CN115175697A - 具有多糖-蛋白质缀合物的a组链球菌免疫原性组合物 - Google Patents

具有多糖-蛋白质缀合物的a组链球菌免疫原性组合物 Download PDF

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Publication number
CN115175697A
CN115175697A CN202180015475.6A CN202180015475A CN115175697A CN 115175697 A CN115175697 A CN 115175697A CN 202180015475 A CN202180015475 A CN 202180015475A CN 115175697 A CN115175697 A CN 115175697A
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seq
polypeptide
immunogenic composition
gas
amino acid
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CN202180015475.6A
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English (en)
Chinese (zh)
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J·C·法尔曼
N·卡普
P·T·戴维
A·A·塞德拉
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Vaxcyte公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0283—Shigella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/2111—C5a peptidase (3.4.21.110)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/116—Polyvalent bacterial antigens
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
CN202180015475.6A 2020-02-18 2021-02-17 具有多糖-蛋白质缀合物的a组链球菌免疫原性组合物 Pending CN115175697A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US202062977886P 2020-02-18 2020-02-18
US62/977,886 2020-02-18
US202063013924P 2020-04-22 2020-04-22
US63/013,924 2020-04-22
US202063090069P 2020-10-09 2020-10-09
US63/090,069 2020-10-09
US202063123293P 2020-12-09 2020-12-09
US63/123,293 2020-12-09
PCT/US2021/018402 WO2021167996A1 (en) 2020-02-18 2021-02-17 Group a strep immunogenic compositions with polysaccharide-protein conjugates

Publications (1)

Publication Number Publication Date
CN115175697A true CN115175697A (zh) 2022-10-11

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ID=74860575

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180015475.6A Pending CN115175697A (zh) 2020-02-18 2021-02-17 具有多糖-蛋白质缀合物的a组链球菌免疫原性组合物

Country Status (13)

Country Link
US (1) US20230293658A1 (enExample)
EP (1) EP4106807A1 (enExample)
JP (1) JP2023514332A (enExample)
KR (1) KR20220143107A (enExample)
CN (1) CN115175697A (enExample)
AU (1) AU2021224585A1 (enExample)
BR (1) BR112022016268A2 (enExample)
CA (1) CA3168201A1 (enExample)
IL (1) IL295702A (enExample)
MX (1) MX2022010129A (enExample)
PH (1) PH12022552118A1 (enExample)
TW (1) TW202136285A (enExample)
WO (1) WO2021167996A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230052958A (ko) 2020-08-19 2023-04-20 박사이트, 인코포레이티드 운반-단백질 폴리삭카라이드 접합 방법
EP4294452A4 (en) * 2021-02-17 2025-09-24 Vaxcyte Inc METHODS FOR PURIFYING POLYSACCHARIDES AND CORRESPONDING POLYPEPTIDE CONJUGATES

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013020090A2 (en) * 2011-08-04 2013-02-07 The Regents Of The University Of California STREPTOCOCCAL GLcNAc-LACKING GLYCOPOLYPEPTIDES, CELL WALL CARBOHYDRATES, STREPTOCOCCUS VACCINES, AND METHODS FOR MAKING AND USING THEM
WO2018126229A2 (en) * 2016-12-30 2018-07-05 Sutrovax, Inc. Polypeptide-antigen conjugates with non-natural amino acids

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6355255B1 (en) * 1998-12-07 2002-03-12 Regents Of The University Of Minnesota Streptococcal C5a peptidase vaccine
BRPI0821240B8 (pt) * 2007-12-21 2022-10-04 Novartis Ag formas mutantes de estreptolisina o
CN102264444B (zh) 2008-10-27 2015-08-05 诺华股份有限公司 纯化方法
RU2662970C2 (ru) * 2012-09-18 2018-07-31 Новартис Аг Везикулы наружной мембраны

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013020090A2 (en) * 2011-08-04 2013-02-07 The Regents Of The University Of California STREPTOCOCCAL GLcNAc-LACKING GLYCOPOLYPEPTIDES, CELL WALL CARBOHYDRATES, STREPTOCOCCUS VACCINES, AND METHODS FOR MAKING AND USING THEM
WO2018126229A2 (en) * 2016-12-30 2018-07-05 Sutrovax, Inc. Polypeptide-antigen conjugates with non-natural amino acids

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BI SHUAI等: "A Multicomponent Vaccine Provides Immunity against Local and Systemic Infections by Group A Streptococcus across Serotypes", 《MBIO》, vol. 10, no. 6, 26 November 2019 (2019-11-26), pages 1 - 12 *
DI BENEDETT0 ROBERTA等: "Rational Design of a Glycoconjugate Vaccine against Group A Streptococcus", 《INT.J.MOL.SCI》, vol. 21, no. 22, 13 November 2020 (2020-11-13), pages 8558 *
G.BENSI等: "Multi High-Throughput Approach for Highly Selective Identification of Vaccine Candidates:the Group A Streptococcus Case", 《MOLECULAR &CELLULAR PROTEOMIC》, vol. 11, no. 6, 1 June 2012 (2012-06-01) *
GA0 NINA J.等: "Site-Specific Conjugation of_Cel1 Wal¹Polyrhamnose to Protein SpyAD Envisioning a Safe Universal Group A Streptococcal Vaccine", 《INFECTIOUS MICROBES AND DISEASES》, 29 December 2020 (2020-12-29) *
RIVERA-HERNANDEZ TANIA 等: "An Experimental Group A Streptococcus Vaccine That Reduces Pharyngitis and Tonsillitis in a Nonhuman Primate Model", 《MBIO》, vol. 10, no. 2, 30 April 2019 (2019-04-30), pages 00693 - 19 *
SABHARWAL HEMANT等: "Group A streptococcus(GAS)carbohydrate as an immunogen for protection against GAS infection", 《JOURNAL OF INFECTIOUS DISEASES》, vol. 193, no. 1, 1 January 2006 (2006-01-01), pages 129 - 135 *
VAN SORGE NINA M等: "The Classical Lancefield Antigen of Group A Streptococcus Is a Virulence Determinant with Implications for_Vaccine Design", 《CELL HOST &MICROBE》, vol. 15, no. 6, 11 June 2014 (2014-06-11), pages 729 - 740 *
WANG SUBO 等: "Group A Streptococcus Cell Wal¹0ligosaccharide-Streptococcal C5a Peptidase Conjugates as Effective Antibacterial Vaccines", 《ACS INFECT. DIS》, vol. 6, no. 2, 24 December 2019 (2019-12-24), pages 281 - 290 *

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Publication number Publication date
AU2021224585A1 (en) 2022-10-13
WO2021167996A1 (en) 2021-08-26
TW202136285A (zh) 2021-10-01
JP2023514332A (ja) 2023-04-05
BR112022016268A2 (pt) 2022-10-11
PH12022552118A1 (en) 2024-01-29
EP4106807A1 (en) 2022-12-28
CA3168201A1 (en) 2021-08-26
KR20220143107A (ko) 2022-10-24
MX2022010129A (es) 2022-09-05
US20230293658A1 (en) 2023-09-21
IL295702A (en) 2022-10-01

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