CN115252446A - Composite cooling agent and application thereof in preparation of oral cleaning products - Google Patents
Composite cooling agent and application thereof in preparation of oral cleaning products Download PDFInfo
- Publication number
- CN115252446A CN115252446A CN202210950782.XA CN202210950782A CN115252446A CN 115252446 A CN115252446 A CN 115252446A CN 202210950782 A CN202210950782 A CN 202210950782A CN 115252446 A CN115252446 A CN 115252446A
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- parts
- cooling agent
- composite cooling
- oral cleaning
- cooling
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002826 coolant Substances 0.000 title claims abstract description 51
- 239000002131 composite material Substances 0.000 title claims abstract description 35
- 238000004140 cleaning Methods 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims abstract description 28
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 22
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 21
- 229940041616 menthol Drugs 0.000 claims abstract description 21
- 239000002994 raw material Substances 0.000 claims abstract description 18
- NFLGAXVYCFJBMK-RKDXNWHRSA-N (+)-isomenthone Natural products CC(C)[C@H]1CC[C@@H](C)CC1=O NFLGAXVYCFJBMK-RKDXNWHRSA-N 0.000 claims abstract description 17
- NFLGAXVYCFJBMK-UHFFFAOYSA-N Menthone Chemical compound CC(C)C1CCC(C)CC1=O NFLGAXVYCFJBMK-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229930007503 menthone Natural products 0.000 claims abstract description 17
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims abstract description 11
- 229940034610 toothpaste Drugs 0.000 claims abstract description 9
- 239000000606 toothpaste Substances 0.000 claims abstract description 9
- 239000002324 mouth wash Substances 0.000 claims abstract description 4
- 229940051866 mouthwash Drugs 0.000 claims abstract description 4
- 239000000843 powder Substances 0.000 claims abstract description 4
- -1 mouth cleaner Substances 0.000 claims description 4
- 239000007921 spray Substances 0.000 claims description 2
- 238000001816 cooling Methods 0.000 abstract description 22
- 230000000694 effects Effects 0.000 abstract description 11
- 210000000214 mouth Anatomy 0.000 abstract description 10
- 229940041678 oral spray Drugs 0.000 abstract description 2
- 239000000668 oral spray Substances 0.000 abstract description 2
- 239000006072 paste Substances 0.000 abstract description 2
- 239000012459 cleaning agent Substances 0.000 abstract 1
- 230000001680 brushing effect Effects 0.000 description 7
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 6
- VUNOFAIHSALQQH-UHFFFAOYSA-N Ethyl menthane carboxamide Chemical compound CCNC(=O)C1CC(C)CCC1C(C)C VUNOFAIHSALQQH-UHFFFAOYSA-N 0.000 description 6
- 239000003205 fragrance Substances 0.000 description 6
- 230000035597 cooling sensation Effects 0.000 description 5
- 230000035807 sensation Effects 0.000 description 5
- 235000019615 sensations Nutrition 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 231100000862 numbness Toxicity 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 235000006679 Mentha X verticillata Nutrition 0.000 description 2
- 235000002899 Mentha suaveolens Nutrition 0.000 description 2
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 2
- UJNOLBSYLSYIBM-WISYIIOYSA-N [(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexyl] (2r)-2-hydroxypropanoate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)[C@@H](C)O UJNOLBSYLSYIBM-WISYIIOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 235000019445 benzyl alcohol Nutrition 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000008368 mint flavor Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- CFJYNSNXFXLKNS-UHFFFAOYSA-N p-menthane Chemical compound CC(C)C1CCC(C)CC1 CFJYNSNXFXLKNS-UHFFFAOYSA-N 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000019504 cigarettes Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention provides a composite cooling agent, which belongs to the technical field of oral cleaning products and comprises 70-80 parts of benzyl alcohol, 5-12 parts of menthol, 6-13 parts of menthone, 31-5 parts of WS-5 and 1-6 parts of N-p-phenylacetonitrile menthyl formamide. The N-p-phenylethanonitrile menthyl formamide is used as a main raw material, and is cooperated with other raw material components, so that the composite cooling agent has the effects of long cooling time, capability of acting on the whole oral cavity and strong numb feeling. Meanwhile, the application also provides the application of the composite cooling agent in the preparation of oral cleaning products, and the composite cooling agent can be specifically used for oral cleaning products such as toothpaste, mouthwash, oral spray, oral cleaning agent, tooth fixing paste, tooth fixing powder and the like.
Description
Technical Field
The invention belongs to the technical field of oral cleaning products, and particularly relates to a composite cooling agent and application thereof in preparation of oral cleaning products.
Background
The cooling agent is a general name of all chemical substances which can generate a cooling effect and have weak medicinal properties, the most common cooling agent is menthol, but with the continuous improvement of the requirements of people on cooling products, the defects and shortcomings of the menthol are gradually exposed, for example, the menthol is easy to volatilize and cannot resist high temperature, and the cooling agent is limited to be used in some foods, cigarettes and the like which need to be subjected to high-temperature treatment; menthol has a short duration of cooling in the skin and mouth of a person and a strong instantaneous effect of cooling, which is unpleasant and bitter, affecting its effectiveness in food and personal care products. Therefore, in order to overcome the above disadvantages, many chemists have modified the structure of menthol and menthone or sought alternatives thereof, such as menthoxy range products, menthol ether products, menthone glycerol ketals, WS range products and other types of cooling agents.
The existing cooling agents such as WS-3, WS-23 and the like have the problems of insufficient cooling feeling, poor cooling feeling explosive power and short cooling time.
Disclosure of Invention
In view of the above, the present invention aims to provide a composite cooling agent and its application in preparing oral cleaning products; the composite cooling agent provided by the application has the advantages of increased cooling degree, long cooling time and capability of acting on the whole oral cavity.
The purpose of the invention is realized by the following technical scheme:
the composite cooling agent comprises the following raw material components in parts by mass: 70-80 parts of benzyl alcohol, 5-12 parts of menthol, 6-13 parts of menthone, 31-5 parts of WS-5 and 1-6 parts of N-p-phenylacetonitrile menthyl formamide.
Preferably, the composite cooling agent comprises the following raw material components in parts by mass: 73-78 parts of benzyl alcohol, 6-10 parts of menthol, 8-10 parts of menthone, 32-4 parts of WS-4 and 2-5 parts of N-p-phenylacetonitrile menthyl formamide.
The application also provides the application of the composite cooling agent in the preparation of oral cleaning products.
Preferably, the mass percentage of the composite cooling agent in the oral cleaning product is 0.1-0.3%.
Preferably, the oral cleaning product comprises toothpaste, mouthwash, oral spray, oral cleanser, tooth paste and tooth powder.
Compared with the prior art, the invention has the following beneficial effects:
the benzyl alcohol added in the invention has certain antiseptic property and the function of perfume components; the menthol and the menthone can give special fragrance of the mint as a cooling agent and can enhance the cooling feeling of the cooling agent; WS-3 can enhance the cool feeling performance and prolong the use effect of the cooling agent; the N-p-phenylacetyl menthane alkyl formamide can coordinate with other raw material components to obtain a compound cooling agent which can obviously prolong the cooling time, can act on the whole oral cavity and can generate strong numb feeling while exerting the refreshing and cooling fragrance of the N-p-phenylacetyl menthane alkyl formamide.
Detailed Description
The invention provides a composite cooling agent which comprises the following raw material components in parts by mass: 70-80 parts of benzyl alcohol, 5-12 parts of menthol, 6-13 parts of menthone, 31-5 parts of WS-5 and 1-6 parts of N-p-phenylacetonitrile menthyl formamide.
In the invention, the composite cooling agent comprises 70-80 parts of benzyl alcohol, preferably 73-78 parts, and more preferably 75-77 parts; the benzyl alcohol has certain antiseptic property, and can be used as perfume component.
In the invention, the composite cooling agent comprises 5-12 parts of menthol, preferably 6-10 parts of menthol, and more preferably 8-9 parts of menthol; the menthol has special fragrance component in herba Menthae, and can increase fragrance and cooling feeling of cooling agent.
In the invention, the composite cooling agent comprises 6-13 parts of menthone, preferably 8-10 parts of menthone, and more preferably 8-9 parts of menthone; the menthone has similar effects with Mentholum, and has functions of enhancing mint fragrance and cooling feeling of cooling agent.
In the invention, the composite cooling agent comprises WS-31-5 parts, preferably 2-4 parts, and more preferably 3 parts; WS-3 has effects of enhancing cooling effect and prolonging cooling effect of cooling agent.
In the invention, the composite cooling agent comprises 1-6 parts of N-p-phenylethanonitrile menthyl formamide, preferably 2-5 parts, and further preferably 3-4 parts; the N-p-phenylethano-menthyl alkyl formamide is an edible spice, is a main raw material component in the invention, has strong fresh and cool fragrance, and can play the effects of prolonging cool time, acting on the whole oral cavity and generating strong numb feeling by cooperating with other raw material components.
The preparation method of the composite cooling agent comprises the following steps: weighing benzyl alcohol, menthol, menthone, WS-3 and N-p-phenylacetonitrile menthyl formamide with specified mass, mixing the raw materials in proportion, and stirring until the raw materials are completely dissolved to obtain the composite cooling agent.
The application also provides application of the composite cooling agent in preparing oral cleaning products. In the present invention, the oral cleaning products include toothpaste, mouthwash, mouth spray, mouth cleaner, tooth fixing paste, and tooth fixing powder. The content of the composite cooling agent in the oral cavity cleaning product is not particularly limited, and different contents are set according to different types of oral cavity cleaning products, and in the specific implementation process, the content is preferably 0.1-0.3%.
The technical solutions provided by the present invention are described in detail below with reference to examples, but they should not be construed as limiting the scope of the present invention.
Example 1
The composite cooling agent comprises the following raw material components: 75% of benzyl alcohol, 9% of menthol, 8% of menthone, 33% of WS and 5% of N-p-phenylacetonitrile menthyl formamide.
The preparation method comprises the following steps: weighing the raw material components according to the mass percentage, and mixing and stirring the raw material components until the raw material components are completely dissolved to obtain the composite cooling agent.
Example 2
The composite cooling agent comprises the following raw material components: 77% of benzyl alcohol, 8% of menthol, 8% of menthone, WS-33% and 4% of N-p-phenylacetonitrile menthyl formamide; the preparation method is the same as that of example 1.
Comparative example 1
The composite cooling agent comprises the following raw material components: 79% of benzyl alcohol, 6% of menthol, 11% of menthone and 34% of WS, and the preparation method is the same as that of example 1.
Test example 1
The composite cooling agents prepared in example 1 and comparative example 1 were used in the sensory test of cooling agents, specifically, they were mixed with the same mint flavor, respectively, to prepare two products, i.e., 1.2% mint flavor +0.1% toothpaste base material of example 1+98.7% to prepare sample a; sample B was prepared with 1.2% peppermint essence +0.1% toothpaste base material comparative example 1+ 98.7%. Then the overall mouthfeel was evaluated by brushing to obtain overall evaluation results as follows:
(1) The cool strength was scored and the average of 100 samples was taken for 100 total points and the results are shown in table 1.
Table 1: comparison of tooth brushing Cool feeling intensity of different samples
| While brushing teeth | Cool and refreshing | Fresh and clean | Numbness sensation |
| Sample A | 80 | 75 | 90 |
| Sample B | 75 | 70 | 70 |
(2) The duration of the cooling sensation was measured and the average of 100 samples was taken and the results are shown in table 2.
Table 2: comparison of duration of tooth-brushing coolness for different samples
| Number of | Cooling time/min |
| Sample A | 40 |
| Sample B | 15 |
The N-p-phenylethano-menthyl alkyl formamide is added into the cooling agent, so that the cooling agent has longer cooling time and stronger using effects of cooling, refreshing and numbing.
Test example 2
The composite cooling agent prepared in example 1 of the present invention was compared with existing cooling agents WS-3, WS-23 and menthyl lactate.
The specific method comprises the following steps: selecting a traditional formula of toothpaste essence, and adding the composite cooling agent, WS-3, WS-23 and menthyl lactate prepared in the embodiment 1 of the invention on the basis of the traditional formula to prepare a sample 1, a sample 2, a sample 3 and a sample 4 respectively; the amounts of the components added are shown in Table 3.
Table 3: the addition amount of each component
Selecting 100 experiencers, and evaluating the overall mouthfeel of the samples 1-4 by tooth brushing to obtain an overall evaluation result, wherein the result is as follows:
(1) The average results of 100 samples for cooling time and oral effect point are shown in table 4.
Table 4: cool feeling time and oral action point comparison
(2) The cool strength was scored and the average of 100 samples was taken for 100 total points and the results are shown in table 5.
Table 5: comparison of Cool feeling
| While brushing teeth | Cooling and refreshing | Fresh and clean | Numbness sensation |
| Sample No. 1 | 75 | 70 | 70 |
| Sample 2 | 85 | 70 | 75 |
| Sample 3 | 80 | 80 | 70 |
| Sample 4 | 95 | 90 | 90 |
| Brushing for 5min | Cool and refreshing | Fresh and clean | Numbness sensation |
| Sample No. 1 | 50 | 55 | 50 |
| Sample 2 | 40 | 50 | 25 |
| Sample 3 | 50 | 60 | 50 |
| Sample 4 | 80 | 90 | 80 |
From the above examples, it can be seen that the addition of the composite cooling agent of the present invention can significantly prolong the stability time of the cooling sensation, expand the action site of the cooling sensation to act on the entire oral cavity, and produce stronger cooling sensation, refreshing sensation and numbing sensation, so that the consumer can experience a continuous cooling sensation after brushing the teeth.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and amendments can be made without departing from the principle of the present invention, and these modifications and amendments should also be considered as the protection scope of the present invention.
Claims (5)
1. The composite cooling agent is characterized by comprising the following raw material components in parts by mass: 70-80 parts of benzyl alcohol, 5-12 parts of menthol, 6-13 parts of menthone, 31-5 parts of WS-and 1-6 parts of N-p-phenylacetonitrile menthyl formamide.
2. The composite cooling agent according to claim 1, characterized by comprising the following raw material components in parts by mass: 73-78 parts of benzyl alcohol, 6-10 parts of menthol, 8-10 parts of menthone, 32-4 parts of WS-4 and 2-5 parts of N-p-phenylacetonitrile menthyl formamide.
3. Use of the composite cooling agent of claim 1 or 2 in the preparation of an oral cleaning product.
4. The use according to claim 3, wherein the composite cooling agent is present in the oral cleaning product in an amount of 0.1 to 0.3% by weight.
5. The use of claim 3 or 4, wherein the oral cleaning product comprises toothpaste, mouthwash, mouth spray, mouth cleaner, tooth paste and tooth powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210950782.XA CN115252446A (en) | 2022-08-09 | 2022-08-09 | Composite cooling agent and application thereof in preparation of oral cleaning products |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210950782.XA CN115252446A (en) | 2022-08-09 | 2022-08-09 | Composite cooling agent and application thereof in preparation of oral cleaning products |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115252446A true CN115252446A (en) | 2022-11-01 |
Family
ID=83751163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210950782.XA Pending CN115252446A (en) | 2022-08-09 | 2022-08-09 | Composite cooling agent and application thereof in preparation of oral cleaning products |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115252446A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20140102138A (en) * | 2013-02-13 | 2014-08-21 | 주식회사 엘지생활건강 | Composition of Flavor In Oral Care Products |
| CN105230940A (en) * | 2015-10-20 | 2016-01-13 | 贵州中烟工业有限责任公司 | Functional hard candy and preparation method thereof |
| CN106281680A (en) * | 2016-08-27 | 2017-01-04 | 山东中烟工业有限责任公司 | A kind of quick-fried pearl of Herba Menthae cigarette cool taste Mint Essence and preparation method and application |
| CN112315833A (en) * | 2020-11-24 | 2021-02-05 | 广州途富香料科技有限公司 | Composite strong cooling agent applied to toothpaste essence |
| CN113662874A (en) * | 2021-08-12 | 2021-11-19 | 广州途富香料科技有限公司 | Application of composite cooling agent in oral product |
-
2022
- 2022-08-09 CN CN202210950782.XA patent/CN115252446A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20140102138A (en) * | 2013-02-13 | 2014-08-21 | 주식회사 엘지생활건강 | Composition of Flavor In Oral Care Products |
| CN105230940A (en) * | 2015-10-20 | 2016-01-13 | 贵州中烟工业有限责任公司 | Functional hard candy and preparation method thereof |
| CN106281680A (en) * | 2016-08-27 | 2017-01-04 | 山东中烟工业有限责任公司 | A kind of quick-fried pearl of Herba Menthae cigarette cool taste Mint Essence and preparation method and application |
| CN112315833A (en) * | 2020-11-24 | 2021-02-05 | 广州途富香料科技有限公司 | Composite strong cooling agent applied to toothpaste essence |
| CN113662874A (en) * | 2021-08-12 | 2021-11-19 | 广州途富香料科技有限公司 | Application of composite cooling agent in oral product |
Non-Patent Citations (1)
| Title |
|---|
| 中华人民共和国卫生部: "卫生部发布2013年第2号公告", 国内外香化信息, no. 04, pages 19 * |
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