CN115197969A - 一种治疗乙型肝炎的慢病毒载体、慢病毒颗粒及其制备方法和应用 - Google Patents
一种治疗乙型肝炎的慢病毒载体、慢病毒颗粒及其制备方法和应用 Download PDFInfo
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- CN115197969A CN115197969A CN202210359887.8A CN202210359887A CN115197969A CN 115197969 A CN115197969 A CN 115197969A CN 202210359887 A CN202210359887 A CN 202210359887A CN 115197969 A CN115197969 A CN 115197969A
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
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Abstract
Description
基因型 | 血清型 | 基因组(bp) |
A | adw2、adw1 | 3221 |
B | adw2、ayw1 | 3215 |
C | adr、ayr、adw2 | 3215 |
D | ayw2、ayw3 | 3182 |
E | ayw4 | 3212 |
F | adw4、ayw4、adw2 | 3215 |
G | adw2 | 3248 |
H | adw3 | 3215 |
I | adw | 3215 |
J | ayw | 3182 |
编号(雄鼠) | HBsAg(IU/mL) | 编号(雌鼠) | HBsAg(IU/mL) |
184 | 809 | 234 | 691 |
188 | 1666 | 236 | 757 |
189 | 1967 | 237 | 1758 |
196 | 1597 | 240 | 300 |
201 | 2134 | 243 | 884 |
208 | 2169 | 249 | 679 |
214 | 1357 | 254 | 498 |
216 | 2094 | 255 | 905 |
217 | 1235 | 264 | 366 |
220 | 1781 | 269 | 80 |
Claims (10)
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CN2021103742342 | 2021-04-07 | ||
CN202110374234.2A CN114107393A (zh) | 2021-04-07 | 2021-04-07 | 一种治疗乙型肝炎的慢病毒载体、慢病毒颗粒及其制备方法和应用 |
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CN115197969B CN115197969B (zh) | 2023-09-01 |
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CN202210359887.8A Active CN115197969B (zh) | 2021-04-07 | 2022-04-06 | 一种治疗乙型肝炎的慢病毒载体、慢病毒颗粒及其制备方法和应用 |
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EP (1) | EP4319805A1 (zh) |
JP (1) | JP2024516115A (zh) |
KR (1) | KR20240004429A (zh) |
CN (2) | CN114107393A (zh) |
AU (1) | AU2022255056A1 (zh) |
BR (1) | BR112023020732A2 (zh) |
CA (1) | CA3214383A1 (zh) |
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WO (1) | WO2022214599A1 (zh) |
Citations (5)
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CN101502650A (zh) * | 2009-03-10 | 2009-08-12 | 邢益平 | 密码子优化的乙型肝炎核酸疫苗 |
CN106928372A (zh) * | 2016-12-30 | 2017-07-07 | 北京大学深圳研究生院 | 乙肝重组抗原及其表达基因、构建方法、病毒样颗粒及其制备方法、应用与疫苗 |
CN107058346A (zh) * | 2017-05-03 | 2017-08-18 | 李军涛 | 一种乙肝病毒表面抗原基因与表达载体及细胞株 |
WO2018080889A1 (en) * | 2016-10-31 | 2018-05-03 | Georgia State University Research Foundation, Inc. | A virus like particle of hepatitis b virus pre-s protein |
WO2020178359A1 (en) * | 2019-03-05 | 2020-09-10 | Glaxosmithkline Biologicals Sa | Hepatitis b immunisation regimen and compositions |
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CN1081069C (zh) | 1998-08-14 | 2002-03-20 | 饶纬华 | 乙型肝炎治疗性疫苗及其制备方法 |
US8158413B2 (en) | 2005-10-17 | 2012-04-17 | Institut Pasteur | Lentiviral vector-based vaccine |
US8748373B2 (en) * | 2007-02-21 | 2014-06-10 | Fox Chase Cancer Center | Hepatitis B virus compositions and methods of use |
CN102083462B (zh) | 2007-08-03 | 2015-02-18 | 巴斯德研究院 | 慢病毒基因转移载体及其医学应用 |
EP2666477A1 (en) | 2012-05-23 | 2013-11-27 | Theravectys | Lentiviral vectors containing an MHC class I promoter |
JP6495653B2 (ja) | 2011-09-26 | 2019-04-03 | テラベクティ | レンチウイルスパッケージ化のための非サブタイプbのgagタンパク質の使用 |
EP3276006A1 (en) * | 2016-07-27 | 2018-01-31 | Theravectys | Lentiviral vectors for expression of hepatitis b virus (hbv) antigens |
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2021
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- 2022-04-07 EP EP22716265.8A patent/EP4319805A1/en active Pending
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TW202239963A (zh) | 2022-10-16 |
CA3214383A1 (en) | 2022-10-13 |
AU2022255056A1 (en) | 2023-10-26 |
WO2022214599A1 (en) | 2022-10-13 |
CN115197969B (zh) | 2023-09-01 |
JP2024516115A (ja) | 2024-04-12 |
BR112023020732A2 (pt) | 2024-01-09 |
EP4319805A1 (en) | 2024-02-14 |
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KR20240004429A (ko) | 2024-01-11 |
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