CN115211849A - Microwave S21 unwrapping phase nondestructive testing method for blood glucose concentration of wrist - Google Patents
Microwave S21 unwrapping phase nondestructive testing method for blood glucose concentration of wrist Download PDFInfo
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- CN115211849A CN115211849A CN202110403364.4A CN202110403364A CN115211849A CN 115211849 A CN115211849 A CN 115211849A CN 202110403364 A CN202110403364 A CN 202110403364A CN 115211849 A CN115211849 A CN 115211849A
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- blood glucose
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- microwave
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- 239000008280 blood Substances 0.000 title claims abstract description 50
- 210000004369 blood Anatomy 0.000 title claims abstract description 50
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims abstract description 41
- 239000008103 glucose Substances 0.000 title claims abstract description 41
- 210000000707 wrist Anatomy 0.000 title claims abstract description 16
- 238000000034 method Methods 0.000 title claims abstract description 11
- 238000009659 non-destructive testing Methods 0.000 title description 3
- 238000002474 experimental method Methods 0.000 claims abstract description 8
- 238000001514 detection method Methods 0.000 claims description 7
- 238000010586 diagram Methods 0.000 claims description 6
- 238000010998 test method Methods 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 230000036962 time dependent Effects 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 2
- 230000003321 amplification Effects 0.000 description 1
- 238000010241 blood sampling Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000016097 disease of metabolism Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- 238000007446 glucose tolerance test Methods 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
- A61B5/7264—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems
Abstract
The invention relates to a method for nondestructively detecting blood glucose concentration by unwrapping phase of microwave S21 parameter of wrist. Firstly, fixing a pair of ultra-wideband patch antennas at the wrist part of a human body; connecting the antenna with a vector network analyzer, calibrating and transmitting an ultra-wideband signal; carrying out an oral glucose tolerance experiment on a subject, and storing the phase of the S21 parameter detected in the experiment and the blood glucose value measured by a household glucometer; reading the phases of S21 parameters of the human blood glucose at different times detected by the vector network analyzer, and performing unwrapping processing; and selecting a frequency point to observe the change relation of the unwrapped phase of the S21 parameter along with time, comparing the change relation with the change value of the blood sugar measured by a commercial glucometer along with time, and if the change trends of the two are consistent, proving that the change of the blood sugar of the human body can be detected by the change of the unwrapped phase of the S21 parameter.
Description
Technical Field
The invention belongs to the technical field of microwave nondestructive testing, and relates to a blood glucose concentration testing method.
Background
Diabetes mellitus is a lifelong metabolic disease characterized by chronic increase of blood glucose level, and the long course of the disease easily causes functional deterioration or pathological changes of tissues and organs such as eyes, kidneys, nerves, hearts, blood vessels and the like. The blood glucose level is clinically detected by drawing venous blood, the detection result of the method is the most standard, and in daily life, a diabetic patient can also adopt a household glucometer to take blood from fingertips for blood glucose detection. In order to monitor the blood sugar level of a diabetic patient in real time and reduce the pain and infection risk of blood sampling of the patient, a microwave noninvasive blood sugar detection method based on an ultra-wideband antenna can be adopted. The detection principle is that when the concentration of glucose in human blood changes, the dielectric property of blood also changes, and when electromagnetic waves emitted by an ultra-wideband antenna penetrate blood layers with different dielectric properties, the obtained receiving signals are different.
Disclosure of Invention
The invention provides a method for nondestructively detecting blood glucose concentration of a wrist by using a microwave S21 unwrapping phase. The target tissue detected by the method is the wrist part of a human body, and the blood sugar level of a patient can be estimated by comparing the time-varying relation of the S21 unwrapping phase of the microwave and the time-varying relation of the blood sugar concentration measured by a household blood sugar meter. The technical scheme of the invention is as follows:
a method for estimating blood glucose level of a human body by using microwave S21 unwrapping phase of wrist, comprising the following steps:
(1) Fixing a pair of ultra-wideband patch antennas at the position of the wrist of a human body, transmitting an ultra-wideband signal by using one antenna, and receiving a signal passing through the wrist of the human body by using the other antenna;
(2) Connecting the antenna with a vector network analyzer, calibrating the vector network analyzer, and setting to generate an ultra-wideband signal;
(3) Carrying out an oral glucose tolerance experiment on a subject, storing the phase of an S21 parameter measured by a vector network analyzer at certain intervals in the experiment process, and carrying out invasive blood glucose detection and recording on the subject by using a household glucometer;
(4) Reading phases of S21 parameters of human blood glucose collected from a vector network analyzer at different times, performing unwrapping processing, and drawing a waveform diagram of frequency domain response of the unwrapped phases of S21;
(5) Selecting a frequency point to give a time-dependent change diagram of the S21 parameter unwrapped phase, comparing the time-dependent change diagram with a time-dependent change value of blood glucose measured by a household glucometer to obtain a rule with a consistent change trend, and proving that the change of the S21 parameter unwrapped phase is caused by the change of blood glucose concentration;
drawings
FIG. 1 diagram of a measuring apparatus
FIG. 2 unwrapping phase of S21 parameter at different times
FIG. 3 is an enlarged view of S21 unwrapping phase at different times in 1.2-1.4GHz frequency band
FIG. 41.32GHz S21 parameter unwrapped phase vs. glucose concentration
Detailed Description
The invention is described below with reference to the figures and examples.
(1) When the blood glucose level of a human body changes, the dielectric properties of the blood part also change obviously, for example, when the blood glucose level of the human body rises, the dielectric constant in the blood is reduced. Because blood vessels at the wrist part of a human body are obvious, a pair of ultra-wideband antennas are fixed at the wrist part of the human body, and noninvasive detection of blood sugar of the human body can be realized by observing the change rule of the parameter unwrapping phase of the microwave circuit S21;
(2) Connecting the antenna with a vector network analyzer, as shown in fig. 1, and then calibrating the vector network analyzer and setting to transmit a broadband signal, for example, an ultra-wideband signal with a bandwidth of 100MHz-3 GHz;
(3) Before an oral glucose tolerance experiment, a subject should fast for 10-16 hours and avoid strenuous exercise, the phase of an S21 parameter measured by a vector network analyzer is stored at intervals from an fasting state in the experiment, and meanwhile, a household blood glucose meter is used for measuring and recording the blood glucose concentration of the subject;
(4) And reading the phase of the S21 parameter measured by the vector network analyzer, unwrapping the phase, and drawing a waveform diagram of the frequency domain response of the unwrapped phase of S21, as shown in FIG. 2. For convenience of observation, the S21 unwrapping phases at the beginning of the glucose tolerance test and at the 15 th, 30 th, 45 th, 60 th, 75 th and 90 th minutes are selected, the frequency domain response of the S21 phase in a certain frequency band is amplified, and as shown in fig. 3, data in the range of 1.2GHZ-1.4GHZ is selected for amplification observation;
(5) For searching the relation between the unwrapped phase of the S21 parameter and the blood glucose concentration, a time-varying curve of the unwrapped phase of the S21 parameter at a certain frequency point can be drawn and compared with a time-varying curve of the blood glucose concentration measured by a household blood glucose meter, for example, as shown in FIG. 4, data at 1.32GHz can be selected for observation to obtain a rule that the variation trends of the unwrapped phase of the S21 parameter are consistent with those of the unwrapped phase of the S21 parameter, so that the variation of the blood glucose concentration of a human body can be represented by the unwrapped phase of the S21 parameter of the microwave circuit due to the variation of the blood glucose concentration.
Claims (1)
1. A microwave S21 unwrapping phase nondestructive test method for blood glucose concentration of wrist, the target tissue detected by the method is human wrist part, and the blood glucose level of a patient can be estimated by comparing the time-varying relation of the microwave S21 unwrapping phase with the time-varying relation of the blood glucose concentration measured by a household blood glucose meter, the technical scheme of the invention is as follows:
a method for estimating blood glucose level of a human body by using a microwave S21 unwrapping phase of a wrist, comprising the steps of:
(1) Fixing a pair of ultra-wideband patch antennas at the position of the wrist of a human body, transmitting an ultra-wideband signal by using one antenna, and receiving a signal passing through the wrist of the human body by using the other antenna;
(2) Connecting the antenna with a vector network analyzer, calibrating the vector network analyzer, and setting to generate an ultra-wideband signal;
(3) Carrying out an oral glucose tolerance experiment on a subject, storing the phase of the S21 parameter measured by the vector network analyzer at certain intervals in the experiment process, and carrying out invasive blood glucose detection and recording on the subject by using a household blood glucose meter;
(4) Reading phases of S21 parameters of human blood glucose detected by a self-vector network analyzer at different times, performing unwrapping processing, and drawing a waveform diagram of frequency domain response of the unwrapped phase of S21;
(5) And selecting a frequency point to give a time-varying graph of the S21 parameter unwrapped phase, comparing the time-varying graph with a time-varying value of blood glucose measured by a household blood glucose meter to obtain a rule with a consistent variation trend, and proving that the variation of the S21 parameter unwrapped phase is caused by the variation of blood glucose concentration.
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| CN202110403364.4A CN115211849A (en) | 2021-04-16 | 2021-04-16 | Microwave S21 unwrapping phase nondestructive testing method for blood glucose concentration of wrist |
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| CN202110403364.4A CN115211849A (en) | 2021-04-16 | 2021-04-16 | Microwave S21 unwrapping phase nondestructive testing method for blood glucose concentration of wrist |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016145582A1 (en) * | 2015-03-13 | 2016-09-22 | 香港应用科技研究院有限公司 | Phase deviation calibration method, 3d shape detection method and system, and projection system |
| JP2018057511A (en) * | 2016-10-03 | 2018-04-12 | 浜松ホトニクス株式会社 | Blood glucose level measuring device, blood glucose level calculation method, and blood glucose level calculation program |
| CN109350076A (en) * | 2018-10-19 | 2019-02-19 | 天津大学 | Blood sugar concentration detection method based on ultra-wideband microwave S21 parameter |
| WO2020179664A1 (en) * | 2019-03-01 | 2020-09-10 | 国立大学法人東京大学 | Blood sugar level measurement device, blood sugar level measurement method, and probe |
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2021
- 2021-04-16 CN CN202110403364.4A patent/CN115211849A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016145582A1 (en) * | 2015-03-13 | 2016-09-22 | 香港应用科技研究院有限公司 | Phase deviation calibration method, 3d shape detection method and system, and projection system |
| JP2018057511A (en) * | 2016-10-03 | 2018-04-12 | 浜松ホトニクス株式会社 | Blood glucose level measuring device, blood glucose level calculation method, and blood glucose level calculation program |
| CN109350076A (en) * | 2018-10-19 | 2019-02-19 | 天津大学 | Blood sugar concentration detection method based on ultra-wideband microwave S21 parameter |
| WO2020179664A1 (en) * | 2019-03-01 | 2020-09-10 | 国立大学法人東京大学 | Blood sugar level measurement device, blood sugar level measurement method, and probe |
Non-Patent Citations (1)
| Title |
|---|
| CAMILLE J. CORDERO 等: "《Quantifying Blood Glucose Level Using S11 Parameters》", PROC. OF THE 2017 IEEE REGION 10 CONFERENCE, 5 November 2017 (2017-11-05), pages 1481 - 1486 * |
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