JP2003528800A - Dental composition for forming acid-resistant coating and method of using the same - Google Patents

Abstract

  (57) [Summary] Reacting with calcium in dentin fluid using 99% potassium oxalate dihydrate precipitates insoluble calcium oxalate and reduces dentin sensitivity and permeability. An effective amount of potassium oxalate dihydrate having a potassium oxalate dihydrate concentration of about 1.5% to about 10.0% by weight and a solution pH of about 2.0 to 4.0 is prepared. A method of reducing dentin transmittance, comprising applying dentin in an aqueous solution.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD OF THE INVENTION

The present invention relates to a method of using an acid resistant film forming liner material to occlude dentin tubules to reduce dentine hypersensitivity, acid permeability and discomfort.

[0002]

[Prior art]

It is often reported that dentin becomes hypersensitive or painful after the operation, and sudden heat stimulation is suddenly applied to a specific tooth or a group of teeth. The output of a system that replaces the existing amalgam alloy or tooth-colored resin composite restorative part before the resting part due to recurrent carious symptom under the resting part or whitens the teeth (light, heat, etc.) ) The above symptoms may occur after the assisting tooth bleaching process. Patients should simply be alerted by the dentist to note that rapid air jets, cold drinks, and discomfort with other factors such as the force of occlusion and acid foods may increase sharply. Not too much. When cold water, cold air, gradual change of osmotic pressure, or stimulation of sweet or acidic solution around the mudron surface of the restoration, irritation of dentin immediately increases. The dentist may refer to this pictorial phenomenon simply as the patient's dentin distress (postoperative hypersensitivity / DPH) or simply as dental discomfort. Patients are often told by the dentist to simply wait for 2-3 days or 2-3 weeks, and the pain of discomfort gradually diminishes, eventually disappearing.

[0003]

[Problems to be Solved by the Invention]

Calcium hydroxide Ca (OH) such as Dycal (r) or Life (r)
) Among many patients who have recently added amalgam alloy or resin composite restorations to live dentin treated with conventional dentin liners such as ₂ materials, dentin is acute and sharp and stinging dentin pain. Is often a very common complaint. Postoperative hypersensitivity of dentin is due to normal physiological decomposition of the coating layer or removal of the coating layer in the vicinity of the sinus surface by changing the pH in the mouth from acidic pH 2.7 to more neutral pH 6.0. Usually occurs by being done.

When a dentist uses some type of appliance, such as a rotary tool with a drill or boring tool, it will be rubbed or abraded by some kind of manual tool, a surface of the tooth called the application layer. A layer of shavings will be left on. When the application layer is damaged by physiology or by the dentist, the dentin tubules open and are exposed to fluid flow from the dentin pulp in both directions. It is this increased bidirectional fluid flow that makes the patient's dentin postoperatively hypersensitive to cold or fast airflow.

In many patients, the existing amalgam alloy, the resin composite restoration part and the underlying Ca (OH) ₂ base of the dical (r) and life (r) are washed out or removed, and the dentin becomes biological. Experience postoperative hypersensitivity of the dentin when the static seal is lost, or early obstructive contact or exposure to extreme heat or cold feels discomfort.

[0006] The physiological mechanism for dentin distress after placement of an amalgam alloy or resin composite restoration is that the flow of pulp fluid through the microchannels increases as soon as the application layer breaks or is lost. (Pashley,
et al. 1984 Arch. Oral. Biol. 29: 65-68). The flow enhancement may be 94% greater than the normal physiological flow of fluid through the normal dentin matrix.

The above Pashley et al. Reference discloses a hydraulic theory of flow for dentinal tubule content and its displacement under various conditions. The painful stimulus is transmitted to the nerve structure by hydraulically moving the force in the tubule in the dentin. A conventional method for relieving pain during the dental restoration process is to create a cavity in the tooth and insert the restoration with a cavity liner or cavity varnish. The restorative material prevents the attack of contaminants from the oral fluid from leaching into the cavity when a small amount of leakage occurs, i.e. when the restorative material leaks around the edge of the tooth, and this restoration It is claimed to reduce the permeability of dentin to other materials placed in the cavities during. Prior art hollow varnishes often include organic rubber dissolved in organic solvents. The organic solvent evaporates, leaving a film of organic rubber on the dentin.

[0008] These hollow liner materials mainly consist of water and a soluble organic substance, and the outer liner material is often placed on the liquid layer that covers the surface of the dentin without adhering. This can weaken the adhesion of the hollow varnish to the tooth surface, but can also lead to leakage.

Cavity natural liners are microcrystalline strips found on the surface of cut dentin and called coating layers. The coating layer occludes the opening of the dentin tube, preventing bacteria from entering the tubule. However, the coating layer is often destroyed by acidification in the oral cavity and by microleakage around the filler that contacts the hollow varnish.

Further, as disclosed in US Pat. No. 4,057,621, in the prior art, oxalate is used to desensitize the hypersensitive dentin or the cement surface on the tooth. U.S. Pat. No. 4,057,621 discloses a two-step method for reducing the permeability of dental cavities prepared for loading restorative materials with different oxalates. In this method, oxalate is sequentially applied to the coating layer. First, a 1-30% weight to volume neutral oxalate solution, eg, dipotassium oxide, is applied, followed by 0.5% weight to volume percent acidic oxalate solution, eg, monobasic, within 1 or 2 minutes. Apply potassium monohydrogen oxalate, etc. Neutral oxalates form large crystalline calcium oxalates on the dentin surface, while acidic oxalates form small crystals around the previously precipitated large crystals, resulting in uniform Form a crystal layer.

US Pat. No. 2,746,905 discloses the use of dihydroacetic acid and a soluble salt to maintain a mouth pH of about 5.2 to prevent the dissolution of inorganic tooth enamel materials. . This method uses oxalate in the composition as an enamel protector to improve tooth acid resistance.

[0012]

SOLUTION OF THE INVENTION

In contrast to the above references and patents, the present invention utilizes 99% of a particular oxalate, potassium oxalate dihydrate, which when applied to the tooth surface. The substance penetrates into the tubules and fibrils of the dentin layer. Potassium oxalate dihydrate, which can also be called potassium oxalate dihydrate, eliminates the movement of fluid in the tubules, thus causing painful irritation in the form of dentine movement of fluid. Can be prevented from being transmitted to the dental pulp. Therefore, the patient. No pain or discomfort over the long term.

The present invention uses 99% potassium oxalate dihydrate, hereinafter referred to as potassium oxalate dihydrate, to react with calcium ions in dentin fluid to produce oxalate including dentin tubules. A soluble white precipitate of sodium acidate is formed. This action reduced dentin permeability, thereby reducing dentin permeability, reducing dentin acid permeability, and reducing dentin sensitivity. Potassium oxalate dihydrate is about
It contains 1.5 to about 10% potassium oxalate dihydrate and has a pH in the range of about 2.4 to about 4.0.

The object of the present invention is to reduce the permeability of dentin using a potassium oxalate salt dihydrate solution. Another object of the present invention is to reduce the sensitivity of dentin using a potassium oxalate dihydrate solution.

Another object of the present invention is to use oxalic acid potassium salt dihydrate solution to reduce the acid permeability of dentin. Yet another object of the present invention is to provide a simple diagnostic test method for determining whether dental distress or discomfort is reversible or irreversible. Still another object of the present invention is to provide a method of solubilizing soluble oxalic acid potassium salt dihydrate in water and making the dihydrate available in a dosage form used as a sensitizer. Is.

[0016]

Embodiments

The mechanistic action of potassium oxalate and its effect in reducing dental susceptibility have been reported in the literature: Pashley, DH et al. Z (1983): “Dentis Permeability-Effects of
Dessensitizing Dentrificeds In Vitro, D. Sensitizing Dentrificeds In Vitro, J. Periodontol, 55: 522-525; Pashley, DH & Gallow
ay (1985): The Effects of Oxalate Treatment on the Smear Layer of Groun
d Surfaces of Human Dentine. Arch. Oral. Biol., 30: 731-737; Pashley, DH (1989): Denti.
n; A dynamic Substrate-A Review. Scanning Micros 3
: 161-176; Pashley, EL et al. (1989) Dentin Permeability and Bond St
rengths after Various Surface Treatments. Dent. Mater. 5: 373-378.

Pashley et al. Disclose a protective layer in the form of potassium oxalate for insoluble calcium oxalate on the surface of exposed dentin and that occludes open tubules. This blockage reduces hydroconductivity and capillary permeability, reduces acid permeability and ultimately reduces dentin sensitivity. U.S. Patent No. 4,057,621
Disclose potassium oxalate compounds useful in the present invention, including methods of reducing the sensitivity of hypersensitive dentin and cementum. In this method, an effective amount of a compound selected from the group consisting of oxalic acid mono-substituted or di-substituted alkali metal and ammonium is applied to an aqueous solution to dentin and cementum to reduce the sensitivity in the same area. There is. The compounds disclosed in this patent include the following, which also exhibit their solubility in water. These are described in the Chemistry / Physics Handbook 54th and 75th editions (1973-74, 1995-96).
.

Dipotassium oxalate (K ₂ C ₂ O ₄ —H ₂ O) 33.0 Hot water solubility Potassium hydrogen oxalate (KHC ₂ O ₄ ) 16.7 Hot water solubility Sodium oxalate (Na ₂ C ₂ O ₄ ) 6.33 Heat Water solubility Sodium hydrogen oxalate (Na ₂ C ₂ O ₄ -H ₂ O) 21.0 Hot water solubility Lithium oxalate (Li ₂ C ₂ O ₄ ) 8.0 Cold water solubility Lithium hydrogen oxalate (KHC ₂ O ₄ -H ₂ O) No reading Ammonium oxalate ((NH) ₂ C ₂ O ₄ -H ₂ O) 11.8 Hot water solubility Hydrogen oxalate (NH ₄ K ₂ C ₂ O ₄ -H ₂ O) No reading

The active ingredient of the present invention is 99% oxalic acid potassium salt dihydrate with a molecular weight of 25.
The chemical formula in 4.19 is C ₄ H ₃ KO ₈ -2H ₂ O. 99% potassium oxalate dihydrate, here potassium oxalate dihydrate, is a white crystalline powder that is slightly soluble in water and has a solubility of 29 Gm / liter. Potassium oxalate hydrate is preferably used in aqueous solution. Although it may be difficult to dissolve potassium oxalate dihydrate in water by conventional conventional methods, the product of the present invention disperses large crystal potassium oxalate in water by exposure to ultrasonic waves. And thus solubilized in water. By this treatment, potassium dihydrate has a particle size necessary and sufficient for the purpose of the present invention. While any treatment of solubilizing potassium oxalate dihydrate in water is satisfactory,
It is preferable to use various high frequency sound waves.

To obtain the product of the present invention, deionized water having a water purity of double distillation and having a resistance of 1,000,000 to 5,000,000 Ω according to the standardized test method of the American National Standards Office is used. High resistance is comparable to high purity. Although other forms of pure water can be used, doubly distilled deionized water is preferred. Sufficient 99% crystals of potassium oxalate dihydrate are added to water to bring the final solution concentration to the range of 1.5% to 4.0 weight to volume. Preferably, the amount is about 2.9% weight in the final product. The water and crystals are then exposed to various high frequency effects, forming crystals into very small particles and forming a solution. Typically, the above steps are performed using an ultrasonic cell disruptor, but any means may be used to solubilize the potassium oxalate salt dihydrate. Preferably, a Branson ultrasonicator or an ultrasonic cell disruptor identified as equivalent can be used. Ultrasonic devices convert electrical energy from a power source into mechanical vibrations. In this device, water and potassium oxalate dihydrate crystals are placed in a mixing container and attached to a pump device. Start the pump and circulate the water as a continuous flow at about 1/2 liter.
The water and crystals are circulated in the tube chamber for about 30 minutes. In this method, various ultra-high frequencies are directly applied to crystals in water with a small chamber. 2000 mechanical vibration
It can be up to Hz. In use, a preferable vibration is a vibration that causes ultrasonic dissociation at a frequency of about 16,000 Hz to about 20,000 Hz at the tip of an ultrasonic horn. The reason is that this breaks the crystals and breaks them down into very small particles, which are released into solution. The mixture of water and crystals is passed through the ultrasonic horn multiple times, continuously making the crystals smaller particles each time the mixture is passed. Preferably, 1 liter of final product has a particle size of from about 1 to about 4 microns when viewed under a 100 × microscope. About 60% of the particles fall into this size. The balance of the particles can range from about 5 to about 10 microns. After solubilization, no particles were seen even after 24 hours with the naked eye without using a microscope. Larger particle sizes are acceptable, but particle sizes in the range of about 1 micron to about 10 microns are preferred, with particle sizes of about 1 to 4 microns being most preferred.

The pH of the acidic solution is about 2.0 to 4.0, with a preferred range of about 2.7 to about 3.0.
Most preferably, the pH is 3.0. The pH of the acidic solution is controlled by the amount of potassium oxalate dihydrate used in the formulation. The higher the amount of potassium oxalate dihydrate, the lower the pH.

In therapy, the use of potassium oxalate dihydrate is a one-step method that immediately stops sensitivity to cold and air. Useful as a diagnostic aid to help dentists in distinguishing between reversible fluid flow in dentin and non-pulp swelling and irreversible fluid flow resulting in pulp swelling . Using forceps, place about 3-6 drops of potassium oxalate dihydrate in a clean Dappen dish and fill a small sterile linen pallet with potassium oxalate dihydrate, then allow the effect for at least 30 seconds. Gently rub or gently tap on the tooth you received.
The solution can also be gently rubbed slowly around or over the cementum in the crown or on the exposed root surface and on the exposed root of the tooth which is sensitive to color and air stimuli. It is not necessary or necessary to brush the product onto the tooth surface. No rinse is needed. After application, the solution can also be evaporated from the area by gently applying a dispersed air stream to the surface. This leaves a frosty white surface that is an acid resistant mineral layer. The mineral layers stop the movement of fluids or stop the movement of cold and air stimuli and stop the hypersensitivity of dentin. As a result, the solution can be removed, so that it is not necessary to blow air strongly.

The product of the invention may be applied to the prepared tooth structure, such as live dentin, before and after prophylactic hygiene of the mouth to clean and remove tartar. The product can be used as a one-step arrangement underneath all crowns and fittings in the form of lamellas. For amalgam alloy and resin composite restorations, the product can be used on dentin in all cases where cavities have been created. The acid resistant film forming liner material can also include an adhesive material that can be applied directly to the surface for adhering to the repair material. Following the bleaching process, the liner material may be applied to the tooth surface, although the bleaching process may be performed at the dentist office or the patient may use the bleaching kit at home. Further, potassium oxalate dihydrate can be used as a diagnostic tool for distinguishing between acute dentin pain and chronic dental pulp pain. Acute dentin distress is commonly referred to as reversible tooth distress. For dentists and patients, this means that the defect is located within the nerve in the pulp when it is located within the dentin matrix. The problem is reversible which requires no invasive endodontic treatment. Instead, chronic toothache is an irreversible stimulus that indicates that the pulp of a tooth is nerve-removing and the nerve must be removed by some biomechanical endodontic device.
The potassium oxalate dihydrate of the present invention provides the dentist with a simple, one step diagnostic tool that allows reversible and irreversible discrimination of tooth distress. Patients complain of coldness and air but radiographs do not have diagnostic features to indicate whether there is a radiolucently broken root around the apical root or other apparent clinical problems In some cases, the dentist may simply rub the potassium oxalate dihydrate of the present invention on the edge of the dental restoration interface or the edge of the cavity. If the patient says that the tooth pain has ceased immediately, the dentist can complete the diagnosis that the problem is dentin fluid flow or a small leak. This is a confirmation of reversible pulp inflammation, which can be treated by repairing the repair and does not require pulp removal.

In order to explain the action mechanism of the present invention, the action mode of the present invention used in, for example, the repair process will be described below. However, this mode of operation is similar for all applications. The acidic solution of potassium oxalate dihydrate of the present invention first destroys the coating layer and opens openings in the dentin matrix as well as the enamel and cementum. A buffering effect acts on the pH of potassium oxalate dihydrate, and the pH of the solution moves to neutral as the reaction proceeds. At the same time, calcium particles settle over the entire cavity, in addition to any physiological small cracks that are usually present in the enamel and / or cementum on the surface of the roots of adults. The sediment of the particles, when dried, becomes an acid resistant lining layer that chemically bonds to the surface and hollow dentin tubule Tubules.
Once the granular crystals have formed, the patient immediately perceives the barrier effect. Even with the naked eye, a slightly whitish coating can be seen on the cavities and tooth surfaces.

[0025]

【Example】

Example 1 Preparation of Solution 29 g of 99% potassium oxalate dihydrate, a white crystalline substance, was added to 1 liter of deionized water that had been double distilled in a mixing vessel. The container was capped and attached to a Branson ultrasonicator manufactured by Ultrasonic in Danbury. Supply and return hoses were connected between the container and the ultrasonicator. The ultrasonic pump was started and water was circulated at a rate of 1/2 liter / minute. Constant duty cycle, hold time,
The output control was set and started at .9 or 18,000 Hz. The water was ultrasonically dissociated or vibrated for 30 minutes. Leave the water for 30 minutes,
The sample was taken out and observed under a 100 × microscope. The crystal size was about 10 microns.

Example 2 Preparation of Solution with Heated Water 1 liter of doubly distilled water was heated in the solution until the temperature went from 85 ° F. to 100 ° F. and mixed with a stir bar. A hot plate was used to heat the water.
29 g of potassium oxalate dihydrate 99% was added to a container and mixed with a stir bar, and the white opaque potassium oxalate dihydrate 99% became clear and relatively transparent with the naked eye. . The potassium salt was in suspension when the solution became relatively clear. Further solution was added to the sonicator and potassium oxalate dihydrate 99 as described in Example 1.
% Was ultrasonically dissociated. The solution was treated with ultrasonic waves at 18,000 Hz for 40 minutes to obtain a clear solution.

Example 3 Clinical Evaluation To demonstrate the desensitizing properties of the potassium oxalate dihydrate of the present invention, patients with amalgam repair are provided with a commercially available hollow varnish or book that is commonly used prior to amalgam placement. Treated with the product of the invention. Prior to anesthesia for pretreatment evaluation and during the first week of treatment, patients completed all questionnaires for distress. Patients were also evaluated 1, 3 and 6 weeks after surgery. The results of the study demonstrate that patients treated with the potassium oxalate dihydrate of the invention have reduced post-treatment hypersensitivity, especially to cold.

(Materials and Methods) A total of 65 human teeth having active caries symptoms except for postoperative hypersensitivity symptoms of acute or chronic dentin were selected, and commercially available amalgam alloy Titin (Tyt.
repaired with in (r)). Only patients who selected the amalgam repair method in the UAB were used in this study. For each tooth, a preliminary anesthesia evaluation was performed on postoperative hypersensitivity of the dentin by cold stimulus and air blast for heat test. For the cold ice test, plastic needle covers were filled with water, frozen in a refrigerator freezer and used as a standard cold stimulus.

For air stimulation, a standard baseline air jet from a syringe was used to blow the air stream directly onto the attack tooth and the defect repair. Using a random number chart,
Copalite (r) varnish controlled teeth and teeth treated with the product of the invention, potassium oxalate dihydrate, were selected.

Preparation of Amalgam After collecting pretreatment data and anesthesia, each tooth was caved with a Class I or Class II cavity in a normal crown. Coronary Copalite® Controlled 35 teeth and 30 teeth treated with the product of the invention, potassium oxalate dihydrate, for a total of 65 teeth sprayed with water In addition, a class I or class H cavity was opened with a new # 245 or # 330 carbide boring tool at a very high speed while discharging at high speed. After the cavities were opened, they were rinsed and gently dried with air, and the whole surface perforated was treated with Copalite® without modifying or removing the coating layer. Each control cavity was treated with 3 layers of Copar varnish and
Prior to applying the (Copalite®) coat, each layer was slightly dispersed with air with a tip syringe. A metal matrix was placed over all of the Class II cavities and the teeth were restored to the anatomical shape with the dispersed phase spherical amalgam alloy Tytin®.

All other clinical preparatory procedures, test criteria and recovery methods were treated with the product of the present invention.
It was identical to that used for 9 teeth. Thirty new new teeth were treated with the product of the invention, potassium oxalate dihydrate. Class I or Class H in the crown
After removing the caries by opening the cavity, the cavity was cleaned with sterile water, gently sprinkled with air, and the resulting cavity surface was treated twice with potassium oxalate dihydrate. The potassium oxalate dihydrate solution was placed in a clean Dappen dish and absorbed into sterile cotton pellets. The entire surface area of the prepared enamel and dentin surface cavities was mechanically cleaned for about 2 minutes, sprinkled with air and treated again as before. The surface was gently dried with air, the matrix was placed and the cavities were repaired with Tytin®.

Prior to anesthesia for pretreatment evaluation and during the first week of treatment, the patient is revisited to the dentist to “feel” to various stimuli including coldness, heat, sweetness, bite and brushing. That is, the form for “response” is filled. Also, one week, three weeks,
To assess postoperative postoperative patient hypersensitivity at 6 weeks. If the patient feels they are in the area of distress, collect a subjective consideration of the patient data by crossing the 10 cm line at that point. At each hour, we noted the McGill visual similarity scale. Thermal tests were performed on ice and air blasts and data recorded for all previous tests.

For all baseline data, each patient prior to treatment in this study was evaluated for cold or air distress or sensitivity. A total of 35 patients were treated in the Copalite® group as controls and 30 patients were treated in the potassium oxalate dihydrate group. The total number of study groups was N = 65.

The cell size in the contingency table of treatment vs. response was analyzed by a variable one-way analysis (ANOVA) at a level of 0.05. Differences between different groups within ANOVA were compared using the Student T test (p <0.050)

Results (Question Answer) The answers from each patient were recorded on a separate sheet and tabulated on the master sheet according to the above criteria. Raw data from the McGill Visual Analog Scale (McGill Visual
Recorded from the Analog Scale (MVAS) evaluation sheet. Data was collected from all patients. No postoperative hypersensitivity, some, and some postoperative preoperative hypersensitivity based on patient response at 0 days preoperatively, and at various time intervals postoperatively on days 5, 7, 21, and 42. In each case, responses were reported for different test stimuli: coldness, heat, sweetness, bite, impact, brushing and interdental brushing. Completed the evaluation form.

The data for each McGill VA scale was tabulated and recorded on a separate sheet containing the patient's name and clinical card record number. A straight line of 10 centimeters was recorded along its axis without specific markings.

Approximately 12% of patients experienced some preoperative hypersensitivity in response to pain, often cold stimuli. However, 65% of patients reported some preoperative response on the MVA scale. Greater than 1/2 (52%) of those patients showed a value of 0-1 mm on the 10-centimeter preoperative scale. Only 2% of the total population is 10
He had experienced some pre-operative distress greater than 5 mm on the centimeter MVA scale.

Usually, caries are removed and potassium oxalate dihydrate or Copalit
e) After application of the control solution and placement of the amalgam restoration, the patient had reduced post-operative susceptibility. Patients who received control Copalite (r) treatment responded to direct questions with a sensitivity of 2.3 to various stimuli, especially cold.
%Diminished. However, in patients treated with the potassium oxalate dihydrate of the invention, the reported distress was reduced overall at a level of 80.3%.

Data collected from the MVA scale showed that post-operative distress was significantly reduced for teeth treated with potassium oxalate dihydrate, whereas Copalite.
68.7% of patients in (r) had a temporary reduction in postoperative distress.

The data show that commercially available Copalite (r) was used as a means to identify coldness.
Compared to, the Super Seal significantly reduced overall pain. Furthermore, it was shown that the majority of the patients who answered the MVA survey did not experience post-operative pain with the product of the present invention, potassium oxalate dihydrate. Overall, 25.7% of patients treated with Copalite (r) and 88.5% of patients treated with the product of the invention, potassium oxalate dihydrate, There was no pain after the procedure.

The complete test results are shown in Table 1. The products of the invention are
r Seal).

[Table 1] While the above disclosure highlights certain embodiments of the present invention, changes and modifications thereto are within the spirit and scope of the invention described herein.

[Procedure amendment]

[Submission date] January 14, 2003 (2003.1.14)

[Procedure Amendment 1]

[Document name to be amended] Statement

[Name of item to be amended] Claims

[Correction method] Change

[Contents of correction]

[Claims]

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Claims (37)

[Claims] 1. An effective amount of potassium oxalate salt having a concentration of about 1.5% to about 10.0% by weight potassium dihydrate dihydrate and a solution pH of about 2.0 to about 4.0. A method of reducing dentin permeability, which comprises applying dihydrate in aqueous solution to dentin. 2. The effective amount of the potassium oxalate salt dihydrate is 2.9%.
The method of claim 1. 3. The method of claim 1, wherein the pH of the aqueous solution containing potassium oxalate dihydrate is 3.0. 4. The concentration of potassium oxalate dihydrate is from about 1.5% by weight to about 10.
Hypersensitivity comprising applying an effective desensitizing amount of potassium oxalate dihydrate at 0 wt% with a solution pH of about 2.0 to about 4.0 to dentin and cementum in an aqueous solution. A method for desensitizing dentin and cement. 5. An effective amount of the potassium oxalate salt dihydrate is 2.9%.
The method of claim 4. 6. The pH of the aqueous solution of potassium oxalate dihydrate is 4.0.
The method of claim 4. 7. A method of diagnosing reversible and irreversible dentin distress by a dental restorative portion having a tooth interface, wherein a solution of potassium oxalate dihydrate is applied to the restorative portion of the tooth. A diagnostic method, comprising applying an aqueous solution containing potassium oxalate dihydrate on and around the cavity surface of the interface, and allowing the patient to indicate whether the dental distress that confirms reversible pulp inflammation has stopped. 8. The method of claim 7, wherein the effective amount of potassium oxalate salt dihydrate is from about 1.5% to about 10% by weight. 9. The method of claim 7, wherein the pH of the aqueous solution containing potassium oxalate salt dihydrate is from about 2.0 to about 4.0. 10. A potassium oxalate dihydrate, which comprises mixing an effective amount of crystals of potassium oxalate dihydrate with water and dissolving the crystals by ultrasonically vibrating the solution at a frequency for an effective time. Method for producing a liquid solution. 11. An effective amount of the potassium oxalate salt dihydrate is an amount that forms a solution that desensitizes dentin and cementum and reduces the permeability of the prepared cavity surface of the tooth. The method of claim 10. 12. An effective amount of the potassium oxalate salt dihydrate is about 1.
12. The method of claim 11, which is 5% to about 10% by weight. 13. An effective amount of the potassium oxalate salt dihydrate is about 2.
The method of claim 11, wherein the method is 9% by weight. 14. The method of claim 7, wherein the pH of the aqueous solution is about 2.0 to 4.0. 15. The method of claim 11, wherein the pH of the aqueous solution is about 3.0. 16. The method of claim 10, wherein the crystal grain size is not visible to the naked eye 24 hours after forming the solution. 17. The method of claim 16, wherein the crystal grain size is from about 1 micron to about 10 microns when the solution is viewed under a 100 × microscope. 18. The crystal grain size is from about 1 micron to about 4 microns.
the method of. 19. The method according to claim 11, wherein the potassium oxalate dihydrate is heated in an aqueous solution before being dissociated or vibrated by ultrasonic waves. 20. A solution of potassium oxalate dihydrate is about 85 ° F. to about 100 °.
20. The method of claim 19, wherein heating to a temperature of F. 21. The method of claim 20, wherein the potassium oxalate salt dihydrate solution is heated and mixed for a time sufficient to form a suspension. 22. The method of claim 21, wherein 1 liter volume of potassium oxalate dihydrate solution is heated and mixed for about 40 minutes prior to ultrasonic dissociation. 23. The method of claim 10, wherein the water is purified. 24. The method of claim 10, wherein the water has been double distilled and deionized. 25. The method of claim 10, wherein the solution is vibrated in an ultrasonicator. 26. The method of claim 10, wherein the ultrasonicator vibrates the solution at energy levels up to 20,000 Hz. 27. The method of claim 10, wherein the solution is vibrated at an energy level of about 16,000 Hz to about 19,000 Hz. 28. The method of claim 27, wherein the solution is vibrated at an energy level of about 18,000 Hz. 29. The method of claim 26, wherein the solution is shaken for about 30 minutes. 30. A stable liquid composition of potassium oxalate dihydrate comprising an effective amount of water and an aqueous solution of potassium oxalate dihydrate effective to reduce dentin permeability. object. 31. The method of claim 30, wherein the potassium oxalate dihydrate has a particle size that is invisible to the naked eye 24 hours after forming the liquid composition. 32. The liquid composition of claim 30, wherein the crystal grain size is from about 1 micron to about 10 microns when the solution is viewed under a 100X microscope. 33. The liquid composition of claim 32, wherein the crystal size of the potassium oxalate salt dihydrate is from about 1 micron to about 4 microns when the solution is viewed under a 100X microscope. 34. An effective amount of the potassium oxalate salt dihydrate is about 1.
31. The liquid composition of claim 30, which is 5% to about 10% by weight. 35. An effective amount of the potassium oxalate salt dihydrate is about 2.9 of the composition.
31. The liquid composition of claim 30, which is wt%. 36. The pH of the aqueous solution containing potassium oxalate dihydrate is about 2.0.
31. The liquid composition of claim 30, which is from about 4.0 to about 4.0. 37. The pH of the aqueous solution containing potassium oxalate dihydrate is about 3.0.
31. The liquid composition of claim 30, which is