CN115154540A - CBD product composition containing plant extracts, preparation method and device - Google Patents
CBD product composition containing plant extracts, preparation method and device Download PDFInfo
- Publication number
- CN115154540A CN115154540A CN202210810624.4A CN202210810624A CN115154540A CN 115154540 A CN115154540 A CN 115154540A CN 202210810624 A CN202210810624 A CN 202210810624A CN 115154540 A CN115154540 A CN 115154540A
- Authority
- CN
- China
- Prior art keywords
- extract
- grinding
- box
- crushing
- primary
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8966—Fritillaria, e.g. checker lily or mission bells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C18/00—Disintegrating by knives or other cutting or tearing members which chop material into fragments
- B02C18/06—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives
- B02C18/14—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives within horizontal containers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C4/00—Crushing or disintegrating by roller mills
- B02C4/02—Crushing or disintegrating by roller mills with two or more rollers
- B02C4/08—Crushing or disintegrating by roller mills with two or more rollers with co-operating corrugated or toothed crushing-rollers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C7/00—Crushing or disintegrating by disc mills
- B02C7/02—Crushing or disintegrating by disc mills with coaxial discs
- B02C7/08—Crushing or disintegrating by disc mills with coaxial discs with vertical axis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Abstract
The invention relates to a CBD product composition containing plant extracts, a preparation method and a device, belonging to the technical field of health care products, wherein the CBD product composition containing the plant extracts comprises the following components: cannabidiol, fritillaria cirrhosa extract, mint extract, dried orange peel extract, patchouli extract, thyme extract, star anise extract and eucalyptus leaf extract; the preparation method comprises the following steps: preparing cannabidiol; preparing a fritillaria cirrhosa extract; preparing herba Menthae extract, pericarpium Citri Tangerinae extract, herba Agastaches extract, herba Thymi extract, fructus Anisi Stellati extract, and folium Eucalypti Globueli extract; mixing, namely uniformly mixing the extracts prepared in the three steps; according to the difference of each plant, different parts are adopted to prepare corresponding components; in addition, the invention contains a plurality of secondary plant substances, and the compatibility of the secondary plant substances can utilize the performance of each substance to achieve the synergistic effect, enhance the curative effect and reduce the drug resistance of the composition.
Description
Technical Field
The invention belongs to the field of health care products, and particularly relates to a CBD product composition containing plant extracts and a preparation method thereof.
Background
Cannabidiol (CBD) is a pure natural component extracted from industrial cannabis sativa, which is widely used in the fields of medicine, health products and cosmetics. Cannabidiol has antioxidant, tranquilizing, antidepressant, antiinflammatory, and blood vessel dilating effects. Cannabidiol has no hallucinogenic and addictive effects, is a novel medicament for clinically treating breast cancer and epilepsy, and is favored in the field of cosmetics. The discomfort of throat such as throat itching and dry throat is gradually increased by the influence of environmental pollution, bad living habits, excessive use of throat and other factors.
At present, aiming at improving the discomfort of throat such as throat itching, dry throat and the like, antiviral, antibacterial and anti-inflammatory drug therapy is generally taken as the main treatment or antipyretic adjuvant therapy, but drug resistance is easy to generate.
Therefore, a CBD product composition which can improve throat discomfort such as throat itching and dry throat, achieves the effects of clearing and moistening throat and is not easy to generate drug resistance is needed to be provided.
Disclosure of Invention
In order to overcome the problems of the background art, the present invention provides, in a first aspect, a CBD product composition comprising a plant extract, comprising: 10-50 parts of cannabidiol, 100-200 parts of bulbus fritillariae cirrhosae extract, 200-400 parts of mint extract, 120-200 parts of dried orange peel extract, 120-200 parts of pogostemon cablin extract, 150-280 parts of thyme extract, 150-300 parts of star anise extract and 120-200 parts of eucalyptus leaf extract.
The invention also provides a preparation method of the CBD product composition containing the plant extract, which comprises the following steps: (1) preparing cannabidiol; (2) preparing a fritillaria cirrhosa extract; (3) Preparing herba Menthae extract, pericarpium Citri Tangerinae extract, herba Agastaches extract, herba Thymi extract, fructus Anisi Stellati extract, and folium Eucalypti Globueli extract; (4) Mixing, and mixing cannabidiol, bulbus Fritillariae Cirrhosae extract, herba Menthae extract, pericarpium Citri Tangerinae extract, herba Agastaches extract, herba Thymi extract, fructus Anisi Stellati extract, and folium Eucalypti Globueli extract.
Further, the step (1) is: cleaning collected industrial hemp stems, drying in a 45 ℃ drying oven to constant mass, grinding by a grinding preparation device, sieving by a 0.2mm sieve, dissolving the powder in a 95% ethanol solution with the weight ratio of 3 times of the powder, soaking, performing ultrasonic heat extraction for 200min, extracting for 3 times, filtering, combining 3 times of extracting solutions, and performing water bath reduced pressure concentration to obtain a primary extract; dispersing the primary extract into purified water with the weight ratio of 5 times, extracting with petroleum ether with the same volume as the purified water for 3 times, mixing the extractive solutions, and concentrating under reduced pressure in water bath to obtain extract; performing normal phase silica gel column chromatography on the obtained extract by using 100-mesh silica gel wet method with the weight ratio of 30 times, performing gradient elution by using petroleum ether as a mobile phase, collecting eluent, concentrating, detecting by using thin layer chromatography, and combining the same parts to obtain crude cannabidiol; and finally, filling the crude cannabidiol into a column by using a C18 reversed phase material with the weight ratio of 60 times, performing reversed phase column chromatography, eluting by using methanol as a mobile phase, performing qualitative analysis by using high performance liquid chromatography, collecting eluent, concentrating, and mixing the same parts to obtain the cannabidiol.
Further, the step (2) is as follows: collecting Bulbus Fritillariae Cirrhosae stem, cleaning, drying in 45 deg.C drying oven to constant mass, grinding with grinding preparation device, sieving with 0.2mm sieve, adding 5 times by weight of hydrochloric acid aqueous solution with pH of 3, dynamically warm-soaking at 60 deg.C for 3 times (each for 70 min), filtering, and mixing the extractive solutions for 3 times to obtain Bulbus Fritillariae Cirrhosae extract.
Further, the step (3) is: collecting folium Menthae, pericarpium Citri Tangerinae, folium Agastaches, herba Thymi, fructus Anisi Stellati or folium Eucalypti Globueli, drying in a drying oven at 60 deg.C to constant mass, grinding with a grinding preparation device, and sieving with a 0.2mm sieve;weighing mint leaves, dried orange peel, patchouli leaves, thyme herbs, star anise or eucalyptus leaf powder, adding 0.5mol/L ammonia water for soaking overnight, loading into an extraction cylinder the next day, putting an entrainer into an entrainer tank, switching on a refrigeration switch, controlling the temperature of a cold box at 4 ℃, and switching on water circulation; introducing CO 2 And then carrying out an extraction process to obtain a mint extract, a dried orange peel extract, a patchouli extract, a thyme extract, an illicium verum extract or a eucalyptus leaf extract.
Further, in the step (3), the conditions of the extraction processes of the mint leaves, the thyme whole herb and the star anise are as follows: the extraction temperature is 40 ℃, the extraction pressure is 10MPa, the extraction time is 300min, the entrainer is methanol, and the use amount of the entrainer is 5 times of the mass of the materials; the conditions of the extraction process of the dried orange peel, the patchouli leaf and the eucalyptus leaf are as follows: the extraction temperature is 20-70 ℃, the extraction pressure is 2-30MPa, the extraction time is 200-500min, the entrainer is ethyl acetate, and the use amount of the entrainer is 5 times of the mass of the materials.
The cannabidiol can block the adverse effect of certain polyphenol on the nervous system of a human body, has a series of physiological activity functions of blocking breast cancer metastasis, treating epilepsy, resisting rheumatoid arthritis, resisting insomnia, diminishing inflammation and the like, and can reduce the release of interleukin-1 beta (interleukin-1 beta, IL-1 beta) and TNF-alpha in peripheral blood, thereby indicating that the cannabidiol has the function of protecting the respiratory system.
The fritillaria cirrhosa extract contains the sibiritin which regulates the expression of inflammatory genes by blocking a TLR 4-mediated MyD 88-dependent and TRIF-dependent signal pathway. In the MyD 88-dependent signal pathway, the sipeimine glycoside can inhibit NF-kB, ERK and p38 MAPK signal pathways simultaneously, but has no influence on the expression of JKMAPK signal pathways. Therefore, the sipeimine glycoside has anti-inflammatory effect.
The herba Menthae extract contains effective component menthol, also called menthol, which is a terpenoid organic compound with chemical formula C 10 H 20 O, also has anti-inflammatory effect.
The dried orange peel extract contains limonene, wherein the limonene has 3 isomers in natural plants, the most common is D-limonene and limonene monoterpene compounds, and the dried orange peel extract is orange red, orange yellow or colorless clear liquid and has specific fragrance; has the effects of promoting bile flow, dissolving calculus, regulating qi-flowing, promoting appetite, diminishing inflammation, and relieving pain.
The fructus Anisi Stellati extract contains trans-Anethole (ANE) as effective component, and has antiinflammatory, antioxidant, anticancer, neuroprotective and vasoactive effects. Their anti-inflammatory properties are mediated by their reduction of pro-inflammatory mediators, including tumor necrosis factor-alpha (TNF-alpha), matrix metalloproteinase 9 (mmp-9), and NO, and their inhibition of nuclear factor- κ B (NF- κ B).
The thyme extract contains thymol and has antioxidant, antibacterial, anticancer, antiinflammatory, and spasm resisting effects. In the present invention, therefore, thymol, in addition to its anti-inflammatory effect, may also be used as an antimicrobial agent for the preservation of the present compositions.
Patchouli alcohol is an important component in patchouli extracts, patchouli Alcohol (PA) is also called patchouli alcohol, is a sesquiterpene compound, has multiple effects of resisting inflammation, gastric ulcer, cancer, protecting lung and brain injury, resisting bacteria, preventing mastitis, colitis and atherosclerosis, resisting photoaging, treating diarrhea type irritable bowel syndrome, resisting oxidative stress, vasodilatation, resisting injury and the like, and preliminary action mechanism research shows that the anti-inflammatory action of the patchouli alcohol is related to the aspects of inhibiting the production of proinflammatory cytokines by reducing the mRNA expression of inflammatory mediators, reducing NF-activated JB mediated by extracellular regulatory protein kinase (ERK) and the like.
The folium Eucalypti Globueli extract is rich in 1, 8-cineole, and has antiinflammatory, analgesic, and mucus secretion promoting effects, so as to dredge blocked nasal cavity and bronchus. Simultaneously, the medicine can stimulate the production and secretion of saliva, immediately activate swallowing reflex and inhibit the impending cough. Thus can be used as a gas inhalant for treating respiratory diseases, influenza, headache, and spasm.
The plant extract contains phenols, alkaloids and terpenoids which are secondary plant substances, and the generation and distribution of the secondary plant substances in the plant are limited, so that the corresponding components are prepared by adopting different parts according to the difference of each plant. In addition, the invention contains various secondary plant substances, and the compatibility of the plant substances can utilize the performance of each substance to achieve the synergistic anti-inflammatory effect, further improve the throat discomfort conditions such as throat itching, dry throat and the like, achieve the effects of clearing and moistening the throat and enhance the curative effect. The composition contains multiple kinds of secondary plant substances, and can reduce drug resistance of the composition.
The utility model provides a CBD product composition's grinding preparation facilities including plant extract, includes feeder hopper 1, broken mechanism 2, one-level grinding mechanism 3, second grade grinding mechanism 4, the top of broken mechanism 2 be provided with feeder hopper 1, the bottom discharge mouth of broken mechanism 2 is connected with the feed inlet at one-level grinding mechanism 3 top, the bottom discharge mouth of one-level grinding mechanism 3 is connected with the feed inlet of second grade grinding mechanism 4.
Furthermore, the crushing mechanism 2 comprises a crushing box 2-1, a crushing shaft 2-2, a motor 2-3, a cutting crushing knife 2-4, a screen 2-5 and a belt wheel transmission mechanism I2-6, wherein the motor 2-3 is fixedly installed on the outer wall of one end of the crushing box 2-1, two ends of the crushing shaft 2-2 are respectively installed on the side walls of two ends of the crushing box 2-1 through bearings, the crushing shaft 2-2 is connected with a driving shaft of the motor 2-3 through the belt wheel transmission mechanism I2-6, the cutting crushing knife 2-4 is evenly installed on the crushing shaft 2-2 at equal intervals, an arc-shaped opening is formed in the bottom of the crushing box 2-1, and the screen 2-5 with the same radius as that of the crushing box 2-1 is arranged at the arc-shaped opening.
Further, the primary grinding mechanism 3 comprises a primary grinding box 3-1, a primary grinding roller 3-2, a secondary grinding roller 3-3, a gear transmission mechanism 3-4 and a belt pulley transmission mechanism II 3-5, wherein the primary grinding box 3-1 is positioned below the crushing box 2-1, a top feed inlet of the primary grinding box 3-1 is connected with a bottom discharge outlet of the crushing box 2-1, the primary grinding roller 3-2 and the secondary grinding roller 3-3 are respectively installed in the primary grinding box 3-1 through bearings, grinding teeth and grinding grooves which are mutually meshed are respectively arranged on the primary grinding roller 3-2 and the secondary grinding roller 3-3, the primary grinding roller 3-2 and the secondary grinding roller 3-3 are connected through the gear transmission mechanism 3-4, the primary grinding roller 3-2 is connected with a driving shaft of the motor 2-3 through the belt pulley transmission mechanism II 3-5, and a bottom discharge outlet of the primary grinding box 3-1 is connected with a feed inlet of the secondary grinding mechanism 4.
Further, the secondary grinding mechanism 4 comprises a secondary grinding box 4-1, an inverted cone-shaped feeding hole 4-2, a fixed grinding disc 4-3, a movable grinding disc 4-4, a rotating shaft 4-5, a grinding motor 4-6, a belt wheel transmission mechanism III 4-7 and a material collecting groove 4-7, wherein the secondary grinding box 4-1 is arranged below the primary grinding mechanism 3, the top of the secondary grinding box 4-1 is provided with the inverted cone-shaped feeding hole 4-2 connected with a discharging hole of the primary grinding mechanism 3, the fixed grinding disc 4-3 is fixedly arranged at the bottom of an inner cavity of the secondary grinding box 4-1, a circular through hole is formed in the middle of the fixed grinding disc 4-3, the upper section of the rotating shaft 4-5 is a square shaft, the middle section and the lower section of the rotating shaft are circular shafts, the rotating shaft 4-5 is arranged in the middle of the bottom of the secondary grinding box 4-1 through a bearing, the upper section of the rotating shaft penetrates through hole of the fixed grinding disc 4-3, the movable grinding disc 4-4 is provided with a sinking hole matched with the upper section of the square shaft 4-5, the movable grinding disc 4-4 is connected with the fixed grinding disc 4-3, a material collecting groove 4-3, and a material collecting groove 4-6 is arranged between the rotating shaft and the fixed grinding disc 4-4.
Drawings
FIG. 1 is a schematic diagram I of the structure of the present invention;
FIG. 2 is a schematic diagram II of the present invention;
FIG. 3 is a perspective view of the internal structure of the present invention;
FIG. 4 is a front view of the internal structure of the present invention;
FIG. 5 is a schematic view of the mounting structure of the cutting and crushing knife of the present invention;
FIG. 6 is a schematic structural view of a primary grinding roller and a secondary grinding roller of the present invention;
FIG. 7 is a schematic view of a two-stage grinding mechanism according to the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, preferred embodiments of the present invention will be described in detail below to facilitate understanding of the skilled person.
The compositions and parts by weight of the compositions of examples 1-3 are shown in Table 1.
TABLE 1 EXAMPLES 1-3 compositions and parts by weight
A method of preparing a CBD product composition comprising plant extracts, comprising the steps of:
(1) Preparing cannabidiol, cleaning collected industrial hemp stems, drying in a 45 ℃ drying oven to constant mass, grinding and grinding by a grinding preparation device, sieving by a 0.2mm sieve, dissolving the powder in 95% ethanol solution with the weight ratio of 3 times of the powder, soaking, performing ultrasonic heat extraction for 200min, extracting for 3 times, filtering, combining the 3 extracting solutions, performing water bath reduced pressure concentration to obtain a primary extract, wherein the power of the ultrasonic heat extraction is 200W, the temperature is 60 ℃, the water bath reduced pressure concentration is performed, the water bath temperature is 60 ℃, and the vacuum pressure is 0.9MPa; dispersing the primary extract into purified water with the weight ratio of 5 times, extracting with petroleum ether with the same volume as the purified water for 3 times, mixing the extractive solutions, and concentrating under reduced pressure in water bath at 60 deg.C under vacuum pressure of 0.9MPa to obtain extract; performing normal phase silica gel column chromatography on the obtained extract by using 100-mesh silica gel wet method with the weight ratio of 30 times, performing gradient elution by using petroleum ether as a mobile phase, collecting eluent, concentrating, detecting by using thin layer chromatography, and combining the same parts to obtain crude cannabidiol; finally, the crude cannabidiol is treated with C with the weight ratio of 60 times 18 Loading the reversed phase material into a column, performing reversed phase column chromatography, eluting with methanol as mobile phase, performing qualitative analysis by high performance liquid chromatography, collecting eluate, concentrating, and mixing the same parts to obtain cannabidiol.
(2) Preparing the fritillaria cirrhosa extract: collecting Bulbus Fritillariae Cirrhosae stem, cleaning, drying in 45 deg.C drying oven to constant mass, grinding with grinding preparation device, sieving with 0.2mm sieve, adding 5 times by weight of hydrochloric acid aqueous solution with pH of 3, dynamically warm-soaking at 60 deg.C for 3 times (each for 70 min), filtering, and mixing the extractive solutions for 3 times to obtain Bulbus Fritillariae Cirrhosae extract.
(3) Preparing mint extract, dried orange peel extract, patchouli extract, thyme extract, star anise extract and eucalyptus leaf extract: collecting folium Menthae, pericarpium Citri Tangerinae, folium Agastaches, herba Thymi, fructus Anisi Stellati or folium Eucalypti Globueli, drying in a drying oven at 60 deg.C to constant mass, grinding with a grinding preparation device, and sieving with a 0.2mm sieve; weighing mint leaves, dried orange peel, patchouli leaves, thyme herbs, star anise or eucalyptus leaf powder, adding 0.5mol/L ammonia water for soaking overnight, loading into an extraction cylinder the next day, putting an entrainer into an entrainer tank, switching on a refrigeration switch, controlling the temperature of a cold box at 4 ℃, and switching on water circulation; introducing CO 2 Then carrying out an extraction process to obtain a mint extract, a dried orange peel extract, a patchouli extract, a thyme extract, an illicium verum extract or a eucalyptus leaf extract; the conditions of the mint leaf, thyme herb and star anise extraction process are as follows: the extraction temperature is 40 ℃, the extraction pressure is 10MPa, the extraction time is 300min, the entrainer is methanol, and the use amount of the entrainer is 5 times of the mass of the materials; the conditions of the extraction process of the dried orange peel, the patchouli leaf and the eucalyptus leaf are as follows: the extraction temperature is 20-70 ℃, the extraction pressure is 2-30MPa, the extraction time is 200-500min, the entrainer is ethyl acetate, and the use amount of the entrainer is 5 times of the mass of the materials.
Supercritical CO 2 The extraction instrument is as follows: HA220-50-06 type supercritical CO of Jiangsu Hua' an scientific research instrument Co Ltd 2 An extraction instrument.
(4) Mixing, and mixing cannabidiol, bulbus Fritillariae Cirrhosae extract, herba Menthae extract, pericarpium Citri Tangerinae extract, herba Agastaches extract, herba Thymi extract, fructus Anisi Stellati extract, and folium Eucalypti Globueli extract to obtain CBD product composition containing plant extract.
The compositions of examples 1-4 were prepared as described above.
The compositions and parts by weight of the compositions of comparative examples 1 to 4 are shown in Table 2.
TABLE 2 compositions and parts by weight of comparative examples 1-4
Comparative examples 1 to 4 were prepared according to the preparation methods of examples 1 to 3.
Evaluation of efficacy
Examples 1-3, comparative examples 1-4 were dissolved in food grade alcohol to prepare solutions at a concentration of 1g/50mL for efficacy evaluation.
1. Acute pharyngitis model rat experiment
Modeling and grouping 90 SD rats weighing 180. + -.20 g were randomly divided into 10 and 10 rats each for a blank control group (group A, throat spray administration of 0.9% sodium chloride solution, single dose: 5 mL/kg), a model control group (group B, throat spray administration of 0.9% sodium chloride solution, dose: 5 mL/kg), comparative example groups (groups C1 to C4, comparative examples 1 to 4, dose: 5mL/kg, throat spray administration), and example groups (groups D1 to D3, examples 1 to 3, dose: 5mL/kg, throat spray administration). Except group A, rats in the other groups were throat sprayed with 25% ammonia water 2 times a day (1 each time in the morning and afternoon), 3 times each (about 0.5 mL), and continuously sprayed for 3 days to replicate the acute dermatitis model in rats. Starting from the 4 th day after the successful modeling (congestion and swelling of mucous membrane at the pharynx part of the rat and scratching of the oropharynx), rats in each group are respectively given the corresponding substances or 0.9% sodium chloride solution once in the morning and evening every day for 7 days continuously.
Detection indexes are as follows: blood normal and inflammatory factors. Anesthetizing the rat after 1h of the last administration, and collecting 2 parts of blood from abdominal aorta, wherein 1 part is used for detecting the counting of neutrophils and leukocytes; and centrifuging the other 1 part of the extract for 10min at the speed of 4000r/min, taking supernatant, placing the supernatant in an EP tube, storing the supernatant at the temperature of-80 ℃, and detecting the IL-1 beta, TNF-alpha and PGE2 levels of serum by adopting an enzyme-linked immunosorbent assay (ELISA).
TABLE 3 white blood cell and neutrophil counts in various groups of rats
As shown in Table 3, the white blood cell count and the neutrophil count in the blood of the rats in the group B are both significantly increased (P < 0.01) compared with the group A; compared with the group B, the white blood cell count and the neutrophil count of the C1-C3 rats in the group C are reduced but the effect is not obvious, and the white blood cell count and the neutrophil count of the C4 rats are reduced obviously (P < 0.05); both white blood cell and neutrophil counts were very significantly reduced in group D rats compared to group B (P < 0.01). See table 1 for details.
2. Effect on carrageenan-induced swelling of rat feet
Examples 1-3, comparative examples 1-4 were dissolved in food grade alcohol to prepare solutions at a concentration of 1g/50mL for efficacy evaluation.
Modeling and grouping SD rats 80 g (180 +/-20) are taken, the weight is randomly divided into 8 groups, 10 animals in each group, 10 animals in the model group (group A, the single dose of 10 mL/kg) in 0.9% sodium chloride solution by intragastric administration, 10 animals in each comparative example (groups B1-B4, comparative examples 1-4, the single dose of 10mL/kg by intragastric administration), 10 animals in the example group (groups C1-C3, examples 1-3, the single dose of 10mL/kg by intragastric administration), 7 animals are continuously intragastric administered for 1 time per day for 7d, the volume of the toes below the right posterior ankle joint of the rat is determined 1h after the last administration, and the volume is used as the volume before inflammation, and the volume is determined and then the volume is injected into the middle part of the right posterior toe of each group of rats to cause inflammation by 1% carrageenan solution and 0.1mL per animal.
Detection indexes are as follows: the volume of the toes below the right posterior ankle of the rats was measured 3h after the inflammation (measured by a glass container method), and the degree of swelling of the soles of the rats in each group was calculated from the difference between the volumes of the soles before and after the inflammation.
TABLE 4 swelling degree of 3h foot metatarsal swelling after inflammation of rats in each group
As can be seen from Table 4, there was no significant difference in swelling degree of toes of group 3h, B1-B3 (P > 0.05) and B4 (P < 0.05) after inflammation, compared with group A; the swelling degree of toes of the C1-C3 groups has very significant difference (P < 0.01) in 3h after inflammation.
80 SD rats were randomly divided into 10 animals each of 10 animals for a blank control group (group A, gavage with 0.9% sodium chloride solution), a positive control group (group B, gavage with 0.9% sodium chloride solution), a comparative example group (groups C1 to C4, comparative examples 1 to 4, 5g/kg, throat spray), and example groups (groups D1 to D3, examples 1 to 3, 5g/kg, throat spray). Except group A, rats in the other groups were throat sprayed with 25% ammonia water 2 times a day (1 each time in the morning and afternoon), 3 times each (about 0.5 mL), and continuously sprayed for 3 days to replicate the acute dermatitis model in rats. From the 4 th day after the successful modeling (congestion, swelling and scratching of mucous membrane in the pharynx of the rat), rats in each group were given the corresponding drug or 0.9% sodium chloride solution 1 time a day for 7 days continuously.
The plant extract contains phenols, alkaloids and terpenoids which are secondary plant substances, and the generation and distribution of the secondary plant substances in the plant are limited, so that the corresponding components are prepared by adopting different parts according to the difference of each plant. In addition, the invention contains various secondary plant substances, and the compatibility of the secondary plant substances can utilize the performance of each substance to achieve the synergistic anti-inflammatory effect, thereby further improving the throat discomfort conditions such as throat itching, throat dryness and the like, achieving the effects of clearing and moistening the throat and enhancing the curative effect. The composition contains multiple kinds of secondary plant substances, and can reduce drug resistance of the composition.
As shown in figure 1, a grinding preparation facilities of CBD product composition containing plant extract, including feeder hopper 1, crushing mechanism 2, one-level grinding mechanism 3, second grade grinding mechanism 4, the top of crushing mechanism 2 be provided with feeder hopper 1, the bottom discharge gate of crushing mechanism 2 is connected with the feed inlet at one-level grinding mechanism 3 top, the bottom discharge gate of one-level grinding mechanism 3 is connected with the feed inlet of second grade grinding mechanism 4. The dried industrial hemp stems, sichuan fritillary stems, mint leaves, dried orange peels, patchouli leaves, thyme herbs, star anise or eucalyptus leaves are added into a crushing mechanism 2 from a feed hopper 1, the crushing mechanism 2 firstly crushes the industrial hemp stems, the Sichuan fritillary stems, the mint leaves, the orange peels or the eucalyptus leaves into corresponding particles, then the particles enter a first-stage grinding mechanism 3 to be ground into fine particle materials, the fine particle materials enter a second-stage grinding mechanism 4, and the fine particle materials are ground into powder materials with the particle size of less than 0.2mm through the second-stage grinding mechanism 4 so as to be used as raw materials of cannabidiol, fritillaria cirrhosa extracts, mint extracts, dried orange peel extracts, patchouli extracts, thyme extracts, star anise extracts and eucalyptus leaf extracts.
In the invention, as shown in fig. 2-4, the crushing mechanism 2 comprises a crushing box 2-1, a crushing shaft 2-2, a motor 2-3, a cutting crushing knife 2-4, a screen 2-5 and a belt wheel transmission mechanism I2-6, wherein the motor 2-3 is fixedly arranged on the outer wall of one end of the crushing box 2-1, two ends of the crushing shaft 2-2 are respectively arranged on the side walls of two ends of the crushing box 2-1 through bearings, the crushing shaft 2-2 is connected with a driving shaft of the motor 2-3 through the belt wheel transmission mechanism I2-6, the cutting crushing knife 2-4 is uniformly arranged on the crushing shaft 2-2 at equal intervals, the bottom of the crushing box 2-1 is an arc opening, and the arc opening is provided with the screen 2-5 with the same radius as that of the crushing box 2-1. After dried industrial hemp stems, sichuan fritillary stems, mint leaves, dried orange peels, patchouli leaves, thyme herbs, star anise or eucalyptus leaves are added into a feed hopper 1, the materials are guided into a crushing box 2-1 by the feed hopper 1, a motor 2-3 drives a crushing shaft 2-2 to rotate by driving a belt wheel transmission mechanism I2-6, the crushing shaft 2-2 drives a cutting and crushing knife 2-4 arranged on the crushing shaft to rotate along with the crushing shaft 2-2 in the rotating process, and the cutting and crushing knife 2-4 cuts and crushes the materials entering the crushing box 2-1 in the rotating process; because the screen 2-5 with the same radius is arranged at the arc-shaped opening at the bottom of the crushing box 2-1, the material crushed by the cutting and crushing knife 2-4 to the qualified particle size can fall into the first-stage grinding mechanism 3 from the meshes of the screen 2-5, the material with the overlarge particle size is left on the screen 2-5, and the situation that the material with the larger particle size enters the first-stage grinding mechanism 3 to cause that the grinding particle size cannot meet the requirement is effectively avoided by arranging the screen 2-5, so that the extraction effect of the extract is poor, and the waste of the raw material is caused.
In the invention, preferably, the end part of the cutting and crushing knife 2-4 is provided with a spoon-shaped arc knife, and the bent part of the arc knife is tangent with the inner walls of the crushing box 2-1 and the screen 2-5. The spoon-shaped arc-shaped knife is arranged, materials with large particle sizes are left on the screen 2-5 after being cut, the materials can be scraped and thrown upwards through the rotating spoon-shaped arc-shaped knife, after the materials are thrown in the crushing box 2-1, the materials are continuously cut and crushed through the rotating cutting crushing knife 2-4, so that the screen 2-5 can be prevented from being stacked to cause the blockage of the screen 2-5, the cut and crushed particle size of the materials is effectively guaranteed, and the waste of raw materials is effectively avoided.
In the invention, as shown in fig. 3-4 and 6, the primary grinding mechanism 3 comprises a primary grinding box 3-1, a primary grinding roller 3-2, a secondary grinding roller 3-3, a gear transmission mechanism 3-4 and a belt wheel transmission mechanism II 3-5, wherein the primary grinding box 3-1 is positioned below the crushing box 2-1, a top feed port of the primary grinding box 3-1 is connected with a bottom discharge port of the crushing box 2-1, the primary grinding roller 3-2 and the secondary grinding roller 3-3 are respectively installed in the primary grinding box 3-1 through bearings, the primary grinding roller 3-2 and the secondary grinding roller 3-3 are respectively provided with mutually meshed grinding teeth and grinding grooves, the primary grinding roller 3-2 and the secondary grinding roller 3-3 are connected through the gear transmission mechanism 3-4, the primary grinding roller 3-2 is connected with a drive shaft of the motor 2-3 through the belt wheel transmission mechanism II 3-5, and a bottom discharge port of the primary grinding box 3-1 is connected with a feed port of the secondary grinding mechanism 4. The materials which are cut and crushed by the crushing mechanism 2 and are compounded with a certain particle size by screening of the screen 2-5 enter the primary grinding box 3-1, the outlet at the bottom of the top feed inlet of the primary grinding box 3-1 is opposite to the meshing part of the main grinding roller 3-2 and the auxiliary grinding roller 3-3, so that the materials can directly fall to the meshing part of the middle part of the main grinding roller 3-2 and the auxiliary grinding roller 3-3, the main grinding roller 3-2 connected with the main grinding roller is driven to rotate by the belt wheel transmission mechanism II 3-5 connected with the driving shaft of the motor 2-3, the main grinding roller 3-2 is rotated to drive the auxiliary grinding roller 3-3 to rotate oppositely by the gear transmission mechanism 3-4, so that the materials falling between the main grinding roller 3-2 and the auxiliary grinding roller 3-3 can be ground in the mutual rotation process of the main grinding roller 3-2 and the auxiliary grinding roller 3-3, and the materials are ground into smaller particles.
In the invention, as shown in figures 3-4 and 7, the secondary grinding mechanism 4 comprises a secondary grinding box 4-1, an inverted cone-shaped feeding port 4-2, a fixed grinding disc 4-3, a movable grinding disc 4-4, a rotating shaft 4-5, a grinding motor 4-6 and a material collecting groove 4-7, wherein the secondary grinding box 4-1 is arranged below the primary grinding mechanism 3, the top of the secondary grinding box 4-1 is provided with the inverted cone-shaped feeding port 4-2 connected with the discharging port of the primary grinding mechanism 3, the fixed grinding disc 4-3 is fixedly arranged at the bottom of the inner cavity of the secondary grinding box 4-1, the middle part of the fixed grinding disc 4-3 is provided with a circular through hole, the upper section of the rotating shaft 4-5 is a square shaft, the middle section and the lower section are round shafts, the rotating shaft 4-5 is installed in the middle of the bottom of the secondary grinding box 4-1 through a bearing, the upper section of the rotating shaft penetrates out of a round through hole in the fixed grinding disc 4-3, the bottom of the movable grinding disc 4-4 is provided with a counter bore matched with the square shaft in the upper section of the rotating shaft 4-5, the movable grinding disc 4-4 is provided with a feed hole capable of guiding materials between the movable grinding disc and the fixed grinding disc 4-3, the lower section of the rotating shaft 4-5 extends out of the secondary grinding box 4-1 and is connected with a drive shaft of a grinding motor 4-6, and the outer edge of the fixed grinding disc 4-3 is provided with a material collecting groove 4-7. The top of the fixed grinding disc 4-3 and the bottom surface of the movable grinding disc 4-4 are both provided with a plurality of inclined grinding lines, materials which are ground to a certain particle size by the primary grinding mechanism 3 fall into the inverted cone-shaped feed port 4-2, the materials are guided into the corresponding feed holes by the inverted cone-shaped feed port 4-2, the materials are added between the fixed grinding disc 4-3 and the movable grinding disc 4-4 through the feed holes, the grinding motor 4-6 drives the rotating shaft 4-5 to rotate, the rotating shaft 4-5 drives the movable grinding disc 4-4 to rotate, and the movable grinding disc 4-4 cooperates with the fixed grinding disc 4-3 in the rotating process to carry out secondary grinding on the materials entering between the fixed grinding disc 4-3 and the movable grinding disc 4-4; because the top of the fixed grinding disc 4-3 and the bottom surface of the movable grinding disc 4-4 are provided with some inclined grinding lines, the grinding lines can better grind materials, and the ground materials can be guided out from the space between the movable grinding disc 4-4 and the fixed grinding disc 4-3 under the guiding action of the grinding lines, so that the materials fall into the material collecting groove 4-7 to be collected in a centralized manner, and are crushed in one stage, and the particle size of the materials after two-stage grinding can reach less than 0.2mm so as to be used as raw materials of cannabidiol, bulbus fritillariae cirrhosae extract, mint extract, dried tangerine peel extract, patchouli extract, thyme extract, illicium verum extract and eucalyptus leaf extract.
The top of the circular through hole of the fixed grinding disc 4-3 is fixedly provided with a sleeve 4-8, the upper section of a counter bore at the bottom of the movable grinding disc 4-4 is a square hole matched with the square shaft, and the lower section of the counter bore is a circular hole convenient for the sleeve 4-8 to be inserted. The sleeve 4-8 with the upper end inserted into the countersunk hole at the bottom of the movable grinding disc 4-4 is arranged on the fixed grinding disc 4-3, so that the materials can be prevented from falling into the circular through hole of the fixed grinding disc 4-3 to cause material waste in the process of grinding the materials by the movable grinding disc 4-4 and the fixed grinding disc 4-3.
Finally, it is noted that the above-mentioned preferred embodiments illustrate rather than limit the invention, and that, although the invention has been described in detail with reference to the above-mentioned preferred embodiments, it will be understood by those skilled in the art that various changes in form and detail may be made therein without departing from the scope of the invention as defined by the appended claims.
Claims (10)
1. A CBD product composition comprising a plant extract, characterized by: the CBD product composition containing the plant extract comprises the following components: 10-50 parts of cannabidiol, 100-200 parts of fritillaria cirrhosa extract, 200-400 parts of mint extract, 120-200 parts of dried orange peel extract, 120-200 parts of patchouli extract, 150-280 parts of thyme extract, 150-300 parts of star anise extract and 120-200 parts of eucalyptus leaf extract.
2. A method of preparing a CBD product composition comprising plant extracts according to claim 1, wherein: the method comprises the following steps: (1) preparing cannabidiol; (2) preparing a fritillaria cirrhosa extract; (3) Preparing herba Menthae extract, pericarpium Citri Tangerinae extract, herba Agastaches extract, herba Thymi extract, fructus Anisi Stellati extract, and folium Eucalypti Globueli extract; (4) Mixing, and mixing cannabidiol, bulbus Fritillariae Cirrhosae extract, herba Menthae extract, pericarpium Citri Tangerinae extract, herba Agastaches extract, herba Thymi extract, fructus Anisi Stellati extract, and folium Eucalypti Globueli extract.
3. According to claim2 the preparation method of the CBD product composition comprising plant extracts, which is characterized by: the step (1) is as follows: cleaning collected industrial hemp stems, drying in a 45 ℃ drying oven to constant mass, grinding by a grinding preparation device, sieving by a 0.2mm sieve, dissolving the powder in a 95% ethanol solution with the weight ratio of 3 times of the powder, soaking, performing ultrasonic heat extraction for 200min, extracting for 3 times, filtering, combining 3 times of extracting solutions, and performing water bath reduced pressure concentration to obtain a primary extract; dispersing the primary extract into purified water with the weight ratio of 5 times, extracting with petroleum ether with the same volume as the purified water for 3 times, mixing the extractive solutions, and concentrating under reduced pressure in water bath to obtain extract; performing normal phase silica gel column chromatography on the obtained extract by using 100-mesh silica gel wet method with the weight ratio of 30 times, performing gradient elution by using petroleum ether as a mobile phase, collecting eluent, concentrating, detecting by using thin layer chromatography, and combining the same parts to obtain crude cannabidiol; finally, the crude cannabidiol is treated with C with the weight ratio of 60 times 18 Loading the reversed phase material into a column, performing reversed phase column chromatography, eluting with methanol as mobile phase, performing qualitative analysis by high performance liquid chromatography, collecting eluate, concentrating, and mixing the same parts to obtain cannabidiol.
4. The method of preparing a CBD product composition comprising plant extracts of claim 2, wherein: the step (2) is as follows: collecting Bulbus Fritillariae Cirrhosae stem, cleaning, drying in 45 deg.C drying oven to constant mass, grinding with grinding preparation device, sieving with 0.2mm sieve, adding 5 times by weight of hydrochloric acid aqueous solution with pH of 3, dynamically warm-soaking at 60 deg.C for 3 times (each for 70 min), filtering, and mixing the extractive solutions for 3 times to obtain Bulbus Fritillariae Cirrhosae extract.
5. The method of preparing a CBD product composition comprising plant extracts of claim 2, wherein: the step (3) is as follows: collecting folium Menthae, pericarpium Citri Tangerinae, folium Agastaches, herba Thymi, fructus Anisi Stellati or folium Eucalypti Globueli, drying in a drying oven at 60 deg.C to constant mass, grinding with a grinding preparation device, and sieving with a 0.2mm sieve; weighing folium Menthae, pericarpium Citri Tangerinae, and folium AgastachesAdding 0.5mol/L ammonia water into the powder of thyme, star anise or eucalyptus leaves for soaking overnight, putting the mixture into an extraction cylinder the next day, putting an entrainer into an entrainer tank, switching on a refrigeration switch, controlling the temperature of a cold box at 4 ℃, and switching on water circulation; introduction of CO 2 And then carrying out an extraction process to obtain a mint extract, a dried orange peel extract, a patchouli extract, a thyme extract, an illicium verum extract or a eucalyptus leaf extract.
6. The method of preparing a CBD product composition comprising plant extracts of claim 5, wherein: in the step (3), the conditions of the extraction process of the mint leaves, the thyme whole grass and the star anise are as follows: the extraction temperature is 40 ℃, the extraction pressure is 10MPa, the extraction time is 300min, the entrainer is methanol, and the use amount of the entrainer is 5 times of the mass of the materials; the conditions of the extraction process of the dried orange peel, the patchouli leaf and the eucalyptus leaf are as follows: the extraction temperature is 20-70 ℃, the extraction pressure is 2-30MPa, the extraction time is 200-500min, the entrainer is ethyl acetate, and the use amount of the entrainer is 5 times of the mass of the materials.
7. An abrasive preparation device for a CBD product composition comprising plant extracts, characterized by: grinding mechanism (3), second grade grinding mechanism (4) including feeder hopper (1), broken mechanism (2), one-level, the top of broken mechanism (2) be provided with feeder hopper (1), the bottom discharge gate and the one-level of broken mechanism (2) are ground the feed inlet at mechanism (3) top and are connected, the bottom discharge gate and the feed inlet that second grade grinding mechanism (4) of one-level grinding mechanism (3) are connected.
8. The device for the abrasive preparation of a CBD product composition comprising plant extracts of claim 7, wherein: the crushing mechanism (2) comprises a crushing box (2-1), a crushing shaft (2-2), a motor (2-3), a cutting crushing cutter (2-4), a screen (2-5) and a belt wheel transmission mechanism I (2-6), wherein the motor (2-3) is fixedly installed on the outer wall of one end of the crushing box (2-1), two ends of the crushing shaft (2-2) are installed on the side walls of two ends of the crushing box (2-1) through bearings respectively, the crushing shaft (2-2) is connected with a driving shaft of the motor (2-3) through the belt wheel transmission mechanism I (2-6), the cutting crushing cutter (2-4) is installed on the crushing shaft (2-2) at equal intervals uniformly, the bottom of the crushing box (2-1) is an arc-shaped opening, and the screen (2-5) with the same radius as that of the crushing box (2-1) is arranged at the arc-shaped opening.
9. The device for the abrasive preparation of a CBD product composition comprising plant extracts of claim 8, wherein: the primary grinding mechanism (3) comprises a primary grinding box (3-1), a primary grinding roller (3-2), a secondary grinding roller (3-3), a gear transmission mechanism (3-4) and a belt wheel transmission mechanism II (3-5), wherein the primary grinding box (3-1) is positioned below the crushing box (2-1), a top feeding port of the primary grinding box (3-1) is connected with a bottom discharging port of the crushing box (2-1), the primary grinding roller (3-2) and the secondary grinding roller (3-3) are respectively installed in the primary grinding box (3-1) through bearings, grinding teeth and grinding grooves which are mutually meshed are respectively arranged on the primary grinding roller (3-2) and the secondary grinding roller (3-3), the primary grinding roller (3-2) and the secondary grinding roller (3-3) are connected through the gear transmission mechanism (3-4), the primary grinding roller (3-2) is connected with a motor (2-3) through the belt wheel transmission mechanism II (3-5), and a driving shaft of the primary grinding box (3-1) is connected with a discharging port of the secondary grinding mechanism (4).
10. A mill preparation apparatus for a CBD product composition comprising plant extracts as claimed in any one of claims 7 to 9, wherein: the secondary grinding mechanism (4) comprises a secondary grinding box (4-1), an inverted cone-shaped feeding hole (4-2), a fixed grinding disc (4-3), a movable grinding disc (4-4), a rotating shaft (4-5), a grinding motor (4-6) and a material collecting groove (4-7), the secondary grinding box (4-1) is arranged below the primary grinding mechanism (3), the inverted cone-shaped feeding hole (4-2) connected with a discharging hole of the primary grinding mechanism (3) is arranged at the top of the secondary grinding box (4-1), the fixed grinding disc (4-3) is fixedly arranged at the bottom of an inner cavity of the secondary grinding box (4-1), and a circular through hole is formed in the middle of the fixed grinding disc (4-3), the upper section of the rotating shaft (4-5) is a square shaft, the middle section and the lower section are round shafts, the rotating shaft (4-5) is arranged in the middle of the bottom of the secondary grinding box (4-1) through a bearing, the upper section of the rotating shaft penetrates out of a round through hole in the fixed grinding disc (4-3), the bottom of the movable grinding disc (4-4) is provided with a counter bore matched with the square shaft in the upper section of the rotating shaft (4-5), the movable grinding disc (4-4) is provided with a feed hole capable of guiding materials between the movable grinding disc and the fixed grinding disc (4-3), and the lower section of the rotating shaft (4-5) extends out of the secondary grinding box (4-1) and is connected with a grinding motor 4-6) and the outer edge of the fixed grinding disc (4-3) is provided with a material collecting groove (4-7).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210810624.4A CN115154540A (en) | 2022-07-11 | 2022-07-11 | CBD product composition containing plant extracts, preparation method and device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210810624.4A CN115154540A (en) | 2022-07-11 | 2022-07-11 | CBD product composition containing plant extracts, preparation method and device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115154540A true CN115154540A (en) | 2022-10-11 |
Family
ID=83493925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210810624.4A Pending CN115154540A (en) | 2022-07-11 | 2022-07-11 | CBD product composition containing plant extracts, preparation method and device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115154540A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117463479A (en) * | 2023-12-22 | 2024-01-30 | 江苏靓百家供应链管理有限公司 | Kitchen waste treatment pulper |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109369344A (en) * | 2018-12-03 | 2019-02-22 | 云南民族大学 | A method of the separation and Extraction cannabidiol from industrial hemp plant |
| CN110151868A (en) * | 2019-05-28 | 2019-08-23 | 厦门梓素生物科技有限公司 | A kind of essential oil and preparation method thereof of the extract of CBD containing cannabidiol |
| CN111150822A (en) * | 2019-12-24 | 2020-05-15 | 金湘范 | Multifunctional herbal essence atomized liquid |
| CN112608312A (en) * | 2020-12-18 | 2021-04-06 | 南京泽朗医药技术有限公司 | Optimized process for supercritical extraction of matrine |
| CN214077144U (en) * | 2020-10-29 | 2021-08-31 | 许晶晶 | Grinding device for food processing machine |
| CN113786440A (en) * | 2021-09-13 | 2021-12-14 | 云南省药物研究所 | Throat clearing composition and application thereof |
-
2022
- 2022-07-11 CN CN202210810624.4A patent/CN115154540A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109369344A (en) * | 2018-12-03 | 2019-02-22 | 云南民族大学 | A method of the separation and Extraction cannabidiol from industrial hemp plant |
| CN110151868A (en) * | 2019-05-28 | 2019-08-23 | 厦门梓素生物科技有限公司 | A kind of essential oil and preparation method thereof of the extract of CBD containing cannabidiol |
| CN111150822A (en) * | 2019-12-24 | 2020-05-15 | 金湘范 | Multifunctional herbal essence atomized liquid |
| CN214077144U (en) * | 2020-10-29 | 2021-08-31 | 许晶晶 | Grinding device for food processing machine |
| CN112608312A (en) * | 2020-12-18 | 2021-04-06 | 南京泽朗医药技术有限公司 | Optimized process for supercritical extraction of matrine |
| CN113786440A (en) * | 2021-09-13 | 2021-12-14 | 云南省药物研究所 | Throat clearing composition and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 王道东等: "川贝母中西贝母碱提取工艺优选", 辽宁中医药大学学报, vol. 18, no. 5, pages 9 - 11 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117463479A (en) * | 2023-12-22 | 2024-01-30 | 江苏靓百家供应链管理有限公司 | Kitchen waste treatment pulper |
| CN117463479B (en) * | 2023-12-22 | 2024-03-08 | 江苏靓百家供应链管理有限公司 | Kitchen waste treatment pulper |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2018058261A1 (en) | Traditional chinese medicine composition for treating psoriasis and preparation method thereof | |
| CN115154540A (en) | CBD product composition containing plant extracts, preparation method and device | |
| Reddy et al. | Evaluation of Phoenix dactylifera fruits for Antiurolithiatic activity | |
| CN101757043A (en) | Liquid traditional Chinese medicine decoction piece and preparation method thereof | |
| EP3881685A1 (en) | Ceratonia siliqua fruit composition and preparation method therefor and use thereof | |
| CN102258094B (en) | Tea drink containing natural plants or natural plant extracts, and preparation method and application thereof | |
| CN104491372B (en) | A kind of Radix Scrophulariae buccal tablet | |
| CN101485454A (en) | Chinese paris rhizome wine | |
| CN104306411A (en) | Taxus chinensis wall-breaking decoction piece preparation method | |
| AU2019100730A4 (en) | Use of Composition of Sunflower Head, Gorgon Euryale Seed and Kudzuvine Root in Lowering Uric Acid and Repair of Liver and Kidney Injury | |
| CN101361932B (en) | Preparation method of high-assay highland barley flavones and use thereof in preparing healthcare products | |
| CN114099609A (en) | Pharmaceutical composition for treating cough and preparation method thereof | |
| CN1248709C (en) | Chinese medicine prepn for stopping drug addiction | |
| CN102764288A (en) | Application of luffa water spray for treating acute pharyngitis | |
| CN107981014B (en) | Preparation method of fragrant plant throat-moistening candy | |
| CN110075147B (en) | Application of Jingdongshan orange total alkaloids | |
| CN105535265A (en) | Pharmaceutical composition for treating pancreatic cancer | |
| CN1985910A (en) | Plaster for treating constipation and its preparing method | |
| CN1546133A (en) | Prescription and preparing process and formulation of Liuwei Nengxiao capsule | |
| CN104840513A (en) | Liquorice extract | |
| CN117838799A (en) | Traditional Chinese medicine composition and preparation method and application thereof | |
| CN117883494A (en) | Spica Prunellae seed oil rich in ursolic acid and application thereof in preparation of anti-cancer fatigue-caused drugs | |
| CN117338829A (en) | Traditional Chinese medicine inclusion compound and preparation method and application thereof | |
| CN103417670B (en) | Medicinal composition for blood fat reduction and antiatherosclerosis, and preparation method thereof | |
| CN117482202A (en) | Traditional Chinese medicine preparation for adjuvant therapy of leukemia and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20230413 Address after: No. 3686, Baiyao street, Chenggong District, Kunming, Yunnan 650500 Applicant after: Yunnan Yunyao Co.,Ltd. Address before: 8th Floor, Building 1, Baida International School, Shangyuan Road, High-tech Zone, Kunming City, Yunnan Province, 650101 Applicant before: Yunnan Wuxi Health Technology Co.,Ltd. |