CN115177705A - Formula and preparation method of plant concentrated foot bath bag - Google Patents
Formula and preparation method of plant concentrated foot bath bag Download PDFInfo
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- CN115177705A CN115177705A CN202110364645.3A CN202110364645A CN115177705A CN 115177705 A CN115177705 A CN 115177705A CN 202110364645 A CN202110364645 A CN 202110364645A CN 115177705 A CN115177705 A CN 115177705A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 238000009472 formulation Methods 0.000 title description 2
- 238000000605 extraction Methods 0.000 claims abstract description 48
- 239000000341 volatile oil Substances 0.000 claims abstract description 47
- 238000000034 method Methods 0.000 claims abstract description 31
- 229920000858 Cyclodextrin Polymers 0.000 claims abstract description 27
- 239000001116 FEMA 4028 Substances 0.000 claims abstract description 27
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims abstract description 27
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims abstract description 27
- 229960004853 betadex Drugs 0.000 claims abstract description 27
- 239000000463 material Substances 0.000 claims abstract description 23
- 241000196324 Embryophyta Species 0.000 claims abstract description 19
- 241000112528 Ligusticum striatum Species 0.000 claims abstract description 16
- 240000002505 Pogostemon cablin Species 0.000 claims abstract description 16
- 235000011751 Pogostemon cablin Nutrition 0.000 claims abstract description 16
- 241001643425 Tinospora sinensis Species 0.000 claims abstract description 16
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 16
- 239000011707 mineral Substances 0.000 claims abstract description 16
- 150000003839 salts Chemical class 0.000 claims abstract description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 32
- 150000001875 compounds Chemical class 0.000 claims description 15
- 238000002156 mixing Methods 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 239000000843 powder Substances 0.000 claims description 8
- 238000005303 weighing Methods 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 6
- 238000001256 steam distillation Methods 0.000 claims description 6
- 238000004821 distillation Methods 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 5
- 241000234314 Zingiber Species 0.000 claims description 4
- 235000006886 Zingiber officinale Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 235000008397 ginger Nutrition 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 4
- 230000008569 process Effects 0.000 abstract description 14
- 238000005516 engineering process Methods 0.000 abstract description 4
- 239000007788 liquid Substances 0.000 abstract description 4
- 238000007670 refining Methods 0.000 abstract description 4
- 229940126589 solid medicine Drugs 0.000 abstract description 4
- 230000036541 health Effects 0.000 abstract description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 8
- 238000002474 experimental method Methods 0.000 description 5
- 229940060184 oil ingredients Drugs 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 239000004480 active ingredient Substances 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 238000005325 percolation Methods 0.000 description 4
- 239000000047 product Substances 0.000 description 4
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- 238000013461 design Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 238000002386 leaching Methods 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
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- 238000010298 pulverizing process Methods 0.000 description 2
- 241001529821 Agastache Species 0.000 description 1
- 208000000044 Amnesia Diseases 0.000 description 1
- 208000031091 Amnestic disease Diseases 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 230000006986 amnesia Effects 0.000 description 1
- 238000000540 analysis of variance Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
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- 230000000857 drug effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
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- 239000004615 ingredient Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
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- 230000000474 nursing effect Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000000967 suction filtration Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/50—Methods involving additional extraction steps
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Abstract
A formula and a preparation method of a plant concentrated foot bath bag, relating to the field of health care products. The foot bath bag comprises, by weight, 13-15g of mineral salt, 29-31g of folium artemisiae argyi, 29-31g of pogostemon cablin, 9-11g of rhizoma zingiberis, 9-11g of tinospora sinensis, 9-11g of ligusticum wallichii and 3-5g of beta-cyclodextrin. According to the invention, formula innovation and process innovation are carried out according to the properties of medicinal materials, a flash extraction technology is applied to a foot bath bag product for extraction and refining, an inclusion technology is applied to volatile components, the problem of instability of volatile oil of effective components is solved, liquid volatile oil is prepared into a stable solid medicine, a foot bath formula is developed into an instant concentrated foot bath bag with stable quality, the use is convenient and fast, the appearance is attractive and fashionable, and the foot bath bag helps modern urban people to solve the sub-health problems possibly caused by fast pace of life and high pressure.
Description
Technical Field
The invention relates to the field of health care products, in particular to a formula and a preparation method of a plant concentrated foot bath bag.
Background
Modern people are quick in moving and high in working pressure, and even though the people are troubled by sub-health states such as heavy moisture, dysmenorrhea and amnesia, the disease is not a real disease, many people are not willing to go to hospitals for seeing a doctor and nursing, or even if doctors prescribe some daily health-care parties such as foot bath, the medicines are difficult to be dispensed, decocted and used regularly. Because the active ingredients of the medicinal materials exist in cell tissues of the medicinal materials, the medicinal materials can better exert the drug effect by extraction, but the simplest decoction process is time-consuming and tedious, and is difficult to maintain every day.
At present, most of foot bath bags on the market are prepared by directly soaking feet with raw medicinal materials or dissolving and soaking the raw medicinal materials after crushing, and the method has a simple process, but the raw medicinal materials are easy to be damaged by worms and go moldy, and the microbial indexes are not easy to control. Moreover, because the active ingredients of the medicinal materials exist in the cell tissues of the medicinal materials, the active ingredients cannot be effectively dissolved from the cell tissues by the mode of directly soaking feet without powdering or powdering the raw medicinal materials, and the ingredient loss is large.
Disclosure of Invention
Objects of the invention
In order to solve the technical problems in the background art, the invention provides a formula and a preparation method of a plant concentrated foot bath bag. According to the invention, formula innovation and process innovation are carried out according to the properties of medicinal materials, a flash extraction technology is applied to a foot bath bag product for extraction and refining, an inclusion technology is applied to volatile components, the problem of instability of volatile oil of effective components is solved, liquid volatile oil is prepared into a stable solid medicine, a foot bath formula is developed into an instant concentrated foot bath bag with stable quality, the use is convenient and fast, the appearance is attractive and fashionable, and the foot bath bag helps modern urban people to solve the sub-health problems possibly caused by fast pace of life and high pressure.
(II) technical scheme
In order to solve the problems, the invention provides a formula of a plant concentrated foot bath bag, and each part of the foot bath bag comprises 13-15g of mineral salt, 29-31g of folium artemisiae argyi, 29-31g of pogostemon cablin, 9-11g of rhizoma zingiberis, 9-11g of tinospora sinensis, 9-11g of ligusticum wallichii and 3-5g of beta-cyclodextrin according to the weight ratio
Preferably, each foot bath bag comprises 13g of mineral salt, 29g of folium artemisiae argyi, 29g of pogostemon cablin, 9g of rhizoma zingiberis, 9g of tinospora sinensis, 9g of ligusticum wallichii and 3g of beta-cyclodextrin according to the weight ratio.
Preferably, each foot bath bag comprises 14g of mineral salt, 30g of folium artemisiae argyi, 30g of pogostemon cablin, 10g of rhizoma zingiberis, 10g of tinospora sinensis, 10g of ligusticum wallichii and 4g of beta-cyclodextrin according to the weight ratio.
Preferably, each foot bath bag comprises 15g of mineral salt, 31g of folium artemisiae argyi, 31g of pogostemon cablin, 11g of rhizoma zingiberis, 11g of tinospora sinensis, 11g of ligusticum wallichii and 5g of beta-cyclodextrin according to the weight ratio.
The invention also provides a preparation method of the plant concentrated foot bath bag, which comprises the following steps:
s1, weighing each raw material component;
s2, putting the folium artemisiae argyi and the cablin potchouli herb into distillation equipment, adding 8 times of water by volume, and extracting for 4 hours by adopting a steam distillation method to prepare volatile oil;
s3, mixing the residues in the step S2 with the other three medicinal materials of dried ginger, tinospora sinensis and ligusticum wallichii, extracting for 1 time by adopting an ethanol flash extraction method, wherein the extraction time is 60 seconds, filtering and concentrating until filtrate is concentrated to be dry paste, and crushing the paste to obtain powder for later use;
s4, performing inclusion on the volatile oil in the S2 by adopting beta-cyclodextrin under the inclusion condition that the ratio of the volatile oil to the beta-cyclodextrin is 1: 8, the inclusion temperature is 45 ℃, and the inclusion time is 1h to obtain an inclusion compound; drying the inclusion compound at a low temperature of 45 ℃ for later use; and (4) uniformly mixing the dried inclusion compound and the powder in the S3 according to a proportion, adding mineral salt, and uniformly mixing.
The technical scheme of the invention has the following beneficial technical effects:
according to the invention, formula innovation and process innovation are carried out according to the properties of medicinal materials, a flash extraction technology is applied to a foot bath bag product for extraction and refining, an inclusion technology is applied to volatile components, the problem of instability of volatile oil of effective components is solved, liquid volatile oil is prepared into a stable solid medicine, a foot bath formula is developed into an instant concentrated foot bath bag with stable quality, the use is convenient and fast, the appearance is attractive and fashionable, and the foot bath bag helps modern urban people to solve the sub-health problems possibly caused by fast pace of life and high pressure.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the description is intended to be exemplary only, and is not intended to limit the scope of the present invention. Moreover, in the following description, descriptions of well-known structures and techniques are omitted so as to not unnecessarily obscure the concepts of the present invention.
Example 1
According to the formula of the plant concentrated foot bath bag provided by the invention, each part of foot bath bag comprises 13g of mineral salt, 29g of folium artemisiae argyi, 29g of pogostemon cablin, 9g of rhizoma zingiberis, 9g of tinospora sinensis, 9g of ligusticum wallichii and 3g of beta-cyclodextrin according to the weight ratio.
Example 2
According to the formula of the plant concentrated foot bath bag provided by the invention, each part of foot bath bag comprises 14g of mineral salt, 30g of folium artemisiae argyi, 30g of pogostemon cablin, 10g of rhizoma zingiberis, 10g of tinospora sinensis, 10g of ligusticum wallichii and 4g of beta-cyclodextrin according to the weight ratio.
Example 3
According to the formula of the plant concentrated foot bath bag provided by the invention, each part of the foot bath bag comprises 15g of mineral salt, 31g of folium artemisiae argyi, 31g of pogostemon cablin, 11g of rhizoma zingiberis, 11g of tinospora sinensis, 11g of ligusticum wallichii and 5g of beta-cyclodextrin according to the weight ratio.
The use effect is contrastively analyzed, and each foot bath bag is selected to be the best mixture ratio of 14g of mineral salt, 30g of folium artemisiae argyi, 30g of pogostemon cablin, 10g of rhizoma zingiberis, 10g of tinospora sinensis, 10g of ligusticum wallichii and 4g of beta-cyclodextrin.
Example 4
1. Study of volatile oil extraction Process
The method comprises the following steps of extracting volatile oil by a steam distillation method, and carrying out comparative study on the yield conditions of the volatile oil under different extraction time. The experimental procedure was as follows: firstly weighing 100g of folium artemisiae argyi and pogostemon cablin according to the formula proportion, adding 8 times of water, placing in a round-bottom flask, connecting with a volatile oil extraction device, and extracting volatile oil. The volatile oil yield is taken as an investigation index, and the extraction time is investigated and researched. And calculating the yield of the volatile oil according to a formula. The volatile oil was stored in a brown glass bottle in a refrigerator for later use, and the extraction results are shown in Table 1.
Volatile oil yield (%) = weight of volatile oil (g)/weight of medicinal material (g) × 100%
TABLE 1 relationship between volatile oil extraction time and yield (n = 3)
The yield of the volatile oil is continuously improved along with the prolonging of the distillation time, the increasing trend of the volatile oil in the first 3h is obvious, the increasing trend becomes slow, when the distillation time is about 4h, the yield of the volatile oil is maximum, the extraction time is continuously prolonged, the yield of the volatile oil is not obviously increased any more, and even the yield of the volatile oil is possibly slightly reduced. The extraction time of the folium artemisiae argyi and the pogostemon cablin is determined to be 4h by comprehensively considering the cost and time factors.
2. Research on process for extracting combined medicine residue and other medicinal materials
Mixing the residue after volatile oil extraction with Zingiberis rhizoma, caulis tinosporae and rhizoma Ligustici Chuanxiong, extracting by water decoction, ethanol reflux extraction, flash extraction or percolation, and comparing the extraction results. The experimental procedure was as follows: mixing the residues, zingiberis rhizoma, caulis tinosporae sinensis and rhizoma Ligustici Chuanxiong at a ratio of 100g, pulverizing into coarse powder under the same conditions, and extracting by water decoction, ethanol reflux extraction, flash extraction and percolation respectively.
(1) A water decoction method: placing the medicinal materials in a container with a cover, adding 8 times of purified water, and decocting for 2 times, each time for 1 hr. Filtering, combining the two filtrates, and concentrating to 100ml.
(2) Ethanol reflux method: adding 8 times of 60% ethanol into the medicinal materials, heating and reflux-extracting for 2 times, each time for 1 hr, dissolving effective components with 60% ethanol to form leaching solution, heating the leaching solution, distilling off 60% ethanol, condensing and refluxing into a leaching device, and repeatedly extracting until the components are completely extracted. Recovering ethanol, and concentrating to 100ml.
(3) Flash extraction: crushing the medicinal materials into fine particles by using high-speed mechanical shearing force at room temperature in a proper solvent, promoting effective components to realize internal and external balance of tissues by violent stirring and strong vibration, and filtering to finish extraction. Carrying out flash extraction on the medicinal materials by 95% ethanol in an amount which is 1.
(4) A percolation method: placing the medicine in a percolation cylinder, adding 60% ethanol to a position 3cm higher than the surface of the medicine, soaking for 24 hours, opening a valve to collect percolate, and adding about 8 times of 60% ethanol fresh solvent. Collecting percolate, and concentrating to 100ml.
The concentrated solution obtained by the method is dried to obtain four groups of dry paste bodies, the yield of dry paste is taken as an examination index, the four different extraction methods are compared, and the result is shown in a table 2:
dry extract yield (%) = dry extract weight (g)/feed weight (g) × 100%
Table 2 comparison table of the average yield of dry paste under four extraction methods (n = 3)
According to the results in table 2, the dry paste yield of the water decoction method and the 60% ethanol flash extraction method are not much different and are both more than 20%. Under the condition of ensuring that the yield of dry paste is basically equal, the ethanol flash extraction method has the advantages of short extraction time, high efficiency, capability of reducing the possibility that certain effective components are damaged due to long-time heating and the like, and can ensure the extraction rate of the content of the effective components, thereby proving that the method is effective and feasible. Determining a flash extraction method as an extraction method by combining with actual conditions, and continuously optimizing flash extraction process conditions, wherein the process conditions are determined as follows: extracting the raw materials with 60% ethanol at a ratio of 1:40 by flash extraction for 1 time for 60 s, filtering, concentrating the filtrate, concentrating with rotary evaporator to obtain dry ointment, and pulverizing. The process has good repeatability, and can be used for extracting the formula.
The flash extraction technology has the advantages of high extraction efficiency, short extraction time, less solvent consumption, low extraction temperature, no damage to thermosensitive components and the like, can maximally retain the effective components of the plants, cannot be damaged due to overhigh temperature, and has short extraction time and small solvent consumption.
3. Research on inclusion process of volatile oil and beta-cyclodextrin
The foot bath bag prepared by the invention is a powdery solid preparation, if the extracted active ingredient volatile oil is sprayed on the surface of the medicinal powder, the volatile oil is easy to volatilize in the long-term storage process, and in order to improve the stability of the volatile oil, the inclusion process research is carried out on the volatile oil ingredients extracted from folium artemisiae argyi and pogostemon cablin. The experimental procedure was as follows:
(1) Extracting volatile oil for packaging: magnifying folium Artemisiae Argyi and herba Agastaches according to formula ratio, weighing 1000g, placing in round bottom flask, adding water 600ml, extracting mixed volatile oil with steam distillation method, extracting the extracted volatile oil with diethyl ether, volatilizing diethyl ether, weighing to obtain oil content in the clathrate for use. The weight of the obtained volatile oil per 1ml is 0.9632g.
(2) Beta-cyclodextrin is adopted as an inclusion material, the proportion of volatile oil and beta-cyclodextrin, the inclusion temperature and the inclusion time are considered factors, the yield of the inclusion compound is considered as an index, and an orthogonal design table L is adopted 9 (3 4 ) Tests were performed and the levels and factors are shown in table 3.
(3) Weighing appropriate amount of beta-cyclodextrin according to orthogonal design results, adding a specified amount of distilled water, continuously stirring and adding a certain amount of volatile oil into an aqueous solution at a set temperature, stirring for a certain time at a constant temperature, refrigerating overnight in a refrigerator, taking out, carrying out suction filtration, washing precipitates with petroleum ether, removing residual volatile oil on the surfaces of the precipitates, drying in an oven at 40 ℃ for 2 hours to obtain white powdery inclusion compounds, and weighing to obtain dry inclusion compounds.
(4) Calculating the clathrate yield, and designing the table according to the orthogonality 9 (3 4 ) The factors and the level design in the process are adopted, the orthogonal experiment is carried out, the result is shown in table 4, the SAS software is adopted to carry out variance analysis on the orthogonal experiment result, and the result is shown in table 5.
The yield of the inclusion compound is that the weight of the dry inclusion compound/(beta-cyclodextrin feeding amount + oil feeding amount) is multiplied by 100 percent
TABLE 3 Inclusion test levels and factors Table
TABLE 4 orthogonal test results Table
TABLE 5 analysis of variance of orthogonal test
The results in tables 3, 4 and 5 show that the ratio of the volatile oil to the beta-cyclodextrin has a significant effect on the yield of the inclusion compound, and the three factors are examined to influence the yield of the inclusion compound in the order of A (oil: beta-cyclodextrin) > B (inclusion temperature ℃) > C (inclusion time h). The final preferred inclusion process combination is A 1 B 3 C 2 Namely: the ratio of oil to beta-cyclodextrin is 1: 8, the inclusion temperature is 45 ℃, and the inclusion time is 1h.
The invention also provides a preparation method of the plant concentrated foot bath bag by combining all the test results, which comprises the following steps:
s1, weighing each raw material component;
s2, putting the folium artemisiae argyi and the cablin potchouli herb into distillation equipment, adding 8 times of water, and extracting for 4 hours by adopting a steam distillation method to prepare volatile oil;
s3, mixing the residues in the step S2 with the other three medicinal materials of dried ginger, tinospora sinensis and ligusticum wallichii, extracting for 1 time by adopting an ethanol flash extraction method, wherein the extraction time is 60 seconds, filtering and concentrating until filtrate is concentrated to be dry paste, and crushing the paste to obtain powder for later use;
s4, performing inclusion on the volatile oil in the S2 by adopting beta-cyclodextrin under the inclusion condition that the ratio of the volatile oil to the beta-cyclodextrin is 1: 8, the inclusion temperature is 45 ℃, and the inclusion time is 1h to obtain an inclusion compound; drying the inclusion compound at a low temperature of 45 ℃ for later use; and (3) uniformly mixing the dried inclusion compound and the powder in the S3 according to a proportion, adding mineral salt, and uniformly mixing.
According to the invention, formula innovation and process innovation are carried out according to the properties of medicinal materials, a flash extraction technology is applied to a foot bath bag product for extraction and refining, an inclusion technology is applied to volatile components, the problem of instability of volatile oil of effective components is solved, liquid volatile oil is prepared into a stable solid medicine, a foot bath formula is developed into an instant concentrated foot bath bag with stable quality, the use is convenient and fast, the appearance is attractive and fashionable, and the foot bath bag helps modern urban people to solve the sub-health problems possibly caused by fast pace of life and high pressure.
It is to be understood that the above-described embodiments of the present invention are merely illustrative of or explaining the principles of the invention and are not to be construed as limiting the invention. Therefore, any modifications, equivalents, improvements and the like which are made without departing from the spirit and scope of the present invention shall be included in the protection scope of the present invention. Further, it is intended that the appended claims cover all such variations and modifications as fall within the scope and boundaries of the appended claims or the equivalents of such scope and boundaries.
Claims (8)
1. The formula of the plant concentrated foot bath bag is characterized in that each part of the foot bath bag comprises 13-15g of mineral salt, 29-31g of folium artemisiae argyi, 29-31g of pogostemon cablin, 9-11g of dried ginger, 9-11g of tinospora sinensis, 9-11g of ligusticum wallichii and 3-5g of beta-cyclodextrin according to the weight ratio.
2. The formula and the preparation method of the plant concentrated foot bath bag according to claim 1, wherein each part of the foot bath bag comprises 13g of mineral salt, 29g of folium artemisiae argyi, 29g of pogostemon cablin, 9g of rhizoma zingiberis, 9g of tinospora sinensis, 9g of ligusticum wallichii and 3g of beta-cyclodextrin according to the weight ratio.
3. The formula and the preparation method of the plant concentrated foot bath bag according to claim 1, wherein each part of the foot bath bag comprises 14g of mineral salt, 30g of folium artemisiae argyi, 30g of pogostemon cablin, 10g of rhizoma zingiberis, 10g of tinospora sinensis, 10g of ligusticum wallichii and 4g of beta-cyclodextrin according to the weight ratio.
4. The formula and the preparation method of the plant concentrated foot bath bag according to claim 1, wherein each part of the foot bath bag comprises 15g of mineral salt, 31g of folium artemisiae argyi, 31g of pogostemon cablin, 11g of rhizoma zingiberis, 11g of tinospora sinensis, 11g of ligusticum wallichii and 5g of beta-cyclodextrin according to the weight ratio.
5. The preparation method of the plant concentrated foot bath bag comprising any one of claims 1 to 4, characterized by comprising the following steps:
s1, weighing each raw material component;
s2, putting the folium artemisiae argyi and the cablin potchouli herb into distillation equipment, adding 8 times of water by volume, and extracting for 3-5 hours by adopting a steam distillation method to prepare volatile oil;
s3, mixing the dregs in the step S2 with the other three medicinal materials of dried ginger, tinospora sinensis and ligusticum wallichii, extracting, filtering and concentrating until the filtrate is concentrated to a dry paste, and crushing the paste to obtain powder for later use;
s4, clathrating the volatile oil in the S2 by beta-cyclodextrin to obtain a clathrate; drying the inclusion compound at a low temperature of 45 ℃ for later use; and (3) uniformly mixing the dried inclusion compound and the powder in the S3 according to a proportion, adding mineral salt, and uniformly mixing.
6. The method for preparing the plant concentrated foot bath bag according to claim 1, wherein in S2, a steam distillation method is adopted for extraction for 4 hours.
7. The method for preparing the plant concentrated footbath bag according to claim 1, wherein in S3, the extraction is performed for 60 seconds by extracting for 1 time with ethanol flash extraction.
8. The preparation method of the plant concentrated foot bath bag according to claim 1, wherein in S4, the ratio of the volatile oil to the beta-cyclodextrin is 1: 8, the inclusion temperature is 45 ℃, and the inclusion time is 1h.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102397190A (en) * | 2011-11-03 | 2012-04-04 | 青岛邦正国际贸易有限公司 | Folium artemisiae argyi pediluvium medicine bag and preparation method thereof |
| CN104984315A (en) * | 2015-08-12 | 2015-10-21 | 理想科技集团有限公司 | Traditional Chinese medicine lavipeditum preparation and preparation method thereof |
| CN107281342A (en) * | 2016-03-30 | 2017-10-24 | 黄雄强 | A kind of Traditional Chinese medicine for steeping foot powder for treating talagia |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102397190A (en) * | 2011-11-03 | 2012-04-04 | 青岛邦正国际贸易有限公司 | Folium artemisiae argyi pediluvium medicine bag and preparation method thereof |
| CN104984315A (en) * | 2015-08-12 | 2015-10-21 | 理想科技集团有限公司 | Traditional Chinese medicine lavipeditum preparation and preparation method thereof |
| CN107281342A (en) * | 2016-03-30 | 2017-10-24 | 黄雄强 | A kind of Traditional Chinese medicine for steeping foot powder for treating talagia |
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