CN115143393A - Fluid system - Google Patents

Fluid system Download PDF

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Publication number
CN115143393A
CN115143393A CN202210920286.XA CN202210920286A CN115143393A CN 115143393 A CN115143393 A CN 115143393A CN 202210920286 A CN202210920286 A CN 202210920286A CN 115143393 A CN115143393 A CN 115143393A
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CN
China
Prior art keywords
valve
port
fluid
power module
container
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Pending
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CN202210920286.XA
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Chinese (zh)
Inventor
隋相坤
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shenzhen Taiguyu Technology Co ltd
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Shenzhen Taiguyu Technology Co ltd
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Priority to CN202210920286.XA priority Critical patent/CN115143393A/en
Publication of CN115143393A publication Critical patent/CN115143393A/en
Priority to PCT/CN2023/081203 priority patent/WO2024027159A1/en
Pending legal-status Critical Current

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    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17DPIPE-LINE SYSTEMS; PIPE-LINES
    • F17D1/00Pipe-line systems
    • F17D1/08Pipe-line systems for liquids or viscous products
    • F17D1/14Conveying liquids or viscous products by pumping
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17DPIPE-LINE SYSTEMS; PIPE-LINES
    • F17D3/00Arrangements for supervising or controlling working operations
    • F17D3/01Arrangements for supervising or controlling working operations for controlling, signalling, or supervising the conveyance of a product

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Water Supply & Treatment (AREA)
  • Pipeline Systems (AREA)
  • Multiple-Way Valves (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)

Abstract

The invention relates to the technical field of fluid delivery, in particular to a fluid system, which comprises a fluid container, a fluid storage device and a control device, wherein the fluid container is used for storing fluid; the control valve group comprises a primary valve group and a plurality of secondary valve groups, and the secondary valve groups are communicated with the primary valve group and the fluid container; the flow cell is communicated with the outlet of the primary valve bank through a common pipeline; a first power module in communication with an outlet of the flow cell, the outlet of the first power module in communication with a waste liquid container and/or the fluid container; a second power module, the second power module pass through a bypass pipeline with the bypass port intercommunication of one-level valves, the export of second power module with the waste liquid container and/or the fluid container intercommunication. The invention can reduce the waste caused by fluid replacement and improve the flexibility.

Description

Fluid system
Technical Field
The invention relates to the technical field of fluid conveying, in particular to a fluid system.
Background
The flow cell is used as a reaction chamber, and a fluid system designed to serve the flow cell is needed for transporting samples, reagents, water, cleaning agents or fluids with other functions into the flow cell, and meanwhile, the fluids used in the flow cell can be transported to a waste liquid container to be discarded or transported to other containers for recycling.
In the prior art, the classic design is a direct flush fluid system. This design requires only a common section of piping before the inlet of the flow cell for the inflow of all kinds of fluids. When a plurality of different fluids are used in the flow cell, the valves or the combination of the valves can be used to connect the pipes for connecting the different fluids with the common pipe respectively, and then the power module is used to drive the fluids into the flow cell through the valves and the common pipe.
A first problem with this design is the waste associated with fluid replacement. The flow rate required for the replacement of the fluid in the common conduit and the flow cell is proportional to the inner volume of the flow space, and only the fluid eventually filled in the flow cell is effectively used, whereas part of the fluid previously consumed for the replacement of the common conduit and the flow cell is wasted. A second problem is the restriction of the flow cell to the use of fluid. During use of the flow cell, other lines cannot be cleaned, and thus cannot be prepared for the next fluid to be flowed into the flow cell, resulting in poor flexibility in fluid delivery.
Therefore, a fluid system is needed to address the above-mentioned problems.
Disclosure of Invention
The invention aims to provide a fluid system which can reduce waste caused by fluid replacement and improve flexibility.
In order to achieve the purpose, the invention adopts the following technical scheme:
a fluidic system, comprising:
a fluid container for storing a fluid;
a control valve block comprising a primary valve block and a plurality of secondary valve blocks, each of the plurality of secondary valve blocks being in communication with the primary valve block and the fluid container;
the flow cell is communicated with the outlet of the primary valve group through a common pipeline;
a first power module in communication with an outlet of the flow cell, the outlet of the first power module in communication with a waste container and/or the fluid container;
the second power module is communicated with a bypass port of the primary valve group through a bypass pipeline, and an outlet of the second power module is communicated with the waste liquid container and/or the fluid container;
the primary valve block is configured to: one of the secondary valve groups is communicated with the public pipeline, and the rest part or all of the secondary valve groups are communicated with the bypass pipeline.
Furthermore, a plurality of liquid storage cavities which are not communicated with each other are arranged in the fluid container, and the liquid storage cavities are used for storing different fluids.
Further, the secondary valve group is communicated with one or more liquid storage cavities.
Further, the flow cell is provided with a plurality of channels which are not communicated with each other, the plurality of channels are communicated with the outlet of the flow cell, and the outlet of the primary valve group is communicated with each channel.
Furthermore, two secondary valve groups are arranged, the two secondary valve groups are respectively communicated with a first port and a second port of the primary valve group, a third port of the primary valve group is communicated with the public pipeline, a fourth port of the primary valve group is communicated with the bypass pipeline, the primary valve group can enable the first port to be communicated with the third port, the second port to be communicated with the fourth port, or the first port is communicated with the fourth port, and the second port is communicated with the third port.
Further, the primary valve group is a four-way reversing valve, a two-position four-way electromagnetic valve or a two-position four-way selector valve.
Further, the primary valve group comprises a first two-position three-way electromagnetic valve, a second two-position three-way electromagnetic valve and a third two-position three-way electromagnetic valve, two bypass pipelines are arranged, the secondary valve group comprises a first selection valve and a second selection valve, one end of the first selection valve and one end of the second selection valve are both communicated with the fluid container, the other end of the first selection valve is communicated with a first port of the first two-position three-way electromagnetic valve, a second port of the first two-position three-way electromagnetic valve is communicated with one bypass pipeline, the other end of the second selection valve is communicated with a first port of the second two-position three-way electromagnetic valve, a second port of the second two-position three-way electromagnetic valve is communicated with the other bypass pipeline, a third port of the first two-position three-way electromagnetic valve is communicated with a first port of the third two-position three-way electromagnetic valve, a third port of the second two-position three-way electromagnetic valve is communicated with a second port of the third two-position three-way electromagnetic valve, and a third port of the third two-position three-way electromagnetic valve is communicated with the common pipeline.
Further, the first power module and the second power module are both injection pumps.
Further, still include first waste liquid pipeline and first filling liquid pipeline, first waste liquid pipeline with the one end of first filling liquid pipeline all with the export intercommunication of first power module, the other end of first waste liquid pipeline with the waste liquid container intercommunication, the other end of first filling liquid pipeline with the fluid container intercommunication.
The power module further comprises a second waste liquid pipeline and a second filling liquid pipeline, one end of the second waste liquid pipeline and one end of the second filling liquid pipeline are both communicated with an outlet of the second power module, the other end of the second waste liquid pipeline is communicated with the waste liquid container, and the other end of the second filling liquid pipeline is communicated with the fluid container.
The invention has the beneficial effects that:
according to the fluid system provided by the invention, the fluid container is used for storing fluid, the primary valve bank is arranged between the secondary valve bank and the flow pool, the first power module is communicated with the flow pool and can drive the fluid to flow into the waste fluid container and/or the fluid container, and the second power module is communicated with the primary valve bank through the bypass pipeline and can drive the fluid to flow into the waste fluid container and/or the fluid container through the bypass pipeline. The primary valve group enables one of the secondary valve groups to be communicated with a public pipeline, and the rest part or all of the secondary valve groups are communicated with the bypass pipeline. The distance between the primary valve bank and the flow pool is short, so that waste caused by fluid replacement can be reduced; when the secondary valve group communicated with the flow pool supplies fluid, the rest secondary valve groups can carry out pipeline cleaning or fluid preparation work through the bypass pipeline, and when the fluid needs to be switched, only the primary valve group needs to be controlled to complete the switching of the secondary valve group. The other two-stage valve group can perform cleaning operation and fluid supply preparation operation while fluid is conveyed to the flow cell, so that the flexibility of fluid supply can be improved, and the efficiency of fluid supply can be improved.
Drawings
FIG. 1 is a schematic view of a fluid system of the present invention;
FIG. 2 is a schematic diagram of a fluid system of the present invention;
FIG. 3 is another schematic diagram of a fluid system of the present invention;
FIG. 4 is yet another schematic diagram of a fluid system of the present invention;
FIG. 5 is yet another schematic diagram of a fluid system of the present invention;
fig. 6 is a schematic diagram of a fluid system in which three sets of secondary valve stacks are provided.
In the figure:
1. a fluid container; 2. a secondary valve bank; 21. a first selector valve; 22. a second selector valve; 23. branch flow channels; 3. a primary valve bank; 31. a first two-position three-way electromagnetic valve; 32. a second two-position three-way solenoid valve; 33. a third two-position three-way solenoid valve; 34. a common conduit; 35. a bypass conduit; 4. a flow cell; 41. a channel; 5. a first power module; 51. a first waste conduit; 52. a first fill fluid conduit; 6. a second power module; 61. a second waste conduit; 62. a second fill fluid conduit; 7. a waste liquid container.
Detailed Description
The technical scheme of the invention is further explained by combining the attached drawings and the embodiment. It is to be understood that the specific embodiments described herein are merely illustrative of the invention and are not to be construed as limiting the invention. It should be further noted that, for the convenience of description, only some but not all of the elements associated with the present invention are shown in the drawings.
In the description of the present invention, it should be noted that unless otherwise explicitly stated or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection or a removable connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in a specific case to those of ordinary skill in the art.
In the present invention, unless otherwise expressly stated or limited, "above" or "below" a first feature means that the first and second features are in direct contact, or that the first and second features are not in direct contact but are in contact with each other via another feature therebetween. Also, the first feature being "on," "above" and "over" the second feature includes the first feature being directly on and obliquely above the second feature, or merely indicating that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature includes the first feature being directly under and obliquely below the second feature, or simply meaning that the first feature is at a lesser elevation than the second feature.
The flow cell is used as a reaction chamber, and a fluid system designed to serve the flow cell is needed for transporting samples, reagents, water, cleaning agents or fluids with other functions into the flow cell, and meanwhile, the fluids used in the flow cell can be transported to a waste liquid container to be discarded or transported to other containers for recycling.
In order to reduce waste caused by fluid replacement and at the same time increase flexibility, the present invention provides a fluid system, as shown in fig. 1-6. The present fluid system comprises a fluid container 1, a set of control valves, a flow cell 4, a first power module 5 and a second power module 6.
Wherein the fluid container 1 is used for storing fluid; the control valve group comprises a primary valve group 3 and a plurality of secondary valve groups 2, and the secondary valve groups 2 are communicated with the primary valve group 3 and the fluid container 1; the flow cell 4 is communicated with the outlet of the primary valve group 3 through a common pipeline 34; the first power module 5 is communicated with the outlet of the flow cell 4, and the outlet of the first power module 5 is communicated with the waste liquid container 7 and/or the fluid container 1; the second power module 6 is communicated with a bypass port of the primary valve group 3 through a bypass pipeline 35, and an outlet of the second power module 6 is communicated with the waste liquid container 7 and/or the fluid container 1; the primary valve group 3 is configured to: one of the secondary valve groups 2 communicates with the common conduit 34, and the remaining part or all of the secondary valve groups 2 communicate with the bypass conduit 35.
The distance between the primary valve group 3 and the flow pool 4 is short, so that waste caused by fluid replacement can be reduced; when the second valve set 2 communicated with the flow cell 4 supplies fluid, the rest second valve sets 2 can perform pipeline cleaning or fluid preparation work through the bypass pipeline 35, and when the fluid needs to be switched, only the first valve set 3 needs to be controlled to complete the switching of the second valve set 2. The remaining two-stage valve block 2 can perform the cleaning operation and the fluid supply preparation operation while the fluid is supplied to the flow cell 4, and thus the flexibility of fluid supply and the efficiency of fluid supply can be improved.
Further, a plurality of liquid storage cavities which are not communicated with each other are arranged in the fluid container 1, and the plurality of liquid storage cavities are used for storing different fluids. Through setting up a plurality of stock solution chambeies, can save different reagent, pure water and sanitizer etc.. When one of the two-stage valve banks 2 is used for conveying the reagent, the rest two-stage valve banks 2 can utilize the cleaning agent to clean the bypass pipeline 35 and the first-stage valve bank 3, and then utilize pure water to clean, so that the cleaning operation is completed; meanwhile, different reagents can be pumped into the rest valve banks to prepare for fluid conveying operation.
Further, the two-stage valve group 2 is communicated with one or more liquid storage cavities. Through the arrangement, when the secondary valve group 2 is communicated with one of the liquid storage cavities, the direct supply of a single reagent can be realized; when the second valve group 2 is communicated with the liquid storage cavities, different reagents can be supplied according to the needs, or after one reagent is supplied, cleaning operation is performed by using a cleaning agent and pure water through the bypass pipeline 35 and the second power module 6, and preparation is made for conveying different reagents. By the aid of the method, the reagent supply flexibility can be improved, and the supply efficiency is improved.
Further, the flow cell 4 has a plurality of channels 41 that do not communicate with each other, the plurality of channels 41 each communicate with an outlet of the flow cell 4, and an outlet of the secondary valve group 2 communicates with each channel 41. Specifically, the number of the first power modules 5 is set according to the number of the passages 41, and the flow of the fluid of each passage 41 can be realized. By providing a plurality of channels 41, secondary valve block 2 in communication with common conduit 34 can supply reagent to a plurality of channels 41 simultaneously, which can improve the efficiency of the test.
Further, exemplarily, two secondary valve banks 2 are provided with two, and in this embodiment, two secondary valve banks 2 are the selector valve, and two secondary valve banks 2 communicate with first mouth and second mouth of one-level valve bank 3 respectively, and the third mouth and the public conduit 34 intercommunication of one-level valve bank 3, and the fourth mouth and the bypass conduit 35 intercommunication of one-level valve bank 3, and one-level valve bank 3 can make first mouth and third mouth intercommunication, second mouth and fourth mouth intercommunication, perhaps first mouth and fourth mouth intercommunication, second mouth and third mouth intercommunication. By controlling the primary valve group 3, the switching between the two secondary valve groups 2 can be realized, and when one of the secondary valve groups 2 supplies fluid, the other secondary valve group 2 can perform cleaning and preparation of the other reagent. Further, in this example, the primary valve set 3 is a four-way reversing valve, a two-position four-way solenoid valve, or a two-position four-way selector valve.
Further, exemplarily, the primary valve group 3 includes a first two-position three-way solenoid valve 31, a second two-position three-way solenoid valve 32, and a third two-position three-way solenoid valve 33, two bypass pipes 35 are provided, the secondary valve group 2 includes a first selection valve 21 and a second selection valve 22, one end of each of the first selection valve 21 and the second selection valve 22 is communicated with the fluid container 1, the other end of the first selection valve 21 is communicated with a first port of the first two-position three-way solenoid valve 31, a second port of the first two-position three-way solenoid valve 31 is communicated with one of the bypass pipes 35, the other end of the second selection valve 22 is communicated with a first port of the second two-position three-way solenoid valve 32, a second port of the second two-position three-way solenoid valve 32 is communicated with the other of the bypass pipes 35, a third port of the first two-position three-way solenoid valve 31 is communicated with a first port of the third two-position three-way solenoid valve 33, a third port of the second two-position three-way solenoid valve 32 is communicated with a second port of the third two-position three-way solenoid valve 33, and a third port of the third three-position three-way solenoid valve 33 is communicated with the common pipe 34. By controlling the first two-position three-way solenoid valve 31, the second two-position three-way solenoid valve 32 and the third two-position three-way solenoid valve 33, the operation of cleaning and preparation for reagent supply can be performed on the other two-position valve set 2 while one of the two-position valve sets 2 supplies fluid to the flow cell 4. In this embodiment, the two-stage valve set 2 can also be replaced by three-way reversing valves or three two-position three-way selector valves, which is not limited herein.
Further, the first power module 5 and the second power module 6 are both syringe pumps. When in use, the first power modules 5 can be arranged according to the number of the arranged channels 41, and the first power modules 5 can adopt one pump body and a plurality of pump ports corresponding to the number of the channels 41 to realize the simultaneous control of the fluid in the channels 41; or a plurality of first power modules 5 can be correspondingly arranged according to the number of the channels 41, so that the control can be accurately realized.
Further, the fluid system further comprises a first waste liquid pipe 51 and a first filling liquid pipe 52, wherein one end of each of the first waste liquid pipe 51 and the first filling liquid pipe 52 is communicated with the outlet of the first power module 5, the other end of the first waste liquid pipe 51 is communicated with the waste liquid container 7, and the other end of the first filling liquid pipe 52 is communicated with the fluid container 1. When the fluid continuously flows to the flow cell 4, the waste liquid used in the flow cell 4 can enter the waste liquid container 7 through the first waste liquid pipeline 51 for collection; it can also be recovered through the first filling liquid pipe 52 into the fluid container 1.
Further, the fluid system further comprises a second waste liquid pipe 61 and a second filling liquid pipe 62, one end of each of the second waste liquid pipe 61 and the second filling liquid pipe 62 is communicated with the outlet of the second power module 6, the other end of the second waste liquid pipe 61 is communicated with the waste liquid container 7, and the other end of the second filling liquid pipe 62 is communicated with the fluid container 1. When the fluid passes through the secondary valve group 2 to clean the bypass pipeline 35, the cleaned waste liquid can enter the waste liquid container 7 through the second waste liquid pipeline 61 to be collected; it can also be recycled through the second filling liquid pipe 62 into the fluid container 1.
Further, this fluid system still includes a plurality of branch runner 23, and a plurality of branch runners 23 set up with a plurality of second grade valves 2 one-to-one, and the one end and the second grade valves 2 intercommunication of branch runner 23, the other end and the waste liquid container 7 intercommunication of branch runner 23.
Further, after the reagent is used up, the kit can also be used as a container for storing waste liquid, and after the cleaning waste liquid is discharged into the kit, the kit is discarded.
Further, as shown in fig. 6, in the present embodiment, three sets of two-stage valve sets 2 are provided, and in other embodiments, the number of two-stage valve sets 2 may be arranged as needed, without being limited too much.
The fluid system provided by the embodiment has the following beneficial effects:
1. the consumption of reagent replacement in common conduit 34 can be controlled, ensuring economy of fluid flow system operation.
2. The sample or reagent can be rapidly transported to the flow cell 4, so that the flexibility of the time sequence of the fluid system is ensured;
3. when the transportation of the sample or the reagent is carried out, part of pipelines of the fluid system can be cleaned deeply in turn, so that the cross contamination and the reagent residue generated by the transportation of different reagents by instrument pipelines are reduced.
It should be understood that the above-described embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. This need not be, nor should it be exhaustive of all embodiments. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the claims of the present invention.

Claims (10)

1. A fluid system, comprising:
a fluid container (1), the fluid container (1) being for storing a fluid;
the control valve group comprises a primary valve group (3) and a plurality of secondary valve groups (2), and the secondary valve groups (2) are communicated with the primary valve group (3) and the fluid container (1);
a flow cell (4), the flow cell (4) being in communication with the outlet of the primary valve block (3) through a common conduit (34);
a first power module (5), the first power module (5) being in communication with an outlet of the flow cell (4), an outlet of the first power module (5) being in communication with a waste liquid container (7) and/or the fluid container (1);
a second power module (6), wherein the second power module (6) is communicated with a bypass port of the primary valve group (3) through a bypass pipeline (35), and an outlet of the second power module (6) is communicated with the waste liquid container (7) and/or the fluid container (1);
the primary valve block (3) is configured to: one of the secondary valve groups (2) is communicated with the common pipeline (34), and the rest part or all of the secondary valve groups (2) are communicated with the bypass pipeline (35).
2. A fluid system according to claim 1, wherein a plurality of reservoirs are provided in the fluid container (1) which are not in communication with each other, the plurality of reservoirs being adapted to store different fluids.
3. A fluid system as claimed in claim 2, wherein the secondary valve block (2) communicates with one or more of the reservoirs.
4. A fluidic system according to claim 1, characterized in that said flow cell (4) has a plurality of channels (41) that are not in communication with each other, a plurality of said channels (41) being in communication with an outlet of said flow cell (4), an outlet of said primary valve group (3) being in communication with each of said channels (41).
5. A fluid system as claimed in claim 1, characterised in that there are two secondary valve groups (2), two secondary valve groups (2) communicating respectively with a first port and a second port of the primary valve group (3), the third port of the primary valve group (3) communicating with the common duct (34), the fourth port of the primary valve group (3) communicating with the bypass duct (35), the primary valve group (3) being able to communicate the first port with the third port, the second port with the fourth port, or the first port with the fourth port, the second port with the third port.
6. A fluid system according to claim 5, characterized in that the primary valve group (3) is a four-way reversing valve, a two-position four-way solenoid valve or a two-position four-way selector valve.
7. The fluid system according to claim 1, characterized in that said primary valve group (3) comprises a first two-position three-way solenoid valve (31), a second two-position three-way solenoid valve (32), a third two-position three-way solenoid valve (33), said bypass ducts (35) being provided in two, said secondary valve group (2) comprises a first selection valve (21) and a second selection valve (22), one end of each of said first selection valve (21) and said second selection valve (22) being in communication with said fluid container (1), the other end of said first selection valve (21) being in communication with a first port of said first two-position three-way solenoid valve (31), the second port of said first two-position three-way solenoid valve (31) being in communication with one of said bypass ducts (35), the other end of said second selection valve (22) being in communication with a first port of said second two-position three-way solenoid valve (32), the second port of said second two-position three-way solenoid valve (32) being in communication with another of said bypass ducts (35), the third port of said first two-position three-way solenoid valve (31) being in communication with a first port of said third three-position three-way solenoid valve (33), said first port of said common three-position three-way solenoid valve (33) being in communication with said first port of said common solenoid valve (34).
8. The fluidic system according to claim 1, characterized in that the first power module (5) and the second power module (6) are both syringe pumps.
9. The fluidic system according to claim 1, further comprising a first waste pipe (51) and a first filling liquid pipe (52), one end of each of said first waste pipe (51) and said first filling liquid pipe (52) communicating with an outlet of said first power module (5), the other end of said first waste pipe (51) communicating with said waste container (7), the other end of said first filling liquid pipe (52) communicating with said fluidic container (1).
10. The fluidic system according to claim 1, further comprising a second waste pipe (61) and a second filling liquid pipe (62), one end of said second waste pipe (61) and one end of said second filling liquid pipe (62) both communicating with an outlet of said second power module (6), the other end of said second waste pipe (61) communicating with said waste container (7), the other end of said second filling liquid pipe (62) communicating with said fluidic container (1).
CN202210920286.XA 2022-08-02 2022-08-02 Fluid system Pending CN115143393A (en)

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Application Number Priority Date Filing Date Title
CN202210920286.XA CN115143393A (en) 2022-08-02 2022-08-02 Fluid system
PCT/CN2023/081203 WO2024027159A1 (en) 2022-08-02 2023-03-14 Fluid system

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Application Number Priority Date Filing Date Title
CN202210920286.XA CN115143393A (en) 2022-08-02 2022-08-02 Fluid system

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