CN1151825C - Health tonic for delaying senility and regualting blood lipoid - Google Patents
Health tonic for delaying senility and regualting blood lipoid Download PDFInfo
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- CN1151825C CN1151825C CNB011301449A CN01130144A CN1151825C CN 1151825 C CN1151825 C CN 1151825C CN B011301449 A CNB011301449 A CN B011301449A CN 01130144 A CN01130144 A CN 01130144A CN 1151825 C CN1151825 C CN 1151825C
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- slow down
- blood lipid
- health product
- health
- down aging
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Abstract
The present invention discloses a health-care product for aging delay and blood fat regulation, which is scientifically prepared from pine needle extract, pine bark extract, beta-cyclodextrin or hydroxypropyl-beta cyclodextrin, ascorbyl palmitate and egg lecithin. The present invention has the advantage of high contents of proanth ocyanidins and total flavonoids, and has the health functions of blood fat regulation and aging delay.
Description
Technical field
The present invention relates to a kind of health product, especially relate to the health product of a kind of slow down aging, blood lipid regulation.
Background technology
Along with improving constantly of people's living standard, it is everyone wish that good health and a long life enjoy life, and people often take some tonic foods and come health invigorating, remain youthful forever.Existing tonic food all is from the refreshing angle of QI invigorating benefit, usually adopt on the batching and make as the Chinese herbal medicine of Radix Ginseng, Nidus collocaliae and Radix Astragali and so on, these tonic play a role to building body, slow down aging, but all do not carry out scientific formula, and raw material such as Radix Ginseng, Nidus collocaliae is famous and precious rare medical material, costs an arm and a leg.
Summary of the invention
The object of the present invention is to provide a kind of is raw material with natural plants Folium Pini, Cortex Pini Massonianae, can slow down aging, the nutrient and healthcare products of blood lipid regulation.
The health product of slow down aging of the present invention, blood lipid regulation comprise the proportioning (weight portion) of following component and each component:
Folium Pini, Cortex Pini Massonianae extract 1-3 part
Cycloheptaamylose or hydroxy propyl-Beta cyclodextrin 0.8-4.5 part
The health product of slow down aging of the present invention, blood lipid regulation preferentially comprise the proportioning (weight portion) of following component and each component:
Folium Pini, Cortex Pini Massonianae extract 1.5-2.5 part
Cycloheptaamylose or hydroxy propyl-Beta cyclodextrin 2-3.5 part
Health product the best of slow down aging of the present invention, blood lipid regulation comprises the proportioning (weight portion) of following component and each component:
2 parts of Folium Pini, Cortex Pini Massonianae extracts
3 parts of cycloheptaamylose or hydroxy propyl-Beta cyclodextrins
The health product of slow down aging of the present invention, blood lipid regulation also comprise the proportioning (weight portion) of following component and each component:
Ascorbyl palmitate 0.0001-0.0015 part
Lecithin 0.001-0.015 part
The dosage form of the health product of slow down aging of the present invention, blood lipid regulation is a capsule.
The present invention is a main component with the extract of natural plants Folium Pini, Cortex Pini Massonianae, record " Folium Pini abnormal smells from the patient hardship, temperature, nontoxic " in the Compendium of Material Medica, " cure mainly the rheumatism skin ulcer, piliation, settling five organs, in keeping, not hungry prolonging life "; " obeying Folium Pini for a long time, make us not old, the QI invigorating of making light of one's life by commiting suicide, not hungry prolonging life ", as seen cure the disease with the pine side of going into from traditional medicine, is food with the pine, can take care of health and be healthy and strong life prolonging.Modern study confirms, contain multiple natural bioactivity substances such as profuse oligomeric proanthocyanidin, flavone in the extract of Folium Pini, Cortex Pini Massonianae, oligomeric proanthocyanidin is one of current the strongest antioxidant, its antioxidant activity is 50 times of vitamin E, ascorbic 20 times, can powerfully remove unnecessary free radical in the body; And the unnecessary free radical that can not remove naturally in the body is deleterious, it causes that the lipid peroxidation product concentration of malondialdehyde increases in the cell, the crosslinked action of malonaldehyde and the chain reaction of free radical, can make protein denaturation, enzyme is an inactivation, make hereditary material DNA infringement and variation, these remain in intravital unnecessary free radical can cause more than 70 kind of disease of health, is the basic reason of human senility.The content of oligomeric proanthocyanidin reaches 45% in the extract of Folium Pini of the present invention, Cortex Pini Massonianae, total flavones reaches 5%, has the health-care effect of blood lipid regulation, slow down aging.
Another main component is cycloheptaamylose or hydroxy propyl-Beta cyclodextrin among the present invention, cyclodextrin is a kind of functional food, owing to do not digested and assimilated at the harmonization of the stomach small intestinal, has antiobesity action, owing in digestive tract, stimulate hormonal system and autonomic nervous system when mobile, thereby reduce the neutral fat content in serum and the liver, suppress to be absorbed, the effect that reduces serum cholesterol is arranged owing to can wrap up cholesterol.Also add emulsifying agent and antioxidants such as lecithin, ascorbyl palmitate in addition, make that the natural bioactivity substance functional component in the extract of Folium Pini, Cortex Pini Massonianae is not suffered a loss, play better blood lipid regulation, delaying senility function.
Detect by Guangdong Province enterprise product standard (Q/SZTS0500-2000) through Guangdong Province health and epidemic prevention station, the health product capsule of slow down aging of the present invention, blood lipid regulation meets following index:
| Project | Index |
| Sense index | Green hard capsule does not have breakage, and smooth content is a light brown powder, mildly bitter flavor, puckery |
| Moisture | ≤9％ |
| Disintegration | ≤ 30 minutes |
| The net content allowed minus deviation | The 30g/ bottle, 9% |
| Oligomeric proanthocyanidin | ≥5％ |
| Total flavones | ≥0.4％ |
| Plumbous (in pb) | ≤1.5mg/kg |
| Arsenic (in As) | ≤1.0mg/kg |
| Hydrargyrum (in Hg) | ≤0.3mg/kg |
| Total plate count | ≤1000cfu/g |
| Coliform | ≤40MPN/100g |
| Mycete | ≤25cfu/g |
| Yeast | ≤25cfu/g |
| Pathogenic bacterium | Do not detect |
By Guangdong Province health and epidemic prevention station the health product capsule of slow down aging of the present invention, blood lipid regulation is reported as follows by " the health food function assessment assessment process and the method for inspection " zoopery:
Respectively give 0.17%, 0.5%, 1.5%, 4.5% of the present invention capsule to Oregon K strain Drosophila melanogaster per os every day, stops to life span of drosophila melanogaster.Respectively give of the present invention capsule 0.05,0.17,0.5g/kg.b.w to the SD rat oral every day, and totally 45 days, the result obtained:
1. each dosage group of 0.17%--4.5% capsule of the present invention, the half death, average life and the maximum life span that are tried fruit bat prolong; 2. each dosage group of 0.05--0.5g/kg.b.w capsule of the present invention, lipid peroxide catabolite malonaldehyde (MDA) content that is tried in the rat blood serum reduces than matched group; 3. 0.05-0.5g/kg.b.w capsule dosage of the present invention group, superoxide dismutase (SOD) vigor that is tried in the rat blood serum improves than matched group.Above-mentioned zoopery result shows that health product capsule of the present invention has delaying senility function.
Give high fat nutrient fodder to SD kind rat every day, give capsule of the present invention 3 times of recommended amounts 0.05g/kg.b.w simultaneously respectively, 10 times of recommended amounts 0.17g/kg.b.w, 30 times of recommended amounts 0.5g/kg.b.w, three dosage prevention animal hyperlipemias, gave capsule of the present invention totally 30 days, the result obtains: 1. serum total cholesterol (TC) level of 0.17g/kg, 0.5g/kg test group reduces, the reduction amplitude is 20.5%, 15.0%, compare with high fat matched group, difference has utmost point significance meaning, significance meaning respectively; 2. serum triglycerides (TG) level of each group of test group and high fat matched group compare, and difference does not have the significance meaning; 3. HDL-C (HDL-C) level of 0.17g/kg and 0.5g/kg test group raises, compare with high fat matched group, and raise respectively 5.2mg/dl and 3.8mg/dl, difference has utmost point significance and significance meaning respectively.Above-mentioned zoopery result shows that health product capsule of the present invention has the blood lipid regulation effect.
To 100 examples (in, old people each 50 people) system's clinical observation and biochemical investigation, take health product capsule of the present invention every day 2 times, each 1-2 grain, following effect is arranged after taking the 2-3 bottle: 1, Fengshi Guanjie pain relief 2, nocturia number of times reduce; 3, cholesterol reduces, hypertension descends, blood glucose regulation is normal; 4, easy catching a cold, the mental status are not good; 5, senile plaque desalination, skin Lightening; 6, lipoma is cleared up.
Specific embodiment example
Embodiment 1
Get Folium Pini, the Cortex Pini Massonianae of Pinus massoniana Lamb, be ground into 40 order fineness after cleaning separately, drying; Take by weighing through pulverizing exsiccant pine needle powder 100kg, Cortex Pini Massonianae powder 50kg drops in the rustless steel extractor, add 70% ethanol 750L, soaked 16 hours, interlayer is heated to 70 ℃, be incubated 2 hours, leach extracting solution, residue extracts for the second time, add 70% ethanol 600L, heat, be incubated 1 hour to 70 ℃, merging filtrate, thin film concentration, vacuum concentration are to Baume degrees 11 degree, be cooled to room temperature, put 8 ℃ of refrigerators, 12 hours, tube centrifuge separate Folium Pini, Cortex Pini Massonianae concentrated extracting solution.
Take by weighing 2 parts of above-mentioned Folium Pini, Cortex Pini Massonianae concentrated extracting solutions by weight, 3 parts of cycloheptaamyloses, 0.005 part in lecithin, 0.0005 part of ascorbinstearate stirs, through colloid mill emulsifying, make 40% concentration, be sprayed into dry powder powder in spray drying tower, its spray drying inlet temperature is 150 ℃, and leaving air temp is 80 ℃.
Add adjuvant Gao Wenxi, microcrystalline Cellulose, micropowder silica gel, magnesium stearate in gained dry powder powder, mixed 15 minutes in three-dimensional mixer, the reuse Autocapsulefillingmachine is made capsule.
Embodiment 2
Get Folium Pini, the Cortex Pini Massonianae of Pinus massoniana Lamb, be ground into 40 order fineness after cleaning separately, drying; Take by weighing through pulverizing exsiccant pine needle powder 150kg, Cortex Pini Massonianae powder 75kg drops in the rustless steel extractor, add 80% ethanol 1000L, soaked 20 hours, interlayer is heated to 85 ℃, be incubated 3 hours, leach extracting solution, residue extracts for the second time, add 80% ethanol 800L, heat, be incubated 2 hours to 85 ℃, merging filtrate, thin film concentration, vacuum concentration are to Baume degrees 15 degree, be cooled to room temperature, put 5 ℃ of refrigerators, 16 hours, tube centrifuge separate concentrated solution.
Take by weighing 3 parts of above-mentioned Folium Pini, Cortex Pini Massonianae concentrated extracting solutions by weight, 4.5 parts of hydroxy propyl-Beta cyclodextrins, 0.015 part in lecithin, 0.0015 part of ascorbinstearate stirs, through colloid mill emulsifying, make 45% concentration, be sprayed into dry powder powder in spray drying tower, its spray drying inlet temperature is 170 ℃, and leaving air temp is 90 ℃.
In gained dry powder powder, add adjuvant Gao Wenxi, microcrystalline Cellulose, micropowder silica gel, magnesium stearate, in three-dimensional mixer, mixed 20 minutes, make capsule with Autocapsulefillingmachine.
Embodiment 3
Get Folium Pini, the Cortex Pini Massonianae of Pinus massoniana Lamb, be ground into 40 order fineness after cleaning separately, drying; Take by weighing through pulverizing exsiccant pine needle powder 50kg, Cortex Pini Massonianae powder 25kg drops in the rustless steel extractor, add 60% ethanol 500L, soaked 15 hours, interlayer is heated to 60 ℃, be incubated 1 hour, leach extracting solution, residue extracts for the second time, add 60% ethanol 300L, heat, be incubated 1 hour to 60 ℃, merging filtrate, thin film concentration, vacuum concentration are to Baume degrees 8 degree, be cooled to room temperature, put 10 ℃ of refrigerators, 12 hours, tube centrifuge separate concentrated solution.
Take by weighing 1 part of above-mentioned Folium Pini, Cortex Pini Massonianae concentrated extracting solution by weight, 0.8 part of cycloheptaamylose, 0.001 part in lecithin, 0.0001 part of ascorbinstearate stirs, through colloid mill emulsifying, make 35% concentration, in spray drying tower, its spray drying inlet temperature is 140 ℃, and leaving air temp is 70 ℃.
In dry powder powder, add adjuvant Gao Wenxi, microcrystalline Cellulose, micropowder silica gel, magnesium stearate, in three-dimensional mixer, mixed 10 minutes, make capsule with Autocapsulefillingmachine.
Claims (5)
1, the health product of a kind of slow down aging, blood lipid regulation is characterized in that mainly being made up of following raw materials according:
Folium Pini and Cortex Pini Massonianae are by making ethanol extraction 1-3 part at 2: 1
Cycloheptaamylose or hydroxy propyl-Beta cyclodextrin 0.8-4.5 part
2, the health product of slow down aging according to claim 1, blood lipid regulation is characterized in that mainly being made up of following raw materials according:
Folium Pini and Cortex Pini Massonianae are by making ethanol extraction 1.5-2.5 part at 2: 1
Cycloheptaamylose or hydroxy propyl-Beta cyclodextrin 2-3.5 part
3, the health product of slow down aging according to claim 1, blood lipid regulation is characterized in that mainly being made up of following raw materials according:
Folium Pini and Cortex Pini Massonianae are by making 2 parts of ethanol extractions at 2: 1
3 parts of cycloheptaamylose or hydroxy propyl-Beta cyclodextrins
4, according to the health product of claim 1 or 2 or 3 described slow down aging, blood lipid regulation, it is characterized in that in raw material, adding:
Ascorbyl palmitate 0.0001-0.0015 part
Lecithin 0.001-0.015 part
5, the health product of slow down aging according to claim 4, blood lipid regulation is characterized in that dosage form is a capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011301449A CN1151825C (en) | 2001-12-28 | 2001-12-28 | Health tonic for delaying senility and regualting blood lipoid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011301449A CN1151825C (en) | 2001-12-28 | 2001-12-28 | Health tonic for delaying senility and regualting blood lipoid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1362250A CN1362250A (en) | 2002-08-07 |
| CN1151825C true CN1151825C (en) | 2004-06-02 |
Family
ID=4669770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB011301449A Expired - Lifetime CN1151825C (en) | 2001-12-28 | 2001-12-28 | Health tonic for delaying senility and regualting blood lipoid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1151825C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101119288B1 (en) * | 2008-06-24 | 2012-03-15 | (주)아모레퍼시픽 | Composition for External Skin Application Containing Pine knot Extract and Method for Preparation of the Same |
| CN102228248A (en) * | 2011-06-29 | 2011-11-02 | 中健行集团有限公司 | Energy-saving and environmentally-protected production process of Songzhen capsules |
| CN103271198A (en) * | 2013-06-03 | 2013-09-04 | 贵州大学 | Pinus massoniaha pine needle instant tea and production technology thereof |
-
2001
- 2001-12-28 CN CNB011301449A patent/CN1151825C/en not_active Expired - Lifetime
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| Publication number | Publication date |
|---|---|
| CN1362250A (en) | 2002-08-07 |
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| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Zhongjianxing Group Co.,Ltd. Assignor: Guangdong Songzhen Nutrient Source Research Inst. Contract fulfillment period: 2007.6.8 to 2012.6.8 Contract record no.: 2009440001434 Denomination of invention: Health tonic for delaying senility and regualting blood lipoid Granted publication date: 20040602 License type: Exclusive license Record date: 20090917 |
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| LIC | Patent licence contract for exploitation submitted for record |
Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2007.6.8 TO 2012.6.8; CHANGE OF CONTRACT Name of requester: ZHONGJIANHANG GROUP CO.,LTD. Effective date: 20090917 |
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| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20150921 Address after: 512229 No. 66 Baisha bridge, Ping Shi Town, Lechang City, Guangdong province (Ping Shi) Patentee after: Zhongjianxing Group Co.,Ltd. Address before: 512229 No. 65 Baisha bridge, Ping Shi Town, Guangdong, Lechang Patentee before: Guangdong Songzhen Nutrient Source Research Inst. |
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| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20040602 |