CN1151771C - Acid resistance film forming dental compoistion and method of use - Google Patents
Acid resistance film forming dental compoistion and method of use Download PDFInfo
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- CN1151771C CN1151771C CNB00803785XA CN00803785A CN1151771C CN 1151771 C CN1151771 C CN 1151771C CN B00803785X A CNB00803785X A CN B00803785XA CN 00803785 A CN00803785 A CN 00803785A CN 1151771 C CN1151771 C CN 1151771C
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- oxalic acid
- acid hydrate
- potassium salt
- hydrate potassium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/25—Compositions for detecting or measuring, e.g. of irregularities on natural or artificial teeth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
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Abstract
A method of utilizing a solution of oxalic acid potassium salt, dihydrate 99 % to react with calcium in the dentinal fluid forming an insoluble white precipitate of calcium oxalate which occludes the dentinal tubules causing decreased sensitivity, permeability and acid penetration of the dentin. A liquid composition of oxalic acid potassium salt, dihydrate 99 % containing about 1.5 % to about 10 % by weight oxalic acid potassium salt, dihydrate 99 % having a particle size of about 1 to about 10 microns when view by a 100 power microscope. The liquid composition has a pH of about 2.0 to 4.0. Methods of preparing the liquid composition are disclosed.
Description
Background of invention
1. invention field
Someone often reports, single tooth or one group of tooth are carried out unexpected extreme heat stimulation, and dentin postoperative allergy or pain increase immediately.This situation or occur in owing to after arranging in the past that repairing that the recurrence dental caries damage following, that the original position that amalgam or tooth colouring resin composite repair is arranged of repairing the position is carried out replaced it perhaps occurs in after energy with system for bleaching tooth (light, heat or other) the supplementary form bleaching teeth.The dentist may remind the patient to note quick air draught, cold drink simply, to the dental articulation masticatory force, or to the increase immediately of the pain that causes such as other factorses such as acidic foods.Show,, change or sweet or acid solution can cause direct increase at the dentin pain reaction as cold water, cold air, osmotic gradient in the stimulation of repairing the concave surface slit.The dentist may claim this phenomenon to be patient dentinalgia (postoperative anaphylactic reaction/DPH) or simple tooth discomfort simply.The patient is often informed by the dentist, only waits for several days or several week, and uncomfortable pain will alleviate gradually, finally should eliminate.
Many in the dentin of living, accepted in the recent period the patients that amalgam or resin composite materials repair usually complain sharply, strongly, the dentinalgia of sensation of pricking, the dentin of this work was treated with conventional dentin cavity lining, this tooth cavity lining such as calcium hydroxide Ca (OH)
2Material is as Dycal (r) or Life (r).The anaphylaxis of dentin postoperative is followed usually by reaching the normal physiological of coating (smear layer) at the concave interstices place that the mouth cavity fluid of acid pH 2.7 to neutral pH 6.0 cause and is peeled off or come off and take place.
If the dentist uses the instrument of any kind, as have awl or the throw that bores is embrocated, perhaps, will stay one deck chip at the dental surface that is called coating with the hand tools polishing of any kind.Peeling off of the coating that causes by the physiological effect or by the dentist opened dentinal tubule's complex and is exposed under the fluidic two-way flow from dental pulp (Pashley, 1981 Arch.Oral.Biol.26:703-706).The bi-directional fluid flow of this increase has caused the dentin postoperative anaphylaxis of patient to cold or quick air-flow just.
Many patients are having amalgam or resin to repair, and the Ca (OH) of Dycal in its lower section (r) or Life (r)
2Substrate is rinsed or is removed and dentin was all experienced the anaphylaxis of dentin postoperative when losing its biological sealing, or only feels the pain that causes owing to discomfort that too early interlock contact or heat or cold extremity are brought.
The physiological mechanism of arranging the dentin pain after amalgam or resin composite materials are repaired has been interpreted as peeling off or losing and cause owing to coating, the peeling off or lose the direct increase (Pashley, et al.1984 Arch.Oral.Biol.29:65-68) that causes subsequently by the fluidic flow of dental pulp of dentin microtubule complex (micro channel complex) of this coating.The increase of this flow may be than big by 94% by the fluidic normal physiologic flow of normal teeth essence matrix.
The present invention relates to a kind of use of antiacid film forming lining material, this lining material can stop up dentinal tubule, thereby reduces Dentinal sensitivity, sour accessibility and discomfort.
2. the general introduction of correlation technique
People's such as above-mentioned Pashley article discloses the fluid dynamic theory that flows and replace of dentinal tubule's content under the various conditions.By the fluid flow forces in the tubule in the dentin, pain stimulation is delivered to neuromechanism.In the prior art, lenitive method is included in hole of preparation in the tooth in the dental repair process, to accept patching material with cavity lining or hole varnish.In this mending course, cavity lining or cavity varnish have been considered to reduce the permeability that dentin is opposite to other material in the hole, just in case patching material allows the little seepage at its edge and tooth, also prevent to come from the appearance of any little seepage of the pollutant of the mouth cavity fluid of attempting to infiltrate tooth cavity.The tooth cavity varnish of prior art comprises the organic gel that is dissolved in organic solvent usually.Organic solvent evaporation stays one deck organic gel thin film on dentin.
These tooth cavity linings mainly are made up of water and dissolved organic matter matter, and this cavity lining places on the liquid level that covers Dentinal surface and not bonding usually.This can weaken any bonding force of tooth cavity varnish to dental surface, and causes seepage.
Natural tooth cavity lining is the crystallite chip of finding in dentin surface, and this dentin surface is cut off and is called as coating.This coating is stopped up the aperture of dentinal tubule, makes antibacterial can not enter dentinal tubule.Yet this coating is often by intraoral sour environment and the little seepage failure that exists around the filler that contacts with the tooth cavity varnish.
Prior art also comprises uses desensitize cementum surface on sensitive dentin or the tooth of oxalates, as at United States Patent (USP) the 4th, 057, in No. 621 disclosed like that.United States Patent (USP) the 4th, 538, disclose in No. 990 use the tooth cavity that different oxalates reduces to make permeability to accept the two-step type method of patching material.This method comprises the oxalates order is coated on the coating.At first, the neutral oxalate solution of coating 1-30% weight/volume, for example the oxidation dipotassium then, in 1 or 2 minute, applies the solution of the salt of sorrel of 0.5-3% weight/volume, as potassium binoxalate.This neutrality oxalates forms a large amount of calcium oxalate crystals in dentin surface, and salt of sorrel former sedimentary than megacryst around form less crystal, thereby form uniform crystal layer.
United States Patent (USP) the 2nd; 746; use dehydroactic acid and soluble-salt are disclosed in No. 905; intraoral pH is maintained about 5.2; to prevent the dissolving of inorganic enamel material; this patent comprises that oxalates that use exists with the form of compositions as the enamel protective agent, strengthens tooth to the destructive repellence of acid.
Be different from above-mentioned document and patent, the present invention uses specific oxalates: 99% dihydrate of oxalic acid potassium salt, when it was coated in dental surface, it was penetrated in the dentinal tubule and tooth fiber of dentin layer.Potassium oxalate (KH3(C2O4)2) dihydrate., or being referred to as two oxalic acid hydrate potassium simply, therefore eliminate fluid flowing in dentinal tubule limit dentin, make it not transmit pain stimulation, thereby make long-time imperceptible pain of patient or discomfort with the form of fluid flow.
Summary of the invention
The method that the present invention relates to utilize 99% two oxalic acid hydrate potassium salt solns (hereinafter being called two oxalic acid hydrate potassium) and the reaction of the ionized calcium in the dentin fluid to form a kind of insoluble white calcium oxalate precipitation, this calcium oxalate precipitation stops up dentinal tubule.This reaction causes the infiltrative reduction of dentin, has reduced Dentinal sour accessibility, and has reduced the dentine hypersensitivity degree.Two oxalic acid hydrate potassium solutions comprise the potassium oxalate dihydrate of about 1.5-10% weight, and pH value arrives in about 4.0 scopes about 2.0.
One object of the present invention is to provide a kind of use two oxalic acid hydrate potassium salt solns to reduce the infiltrative method of dentin.
Another object of the present invention is to provide a kind of use two oxalic acid hydrate potassium salt solns to reduce the method for dentine hypersensitivity degree.
Another object of the present invention is to provide a kind of use two oxalic acid hydrate potassium salt solns to reduce the method for dentin acid accessibility.
Another purpose of the present invention is to provide a kind of simple diagnostic test, determines whether toothache or discomfort are reversible or irreversible.
Another object of the present invention is to provide a kind of method to make it can be with the form of medicament as desensitizer with two oxalic acid hydrate potassium salt are soluble in water.
Detailed description of the present invention
People such as Pashley have reported reaction mechanism and its effectiveness in reducing the odonthemodia degree of potassium oxalate in the literature, referring to Pashley, D.H. wait people (1983): dentin permeability-external Dentrifices desensitization effect (Dentin Permeability-Effects ofDesensitizing Dentrifices In Vitro), J.Periodontol.55:522-525; Pashley, D.H. and Galloway (1985): to oxalates treatment effect (The Effects of Oxalate Treatment on the Smear Layer of GroundSurfaces of Human Dentine) the Arch Oral of ground people dentin surface coating, Biol.30:731-737; Pashley, D.H. (1989): dentin: power matrix (Dentin:A Dynamic Substrate)-A Review.Scanning Micros 3:16-176; Pashley, dentin permeability after people such as E.L. (1989) different surface treatment and bonding strength (Dentin Permeability and Bond Strengthsafter Various Surface Treatments), Dent.Mater 5:375-378.
People such as Pashley disclose and have utilized potassium oxalate to form insoluble calcium oxalate protective layer in the dentin surface that exposes, and this protective layer has stopped up open dentinal tubule.This obstruction has caused the infiltrative reduction of water conductivity and dentinal tubule and has reduced sour infiltration, finally reduced the odonthemodia degree.United States Patent (USP) the 4th, 057 discloses the potassium oxalate chemical compound that the present invention uses for No. 621, comprises desensitization sensitive dentin and cemental method.In the method, a kind of aqueous solution that is selected from the oxalates of single and disubstituted alkali metal and ammonium is coated on dentin and the cementum with effective dose, thereby desensitizes this zone.Disclosed chemical compound comprises following chemical compound in this patent, and shows its water solubility." in chemistry and the physics handbook (Handbook ofChemistry and Physics) (1973-74 and 1995-96) these chemical compounds have been described at the 54th edition and the 76th edition.
Oxalic acid dipotassium (K
2C
2O
4H
2O) hot water dissolving's degree 33.0
Potassium binoxalate (KHC
2O
4) hot water dissolving's degree 16.7
Disodium oxalate. (Na
2C
2O
4) hot water dissolving's degree 6.33
Sodium bioxalate (NaHC
2O
4H
2O) hot water dissolving's degree 21.0
Lithium oxalate (Li
2C
2O
4) cold water solubility 8.0
Oxalic acid hydrogen lithium (LiHC
2O
4H
2O) free of data
Ammonium oxalate [(NH
4)
2C
2O
4H
2O] hot water dissolving's degree 11.8
Ammonium binoxalate (NH
4HC
2O
4H
2O) free of data
Active component of the present invention is 99% two oxalic acid hydrate potassium salt, and its molecular weight is 254.19, and molecular formula is C
4H
3KO
8.2H
2O.These two oxalic acid hydrate potassium salt of 99% (being referred to as two oxalic acid hydrate potassium herein) are the white crystalline powder that is slightly soluble in water, and dissolubility is 29 grams per liters.The preferred two oxalic acid hydrate potassium that use the aqueous solution form.In conventional practice with two oxalic acid hydrate potassium are water-soluble may be very difficult, still, product of the present invention is handled through superaudio, the megacryst potassium oxalate is dispersed in the water, thereby it is dissolved in the water.This processing makes the granularity that the dihydrate of potassium has is enough to satisfy the object of the invention.Any processing method that two oxalic acid hydrate potassium are dissolved in the water all meets the demands, and still, preferably uses variable high frequency sound wave.
In order to prepare product of the present invention, according to the standard testing of American National Standards Institute (ANSI) (AmericanNational Standards Institute), using purity is 1,000,000 to 5,000, the dual distillation deionized water of 000 ohmage.High resistance is equivalent to high-purity.Can use the water of the purification of other form, still, preferred dual distillation deionized water.Enough 99% two oxalic acid hydrate potassium salt crystal are added to the water, and the amount that makes final solution is the 1.5%-4.0% weight/volume.Preferably, the amount of final products is about 2.9% weight/volume.Then with water and crystal through variable hyperfrequency mechanical wave effect, thereby be very little granule with crystal separation, formation solution.This utilizes the ultrasonic tank splitter to finish usually, still, can use any device to dissolve two oxalic acid hydrate potassium salt.Preferably, can use ultrasonic tank splitter such as the Fa Yie of Branson Sony ultrasound wave splitter (Sonifier) or equivalent.This ultrasonic disintegrator will be converted into the vibration of electric energy gadgetize by power.In this device, Jiang Shui and two oxalic acid hydrate potassium crystal are placed in the mixer, and are connected to pumping system.This pump begins recirculated water with the continuous flow of 1/2 liter of about per minute.Water and crystal circulated in the operating room about 30 minutes.This method uses variable hyperfrequency waves directly to focus in cell on the crystal in the water.These mechanical vibration can reach 20,000Hz.In use, preferred vibration is that the top frequency at the ultrasonic horn mouth is about 16,000Hz to 20, and the ultrasonic disassociation of 000Hz, it is with the crystal division and be separated to very little granule, so that these granules enter solution.Water and crystalline mixture repeatedly pass through the ultrasonic horn mouth, at every turn all crystal continuous are decomposed into littler granule through out-of-date.When preferably, the granularity of 1 liter of end product is observed be about 1 to 4 micron under 100 power microscopes.Nearly 60% granule is this size.Remaining granule arrives in about 10 micrometer ranges about 5.After the dissolving, with the naked eye can't see precipitation after 24 hours.Can accept bigger granule, still, preferred about 1 micron to 10 microns granularity, most preferably, granularity is about 1 to 4 micron.
The pH of acid solution is about 2.0 to 4.0, and preferable range is about 2.7 to about 3.0.Most preferably, pH is 3.0.The pH value of acid solution is the amount control by the potassium oxalate dihydrate that is used to fill a prescription.The big more pH value of the amount of two oxalic acid hydrate potassium is more little.
In operation, the use of two oxalic acid hydrate potassium is the single steppings that stop immediately the cold-peace air sensitive.It is also as the diagnosis auxiliary agent, helps that the dentist distinguishes that reversible dentin inner fluid flows and non-dental pulp inflammation and the irreversible fluid flow that causes the dental pulp inflammation.Available suction pipe pincers are placed on about 3 to 6 two oxalic acid hydrate potassium in the clean Dappen dish, available like this two oxalic acid hydrate potassium with little, sterilized cotton ball is saturated, be coated with lightly or put on the skin with cotton balls then the tooth regions that infects at least 30 seconds.This solution can be spread upon lightly around the space of the root surface of cold or corona sclerotin that air stimulation is responsive or exposure or above the corona sclerotin, and above the root of the tooth that exposes.Do not need and should be with the product brush at tooth surface.Do not need to clean.After the coating, can apply gentle air to the surface and disperse, solution is gone out from this regional evapotranspiration, stay white shape white surface, this surface is antiacid layer mineral, can stop the anaphylaxis to the cold-peace air stimulation of fluid flow or dentin.Needn't dry to dental surface, because it can remove this solution.
Before or after the treatment of the oral hygiene of cleaning that is used to prevent and scale removal, product of the present invention can be coated on the dentin of this work of tooth structure of preparation.When preparing all coronas and insert, this product can be replaced as a step with veneer (veneer).This product can be used on the dentin of all holes preparations that are used for amalgam and resin composite materials repairing.This antiacid film forming hole lining material can have and is applied directly to its surperficial binding material to be used to the patching material that bonds.Also can after bleaching schedule product of the present invention be coated in tooth surface, no matter this bleaching schedule is to finish in dentist's clinic or the patient uses home bleaching test kit is finished.In addition, this two oxalic acid hydrates potassium solution can be used as diagnostic tool and distinguishes acute dentinalgia and chronic pulpalgia.Acute dentinalgia is commonly referred to reversible toothache.For dentist and patient, this meaning has a defective to be arranged in the dentin material and not at the nerve of dental pulp.This problem is reversible and without any need for the treatment of the endodontics of invasive.On the contrary, chronic toothache is irreversible stimulation, shows the neural inflammation of dental pulp, must eradicate by the endodontics means of some biomechanicss.Two oxalic acid hydrate potassium of the present invention provide an a kind of simple step diagnostic treatment, can make the dentist differentiate reversible and irreversible toothache.The toothache that the cold-peace air stimulation is produced when patient complaint and do not have the root of the tooth of diagnostic characteristic, fracture of the X-ray photographs that periapical X ray exists or during other tangible clinical symptoms, the dentist can put two oxalic acid hydrate potassium of the present invention on the skin at the edge at dental repair interface and or concave interstices simply on every side.If the patient claims toothache to stop immediately, the dentist can make diagnosis so, and promptly problem is fluid flow or the little seepage in the dentin.This can confirm reversible dental pulp inflammation, can be by replacing this repairing rather than dental pulp being removed.
Be used for reaction pattern of the present invention, for example Hotfix in order to explain reaction mechanism of the present invention, to describe below.But this reaction pattern all is similar concerning all application.Two oxalic acid hydrate potassium acid solutions of the present invention begin to be used for peeling off coating and to open dentin matrix and enamel and cementum.The pH value of the corresponding two oxalic acid hydrate potassium of cushioning effect produces, and along with the carrying out that reacts, the pH value of solution moves to neutrality.Simultaneously, the calcium granular solid matter precipitates on the ripe enamel of root surface and/or cemental crackle at surface, whole hole and any normal presence.When dry, this granular precipitation is as antiacid lining, this lining can chemical bonding in the dentinal tubule in surface and hole.In case form granular crystal, the patient can feel the obstruction effect immediately.Can with the naked eye see the little white thin film of one deck on the surface of hole and tooth.
Embodiment 1
The preparation of solution
29 grams, 99% two oxalic acid hydrate potassium salt (white crystalline material) are joined in 1 liter of dual distillation deionized water in the mixer.This container is covered and is fixed on by Danbury, on the Fa Yie of the Branson Sony ultrasound wave splitter that the Branson Ultrasonic Corporation of CT makes.Connect charging between in container and the ultrasonic disintegrator and return flexible pipe.Pump on the Fa Yie of the Sony ultrasound wave splitter begins recirculation water with the setting value of 1/2 liter of per minute.Ultrasonic disintegrator is started working with the constant duty cycle of setting, and keeps the regular hour, and output frequency is controlled at 9 or 18,000Hz.
Water is passed through ultrasonic disassociation or vibrates 30 minutes.Water was left standstill 30 minutes, take out sample, under 100 power microscopes, observe.Crystalline size is about 10 microns.
Embodiment 2
Use hot water preparation solution
In container, reach 85 °F to 100 °F (29.4-37.8 ℃) up to temperature with 1 liter redistilled water heating and with the stirring rod mixing.Add hot water with a hot plate.29 grams, 99% two oxalic acid hydrate potassium salt are added in the container, and mix with stirring rod and to make 99% two oxalic acid hydrate potassium salt of White-opalescent become concerning naked eyes transparent or transparent relatively.When solution becomes gets when transparent relatively, potassium salt is in suspended state.Then solution is joined as two oxalic acid hydrate potassium salt to 99% in the embodiment 1 described Fa Yie of the Sony ultrasound wave splitter and carry out ultrasonic disassociation.18, ultra-sonic dispersion is about 40 minutes under the 000Hz, generates transparent solution.
Embodiment 3
Clinical assessment
In order to show the desensitization performance of two oxalic acid hydrate potassium of the present invention, before arranging amalgam, repair the patient with normally used commercially available cavity varnish or product of the present invention treatment amalgam.With first all therapeutic processes, the patient finishes the pain application form before the anesthesia that is used for the pretreat assessment.1,3 and 6 all assess patient after surgery also.Result of study shows that patient's postoperative anaphylaxis for the treatment of with two oxalic acid hydrate potassium of the present invention alleviates, especially to the allergy of cold stimulation.
Material and method
Selecting altogether, 65 the activeness dental caries of suffering from damage and for prophylaxis of acute or the hypersensitive tooth of chronic dentin postoperative, repair with commercially available amalgam Tytin (r).Have only those patients that have been chosen in the amalgam Hotfix of UAB to be used for this research.Assess the anaphylaxis of dentin postoperative for the cold stimulation and the air draught that use the heat test, each tooth is accepted prenarcotic assessment.For cold-ice test, plastics needle-like lid filled water and freezing to be used for the standard cold stimulation in refrigerator.
For air stimulation, be used for directly drying in the position that stimulates tooth and defectiveness to repair from the demarcation original air injection stream of chip syringe.Adopt the random data table to select to use Copalite (r) cavity varnish tester or use product of the present invention, the tooth that two oxalic acid hydrate potassium are handled.
The amalgam preparation
According to data acquisition before the art and anesthesia, each tooth is accepted group I or group II hole preparation in the conventional corona.
In 65 teeth, in corona, use Copalite for 35
Control treatment is handled with product two oxalic acid hydrate potassium of the present invention for 30, all acceptance groups of 65 teeth I or group II hole preparation-and with the preparation that is drilled in that ultrahigh speed water sprays and high speed is dug a hole down of novel #245 or #330 carbide.After the hole preparation was finished, cleaning was also used the mild wind drying, uses Copalite
Cavity varnish is handled whole surface of making and is not changed or remove coating.Three layers of Copalite are all used in each contrast hole
Cavity varnish is handled, and every layer at next Copalite of coating
Use chip syringe to disperse before the coating with mild wind.Metallic matrix is arranged on all group II holes, with the spherical amalgam Tyti of decentralized photo
With dental repair to anatomical contours.
The clinical preparation of all other, program, testing standard and record are all identical with those 30 teeth with product treatment of the present invention.30 teeth are in addition handled with product two oxalic acid hydrate potassium of the present invention.After being used to remove in the corona of dental caries group I or group II hole preparation and finishing, clean this hole, disperse with mild wind with disinfectant, and the surface, hole that makes for twice with the processing of two oxalic acid hydrate potassium.Two oxalic acid hydrate potassium solutions are assigned in the clean Dappen dish, suck sterilized cotton ball then.With about 2 minutes of the whole surf zone machinery erasing in the hole of the enamel that makes and dentin surface, disperse air and processing more as described above.With mild wind the surface is dried up, place matrix and use Tytin
Repair the hole.
Before the anesthesia of before art, assessing and in first week of treatment, remind the patient clinical fill in about they to different comprise hot and cold, sweet, chew and oneself's " sensation " of the stimulation of brushing teeth or the table that reacts.The postoperative allergy of 1,3 and 6 all assess patient after surgery also.Subjective understanding, patient data are inferred by allowing the patient draw the 10cm line, show that with this 10cm line they feel the scope of pain.At each interval record McGill visual simulation scale (Visual Analog Scale).Carry out heat test, record data as former test at ice and air draught.
For base-line data, this research in to patient treatment before, assess pain or the sensitivity of each patient to the cold-peace air stimulation.Copalite at matched group
Treat 35 patients altogether in the group, in two oxalic acid hydrate potassium groups, treat patient N=65 altogether in 30 patient-seminar.
According to the size of the chamber (cell) in the probability table of relation of our treatment and reaction, analyze all data by one-way analysis of variances (ANOVA) in 0.05 level.Utilize the relatively difference between on the same group not in the ANOVA of Student T experiment (p<0.050).
The result
The reaction application form
Each reaction is recorded on the independent page, then according to identical standard in home page lists.From McGill visual simulation scale (MVAS) assessment page or leaf record initial data.Experience nothing pain, some pain or the serious anaphylactoid data of postoperative of keenly feeling based on the patient all patients of reacting record of different time interval (0 day day before yesterday of art and postoperative 5,7,21 and 42 days).Report reaction in each case at different testing stimuluses (hot and cold, sweet, percussion is chewed and brush and use the teeth space backguy to remove tartar).Finish evaluation form.
To be used for the data list of each McGill VA scale, and on independent page the name and the clinography label of record patient--there not to be 10 centimetres of straight lines of same tag along its axis.
Preceding allergy-the great majority of art that the problem of corresponding relevant pain, about 12% patient experiences are crossed some type are to cold stimulation.But 65% patient reacts claim the art of some type in the MVA scale before, wherein, surpasses patient's (52%) of 1/2 labelling 0-1mm value in the scale before 10 centimetres of arts.Only 2% of total number of persons experienced in 10 centimetres of MVA scales greater than the art of 5mm before pain.
After conventional dental caries holed, applies two oxalic acid hydrate potassium or Copalite contrast solution and arranges that amalgam is repaired, the patient showed the postoperative sensitivity and reduces.Accept the philtrum of Copalite (r) treatment of contrast at those, in the feedback to direct access inquiry, have the sensitivity of 2.3% pair of various stimulation (especially cold) to reduce.Yet in the middle of the patient with two oxalic acid hydrate potassium treatment of the present invention, having altogether, 80.3% people reports pain relief.
The data of inferring from the MVA scale show that the postoperative pain sharply alleviates in the people that those teeth are treated with two oxalic acid hydrate potassium, and has only 68.7% the patient with Copalite (r) treatment to represent that postoperative pain temporarily alleviates.
These data show, measure for cold discriminating, use the overall pain of patient of ultra dense envelope (Super Seal) to alleviate greater than the patient who uses commercially available Copalite (r).In addition, the patient shows that to the reaction of MVA measurement data great majority have used product of the present invention: the people of two oxalic acid hydrate potassium does not feel postoperative pain.Generally, the patient that 25.7% patient and 88.5% usefulness, two oxalic acid hydrate potassium with Copalite (r) treatment are treated does not feel pain after first program.
Whole experimental results have been displayed in Table 1.In table, product of the present invention is defined as ultra dense envelope (Super Seal).
Should be appreciated that above-mentioned some specific embodiment of the present invention of openly having emphasized, all modifications that is equal to it or change all fall in the spirit and scope of the present invention described herein.
Claims (8)
1. method that forms the solution of two oxalic acid hydrate potassium salt comprises:
Under 29-38 ℃ temperature, be in the 2.0-4.0 scope with pH value, in water, be mixed with the crystalline solution heating of two oxalic acid hydrate potassium salt of effective dose, up to forming suspension;
With the time and the described suspension of frequency supersonic vibration of effective dose, so that when observing solution by 100 power microscopes, the crystalline granularity of described two oxalic acid hydrate potassium salt reduces to the 1-10 micron.
2. the method for claim 1 is wherein before supersonic vibration, with the described two oxalic acid hydrate potassium salt suspensions heating of 1 liter of volume and mixed 40 minutes.
3. the method for claim 1, wherein the amount of two oxalic acid hydrate potassium salt described in the finished product is 1.5-10.0 weight %.
4. crystalline solution of two oxalic acid hydrate potassium salt with the preparation of the described method of claim 1.
5. solution as claimed in claim 4 is wherein before supersonic vibration, with the described two oxalic acid hydrate potassium salt suspensions heating of 1 liter of volume and mixed 40 minutes.
6. solution as claimed in claim 4, wherein the amount of two oxalic acid hydrate potassium salt described in the finished product is 1.5-10.0 weight %.
7. the application of the crystalline solution of the described two oxalic acid hydrate potassium salt of claim 4 in the medicine of preparation reduction dentin infiltration.
8. the application of the crystalline solution of the described two oxalic acid hydrate potassium salt of claim 4 in the medicine for preparing the reversible and irreversible dentin pain of diagnosing the patient that the tooth repairing is arranged.
Applications Claiming Priority (4)
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US25044399A | 1999-02-16 | 1999-02-16 | |
US09/250,443 | 1999-02-16 | ||
US09/502,912 | 2000-02-11 | ||
US09/502,912 US6458339B1 (en) | 2000-02-11 | 2000-02-11 | Acid resistant film forming dental composition and method of use |
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CN1339957A CN1339957A (en) | 2002-03-13 |
CN1151771C true CN1151771C (en) | 2004-06-02 |
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CNB00803785XA Expired - Fee Related CN1151771C (en) | 1999-02-16 | 2000-02-15 | Acid resistance film forming dental compoistion and method of use |
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EP (1) | EP1152740A4 (en) |
JP (2) | JP3851777B2 (en) |
KR (1) | KR100572015B1 (en) |
CN (1) | CN1151771C (en) |
AU (1) | AU766540B2 (en) |
BR (1) | BR0008304A (en) |
HK (1) | HK1043547B (en) |
IL (1) | IL144899A0 (en) |
MX (1) | MXPA01008247A (en) |
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KR101039802B1 (en) * | 2008-10-08 | 2011-06-09 | 주식회사 나이벡 | A Composition for Teeth Desensitizing |
JP6271727B2 (en) * | 2013-10-28 | 2018-01-31 | ザ プロクター アンド ギャンブル カンパニー | Oral care composition for desensitizing teeth |
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US4057621A (en) * | 1976-05-24 | 1977-11-08 | Pashley David H | Desensitizing oxalate dental composition and method of treatment |
US4538990A (en) * | 1984-09-24 | 1985-09-03 | Medical College Of Ga. Research Institute, Inc. | Method of decreasing the permeability of a dental cavity |
DE3840153A1 (en) * | 1987-12-01 | 1989-06-15 | Flachglas Ag | Method for cleaning a surface, which is exposed to the external atmosphere and is coated with metal oxide, of a pane of glass which is fitted in conjunction with a metal façade lining and/or a metal frame |
US5874666A (en) * | 1997-09-19 | 1999-02-23 | Brookfield Engineering Laboratories | Spindle quick-connect and rotary viscometer |
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2000
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- 2000-02-15 KR KR1020017010301A patent/KR100572015B1/en not_active IP Right Cessation
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MXPA01008247A (en) | 2003-09-10 |
AU766540B2 (en) | 2003-10-16 |
KR20010105351A (en) | 2001-11-28 |
JP3851777B2 (en) | 2006-11-29 |
HK1043547A1 (en) | 2002-09-20 |
BR0008304A (en) | 2002-01-22 |
HK1043547B (en) | 2005-02-25 |
JP4458373B2 (en) | 2010-04-28 |
KR100572015B1 (en) | 2006-04-17 |
JP2006316067A (en) | 2006-11-24 |
CN1339957A (en) | 2002-03-13 |
EP1152740A1 (en) | 2001-11-14 |
IL144899A0 (en) | 2002-06-30 |
AU2995700A (en) | 2000-09-04 |
EP1152740A4 (en) | 2005-12-21 |
JP2003528800A (en) | 2003-09-30 |
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