CN115153499A - Expiratory sampling method and device - Google Patents
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- CN115153499A CN115153499A CN202210777536.9A CN202210777536A CN115153499A CN 115153499 A CN115153499 A CN 115153499A CN 202210777536 A CN202210777536 A CN 202210777536A CN 115153499 A CN115153499 A CN 115153499A
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- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
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Abstract
The invention discloses an expiratory sampling method and device, wherein the expiratory sampling method comprises the following steps: real-time acquisition of patient respiratory CO 2 Concentration value v [ n ]]Stored in a first array; calculating a slope ratio k according to a slope ratio calculation formula, and storing the slope ratio k in a fourth array; comparing and analyzing the slope ratio k and the current CO 2 Concentration value v [ i]If k is equal to (0, K) out ) And v [ i ]]＞T out When the sampling valve is opened, sampling is carried out; wherein, K out Is a preset exhalation slope ratio threshold, T out Is a preset exhalation concentration threshold; comparative analysis of Current CO 2 Concentration value v [ i ]]If v is i ＜T in Closing the sampling valve and stopping sampling; wherein, T in Is a preset inhalation concentration threshold. The breath sampling method and the breath sampling device can automatically collect alveolar gas, reduce the difficulty of breath sampling and improve the sampling precision and efficiency.
Description
Technical Field
The invention relates to the technical field of breath collection, in particular to a breath sampling method and device.
Background
The detection mode of breath disease diagnosis has the characteristics of no wound, rapidness, convenience and the like, and is more and more emphasized by people. For the breath diagnostic apparatus used clinically at present, it is more meaningful to analyze the gas at the end of the breath, because the gas at the front end of the breath is generally mixed with more air, the measurement is greatly influenced by the environment; the gas at the end of expiration is basically alveolar gas, which is the gas directly discharged out of the body through alveolar gas exchange after the human body is subjected to blood circulation and can carry a large amount of health state information, and the current health condition of the human body can be reflected most effectively.
At present expiration sampling mode mainly through medical personnel's artificial judgement and control, collects the terminal gas of exhaling through operating the solenoid valve at the disease expiration in-process. However, this sampling method has a high demand on the respiratory stability of the patient, and for some infants with low cognitive ability and adults without active consciousness or with cognitive impairment, it is difficult to collect alveolar gas at the end of expiration.
Disclosure of Invention
The invention aims to provide an expired air sampling method and device, which can automatically collect alveolar air, reduce difficulty in expired air sampling and improve sampling precision and efficiency.
In order to achieve the purpose, the invention adopts the following technical scheme:
a method of breath sampling comprising the steps of:
real-time acquisition of patient respiratory CO 2 Concentration value v [ n ]]Stored in a first array; wherein n is an integer and is not less than 3;
calculating a slope ratio k according to a slope ratio calculation formula, and storing the slope ratio k in a fourth array; the slope ratio calculation formula is as follows: k = (vi-1)/(vi-1-vi-2) wherein i is an integer and i is 3. Ltoreq. N; if v [ i ] -v [ i-1] =0, k =0; if v [ i-1] -v [ i-2] =0, k =0xFFFF;
comparing and analyzing the slope ratio k and the current CO 2 Concentration value v [ i]If k is equal to (0, K) out ) And v [ i ]]＞T out When the sampling valve is opened, sampling is carried out; wherein, K out Is a preset exhalation slope ratio threshold, T out Is a preset exhalation concentration threshold;
comparative analysis of Current CO 2 Concentration value v [ i]If vi < T in Closing the sampling valve and stopping sampling; wherein, T in Is a preset inhalation concentration threshold.
Wherein an exhalation concentration threshold T is obtained out And T in The method comprises the following steps:
obtaining the maximum CO of each respiratory cycle from the first array 2 Concentration value and minimum CO 2 Concentration values which are respectively stored in the second array and the third array;
calculating the average value of all the values in the second array
Average value of all data in the third array
And the difference value Deltav, and,
；
calculating the exhalation concentration threshold T according to a formula out And T in ，
Wherein, a call-out slope ratio threshold value K is obtained out The method comprises the following steps:
acquiring a first numerical value smaller than 1 of each respiratory cycle from the fourth array, and storing the first numerical value in a fifth numerical value;
acquiring a maximum value and a minimum value from the fifth array, and calculating a difference value delta k between the maximum value and the minimum value; calculating the average value of all the numerical values in the fifth array;
calculating an exhalation slope ratio threshold K out ，K out =
+ δ Δ k; wherein, the delta is more than 0 and less than 1.
Wherein, still include the following step:
acquiring sampling flow and sampling time;
accumulating and calculating the sampling amount;
and when the sampling quantity is greater than or equal to the preset value, closing the sampling valve and stopping sampling.
An breath sampling device comprising:
collecting a front end;
a gas pipeline having a gas inlet, a gas collection port and a gas outlet; the air inlet is communicated with the acquisition front end; the exhaust port is communicated with the outside;
the gas collecting container is communicated with the gas collecting port;
CO connected in the gas line 2 The device comprises a concentration sensor, a flow sensor, an air pump and a three-way valve; the CO is 2 The concentration sensor is used for collecting CO in the gas pipeline in real time 2 Concentration; the flow sensor is used for collecting the gas flow in the gas pipeline in the gas collection process; the three-way valve is used for controlling the conduction of the outlet end of the air pump and the air inlet or the air outlet;
control unit, with said CO 2 The concentration sensor, the flow sensor, the air pump and the three-way valve are electrically connected, and the exhalation slope ratio threshold K can be set according to the exhalation rule out Exhalation concentration threshold T out And inhalation concentration threshold T in And in the collected CO 2 The concentration data satisfies an exhalation slope ratio threshold K out And a threshold value T of exhalation concentration out When the condition is met, controlling a three-way valve to enable the outlet end of the air pump to be communicated with the air inlet only; and at the satisfaction of inhalation concentration threshold T in And when the condition is met, the three-way valve is controlled to enable the outlet end of the air pump to be communicated with the air outlet only.
Wherein a filter is arranged between the acquisition front end and the air inlet.
The system also comprises a human-computer interface, wherein the human-computer interface is connected with the control unit and used for inputting parameters and instructions by a user and displaying sampling data.
The beneficial effects of the invention are as follows: the invention provides an expired air sampling method and device, which can be used for collecting CO in expired air 2 The concentration data meets an exhalation slope ratio threshold K out And an exhalation concentration threshold T out When the conditions are met, gas collection is started; when the inhalation concentration threshold T is met in Stopping gas collection under the condition; therefore, the automatic collection of the alveolar gas can be realized, the difficulty of breath sampling is reduced, and the sampling precision and efficiency are improved.
Drawings
Fig. 1 is a schematic structural diagram of an expiratory sampling device provided by the invention.
Detailed Description
The technical scheme of the invention is further explained by the specific implementation mode in combination with the attached drawings.
A method of breath sampling comprising the steps of:
real-time acquisition of patient respiratory CO 2 Concentration value v [ n ]]Stored in a first array; wherein n is an integer and is more than or equal to 3;
calculating a slope ratio k according to a slope ratio calculation formula, and storing the slope ratio k in a fourth array; the slope ratio is calculated by the formula: k = (vi-1)/(vi-1-vi-2) wherein i is an integer and i is 3. Ltoreq. N; if v [ i ] -v [ i-1] =0, k =0; if v [ i-1] -v [ i-2] =0, k =0xFFFF;
comparing and analyzing the slope ratio k and the current CO 2 Concentration value v [ i ]]If k ∈ (0, K) out ) And v [ i ]]＞T out When the sampling valve is opened, sampling is carried out; wherein, K out Is a preset exhalation slope ratio threshold, T out Is a preset exhalation concentration threshold;
comparative analysis of Current CO 2 Concentration value v [ i]If vi < T in Closing the sampling valve and stopping sampling; wherein, T in Is a preset inhalation concentration threshold.
Wherein an exhalation concentration threshold value T is obtained out And T in The method comprises the following steps:
obtaining the maximum CO of each respiratory cycle from the first array 2 Concentration value and minimum CO 2 Concentration values, which are respectively stored in the second array and the third array;
calculating the average value of all the values in the second array
Average value of all data in the third array
And a difference value deltav to be used for calculating the difference value deltav,
；
calculating the exhalation concentration threshold T according to a formula out And T in ，
Wherein, a call-out slope ratio threshold value K is obtained out The method comprises the following steps:
acquiring a first numerical value smaller than 1 of each respiratory cycle from the fourth array, and storing the first numerical value in a fifth numerical value;
acquiring a maximum value and a minimum value from the fifth array, and calculating a difference value delta k between the maximum value and the minimum value; calculating the average value of all the numerical values in the fifth array;
calculating an exhalation slope ratio threshold K out ，K out =
+ δ Δ k; wherein, delta is more than 0 and less than 1.
Wherein, still include the following step:
acquiring sampling flow and sampling time;
accumulating and calculating the sampling amount;
and when the sampling amount is greater than or equal to the preset value, closing the sampling valve and stopping sampling.
The invention also provides an expired air sampling device which comprises a collection front end 1, a gas pipeline 3, a gas collection container 9 and CO connected in the gas pipeline 2 Concentration sensor 4, flowA quantity sensor 5, an air pump 6, a three-way valve 7 and a control unit 8. Wherein the collecting front end 1 is a nasal tube or a face mask and the like. The gas pipeline is provided with a gas inlet 31, a gas collecting port 32 and a gas outlet 33, the gas inlet 31 is communicated with the acquisition front end 1, the gas outlet 33 is communicated with the outside, and the gas collecting port 32 is communicated with the gas collecting container 9. CO 2 2 The concentration sensor 4 is used for collecting CO in the gas pipeline in real time 2 Concentration; the flow sensor 5 is used for collecting the gas flow in the gas pipeline in the gas collection process; the three-way valve 7 is used for controlling the conduction of the outlet end of the air pump 6 with the air collecting port 32 or the air outlet 33; control unit 8 and CO 2 The concentration sensor 4, the flow sensor 5, the air pump 6 and the three-way valve 7 are electrically connected, and the exhalation slope ratio threshold K can be set according to the exhalation rule out Threshold value of exhalation concentration T out And inhalation concentration threshold T in， And in the collected CO 2 The concentration data satisfies an exhalation slope ratio threshold K out And a threshold value T of exhalation concentration out When the conditions are met, the three-way valve 7 is controlled to lead the outlet end of the air pump 6 to be communicated with the air collecting port 32 only; and at the satisfaction of inhalation concentration threshold T in In the case of the condition, the three-way valve 7 is controlled to allow the outlet end of the air pump 6 to communicate only with the air outlet 33.
The gas collection container 9 may be a gas collection bag, or may directly collect gas by using a buffer chamber or an analysis chamber of the detection device.
Further, a filter 2 is arranged between the collection front end 1 and the air inlet 3 for water-air separation.
The breath sampling device further comprises a human-computer interface, which is connected with the control unit 8 and used for inputting parameters and instructions by a user and displaying sampling data.
The invention relates to an expired air sampling method and an expired air adopting device, which utilize CO 2 Concentration and CO 2 The concentration slope ratio k judges whether the exhaled gas is alveolar gas or not, and gas collection is performed only when two parameters simultaneously meet the conditions; when CO is present 2 And stopping gas collection when the concentration drops below the suction concentration threshold value Tin. Therefore, the breath sampling method and the breath sampling device can realize automatic collection of alveolar gas, reduce the difficulty of breath sampling and improve the sampling precision and efficiency.
The technical principle of the present invention is described above in connection with specific embodiments. The description is made for the purpose of illustrating the principles of the invention and should not be construed in any way as limiting the scope of the invention. Based on the explanations herein, those skilled in the art will be able to conceive of other embodiments of the present invention without inventive effort, which would fall within the scope of the present invention.
Claims (7)
1. A method of breath sampling comprising the steps of:
real-time acquisition of patient respiratory CO 2 Concentration value v [ n ]]Stored in a first array; wherein n is an integer and is not less than 3;
calculating a slope ratio k according to a slope ratio calculation formula, and storing the slope ratio k in a fourth array; the slope ratio calculation formula is as follows: k = (vi-1)/(vi-1-vi-2) wherein i is an integer and i is 3. Ltoreq. N; if v [ i ] -v [ i-1] =0, k =0; if v [ i-1] -v [ i-2] =0, k =0xFFFF;
comparing and analyzing the slope ratio k and the current CO 2 Concentration value v [ i ]]If k is equal to (0, K) out ) And v [ i ]]＞T out When the sampling valve is opened, sampling is carried out; wherein, K out Is a preset exhalation slope ratio threshold, T out Is a preset exhalation concentration threshold;
comparative analysis of Current CO 2 Concentration value v [ i ]]If v is i ＜T in Closing the sampling valve and stopping sampling; wherein, T in Is a preset inhalation concentration threshold.
2. The breath sampling method according to claim 1, wherein the exhalation concentration threshold T is obtained out And T in The method comprises the following steps:
obtaining the maximum CO of each respiratory cycle from the first array 2 Concentration value and minimum CO 2 Concentration values, which are respectively stored in the second array and the third array;
calculating the average value of all the values in the second array
Average value of all data in the third array
And a difference value deltav to be used for calculating the difference value deltav,
；
calculating the exhalation concentration threshold T according to a formula out And T in ，
3. The breath sampling method of claim 1 wherein the expiratory slope ratio threshold K is obtained out The method comprises the following steps:
acquiring a first numerical value smaller than 1 of each respiratory cycle from the fourth array, and storing the first numerical value in a fifth numerical value;
acquiring a maximum value and a minimum value from the fifth array, and calculating a difference value delta k between the maximum value and the minimum value; calculating the average value of all the values in the fifth array
；
Calculating an exhalation slope ratio threshold K out ，K out =
+ δ Δ k; wherein, delta is more than 0 and less than 1.
4. The method of breath sampling according to claim 1, further comprising the steps of:
acquiring sampling flow and sampling time;
accumulating and calculating the sampling amount;
and when the sampling amount is greater than or equal to the preset value, closing the sampling valve and stopping sampling.
5. An breath sampling device, comprising:
collecting a front end;
a gas line having a gas inlet, a gas collection port, and a gas outlet; the air inlet is communicated with the acquisition front end; the exhaust port is communicated with the outside;
the gas collecting container is communicated with the gas collecting port;
CO connected in the gas line 2 The device comprises a concentration sensor, a flow sensor, an air pump and a three-way valve; said CO 2 The concentration sensor is used for collecting CO in the gas pipeline in real time 2 Concentration; the flow sensor is used for collecting the gas flow in the gas pipeline in the gas collection process; the three-way valve is used for controlling the conduction of the outlet end of the air pump and the air inlet or the air outlet;
control unit, with said CO 2 The concentration sensor, the flow sensor, the air pump and the three-way valve are electrically connected, and the exhalation slope ratio threshold K can be set according to the exhalation rule out Threshold value of exhalation concentration T out And inhalation concentration threshold T in And in the collected CO 2 The concentration data satisfies an exhalation slope ratio threshold K out And an exhalation concentration threshold T out When the condition is met, controlling a three-way valve to enable the outlet end of the air pump to be communicated with the air inlet only; and at the satisfaction of inhalation concentration threshold T in And when the condition is met, the three-way valve is controlled to enable the outlet end of the air pump to be communicated with the air outlet only.
6. The breath sampling device according to claim 1, wherein a filter is disposed between said collection front end and said air inlet.
7. The breath sampling device according to claim 1, further comprising a human-machine interface, connected to said control unit, for user input of parameters, instructions, and display of sampled data.
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| CN202210777536.9A CN115153499A (en) | 2022-07-04 | 2022-07-04 | Expiratory sampling method and device |
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| CN202210777536.9A CN115153499A (en) | 2022-07-04 | 2022-07-04 | Expiratory sampling method and device |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130165806A1 (en) * | 2011-12-21 | 2013-06-27 | Capnia, Inc. | Collection and analysis of a volume of exhaled gas with compensation for the frequency of a breathing parameter |
| CN205157269U (en) * | 2015-12-04 | 2016-04-13 | 无锡市尚沃医疗电子股份有限公司 | Moisture end gas sampling device |
| CN205228892U (en) * | 2015-12-04 | 2016-05-11 | 无锡市尚沃医疗电子股份有限公司 | Last sampling device of exhaling |
| US20170367618A1 (en) * | 2016-06-28 | 2017-12-28 | Treymed, Inc. | Side-Stream Respiratory Gas Monitoring System |
| CN113069102A (en) * | 2020-01-06 | 2021-07-06 | 深圳市先亚生物科技有限公司 | Breath collection system and method |
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- 2022-07-04 CN CN202210777536.9A patent/CN115153499A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130165806A1 (en) * | 2011-12-21 | 2013-06-27 | Capnia, Inc. | Collection and analysis of a volume of exhaled gas with compensation for the frequency of a breathing parameter |
| CN107874761A (en) * | 2011-12-21 | 2018-04-06 | 卡普尼亚公司 | Collected in the case where compensating respiration parameter frequency and analyze the gas of the exhalation of certain volume |
| CN205157269U (en) * | 2015-12-04 | 2016-04-13 | 无锡市尚沃医疗电子股份有限公司 | Moisture end gas sampling device |
| CN205228892U (en) * | 2015-12-04 | 2016-05-11 | 无锡市尚沃医疗电子股份有限公司 | Last sampling device of exhaling |
| US20170367618A1 (en) * | 2016-06-28 | 2017-12-28 | Treymed, Inc. | Side-Stream Respiratory Gas Monitoring System |
| CN113069102A (en) * | 2020-01-06 | 2021-07-06 | 深圳市先亚生物科技有限公司 | Breath collection system and method |
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