230000002087 whitening effect Effects 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 235000009024 Ceanothus sanguineus Nutrition 0.000 claims abstract description 13
- 235000005979 Citrus limon Nutrition 0.000 claims abstract description 13
- 244000131522 Citrus pyriformis Species 0.000 claims abstract description 13
- 244000178870 Lavandula angustifolia Species 0.000 claims abstract description 13
- 235000010663 Lavandula angustifolia Nutrition 0.000 claims abstract description 13
- 240000003553 Leptospermum scoparium Species 0.000 claims abstract description 13
- 235000015459 Lycium barbarum Nutrition 0.000 claims abstract description 13
- 239000001102 lavandula vera Substances 0.000 claims abstract description 13
- 235000018219 lavender Nutrition 0.000 claims abstract description 13
- 235000007866 Chamaemelum nobile Nutrition 0.000 claims abstract description 8
- 244000042664 Matricaria chamomilla Species 0.000 claims abstract description 8
- 235000007232 Matricaria chamomilla Nutrition 0.000 claims abstract description 8
- 239000001224 daucus carota l. seed absolute Substances 0.000 claims abstract description 8
- 239000002537 cosmetic Substances 0.000 claims description 16
- 239000003921 oil Substances 0.000 claims description 10
- 235000019198 oils Nutrition 0.000 claims description 9
- 240000004277 Pelargonium radens Species 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 3
- 239000002569 water oil cream Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 21
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 abstract description 14
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- 239000006071 cream Substances 0.000 description 5
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- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 2
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- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 206010033733 Papule Diseases 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
- 229930003427 Vitamin E Natural products 0.000 description 2
- 230000006838 adverse reaction Effects 0.000 description 2
- 239000008168 almond oil Substances 0.000 description 2
- 229940082500 cetostearyl alcohol Drugs 0.000 description 2
- 239000003240 coconut oil Substances 0.000 description 2
- 235000019864 coconut oil Nutrition 0.000 description 2
- 230000035618 desquamation Effects 0.000 description 2
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- 239000012153 distilled water Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 230000001804 emulsifying effect Effects 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- 239000008169 grapeseed oil Substances 0.000 description 2
- 235000010445 lecithin Nutrition 0.000 description 2
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- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
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- 239000000049 pigment Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 229940092258 rosemary extract Drugs 0.000 description 2
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- 239000001233 rosmarinus officinalis l. extract Substances 0.000 description 2
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- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
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- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 235000019165 vitamin E Nutrition 0.000 description 2
- 239000011709 vitamin E Substances 0.000 description 2
- 229940046009 vitamin E Drugs 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- VCUFZILGIRCDQQ-KRWDZBQOSA-N N-[[(5S)-2-oxo-3-(2-oxo-3H-1,3-benzoxazol-6-yl)-1,3-oxazolidin-5-yl]methyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical group O=C1O[C@H](CN1C1=CC2=C(NC(O2)=O)C=C1)CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F VCUFZILGIRCDQQ-KRWDZBQOSA-N 0.000 description 1
- 208000012641 Pigmentation disease Diseases 0.000 description 1
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- 229940125810 compound 20 Drugs 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 239000008387 emulsifying waxe Substances 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- JAXFJECJQZDFJS-XHEPKHHKSA-N gtpl8555 Chemical compound OC(=O)C[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](B1O[C@@]2(C)[C@H]3C[C@H](C3(C)C)C[C@H]2O1)CCC1=CC=C(F)C=C1 JAXFJECJQZDFJS-XHEPKHHKSA-N 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- -1 jojoba oil Substances 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
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- 230000002829 reductive effect Effects 0.000 description 1
- 239000010667 rosehip oil Substances 0.000 description 1
- 239000002884 skin cream Substances 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention relates to a repairing and whitening essential oil formula composition and a preparation method thereof. The invention relates to a compound essential oil composition with whitening and after-sun restoration effects, which comprises the following components in percentage by weight: 30-38% of lavender essential oil, 16-23% of lemon essential oil, 14-22% of tea tree essential oil, 10-16% of geranium essential oil, 5-13% of romaine chamomile essential oil and 4-8% of carrot seed oil. The essential oil composition provided by the invention has an unexpected effect on inhibiting various cell melanin increases caused by sunburn, skin damage and inflammation, and has remarkable effects on whitening and after-sun repair.
Description
Technical Field
The invention belongs to the field of skin care products, and particularly relates to an essential oil composition with after-sun restoration and whitening effects.
Background
The plant essential oil is volatile aromatic substance prepared from flower, stem, leaf, fruit, skin, etc. of plant by specific water distillation and squeezing. Plant essential oils contain complex structures of compounds (tens to hundreds), and the effects produced by the combination of different essential oil compounds may vary widely.
Whitening is an important requirement in the field of skin care products in China. Many essential oils are being attempted to be used in whitening skin care products, including some single and compound essential oil combinations. Because of the uncertainty of the efficacy of the combination of the essential oils, many attempts of the essential oils, whether single or compound, fail to achieve the expected whitening effect. For example, CN105686981a relates to a whitening and acne-removing essential oil, which is declared to have remarkable whitening and acne-removing effects. But it was verified by the present inventors that it did not achieve the expected significant effect.
Disclosure of Invention
According to the invention, a large amount of essential oil components are widely researched, and a specific essential oil composition is finally obtained, so that the effect of the specific essential oil composition has unexpected effects on inhibiting various cell melanin increases caused by sunburn, skin damage and inflammation, and has remarkable effects on whitening and after-sun repair.
It is verified that this effect results from the synergistic effect of specific essential oil compositions in precise proportions.
The invention relates to a compound essential oil composition with whitening or after-sun restoration, which comprises the following components in parts by weight:
lavender essential oil: 30-38%
Lemon essential oil: 16-23%
Tea tree essential oil: 14-22%
Pelargonium roseum essential oil: 10-16%
Romaine chamomile essential oil: 5-13%
Carrot seed oil: 4-8%.
Preferably, the essential oil composition consists of the six components described above.
Preferably, the essential oil composition comprises the following components in parts by weight:
lavender essential oil: 34-36%
Lemon essential oil: 19-21%
Tea tree essential oil: 17-19%
Pelargonium roseum essential oil: 12-14%
Romaine chamomile essential oil: 8-10%
Carrot seed oil: 5-7%.
Preferably, the essential oil composition consists of the six components described above.
More preferably, the essential oil composition comprises the following components in parts by weight:
lavender essential oil 34.5%
Lemon essential oil: 19.5%
Tea tree essential oil: 18%
Pelargonium roseum essential oil: 13%
Romaine chamomile essential oil: 9%
Carrot seed oil: 6%.
Preferably, the essential oil composition consists of the six components described above.
The preparation method of the essential oil composition comprises the following steps: the essential oil components are added in portions or simultaneously in a vessel and mixed or stirred (e.g., 10-30 minutes, e.g., 20 minutes) at room temperature until uniform to obtain the essential oil composition of the present invention.
The essential oil composition can be directly or indirectly added into a cosmetically acceptable carrier according to a certain content, can reduce pigmentation caused by inflammation and the like, has obvious whitening effect and obvious after-sun repair effect. The content is preferably from more than 0% to 30% by weight or less, more preferably from 1% to 20% by weight, still more preferably from 2 to 6% by weight. In one embodiment of the invention, the content is 2.5wt%. In one embodiment of the invention, the content is 5wt%. In another embodiment of the invention, the content is 10wt%. In another embodiment of the invention, the content is 20wt%.
The cosmetically acceptable carriers are classified by type: water-oil emulsion (cream), pure oil (essential oil), and the like.
Common water-oil emulsion type carriers for cosmetics include: oily cosmetic water, skin caring cream, skin caring lotion, facial cleanser, hair washing cream, cleaning cream, etc.
Common pure oil carriers include: massage oil, skin-moistening oil, cleansing oil, etc.
A preparation method of the cosmetic composition comprises the following steps: the cosmetically acceptable carrier components are mixed and dissolved in one or more containers, either batchwise or simultaneously, and the essential oil composition of the present invention is added to the obtained carrier in the amounts indicated above.
For example, the following table illustrates a cosmetic composition of the present invention, wherein an exemplary neat oil (emollient oil) cosmetic carrier of the present invention comprises the following components 1-7:
the preparation steps of the exemplary cosmetic compositions of the present invention shown in the above table are:
sequentially adding the components 1, 2, 3, 4 and 5 into a container, and continuously and uniformly stirring at room temperature; and (3) adding the components 6, 7 and 8 sequentially or simultaneously after the components are completely and uniformly mixed, stirring for about 20 minutes or uniformly, discharging and filling. For example, the following table illustrates a cosmetic composition of the present invention, wherein an exemplary water-oil emulsified (skin cream) cosmetic carrier of the present invention comprises the following components 1-14:
for example, the preparation steps of the exemplary cosmetic compositions of the present invention shown in the above tables are:
dissolving the components 1, 2, 3, 4, 11 and 12 in water, stirring in a container until the components are uniformly mixed, and heating to 80 ℃; mixing the components 5, 6, 7, 8, 9 and 10 in another container, heating to 80 ℃ to melt to uniform liquid; mixing and homogenizing the two solutions for 3-5 min, fully emulsifying uniformly, continuously stirring and cooling to below 40 ℃; and sequentially adding 13, 14 and 15, stirring, uniformly mixing, cooling to room temperature, and filling.
The percentages stated in this application are percentages by weight unless otherwise indicated.
The following examples further describe and demonstrate exemplary embodiments within the scope of the present invention. These examples are for illustration only and should not be construed as limiting the invention since many variations thereof are possible without departing from the spirit and scope thereof. Various modifications of the invention, in addition to those shown and described herein, will be apparent to those skilled in the art and are intended to fall within the scope of the appended claims.
Drawings
Figure 1 shows effect data of an embodiment of the invention.
Description of the embodiments
The essential oil raw materials meet the requirements of the catalogue of used cosmetic raw materials (2021 edition) and meet the technical specifications of safety of the cosmetic raw materials.
Example 1:
the invention relates to a repairing and whitening essential oil composition which comprises the following components in percentage by weight:
lavender essential oil 34.5%
Lemon essential oil: 19.5%
Tea tree essential oil: 18%
Pelargonium roseum essential oil: 13%
Romaine chamomile essential oil: 9%
Carrot seed oil: 6%
The preparation method comprises the following steps: the essential oil component is added in batches into a container and stirred for 20 minutes or even at room temperature to obtain the essential oil composition of the invention.
Example 2:
a whitening essential oil cosmetic containing the essential oil composition of the invention. The weight percentage of the components is as follows:
essential oil composition of example 1 10%
Coconut oil 48.5%
Jojoba oil 22%
Sweet almond oil 13%
Rose fruit oil 5%
Cactus seed oil 1%
Rosemary extract 0.25%;
vitamin E0.25%
The preparation method comprises the following steps:
sequentially adding coconut oil, jojoba oil, sweet almond oil, rose-hip oil and cactus seed oil into a container, and continuously and uniformly stirring at room temperature; after the components are completely mixed, finally, the rosemary extract, the vitamin E and the essential oil composition of the example 1 are added, stirred for 20 minutes or until the components are uniform, discharged and filled.
Performance experiment 1:
the test researches the whitening and freckle removing effects of the product on the skin of a subject.
30 volunteers (subjects) were randomly selected to try out the essential oil component of the present invention.
The standard of the subject is 30-60 years old male or female, the test part is an arm or a face, the test part has obvious color sinking and color spots, and the subject does not use the whitening product within 1 month.
The using method comprises the following steps: the product of example 2 was applied to the test site in an appropriate amount, and the product was continuously used for 8 weeks in the morning and evening, and discomfort and adverse reaction were recorded.
The standard skin color card is adopted to evaluate the skin color before and after the test and the control (namely, the test has obvious color sinking or color spots near the test but is not smeared with the product of the invention), and the color change before and after the score comparison test is recorded. The skin color cards are classified into 1-10 grades according to chromaticity, and the lower the score is, the whiter the skin is.
Results: no discomfort or adverse reaction occurred at all test sites of the subjects. Before use, the maximum value of the color card in 30 subjects is 10, the minimum value is 4, and the average value is 7; after 8 weeks of continuous use of the product of example 2, the subjects had a maximum of 7, a minimum of 2 and an average of 4. The test sites of 30 subjects were improved in color spots and color deposition to different extents, and the effective rate was 100%. The chromaticity variation was counted with a maximum variation of 67%, a minimum of 22% and an average drop of about 46%. After 8 weeks in comparison with the 30 subject control sites, 29 were unchanged from the initial value control, only 1 was slightly changed, and the color chip value was decreased by 1.
Example 3
A whitening and repairing cream cosmetic containing the essential oil composition. The weight percentage of the components is as follows:
essential oil composition of example 1 5%
Rose hydrosol 63.4%
Glycerol 5%
Propylene glycol 3%
0.2% of carbomer
Olive oil emulsified wax 5.5%
Cetostearyl alcohol 2.5%
Lecithin 1%
Grape seed oil 8%
Jojoba oil 5%
Vitamin E0.5%
Phenoxyethanol 0.4%
Triethanolamine 0.2%
Essence and pigment 0.2%
EDTA disodium 0.1%
The preparation method comprises the following steps:
dissolving rose hydrosol, glycerol, propylene glycol, carbopol, phenoxyethanol and disodium EDTA in water in a container 1, continuously stirring until the mixture is uniformly mixed, and heating to 80 ℃; adding olive oil emulsifying wax, cetostearyl alcohol, lecithin, jojoba oil, grape seed oil, and vitamin E into container 2, heating to 80deg.C, and completely thawing. Pouring the materials in the container 2 into the container 1, mixing and homogenizing for 3 minutes, fully emulsifying and dispersing the two phases, continuously stirring and cooling to 40 ℃, sequentially adding triethanolamine, essence pigment and the essential oil composition of the embodiment 1, discharging and filling after the materials are completely cooled to room temperature.
Performance experiment 2:
the test researches the post-sun erythema repairing condition of the product of the invention on a subject.
20 volunteers (subjects) were randomly selected to try out the product of example 3. The standard of the subject is 18-60 years old male or female, the subject has sunburn within one week, the test part is neck, back or arm with obvious sunburn skin, the sunburn part has obvious erythema compared with the surrounding skin, and skin damage symptoms such as desquamation and the like do not appear.
The experimental method comprises the following steps: the product of example 3 was applied to a portion of erythema, and applied once in the morning and evening for 7 days continuously, and compared with the skin of the erythema nearby without the product of the invention.
Several aspects of erythema regression, reduced dryness, desquamation were observed and scored by an experienced panel. Score definition: severe sunburn 5 min, severe sunburn 4 min, moderate sunburn 3 min, mild sunburn 2 min, mild sunburn 1 min, and normal skin 0 min.
Experimental results: the product of example 3 according to the invention was applied to a portion of sunburned skin and after 7 days the average score of the experimental group was 1.6 points compared to the score of the control group, which was 4.6 points. Sunburn relief was shown to be a reduction of 14.3% in erythema and papules from the next day after application, and 65.2% in erythema and papules after 7 consecutive days. The number of subjects with severe sunburn and significant peeling in the control area was 11 (usually the population with severe sunburn generally started peeling 2-3 days after sunburn and stopped peeling after 10-15 days). After the 11 persons continuously apply the product for 7 days, 7 persons tested the area without peeling, 3 persons tested the area with only slight peeling, and only 1 person did not change significantly compared with the control skin around which the product of the invention was not applied.
The results show that: the product of the embodiment 3 of the invention is smeared after sun-drying, can obviously reduce the degree of skin erythema and pimple after sun-drying, has obvious effect of relieving peeling phenomenon, and has the effect obviously exceeding the self-healing degree of skin.
Comparison experiment:
in this example, the compositions of lavender essential oil, lemon essential oil, tea tree essential oil, geranium essential oil and these four essential oils according to the formulation disclosed in CN105686981a according to the present invention were used to test melanin inhibiting effects in comparison with the essential oil composition of example 1 (5%, 20% concentration) according to the present invention. The above essential oils were used in an amount of 20% by weight, and after dilution treatment with the cosmetic carrier exemplified in example 3, the test materials were as follows:
1. lavender essential oil 20%
2. Lemon essential oil 20%
3. Tea tree essential oil 20%
4. Geranium essential oil 20%
5. Lavender essential oil, lemon essential oil, tea tree essential oil and geranium essential oil compound 20% (CN 105686981A, weight ratio of the above four components is 25:5:2:3)
6. Essential oil composition of example 1 of the present invention 5%
7. 20% of essential oil composition of example 1 of the present invention
The experimental method adopts an in vitro whitening experiment, namely a tyrosinase activity inhibition experiment. Tyrosinase plays a key role in the biosynthesis of skin melanin, and the amount of melanin produced is directly related to tyrosinase activity. Therefore, the intensity of the inhibition effect on tyrosinase can be used as a main index of melanin inhibition rate.
The experimental steps are as follows:
buffer solution configuration: 7.8g of sodium dihydrogen phosphate and 17.91g of disodium hydrogen phosphate are weighed, distilled water is used for constant volume to 500ml respectively, a proper amount of PBS buffer solution with pH value of 6.8 and 0.1mol/L is mixed and prepared,
preparing a tyrosine solution: 0.05g g L-Aminocystic acid was dissolved in 35ml of a 0.1mol/L hydrochloric acid solution, and 65ml of the buffer solution was added to obtain a 0.05% tyrosine solution.
Preparing tyrosinase solution: dissolving tyrosinase with enzyme activity of 25000U in 250ml distilled water to obtain 100U/ml
The tyrosinase solution was dispensed into test tubes.
Tyrosinase activity assay: the above test sample (1 g) was added to a tyrosine solution, water-bath was conducted at 37℃for 10 minutes, tyrosinase was added to each test substance separately, and the reaction was stopped by shaking thoroughly and accurately for 15 minutes, and the absorbance at 475nm was measured by an enzyme-labeled instrument. And the inhibition ratio was calculated.
The experiment uses PBS buffer solution to replace the test sample to carry out the same operation steps, and the result is that: tyrosinase inhibition rates of the above 7 experimental groups were respectively: 1.4% of lavender, 4.7% of lemon, 8.2% of tea tree, 11.3% of geranium, and 23.5% of lavender, lemon, tea tree and geranium compound; whereas the inhibition at 5% concentration of the composition of the present invention was 78.2%, the inhibition at 20% concentration was 92.1%.
Conclusion: the essential oil composition has a synergistic effect on melanin inhibition, and the effect of the essential oil composition is obviously superior to that of the essential oil composition in the prior art.
Claims (9)
1. The essential oil composition for whitening or after-sun repair comprises the following six components in percentage by weight:
lavender essential oil: 30-38%
Lemon essential oil: 16-23%
Tea tree essential oil: 14-22%
Pelargonium roseum essential oil: 10-16%
Romaine chamomile essential oil: 5-13%
Carrot seed oil: 4-8%.
2. The essential oil composition of claim 1, wherein the essential oil composition consists of the following six components in weight percent:
lavender essential oil: 34-36%
Lemon essential oil: 19-21%
Tea tree essential oil: 17-19%
Pelargonium roseum essential oil: 12-14%
Romaine chamomile essential oil: 8-10%
Carrot seed oil: 5-7%.
3. The essential oil composition of claim 1, wherein the essential oil composition consists of the following six components in weight percent:
lavender essential oil 34.5%
Lemon essential oil: 19.5%
Tea tree essential oil: 18%
Pelargonium roseum essential oil: 13%
Romaine chamomile essential oil: 9%
Carrot seed oil: 6%.
4. A cosmetic for whitening or after-sun repair comprising the essential oil composition of any one of claims 1 to 3, and a cosmetically acceptable carrier thereof, wherein the essential oil composition is present in an amount of greater than 0% to less than or equal to 30% by weight.
5. The cosmetic according to claim 4, wherein the essential oil composition is contained in an amount of 1 to 20wt%.
6. The cosmetic according to claim 4, wherein the essential oil composition is contained in an amount of 2 to 6wt%.
7. The cosmetic of claim 4, wherein the cosmetically acceptable carrier is a water-oil emulsion or a pure oil.
8. A process for the preparation of an essential oil composition, wherein the components of the essential oil composition of any of claims 1-3 are added in a vessel in batches or simultaneously, mixed or stirred to homogeneity at room temperature.
9. A process for the preparation of cosmetics, wherein the cosmetically acceptable carrier components are mixed and dissolved in one or more containers in batches or simultaneously and the essential oil composition according to any of claims 1 to 3 is added to the obtained carrier in an amount of more than 0% to less than or equal to 30% by weight.
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| CN103385813A (en) * | 2012-05-11 | 2013-11-13 | 苏州纳特苏生物科技有限公司 | Compound essential oil for cleaning, refreshing and back beautifying |
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