KR20010105351A - Acid resistant film forming dental composition and method of use - Google Patents

Abstract

A method of using potassium oxalate salt, 99% dihydrate, to react with calcium in dentin fluid to form calcium oxalate of white precipitate that occludes dentin tubules resulting in reduced sensitivity, permeability and acid penetration of dentin. The liquid composition of potassium oxalate salt, dihydrate 99% comprises from about 1.5% to about 10% by weight of potassium oxalate salt, dihydrate 99% having a particle size of about 1 to about 10 microns when viewed under a 100-fold microscope. The liquid composition has a pH of about 2.0 to 4.0. A method for preparing the liquid composition is disclosed.

Description

Acid resistant thin film for forming dental composition and method of using the same {ACID RESISTANT FILM FORMING DENTAL COMPOSITION AND METHOD OF USE}

The paper by Pashali et al. Discloses changes in the hydrodynamic theory of fluids and the components of dental tubules under various conditions. Pain irritants are delivered to nerve tissue by hydrodynamic transfer of force to the tubules in the dentin. Conventional methods of alleviating pain during the dental healing process include preparing a cavity in the tooth to receive the recovery material with a vortex liner or vortex varnish. Such materials reportedly not only block the attack of all microleakage but also reduce the dentin permeability to other materials that vortex during this recovery. That is, if the recovery material allows microleakage around the teeth and their edges, it blocks the attack of contaminants due to oral fluids attempting to penetrate the cavity. Vortex varnishes of the prior art often include an organic gum dissolved in an organic solvent. The organic solvent evaporates leaving a thin film of organic gum on the dentin.

Such vortex lining agents consist mainly of water and soluble organic materials which are often placed on a liquid layer covering the dentin without any binding. This weakens all the adhesion of the vortex varnish to the tooth surface and can cause leakage.

Natural vortex liners are microscopic tissue debris found on the surface of the cut dissimilar material called the smear layer. The smear layer mates the hole in the dentin tubule to the point where bacteria cannot access the tubule. However, the smear layer is often destroyed due to the presence of microleakage around the filler material in contact with the acidic and vortex varnishes in the oral cavity.

The prior art also includes the use of oxalates to desensitize hypersensitive dentin or cementitious surfaces on teeth, as disclosed, for example, in US Pat. No. 4,057,621. U. S. Patent No. 4,538, 990 discloses a two step method using different oxalates to reduce the vortex permeability of dental fabrics prepared to accommodate restorative materials. The method involves the serial application of oxalate to the smear layer. First, 1 to 30% weight is applied to neutral oxalate solution, for example, potassium oxide volume, and then 0.5 to 3 to volume percent of acidic oxalate solution such as monopotassium monohydrogen oxalate within 1 or 2 minutes. Apply% weight. Neutral oxalate forms large calcium oxalate crystals on the dentin surface, and acidic oxalate forms smaller crystals around larger crystals that have previously precipitated to form a uniform crystal layer.

U.S. Patent No. 2,746,905 discloses the use of dehydrogenacetic acid and soluble salts to maintain pH of the mouth at about 5.2 to prevent dissolution of inorganic tooth enamel materials, enameling to increase tooth resistance from acidic attack Use of oxalate in the composition as a protective agent is included.

In contrast to the above documents and patents, the present invention utilizes certain oxalate salts, potassium oxalate salts, dihydrates and penetrates into the tubules and fibrils of the dentin layer when 99% of it is applied to the tooth surface. Oxalate potassium salt dihydrate, simply called potassium oxalate dihydrate, restricts dentin to eliminate fluid movement in the tubules and thus cannot deliver painful irritants to the pulp in the form of fluid movement. Therefore, no pain or discomfort is felt by the patient for a long time.

Individuals say that hypersensitivity or pain immediately increases after dentin surgery for a particular extreme or thermal stimulus to a group of teeth. This may be due to the return of recovery due to recurrent caries lesions underneath the previously placed recovery, i.e., after the initial placement of recovery of the existing amalgam alloy or tooth colored resin composite, or the power (light, heat or other) of the tooth whitening system. This can happen after bleaching the teeth in tidal forms. Patients are simply warned by the dentist to notice an immediate increase in pain sensation for other factors such as rapid jets of air, cold drinks, bite bite or acidic foods. Vortexing in the recovery showed that irritation, such as cold water, cold air, osmotic component migration, or sweet or acidic solutions in the right angle all resulted in an immediate increase in dentin pain response. Dentists may simply refer to this phenomenon as patient dentin pain (hypersensitivity after surgery / DPH) or simply dental discomfort. Often patients are told by dentists that if they wait a few days or weeks, those unpleasant pains will lessen and eventually go away.

Acute, sharp, bone-bearing dentin pain is treated with conventional dentin liners such as calcium hydroxide Ca (OH) ₂ materials such as Dycal (r) or Life (r). It is often a fairly common complaint among many patients who have recently undergone amalgam alloy or resin composite recovery to vital vital dentin. Hypersensitivity after dentin surgery usually results from normal physiological disruption of the smear layer or removal of the smear layer from the right angle when vortexed with oral fluid resulting in more acidic pH 2.7.

If dentists use all types of instruments, such as rotary instruments with drills or burrs, mowing or polishing with all kinds of manual instruments will leave a layer of tissue debris on the tooth surface called the smear layer. Breakage of the smear layer by physiological action or by a dentist opens and exposes the dentin tubular complex to the bidirectional flow of fluid in the pulp (Pashali, 1981 structure. Oral. Biology 26: 703-706). Increased bidirectional fluid flow is responsible for hypersensitivity after dentin surgery in patients with cold or rapid air flow.

Many patients recover the existing amalgam alloy or resin composites and the underlying Ca (OH) ₂ bases of the underlying dical (al) or life (al) so that the dentin loses its biological seal, or You may experience hypersensitivity after dentin surgery when you simply feel pain from immature occlusion or discomfort due to heat or cold extremes.

Physiological mechanisms for dentin pain following the placement of amalgam alloys or resin composites are described as being due to the destruction or loss of the smear layer resulting in an instant increased flow of pulp fluid through the fine channel complex (Pashali et al., 1984). Structure, oral, biology 29: 65-68). This increase in flow is 94% higher than the normal physiological flow of fluid through the normal dentin matrix.

The present invention relates to the use of acid resistant thin films that form a liner material that engages dentin tubules to reduce dentin sensitivity, acid penetration and discomfort.

The present invention provides a solution of potassium oxalate, dihydrate, 99% (hereinafter referred to as potassium oxalate dihydrate) solution to react with ionized calcium in the dentin fluid to form an insoluble white precipitate of calcium oxalate containing dentin tubules. It relates to a method using. This action leads to reduced permeability of dentin, reduced acid penetration of dentin and reduced dentin sensitivity. The potassium oxalate dihydrate solution comprises about 1.5 to about 10 weight percent of potassium oxalate dihydrate and has a pH of about 2.0 to about 4.0.

It is an object of the present invention to provide a method of using a potassium oxalate dihydrate solution to reduce dentin permeability.

Another object of the present invention is to provide a method of using a potassium oxalate dihydrate solution to reduce dentin sensitivity.

It is yet another object of the present invention to provide a method of using potassium oxalate dihydrate solution to reduce acid penetration of dentin.

Another object of the present invention is also to provide a simple diagnostic test for determining whether the pain or malaise of the dentin is reversible or irreversible.

It is yet another object of the present invention to provide a method for dissolving potassium oxalate dihydrate in water for use in a dosage form to act as a desensitizer.

The effect of potassium oxalate on its mechanism as well as its reduction in dentin sensitivity has been reported in the literature by Pashali et al. (Pashali, D. H., et al. Pasili, D. H. and Galloway (1985): The Effect of Oxalate Treatment on the Smear Layer of the Basal Surface of Human Dentin Structure Oral Biology 30: 731-737; Pasili, DD (1989): Dentin: Dynamic Substrate-Review, Scanning Micros 3: 161-176; Pasili, E.L. et al. (1989) Dentin Permeability and Bond Strength After Various Surface Treatments Dent, Mater 5 See 375-378)

Pacheley et al. Published a protective layer in the form of potassium oxalate of insoluble calcium oxalate on the exposed dentin surface that occludes open tubules. Occlusal causes not only a decrease in hydrogen conductance and tubular permeability but also a decrease in acid penetration and, ultimately, a decrease in dentin sensitivity. U.S. Patent No. 4,057,621 discloses potassium oxalate compounds useful in the present invention, including methods for desensitizing hypersensitive dentin and cementitious. In that method, one element selected from the group consisting of single and double substituted alkali metals and ammonium oxalate in an aqueous solution is applied to the dentin and cementum in an amount effective to desensitize the zone. Compounds disclosed in this patent include the following and exhibit water solubility below. They are described in the Chemistry and Physics Handbook, 54th and 76th editions (1973-74 and 1995-96).

Di-potassium oxalate _{(K 2 C 2 O 4 ·} H 2 O) 33.0 water solubility

Potassium Hydrogen Oxalate (KHC ₂ O ₄ ) 16.7 Hot Water Solubility

Sodium Oxalate (Na ₂ C ₂ O ₄ ) 6.33 Hot Water Solubility

Sodium hydrogen oxalate _{(NaHC 2 O 4 · H 2} O) 21.0 water solubility

Lithium Oxalate (Li ₂ C ₂ O ₄ ) 8.0 Cold Water Solubility

Lithium hydrogen oxalate _{(LiHC 2 O 4 · H 2} O) is not recorded

Ammonium oxalate _{[(NH 4) 2 C 2} O 4 · H 2 O] 11.8 Hot Water Solubility

Hydrogen oxalate _{(NH 4 HC 2 O 4 ·} H 2 O) is not recorded

The active ingredient of the present invention is potassium oxalate, dihydrate 99%, molecular weight is 254.9, and the chemical formula is C ₄ H ₃ KO ₈ .2 H ₂ O. The potassium oxalate salt, dihydrate 99%, referred to herein as potassium oxalate dihydrate, is a white crystalline powder slightly soluble in water and having a solubility of 29 Gm / liter. Potassium oxalate dihydrate is preferably used in an aqueous solution. Dissolution of potassium oxalate dihydrate in water is difficult under normal practice, but the product of the present invention is subjected to ultrasonic frequencies so that large crystals of potassium oxalate are dispersed and dissolved in water. This treatment makes the potassium dihydrate suitable for the purposes of the present invention and of sufficient particle size. All treatments for dissolving potassium oxalate dihydrate in water are satisfactory, but it is desirable to use various high frequency sound waves.

To prepare the product of the present invention, deionized water was distilled twice with water purity of 1,000,000 to 5,000,000 ohm resistance, according to standardized tests of the American National Standards Institute. High resistance is comparable with high purity. Other forms of purified water may be used, but double purified deionized water is preferred. Sufficient potassium oxalate salt, dihydrate 99% crystals are added to the water so that the amount of the final solution is 1.5% to 4.0% by weight. Water and crystals are subjected to a variety of ultrahigh frequency reactions, causing the crystals to break down into very small particles, forming solutions. This is typically done using an ultrasonic cell disruptor, but any method can be used to dissolve the potassium oxalate salt, dihydrate. Preferably, an ultrasonic cell disruptor or equivalent, such as identified by Branson Sonifier, may be used. This sonifier converts the electrical energy of the power supply into mechanical vibrations. In such a device, the water and potassium oxalate dihydrate crystals are placed in a mixing vessel and attached to a pump system. The pump begins to circulate a continuous stream of water at about 1/2 liter per minute. Water and crystals are circulated in the chamber for about 30 minutes. This process utilizes a variety of ultrahigh frequencies focused directly in the chamber for the determination of water. Mechanical vibrations can reach 20,00 Hz. In use, the preferred vibration provides sonication at a frequency of about 16,000 Hz to about 20,000 Hz at the end of the ultrasonic horn to disintegrate and disintegrate the crystal into very small particles to enter the solution. The water and crystal mixture passes through the ultrasonic horn several times and continuously disintegrates the crystal into smaller particles each time through the horn. Preferably, the particle size in one liter of the final product is close to about 1 to 4 microns when viewed under a 100-fold microscope. The remaining particles range from about 5 to about 10 microns. After dissolution, no precipitation was observed after 24 hours visually without any assistance.

The acidic solution has a pH of 2.0 to 4.0, preferably about 2.7 to 3.0. Most preferably, the pH is 3.0. The pH of the acidic solution is controlled by the amount of potassium oxalate dihydrate used in the formulation. The higher the amount of potassium oxalate dihydrate, the lower the pH.

In operation, the use of potassium oxalate dihydrate is a one-step process that immediately stops coldness and sensitivity to air. It is beneficial as a diagnostic aid to dentists in distinguishing between reversible fluid flow in dentin and non-water inflammation and irreversible fluid flow resulting in pulp inflammation. About 3-6 drops of potassium oxalate dihydrate is placed on a clean Dappen dish with pitsen, and the small, sterile cotton pad is saturated with potassium oxalate dihydrate, followed by potassium oxalate dihydrate for at least 30 seconds. Gently rub and apply over sore tooth area. The solution is gently applied around the edges or over the crown cement or on the exposed root surfaces as well as on exposed roots of teeth that are sensitive to cold or air irritants. The product does not need to be brushed on the tooth surface and does not have to be carried out. No rinse is needed. After application, a gentle air dispersion may be applied to the surface to evaporate the solution in a region that leaves a cold white surface, an acid resistant inorganic layer that stops fluid migration or dentin hypersensitivity to cold and air irritants. It is not necessary to blow air strongly on the tooth surface because the solution can be removed.

The product of the present invention can be applied on prepared dental structures, such as vital dentin, before and after oral hygiene treatment for cleaning or scaling prevention. The product can be used as a one step replacement under all crowns and inlays of single plate manufacturing. It can be used on the dentin of all vortex preparations for amalgam alloy and resin composite recovery. The acid resistant thin film forming the liner material may have a bonding material applied directly on its surface to bond the recovery material. It may also be applied on the tooth surface after the bleaching process, whether the bleaching process is done in a dentist's clinic or the patient uses a home bleaching set. Potassium oxalate dihydrate solution can also be used as a diagnostic tool for differentiating extreme dentin pain and chronic pulp pain. Extreme dentin pain is commonly referred to as reversible tooth pain. For dentists and patients, this means that there is a flaw that lies on the surface of the dentin, not the nerve bundle in the pulp. The problem is reversible without any invasive root canal treatment. Chronic tooth pain, on the other hand, is an irreversible stimulus that indicates that nerves in the pulp are inflamed and must be removed using a kind of biomechanical root canal device. The potassium oxalate dihydrate of the present invention provides a simple one-step diagnostic process that allows dentists to identify reversible and irreversible dental pain. When a patient complains of cold and air pain and there is no diagnostic form of periradial radiopaque presence, fractured roots or other obvious clinical problems, dentists may use the potassium oxalate dihydrate of the present invention to Vortexing or cornering the recovery interface can simply apply over or around the right corner. If the patient expresses immediate discontinuation of dentin pain, the dentist can diagnose that the problem is dentin or microleakage fluid flow. This is a confirmation of reversible pulp inflammation and can be treated without recovery and removal of pulp.

To illustrate the mechanism of action of the present invention, the following is a description of the mode of action of the present invention used, for example, in the recovery process. However, the mode of action is similar for all applications. The acidic solution of potassium oxalate dihydrate of the present invention initially acts to destroy the smear layer and open the dentin substrate, as well as enamel and cementitious. As the pH of the potassium oxalate dihydrate buffers and the reaction progresses, the pH of the solution shifts towards neutrality. At the same time, calcium granule particles precipitate on the entire vortex surface in addition to all small physiological defects normally present in the adult enamel and / or cementum of the root surface. This granule precipitation is an acid resistant lining layer which, when dried, chemically bonds to the surface as well as to the dentin tubular interior of the vortex. Once granular crystals are formed, the barrier effect is immediately felt by the patient. When visually seen without assistance, there is a weakly slightly white thin film visible on the surface of the vortex and teeth.

Example 1

Preparation of the solution

Potassium oxalate, 99% dihydrate, 29 grams of white crystalline material were added to 1 liter of double distilled deionized water in a mixing vessel. The vessel was covered and attached to CT, Branson Sony, manufactured by Branson Ultrasonics, Danbury. The supply and return hoses are connected between the vessel and the sonifer. The pump on Sony began to recycle water at 1/2 liters per minute. Sony's peers began with constant efficiency cycles, duration, and power control at .9 or 18,000 Hz.

The water was subjected to sonication or vibration for 30 minutes. Samples were taken to leave for 30 minutes of water and viewed under a 100x microscope. The crystals were about 10 microns in size.

Example 2

Solution preparation with heated water

One liter of the distilled water was heated and mixed in a vessel with stirring bar until the temperature reached 85 ° F to 100 ° F. Hot plates were used to heat the water. Adding 29 grams of 99% potassium oxalate salt, dihydrate to the vessel and mixing immediately with stirring stirs 99% of the white opaque potassium oxalate salt dihydrate to be visually clear or relatively transparent. When the solution became relatively clear, the potassium salt was suspended. The solution was then added to Sony pier as described in Example 1 for sonication of potassium oxalate, 99% dihydrate. Sonication at 18,000 Hz for about 40 minutes gave a clear solution.

Example 3

Clinical evaluation

In order to exhibit the desensitizing properties of the potassium oxalate dihydrate according to the invention, amalgam patients were treated with the products of the invention prior to commercially available vortex varnishes or amalgam batches which were commonly used. Before anesthesia for the pre-treatment evaluation and during the first week of treatment, patients completed a questionnaire on pain. Patients were also evaluated at 1 week, 3 weeks, and 6 weeks after surgery. The results of the study demonstrated that postoperative hypersensitivity, especially cold hypersensitivity, was reduced in patients treated with the potassium oxalate dihydrate of the present invention.

Substances and Methods

A total of 64 people with teeth with active caries lesions were selected to recover to commercially available amalgam alloy titine (egg), except for presensitization after acute or chronic dentin surgery. Only patients who elected amalgam recovery in the UAB were selected for this study. Each tooth was subjected to a pre-anesthetic evaluation of the hypersensitivity after denture surgery of the dentin with cold irritants and air jets for thermal testing. For cold-ice testing, plastic injection covers were filled in water and frozen in refrigerator freezers to be used as standardized cold irritants.

For air stimulation, standardized baseline air jets from syringes are used to direct the wind of air to the spoiled teeth and defective recovery. A chart of randomly extracted numbers was adopted to select teeth treated with potassium oxalate dihydrate, or the product for copallite (AL) varnish control, the product of the present invention.

Amalgam

After preoperative data collection and anesthesia, each tooth received a routine endogenous Class-I or Class-II vortex preparation.

35 All 65 teeth treated with endothelial Copallite® control and potassium oxalate dihydrate, the product of the present invention, were classified as Class-I or Class-II vortex preparation (ultra-high-speed new # under water spray and fast discharge). Manufactured from either 245 or # 330 carbide bars). After vortex preparation, rinsing and gentle air drying, the entire preparation surface was treated with Copallite® varnish without deformation or removal of the smear layer. Each control vortex was treated with three layers of copal varnish, each layer slowly dispersed with air through a chip syringe before subsequent application of Copallite® coating. Metal substrates were placed on all Class II vortex preparations and the teeth were reconstructed to anatomical appearance with dispersed spherical amalgam alloy Titin®.

All other clinical manufacturing procedures, test criteria and recovery are the same as those adopted with 39 teeth treated with the product of the present invention. An additional 30 teeth were treated with potassium oxalate dihydrate, the product of the present invention. After preparation of intubated Class-I or Class-H vortex for removal of cavities, the vortex was washed with sterile water, gently dispersed in air and the prepared vortex surface treated twice with potassium oxalate dihydrate. The potassium oxalate dihydrate solution is dispensed into clean dippene dishes and then absorbed into sterile cotton pellets. The entire vortex surface area and dentin surface of the enamel prepared were mechanically sterilized for about 2 minutes, air dispersed and treated again as described above. The surface was gently air dried, the substrate laid and the vortex recovered with Titin®.

Prior to anesthesia for pretreatment evaluation and during the first week, patients were summoned to the clinical laboratory to respond to their detection of the response or “feel” to various irritants, including cold, hot, sweet, blistered and brushed. I made a paper about it. The patient was also evaluated for postoperative hypersensitivity at 1, 3 and 6 weeks after surgery. Essential considerations of the patient's data were collected by having patients across the 10 cm line at the point where they felt the extent of their indicated pain. The McVille visual analysis scale was noted every hour. Thermal tests for ice and air blast were performed and data recorded as in all of the previous tests.

For baseline data, each patient was evaluated for pain or sensitivity to cold and air prior to treatment in this study. A total of 35 patients were treated under the control of the Copallite® group and 30 patients were treated within the potassium oxalate dihydrate group--for a total study group of N = 65.

All data were analyzed by one-way analysis of variables (ANOVA) at the 0.05 level, depending on the cell size in our chance table for treatment versus response. Differences between the various groups in ANOVA were compared using Student's T test (p <0.050).

result

Survey response

Each patient's response was recorded on a separate sheet and tabulated on the administrator's sheet according to distinct criteria. Raw data was recorded from McVille Visual Analog Scale (MVAS) evaluation sheets. Data were recorded from all patients who experienced no or little or severe post-surgical hypersensitivity based on the response of the patients at various intervals on day 0 before surgery, 5, 7, 21 and 42 days after treatment. In each case, responses to various test stimuli such as cold, hot, sweet, chewing shock, and brushing and interdental cleaning were recorded. The evaluation form is complete.

Data for each McVill VA scale was tabulated and recorded on a separate sheet with the patient's name and the number of clinical records (in a 10 cm straight line with no indication recognized along the axis).

Approximately 12% of patients experienced some kind of presurgical hypersensitivity in response to questions about pain (primarily for cold irritants). However, 65% of patients insisted on some kind of preoperative response on MVA scaling--more than half of these patients (52%) displayed 0-1mm scale on a 10cm preoperative scale. Only 2% of the total population experienced all preoperative pain greater than 5 mm on a 10 cm MVA scale.

After conventional caries excavation, applying potassium oxalate dihydrate or copallite control solution and deploying amalgam recovery, patients showed reduced sensitivity after surgery. Among individuals who received control copallite (egg) treatment, in response to a direct questionnaire, the sensitivity to various irritants (particularly cold) was reduced by 2.3%. However, among patients treated with the potassium oxalate dihydrate of the present invention, the overall reduction in pain reported was 80.3%.

Collected data from the MVA scale showed a dramatic reduction in postoperative pain in teeth treated with potassium oxalate dihydrate, while only 68.7% of copallite (AL) patients showed temporary pain reduction after surgery.

Such data indicated that the overall pain reduction was much lower with super seals than commercially available copallite (al) for identifier measurements. In addition, patient responses to the MVA investigation paper showed that the majority of individuals did not experience postoperative pain with potassium oxalate dihydrate, the product of the present invention. Overall, 25.7% of patients treated with copallite (al) and 88.5% of patients whose teeth were treated with potassium oxalate dihydrate were painless in the primary process below.

The completed test results are shown in Table 1. The products of the present invention are defined as super seals in the table.

Patient Response Data / Amalgam Alloy Study 35 Copallite® 30 Super Seal Full Recovery = 65 stimulant ache matter Before treatment 5 days 7 days 21st 42 days Cold Severe Copallite® 0 0 0 0 0 Super thread 0 0 0 0 0 slightly Copallite® 8 7 7 4 3 Super thread 8 One 0 0 0 none Copallite® 27 28 28 31 32 Super thread 22 29 30 30 30 Hot thing Severe Copallite® 0 0 0 0 0 Super thread 0 0 0 0 0 slightly Copallite® 0 One One 2 2 Super thread 0 0 0 0 0 none Copallite® 35 34 34 33 33 Super thread 30 30 30 30 30 sweet Severe Copallite® One One One One One Super thread 0 0 0 0 0 slightly Copallite® 0 One One 2 2 Super thread 2 One 0 0 0 none Copallite® 34 33 33 32 32 Super thread 28 29 30 30 30 Bite sensitivity Severe Copallite® 0 0 0 0 0 Super thread 0 0 0 0 0 slightly Copallite® One One One One One Super thread 4 5 One 2 2 none Copallite® 34 34 34 34 34 Super thread 26 25 29 28 28 Brushing Interdental Cleaning Severe Copallite® 0 0 0 0 0 Super thread 0 0 0 0 0 slightly Copallite® 2 2 3 3 3 Super thread 4 One 0 0 0 none Copallite® 33 33 32 32 32 Super thread 26 29 30 30 30

The foregoing description highlights specific embodiments of the invention and all variations or alternative equivalents thereto are within the spirit and scope of the invention described herein.

Claims (37)

Permeability of dentin is characterized by applying an effective amount of potassium oxalate salt dihydrate to an dentin in an aqueous solution having a concentration of about 1.5% to about 10.0% by weight of potassium oxalate dihydrate and having a pH of about 2.0 to about 4.0 How to reduce. The method of claim 1 wherein the effective amount of said potassium oxalate dihydrate is 2.9%. The method of claim 1 wherein the pH of the solution comprising potassium oxalate dihydrate is 3.0. An effective desensitization amount of potassium oxalate dihydrate in an aqueous solution having a concentration of about 1.5% to about 10% by weight of potassium oxalate dihydrate and having a pH of about 2.0 to about 4.0 is applied to dentin and cementitious Desensitization of hypersensitive dentin and cementum. 5. The method of claim 4 wherein the amount of potassium oxalate dihydrate is 2.9%. 5. The method of claim 4 wherein the pH of said potassium oxalate dihydrate solution is 4.0. When the vortex of the tooth recovery boundary is applied, a potassium oxalate dihydrate solution is placed on and around the right corner, and the patient is instructed whether or not to stop the dentin pain, proving that stopping the pain is a reversible pulp in the tooth. A method of diagnosing reversible and irreversible dentin pain in a patient with recovery of dentin recovery with a borderline of. 8. The method of claim 7, wherein the effective amount of potassium oxalate dihydrate is in the range of about 1.5% to about 10% by weight. 8. The method of claim 7, wherein the solution comprising potassium oxalate dihydrate has a pH in the range of about 2.0 to about 4.0. Oxalate potassium salt dihydrate crystals are mixed with water; A method of forming a potassium oxalate salt dihydrate solution comprising ultrasonically vibrating the solution at an effective time and frequency to dissolve the crystals. The method of claim 10, wherein the effective amount of potassium oxalate dihydrate is an amount necessary to desensitize dentin and cementum and form a solution that reduces the permeability of the prepared vortex surface in the tooth. 12. The method of claim 11, wherein the amount of potassium oxalate dihydrate is from about 1.5% to about 10% by weight in the final product. 13. The method of claim 12, wherein the amount of potassium oxalate dihydrate is about 2.9% by weight in the final product. The method of claim 10, wherein the pH of the solution is about 2.0 to 4.0. The method of claim 14, wherein the pH of the solution is about 3.0. The method of claim 10, wherein the grain size of the crystal is indicated to be invisible by visual observation about 24 hours after solution formation. 17. The method of claim 16, wherein the particle size of the crystal is from about 1 micron to about 10 microns when the solution is viewed under a 100x microscope. 17. The method of claim 16, wherein the grain size of the crystal is about 1 to about 4 microns. 12. The method of claim 11, wherein said potassium oxalate salt is heated in an aqueous solution prior to sonication or vibration. 20. The method of claim 19, wherein the potassium oxalate dihydrate solution is heated to a temperature of about 85 degrees to about 100 degrees Fahrenheit. 21. The method of claim 20, wherein the potassium oxalate dihydrate solution is heated and mixed for an amount of time sufficient to form a suspension. 22. The method of claim 21, wherein one liter of said potassium oxalate dihydrate solution is heated and mixed for about 40 minutes prior to sonication. The method of claim 10 wherein the water is purified. The method of claim 10 wherein the water is double distilled and deionized. The method of claim 10, wherein the solution is vibrated with a sonifier. 11. The method of claim 10, wherein said Sony pear vibrates said solution at an energy level of up to 20,000 Hz. The method of claim 10, wherein the solution vibrates at an energy level of about 16,000 Hz to about 19,000 Hz. The method of claim 27, wherein the solution is vibrated at an energy level of about 18,000 Hz. 27. The method of claim 26, wherein the solution is vibrated for about 30 minutes. Effective amount of water; A stable, liquid composition of potassium oxalate dihydrate comprising an effective amount of potassium oxalate dihydrate to reduce the permeability of dentin in a solution of water. 31. The liquid composition of claim 30, wherein the potassium oxalate dihydrate has a particle size that is invisible to the naked eye for about 24 hours after formation of the liquid composition. 31. The liquid composition of claim 30, wherein the particle size of the potassium oxalate dihydrate is about 1 to 10 microns when viewed under a 100x microscope. 33. The liquid composition of claim 32, wherein the particle size of the potassium oxalate dihydrate is about 1 to about 4 microns when viewed in a 100-fold microscope. 31. The liquid composition of claim 30, wherein the amount of potassium oxalate dihydrate is from about 1.5% to about 10% by weight of the composition. 31. The liquid composition of claim 30, wherein the potassium oxalate dihydrate is about 2.9% by weight of the composition. 31. The liquid composition of claim 30, wherein the pH is about 2.0 to 4,0. 31. The liquid composition of claim 30, wherein the pH is about 3.0.