CN106110220A - A kind of preparation technology of the Chinese patent medicine treating biliary tract - Google Patents
A kind of preparation technology of the Chinese patent medicine treating biliary tract Download PDFInfo
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- CN106110220A CN106110220A CN201610701240.3A CN201610701240A CN106110220A CN 106110220 A CN106110220 A CN 106110220A CN 201610701240 A CN201610701240 A CN 201610701240A CN 106110220 A CN106110220 A CN 106110220A
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- Prior art keywords
- crude drug
- chinese patent
- patent medicine
- volatile oil
- biliary tract
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- 239000003814 drug Substances 0.000 title claims abstract description 85
- 210000003445 biliary tract Anatomy 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 229940079593 drug Drugs 0.000 claims abstract description 48
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 29
- 239000000341 volatile oil Substances 0.000 claims abstract description 26
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 24
- 238000001914 filtration Methods 0.000 claims abstract description 13
- 239000000203 mixture Substances 0.000 claims abstract description 13
- 238000000151 deposition Methods 0.000 claims abstract description 11
- 230000008021 deposition Effects 0.000 claims abstract description 11
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims abstract description 9
- 238000004821 distillation Methods 0.000 claims abstract description 9
- 238000009835 boiling Methods 0.000 claims abstract description 7
- 239000012535 impurity Substances 0.000 claims abstract description 7
- 239000000084 colloidal system Substances 0.000 claims abstract description 6
- 239000012153 distilled water Substances 0.000 claims abstract description 6
- 238000004321 preservation Methods 0.000 claims abstract description 6
- 238000003756 stirring Methods 0.000 claims abstract description 6
- 238000001291 vacuum drying Methods 0.000 claims abstract description 5
- 239000000284 extract Substances 0.000 claims description 14
- 239000000706 filtrate Substances 0.000 claims description 8
- WHGYBXFWUBPSRW-UHFFFAOYSA-N Cycloheptaamylose Natural products O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO WHGYBXFWUBPSRW-UHFFFAOYSA-N 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 6
- 239000012141 concentrate Substances 0.000 claims description 5
- 239000006071 cream Substances 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 11
- 239000004615 ingredient Substances 0.000 abstract description 3
- 229920000858 Cyclodextrin Polymers 0.000 abstract 2
- 239000001116 FEMA 4028 Substances 0.000 abstract 2
- 235000011175 beta-cyclodextrine Nutrition 0.000 abstract 2
- 229960004853 betadex Drugs 0.000 abstract 2
- 238000000605 extraction Methods 0.000 abstract 1
- 239000002775 capsule Substances 0.000 description 13
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- 210000000232 gallbladder Anatomy 0.000 description 9
- 230000000694 effects Effects 0.000 description 7
- 239000009628 lidan Substances 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 6
- 208000002193 Pain Diseases 0.000 description 5
- 235000013339 cereals Nutrition 0.000 description 5
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 5
- 239000010931 gold Substances 0.000 description 5
- 229910052737 gold Inorganic materials 0.000 description 5
- 201000001352 cholecystitis Diseases 0.000 description 4
- 239000003292 glue Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 239000001606 7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)chroman-4-one Substances 0.000 description 3
- 206010000087 Abdominal pain upper Diseases 0.000 description 3
- 244000025254 Cannabis sativa Species 0.000 description 3
- 210000001015 abdomen Anatomy 0.000 description 3
- 239000012467 final product Substances 0.000 description 3
- 239000013558 reference substance Substances 0.000 description 3
- 206010008617 Cholecystitis chronic Diseases 0.000 description 2
- 241000209094 Oryza Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 230000004596 appetite loss Effects 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 201000006549 dyspepsia Diseases 0.000 description 2
- 208000020694 gallbladder disease Diseases 0.000 description 2
- 208000019423 liver disease Diseases 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 235000021266 loss of appetite Nutrition 0.000 description 2
- 208000019017 loss of appetite Diseases 0.000 description 2
- DFPMSGMNTNDNHN-ZPHOTFPESA-N naringin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](OC=2C=C3O[C@@H](CC(=O)C3=C(O)C=2)C=2C=CC(O)=CC=2)O[C@H](CO)[C@@H](O)[C@@H]1O DFPMSGMNTNDNHN-ZPHOTFPESA-N 0.000 description 2
- 229940052490 naringin Drugs 0.000 description 2
- 229930019673 naringin Natural products 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 238000007560 sedimentation technique Methods 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 230000008719 thickening Effects 0.000 description 2
- 201000001883 cholelithiasis Diseases 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000005202 decontamination Methods 0.000 description 1
- 230000003588 decontaminative effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000009207 exercise therapy Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000000295 fuel oil Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- YTJSFYQNRXLOIC-UHFFFAOYSA-N octadecylsilane Chemical compound CCCCCCCCCCCCCCCCCC[SiH3] YTJSFYQNRXLOIC-UHFFFAOYSA-N 0.000 description 1
- 229940071462 oralone Drugs 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
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- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses the preparation technology of a kind of Chinese patent medicine treating biliary tract, this technique comprises the following steps: mix after one, crude drug Herba Artemisiae Scopariae, Radix Curcumae, Herba Lysimachiae and Fructus Aurantii being smashed, and then uses distilled water moistening, uses the way of distillation to extract volatile oil；Two, by the crude drug boiling after extraction volatile oil 3 times, collecting decoction, filtering, concentrating under reduced pressure becomes thick paste, then adds ethanol in thick paste and stirs, is dried, obtains dried object A after filtering impurity；Three, grind with colloid mill after beta-cyclodextrin, water and volatile oil being mixed, sucking filtration after cold preservation, obtain white depositions, vacuum drying, obtain dried object B；Four, mix homogeneously after dried object A and dried object B being pulverized, encapsulated, the Chinese patent medicine of the biliary tract that obtains medical treatment.The present invention uses the way of distillation first by the volatile oil is drawn in crude drug out, remains the effective ingredient in crude drug, and uses beta-cyclodextrin to wrap up the volatile oil extracted so that drug quality is more stable.
Description
Technical field
The invention belongs to pharmaceutical technology field, be specifically related to the preparation technology of a kind of Chinese patent medicine treating biliary tract.
Background technology
Gold mattress Lidan Capsule has clearing away heat-damp and promoting diuresis, and effect of 'Shugan Lidan ', it is adaptable to stagnation of QI due to depression of the liver, dampness-heat in the liver and gallbladder disease causes
Hypochondriac pain, stomachache, the improvement of the symptoms such as lack of appetite is indigestion and loss of appetite.The preparation technology of existing gold mattress Lidan Capsule is boiling 3 times, first
Secondary 6 times amount that add, decoct 3 hours, and second and third time respectively adds 4 times amount, decoct 2 hours, collecting decoction, filter, and filtrate reduced in volume is extremely
Relative density is about 1.2 (60 DEG C), cold drying at 80 DEG C, pulverizes, sieves, and mixing loads capsule, to obtain final product.But, add water
Substantial amounts of volatile oils in decoction process, and the effective ingredient of cholecystitis, cholelithiasis treated just by the volatile oil volatilized so that
Mass efficient component damages in crude drug, and golden mattress Lidan Capsule 0.4g/ grain prepared by existing technique, three times on the one, often
Secondary need take 5, and loading amount is big, dose is bigger.
Summary of the invention
It is an object of the invention to the deficiency for overcoming background technology, it is provided that the preparation of a kind of Chinese patent medicine treating biliary tract
Technique.This technique uses the way of distillation first by the volatile oil is drawn in crude drug out, remains the effective ingredient in crude drug, and
Use cycloheptaamylose that the volatile oil extracted is wrapped up so that drug quality is more stable；Then use decoction and alcohol sedimentation technique, remove
Decontamination, greatly reducing the dose of medicine, loading amount 0.3g/ grain, oral three times on the one, one time 2～3, reach to take
Measure little, quality controllable, the significantly more efficient purpose of curative effect.
To achieve these goals, the technical solution used in the present invention is: the system of a kind of Chinese patent medicine treating biliary tract
For technique, this Chinese patent medicine is made up of the crude drug of following weight portion: Herba Artemisiae Scopariae 1200 parts, Radix Curcumae 600 parts, Herba Lysimachiae 600 parts, Fructus Aurantii
300 parts；It is characterized in that, the preparation technology of this Chinese patent medicine comprises the following steps:
Step one, crude drug is smashed after mix, then with distilled water by mixed crude drug moistening, use the way of distillation
Extract the volatile oil of the crude drug after moistening；
Step 2, will extract crude drug boiling after volatile oil 3 times, amount of water is crude drug gross mass for the first time
6 times, decocting time is 3 hours, and amount of water and third time amount of water are 4 times of crude drug gross mass, decocting time for the second time
It is 2 hours, collecting decoction, filters, concentrate filtrate to 60 DEG C and record the thick paste that relative density is 1.20, then to institute
State addition ethanol in thick paste to stir, be dried after filtering impurity, obtain dried object A；
Step 3, by the volatile oil that extracts in cycloheptaamylose, water and step one by (4～8): (150～200): the matter of 1
Amount is ground with colloid mill than after mixing, and sucking filtration after cold preservation obtains white depositions, described white depositions is vacuum dried,
To dried object B；
Step 4, by dried object B described in dried object A described in step 2 and step 3 pulverize after mix homogeneously, fill glue
Capsule, the Chinese patent medicine of the biliary tract that obtains medical treatment.
The preparation technology of above-mentioned a kind of Chinese patent medicine treating biliary tract, it is characterised in that ethanol described in step 2
8 times that quality is described thick paste quality.
The preparation technology of above-mentioned a kind of Chinese patent medicine treating biliary tract, it is characterised in that be dried described in step 2
Temperature be 70 DEG C～80 DEG C, drying time is 6h～12h.
The preparation technology of above-mentioned a kind of Chinese patent medicine treating biliary tract, it is characterised in that vacuum described in step 3
The temperature being dried is 70 DEG C～80 DEG C, and the time is 10h～15h.
Described weight portion can be gram, two, jin, the weight metering unit such as kilogram, ton.
Chinese patent medicine prepared by the present invention has clearing away heat-damp and promoting diuresis, effect of 'Shugan Lidan ', it is adaptable to stagnation of QI due to depression of the liver, dampness-heat in the liver and gallbladder
The hypochondriac pain that disease causes, stomachache, the improvement of the symptoms such as lack of appetite is indigestion and loss of appetite.
The present invention compared with prior art has the advantage that
1, the present invention uses the way of distillation first by the volatile oil is drawn in crude drug out, remains the effective one-tenth in crude drug
Point, and using cycloheptaamylose that the volatile oil extracted is wrapped up so that drug quality is more stable.
2, the present invention uses decoction and alcohol sedimentation technique, removes impurity, greatly reducing the dose of medicine, oral one day three
Secondary, one time 2～3 (0.3g/ grain), reach dose little, quality controllable, the significantly more efficient purpose of curative effect.
Below by embodiment, technical scheme is described in further detail.
Detailed description of the invention
Embodiment 1
The Chinese patent medicine of the present embodiment treatment biliary tract, is made up of following crude drug: Herba Artemisiae Scopariae 1200g, Radix Curcumae 600g, money
Grass 600g, Fructus Aurantii 300g.
Its preparation technology comprises the following steps:
Step one, crude drug is smashed after mix, then with distilled water by mixed crude drug moistening, use the way of distillation
Extract the volatile oil of the crude drug after moistening；
Step 2, will extract crude drug boiling after volatile oil 3 times, amount of water is crude drug gross mass for the first time
6 times, decocting time is 3 hours, and amount of water and third time amount of water are 4 times of crude drug gross mass, decocting time for the second time
It is 2 hours, collecting decoction, filters, concentrate filtrate to 60 DEG C and record the thick paste that relative density is 1.20, then to institute
Stating addition ethanol in thick paste to stir, be dried after filtering impurity, the temperature being dried is 80 DEG C, and drying time is 6h, is done
Dry thing A；The quality of described ethanol is 8 times of thick paste quality；
Step 3, by cycloheptaamylose, water and step one extract volatile oil press 6:200:1 mass ratio mixing after use
Colloid mill grinds, and sucking filtration after cold preservation obtains white depositions, described white depositions is vacuum dried, vacuum drying temperature
Being 80 DEG C, the time is 10h, obtains dried object B；
Step 4, by dried object B described in dried object A described in step 2 and step 3 pulverize after mix homogeneously, fill glue
Capsule, every dress 0.3g, the Chinese patent medicine of the biliary tract that obtains medical treatment.
Embodiment 2
The Chinese patent medicine of the present embodiment treatment biliary tract, is made up of following crude drug: Herba Artemisiae Scopariae 1200g, Radix Curcumae 600g, money
Grass 600g, Fructus Aurantii 300g.
Its preparation technology comprises the following steps:
Step one, crude drug is smashed after mix, then with distilled water by mixed crude drug moistening, use the way of distillation
Extract the volatile oil of the crude drug after moistening；
Step 2, will extract crude drug boiling after volatile oil 3 times, amount of water is crude drug gross mass for the first time
6 times, decocting time is 3 hours, and amount of water and third time amount of water are 4 times of crude drug gross mass, decocting time for the second time
It is 2 hours, collecting decoction, filters, concentrate filtrate to 60 DEG C and record the thick paste that relative density is 1.20, then to institute
Stating addition ethanol in thick paste to stir, be dried after filtering impurity, the temperature being dried is 70 DEG C, and drying time is 12h, is done
Dry thing A；The quality of described ethanol is 8 times of thick paste quality；
Step 3, by cycloheptaamylose, water and step one extract volatile oil press 4:180:1 mass ratio mixing after use
Colloid mill grinds, and sucking filtration after cold preservation obtains white depositions, described white depositions is vacuum dried, vacuum drying temperature
Being 70 DEG C, the time is 15h, obtains dried object B；
Step 4, by dried object B described in dried object A described in step 2 and step 3 pulverize after mix homogeneously, fill glue
Capsule, every dress 0.3g, the Chinese patent medicine of the biliary tract that obtains medical treatment.
Embodiment 3
The Chinese patent medicine of the present embodiment treatment biliary tract, is made up of following crude drug: Herba Artemisiae Scopariae 1200g, Radix Curcumae 600g, money
Grass 600g, Fructus Aurantii 300g.
Its preparation technology comprises the following steps:
Step one, crude drug is smashed after mix, then with distilled water by mixed crude drug moistening, use the way of distillation
Extract the volatile oil of the crude drug after moistening；
Step 2, will extract crude drug boiling after volatile oil 3 times, amount of water is crude drug gross mass for the first time
6 times, decocting time is 3 hours, and amount of water and third time amount of water are 4 times of crude drug gross mass, decocting time for the second time
It is 2 hours, collecting decoction, filters, concentrate filtrate to 60 DEG C and record the thick paste that relative density is 1.20, then to institute
Stating addition ethanol in thick paste to stir, be dried after filtering impurity, the temperature being dried is 75 DEG C, and drying time is 10h, is done
Dry thing A；The quality of described ethanol is 8 times of thick paste quality；
Step 3, by cycloheptaamylose, water and step one extract volatile oil press 8:150:1 mass ratio mixing after use
Colloid mill grinds, and sucking filtration after cold preservation obtains white depositions, described white depositions is vacuum dried, vacuum drying temperature
Being 75 DEG C, the time is 12h, obtains dried object B；
Step 4, by dried object B described in dried object A described in step 2 and step 3 pulverize after mix homogeneously, fill glue
Capsule, every dress 0.3g, the Chinese patent medicine of the biliary tract that obtains medical treatment.
The Chinese patent medicine usage and dosage of the present invention: oral, one time 2～3,3 times on the one.
Measure according to high performance liquid chromatography (Chinese Pharmacopoeia one annex VI D of version in 2000).
Chromatographic condition and system test octadecylsilane chemically bonded silica are filler；Acetonitrile-water (20:80) is
Flowing phase；Detection wavelength 283nm.Number of theoretical plate is calculated by naringin peak should be not less than 2000.
The preparation of reference substance solution is taken at 110 DEG C and is dried to the naringin reference substance of constant weight appropriate, accurately weighed, adds methanol
Make every 1mL solution containing 60 μ g, to obtain final product.
The preparation of need testing solution takes the content under this product content uniformity item, mixing, finely ground, takes about 1g, accurately weighed,
Adding methanol 30mL, supersound process 30 minutes (power 250W), filter, filtrate is put in 50mL measuring bottle, and it is few that residue and container add methanol
Amount mark time washing, cleaning mixture filters in same measuring bottle, adds methanol to scale, shakes up, filter with microporous filter membrane (0.45 μm), take
Filtrate, to obtain final product.
Algoscopy precision respectively draws reference substance solution and each 10 μ L of need testing solution, injects chromatograph of liquid, measures, i.e.
?.
This product every (C Han naringin27H32O14) no less than 0.8mg.
Curative effect determinate standard: stagnation of QI due to depression of the liver, dampness-heat in the liver and gallbladder disease mostly is chronic cholecystitis.
Effective: upper right abdomen pain relief, B ultrasonic display gallbladder wall makes moderate progress.
Taking a turn for the better: right Upper abdominal pain disappears, B ultrasonic display gallbladder wall makes moderate progress.
Cure: gallbladder lipoid-food test (-), gallbladder wall recovers normal.
Invalid: without improving.
General clinical data: clinical observation case 100 example of the present invention (mud type calculus 18 example), wherein treatment group 50 example,
Matched group 50 example.Treatment group uses the Chinese patent medicine of the embodiment of the present invention 1 preparation, oral, three times a day, and each 2；Matched group is adopted
Treating with conventional medicine gold mattress Lidan Capsule, conventional amount used shown in usage by specification is administered.Treatment group and the total physical exercise therapy of matched group
Effect compares, and its result see table.
Table 1 treatment group and matched group Comparison of therapeutic
From table 1 it follows that use Chinese patent drugs for treatment biliary tract prepared by present invention process, cure rate reaches 96%,
Apparently higher than conventional medicine gold mattress Lidan Capsule, illustrate that the Chinese patent medicine curative effect using present invention process to prepare is substantially better than conventional medicine
Thing gold mattress Lidan Capsule.
Model case
Case 1
Zhang, man, 52 years old, right upper quadrant of the abdomen dull pain, edible heavy oil feels sick more than 2 years, B ultrasonic display thickening of capsule wall of gallbladder and crude,
There is the grain of rice big microlith number, be diagnosed as Chronic cholecystitis with calculus.The Chinese patent medicine prepared with present invention process, each takes 2
Grain, three times a day, is used in conjunction 28 days, and gallbladder recovers normal, and calculus disappears.
Case 2
Week certain, female, 45 years old, right upper quadrant of the abdomen dull pain more than 3 years, B ultrasonic display thickening of capsule wall of gallbladder, have the big brief summary of rice 1.5 × 1.6cm
2, stone, is diagnosed as calculus type cholecystitis.The Chinese patent medicine prepared with present invention process, each takes 2, three times a day, is used in conjunction 3
After Yue, check, calculus disappears, and gallbladder recovers normal.
Claims (4)
1. treating a preparation technology for the Chinese patent medicine of biliary tract, this Chinese patent medicine is made up of the crude drug of following weight portion: mattress
Old 1200 parts, Radix Curcumae 600 parts, Herba Lysimachiae 600 parts, Fructus Aurantii 300 parts；It is characterized in that, the preparation technology of this Chinese patent medicine include with
Lower step:
Step one, crude drug is smashed after mix, then with distilled water by mixed crude drug moistening, use the way of distillation to extract
The volatile oil of the crude drug after moistening；
Step 2, will extract crude drug boiling after volatile oil 3 times, amount of water is 6 times of crude drug gross mass for the first time,
Decocting time is 3 hours, and amount of water and third time amount of water are 4 times of crude drug gross mass for the second time, and decocting time is 2
Hour, collecting decoction, filter, concentrate filtrate to 60 DEG C and record the thick paste that relative density is 1.20, then to described thick
Cream adds ethanol stir, be dried after filtering impurity, obtain dried object A；
Step 3, by the volatile oil that extracts in cycloheptaamylose, water and step one by (4～8): (150～200): the mass ratio of 1
Grind with colloid mill after mixing, sucking filtration after cold preservation, obtain white depositions, described white depositions is vacuum dried, is done
Dry thing B；
Step 4, by dried object B described in dried object A described in step 2 and step 3 pulverize after mix homogeneously, encapsulated,
Chinese patent medicine to treatment biliary tract.
The preparation technology of a kind of Chinese patent medicine treating biliary tract the most according to claim 1, it is characterised in that step 2
Described in 8 times that quality is described thick paste quality of ethanol.
The preparation technology of a kind of Chinese patent medicine treating biliary tract the most according to claim 1, it is characterised in that step 2
Described in be dried temperature be 70 DEG C～80 DEG C, drying time is 6h～12h.
The preparation technology of a kind of Chinese patent medicine treating biliary tract the most according to claim 1, it is characterised in that step 3
Described in vacuum drying temperature be 70 DEG C～80 DEG C, the time is 10h～15h.
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| CN201610701240.3A CN106110220B (en) | 2016-08-22 | 2016-08-22 | Preparation process of Chinese patent medicine for treating biliary tract diseases |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112526014A (en) * | 2020-11-20 | 2021-03-19 | 兰州市第二人民医院 | Jinyinliang oral liquid fingerprint spectrum and establishing method thereof |
| CN114306500A (en) * | 2022-01-12 | 2022-04-12 | 苏州源流铭医疗科技有限公司 | Novel Chinese patent medicine formula |
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| CN1814255A (en) * | 2005-12-04 | 2006-08-09 | 陕西盘龙制药集团有限公司 | Chinese remedy capsule for treating biliary tract disease |
| CN101062299A (en) * | 2006-04-28 | 2007-10-31 | 通化盛和药业股份有限公司 | Medicine for treating cholecystitis and its preparation |
| CN101549017A (en) * | 2008-04-01 | 2009-10-07 | 北京因科瑞斯医药科技有限公司 | Traditional Chinese medicine composition for treating arrhythmia and preparation method thereof |
| CN102711759A (en) * | 2010-01-29 | 2012-10-03 | 东丽株式会社 | Therapeutic or prophylactic agent for biliary diseases |
| CN104524403A (en) * | 2014-12-12 | 2015-04-22 | 扬子江药业集团四川海蓉药业有限公司 | Traditional Chinese medicine composition capsule for treating climacteric syndrome and preparation method of traditional Chinese medicine composition capsule |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1814255A (en) * | 2005-12-04 | 2006-08-09 | 陕西盘龙制药集团有限公司 | Chinese remedy capsule for treating biliary tract disease |
| CN101062299A (en) * | 2006-04-28 | 2007-10-31 | 通化盛和药业股份有限公司 | Medicine for treating cholecystitis and its preparation |
| CN101549017A (en) * | 2008-04-01 | 2009-10-07 | 北京因科瑞斯医药科技有限公司 | Traditional Chinese medicine composition for treating arrhythmia and preparation method thereof |
| CN102711759A (en) * | 2010-01-29 | 2012-10-03 | 东丽株式会社 | Therapeutic or prophylactic agent for biliary diseases |
| CN104524403A (en) * | 2014-12-12 | 2015-04-22 | 扬子江药业集团四川海蓉药业有限公司 | Traditional Chinese medicine composition capsule for treating climacteric syndrome and preparation method of traditional Chinese medicine composition capsule |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112526014A (en) * | 2020-11-20 | 2021-03-19 | 兰州市第二人民医院 | Jinyinliang oral liquid fingerprint spectrum and establishing method thereof |
| CN114306500A (en) * | 2022-01-12 | 2022-04-12 | 苏州源流铭医疗科技有限公司 | Novel Chinese patent medicine formula |
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| Publication number | Publication date |
|---|---|
| CN106110220B (en) | 2020-01-07 |
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