CN115136899B - IVC cage for biological experiment - Google Patents
IVC cage for biological experiment Download PDFInfo
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- CN115136899B CN115136899B CN202210572168.4A CN202210572168A CN115136899B CN 115136899 B CN115136899 B CN 115136899B CN 202210572168 A CN202210572168 A CN 202210572168A CN 115136899 B CN115136899 B CN 115136899B
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- air inlet
- pipe
- cage
- branch pipe
- air
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- 238000002474 experimental method Methods 0.000 title claims abstract description 40
- 230000003542 behavioural effect Effects 0.000 claims abstract description 40
- 238000005286 illumination Methods 0.000 claims description 36
- 238000007789 sealing Methods 0.000 claims description 26
- 238000009423 ventilation Methods 0.000 claims description 14
- 230000000903 blocking effect Effects 0.000 claims description 9
- 230000001276 controlling effect Effects 0.000 claims 3
- 230000001105 regulatory effect Effects 0.000 claims 2
- 241000699670 Mus sp. Species 0.000 abstract description 20
- 239000007789 gas Substances 0.000 description 53
- 239000003674 animal food additive Substances 0.000 description 9
- 125000006850 spacer group Chemical group 0.000 description 9
- 241000699666 Mus <mouse, genus> Species 0.000 description 6
- 238000005192 partition Methods 0.000 description 5
- 238000010586 diagram Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 238000013016 damping Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
- A01K1/03—Housing for domestic or laboratory animals
- A01K1/031—Cages for laboratory animals; Cages for measuring metabolism of animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/0047—Air-conditioning, e.g. ventilation, of animal housings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
- A01K1/035—Devices for use in keeping domestic animals, e.g. fittings in housings or dog beds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- General Health & Medical Sciences (AREA)
- Ventilation (AREA)
Abstract
The invention claims an IVC cage for biological experiments, which comprises a cage frame and a cage box; the cage frame is provided with a plurality of behavioral cabins, biological cabins and a placement cabin for placing the cage box, an air inlet main pipe, an air outlet main pipe, a plurality of air inlet branch pipes communicated with the air inlet main pipe and a plurality of air outlet branch pipes communicated with the air outlet main pipe are arranged in the cage frame, each of the behavioural bin, the biological bin and the placement bin corresponds to an air inlet branch pipe and an air outlet branch pipe. The biological cabin is characterized by further comprising a gas generating device, wherein the gas generating device is communicated with the air inlet branch pipe corresponding to the biological cabin through a gas pipeline, and an adjusting structure is arranged in the gas pipeline. The arrangement bin is used for placing the cage box, the behavioural bin and the biological bin are used for carrying out related experiments, the air inlet main pipe and the air outlet main pipe are used for conveying sterilized air to each bin, the gas generating device is communicated with the air inlet branch pipe corresponding to the biological bin through the gas pipeline and used for carrying out related gas experiments, and air with different gas components is conveyed to experimental mice.
Description
Technical Field
The invention relates to the field of test cage boxes, in particular to an IVC cage for biological experiments.
Background
IVC (individual ventilated cages, independent ventilation cage) cage means miniature SPF-class experimental animal raising and experimental equipment which is independently circulated in a closed independent cage by clean air flow with high ventilation frequency (20-60 times/hour), the exhaust gas is concentrated and discharged, and the experiment can be operated in an ultra-clean workbench or a biosafety cabinet. At present, chinese patent with publication number of CN109089891A discloses an IVC cage, which comprises a cage frame, a plurality of cage boxes and a ventilation assembly arranged on the cage frame, wherein the cage boxes are connected with the ventilation assembly, a plurality of cage box placement bins are arranged on the cage frame, and the ventilation assembly comprises an air inlet main pipe, an air outlet main pipe, a plurality of air inlet branch pipes connected with the air inlet main pipe and a plurality of air outlet branch pipes connected with the air outlet main pipe which are arranged on the cage frame; each cage box placement bin is at least provided with two air inlet branch pipes and two air outlet branch pipes. The present IVC cage is mainly used for raising laboratory mice, and because the cage frame for raising the laboratory mice is large, a large amount of space is occupied, so when the laboratory mice need to be tested, the laboratory mice need to be taken out to another laboratory for testing, and the IVC cage occupies a large amount of space and has a single function.
Therefore, how to make the IVC cage have experimental functions is a matter of consideration in the present application.
Disclosure of Invention
Aiming at the defects existing in the prior art, an IVC cage is provided, and the IVC cage is provided with a placement cabin for feeding experimental mice, and a behavioural cabin and a biological cabin for experiments.
In order to achieve the above purpose, the following technical scheme is provided:
an IVC cage for biological experiments, which comprises a cage frame and a cage box; the cage frame is provided with a plurality of behavioral bins, biological bins and placement bins for placing the cage boxes, the cage frame is internally provided with an air inlet main pipe, an air outlet main pipe, a plurality of air inlet branch pipes communicated with the air inlet main pipe and a plurality of air outlet branch pipes communicated with the air outlet main pipe, each behavioral bin corresponds to one air inlet branch pipe and one air outlet branch pipe, each biological bin corresponds to one air inlet branch pipe and one air outlet branch pipe, and each placement bin corresponds to one air inlet branch pipe and one air outlet branch pipe.
The biological cabin is characterized by further comprising a gas generating device, wherein the gas generating device is communicated with the air inlet branch pipe corresponding to the biological cabin through a gas pipeline, and an adjusting structure is arranged in the gas pipeline.
When the gas generating device generates gas, the adjusting structure controls the gas pipeline to be communicated with the corresponding air inlet branch pipe and controls the air inlet main pipe to be separated from the corresponding air inlet branch pipe.
When the gas generating device stops generating gas, the adjusting structure controls the gas pipeline and the corresponding air inlet branch pipe to be blocked, and controls the air inlet main pipe and the corresponding air inlet branch pipe to be communicated.
In summary, the above technical scheme has the following beneficial effects: offer the behavioural storehouse on the cage, biological storehouse and arrangement storehouse, arrangement storehouse is used for placing the cage box, behavioural storehouse and biological storehouse are used for carrying out relevant experiment, the air inlet is responsible for and the air-out is responsible for being connected with air supply equipment and negative pressure equipment respectively, be used for carrying sterile air for each storehouse, gas generator passes through the air duct and the air inlet branch pipe intercommunication that biological storehouse corresponds, be used for carrying out relevant gas experiment, carry the air of different gaseous components for the laboratory mouse, when providing gas for biological storehouse with gas generator, then the air inlet branch pipe in automatic partition biological storehouse, let biological storehouse both can carry out the raising of laboratory mouse also can carry out biological experiment, behavioural storehouse has a plurality ofly, and each behavioural storehouse can have different space sizes, behavioural storehouse is used for carrying out relevant behavioural experiment, still can use its corresponding air inlet branch pipe and air-out branch pipe to provide sterile air for each storehouse, this IVC feeds the space for the laboratory mouse, can provide space for the laboratory mouse again, space has been practiced thrift greatly, and the laboratory mouse does not change its environmental factor when carrying out the laboratory mouse when having reduced the laboratory experiment.
Drawings
FIG. 1 is a schematic diagram of a cage structure of an IVC cage feed-adding device;
FIG. 2 is a first cross-sectional illustration of an adjustment structure of an IVC cage feed additive device;
FIG. 3 is an enlarged pictorial illustration of FIG. 2;
FIG. 4 is a second cross-sectional view of an adjustment structure of an IVC cage feed additive device;
FIG. 5 is an enlarged pictorial illustration of FIG. 4;
FIG. 6 is a schematic diagram of the movable core structure of an IVC cage feed additive device;
FIG. 7 is a schematic view of the gas piping of an IVC cage feed additive device;
FIG. 8 is a schematic view of the structure of an air inlet pipe and an air outlet pipe of the IVC cage feed adding device;
FIG. 9 is a schematic diagram of a cage structure of an IVC cage feed additive device;
FIG. 10 is a schematic cross-sectional view of a cage of an IVC cage feed additive device;
FIG. 11 is a schematic view of the structure of an illumination lamp of an IVC cage feed adding device;
FIG. 12 is a first cross-sectional view of a seal arrangement of an IVC cage feed additive device;
FIG. 13 is an enlarged pictorial illustration of FIG. 12;
FIG. 14 is a second cross-sectional view of a seal arrangement of an IVC cage feed additive device;
FIG. 15 is an enlarged pictorial illustration of FIG. 14;
fig. 16 is a schematic view of a structure of a clamping part of the IVC cage feed adding device;
fig. 17 is a schematic view of a sliding trough of an IVC cage feed additive device.
Reference numerals: 10. a cage; 11. a behavioural bin; 12. a biological bin; 13. a storage bin is arranged; 14. an air inlet main pipe; 141. an air inlet branch pipe; 15. an air outlet main pipe; 151. an air outlet branch pipe; 16. sealing the door; 17. a lighting lamp; 18. a vent; 19. a buckle; 20. a cage; 21. an illumination zone; 211. an illumination cover; 212. an illumination aperture; 22. an air inlet pipe; 23. an air outlet pipe; 30. a gas generating device; 40. a gas conduit; 41. entering the cavity; 42. a movable cavity; 43. a reset chamber; 50. an adjustment structure; 51. a movable core; 52. an air intake passage; 53. a first reset section; 531. a stop block; 532. a first elastic member; 61. an air supply pipe; 62. an exhaust pipe; 71. an arc-shaped outer wall portion; 711. a slip groove; 72. an end face blocking portion; 721. an outer spacer; 80. a sealing structure; 81. a second reset section; 811. a reset block; 812. a second elastic member; 82. an engagement portion; 821. a slip bar; 822. a limiting block; 823. an inner spacer; 824. and (5) abutting the block.
Detailed Description
The invention will now be described in further detail with reference to the drawings and examples. Wherein like parts are designated by like reference numerals. It should be noted that the words "front", "back", "left", "right", "upper" and "lower" used in the following description refer to directions in the drawings, and the words "bottom" and "top", "inner" and "outer" refer to directions toward or away from, respectively, the geometric center of a particular component.
As shown in fig. 1 to 4, an IVC cage for biological experiments includes a cage 10 and a cage 20; the cage frame 10 is provided with a plurality of behavioral bins 11, biological bins 12 and a placement bin 13 for placing the cage box 20, an air inlet main pipe 14, an air outlet main pipe 15, a plurality of air inlet branch pipes 141 communicated with the air inlet main pipe 14 and a plurality of air outlet branch pipes 151 communicated with the air outlet main pipe 15 are arranged in the cage frame 10, each behavioral bin 11 corresponds to one air inlet branch pipe 141 and one air outlet branch pipe 151, each biological bin 12 corresponds to one air inlet branch pipe 141 and one air outlet branch pipe 151, and each placement bin 13 corresponds to one air inlet branch pipe 141 and one air outlet branch pipe 151; the biological bin also comprises a gas generating device 30, wherein the gas generating device 30 is communicated with an air inlet branch pipe 141 corresponding to the biological bin through a gas pipeline 40, and an adjusting structure 50 is arranged in the gas pipeline 40; when the gas generating device 30 generates gas, the adjusting structure 50 controls the gas pipeline 40 to be communicated with the corresponding air inlet branch pipe 141, and controls the air inlet main pipe 14 to be separated from the corresponding air inlet branch pipe 141; when the gas generating device 30 stops generating gas, the adjusting structure 50 controls the gas pipe 40 to be blocked from the corresponding air inlet branch pipe 141, and controls the air inlet main pipe 14 to be communicated with the corresponding air inlet branch pipe 141. The cage frame 10 is provided with a behavioural bin 11, a biological bin 12 and a placement bin 13, the placement bin 13 is used for placing a cage box 20, the behavioural bin 11 and the biological bin 12 are used for carrying out relevant experiments, an air inlet main pipe 14 and an air outlet main pipe 15 are respectively connected with an air supply device and a negative pressure device and are used for conveying sterilized air to each bin, the gas generating device 30 is communicated with an air inlet branch pipe 141 corresponding to the biological bin 12 through a gas pipeline 40 and is used for carrying out relevant gas experiments and conveying air with different gas components to the laboratory mice, when the gas generating device 30 is used for providing gas for the biological bin 12, the air inlet branch pipe 141 of the biological bin 12 is automatically cut off, so that the biological bin 12 can be used for carrying out feeding of the laboratory mice and also can be used for carrying out biological experiments, the behavioural bin 11 has a plurality of different space sizes, the behavioural bin 11 can be used for carrying out relevant behavioural experiments, the corresponding air inlet branch pipe 141 and air outlet branch pipe 151 can still be used for providing sterilized air for the laboratory mice when the behavioural experiment 11 is used for carrying out the behavioural experiments, the space of the laboratory mice can be provided, the environment of the laboratory mice can be reduced, the laboratory environment of the laboratory is not can be changed, and the laboratory environment of the laboratory mice can be changed, and the laboratory environment of the laboratory environment can be not be changed, and the laboratory environment can be the laboratory space can be reduced.
As shown in fig. 5 to 7, the adjusting structure 50 includes a movable core 51, the movable core 51 is provided with an air inlet channel 52, and a first reset portion 53 is provided on the movable core 51; the gas pipeline 40 comprises an inlet cavity 41, a movable cavity 42 and a reset cavity 43, one end of the inlet cavity 41 is communicated with the gas generating device 30, the other end of the inlet cavity is communicated with the movable cavity 42, the movable cavity 42 is communicated with a corresponding air inlet branch pipe 141, and the reset cavity 43 is communicated with the inlet cavity 41; the movable core 51 is slidably arranged in the entering cavity 41, and the first reset portion 53 is arranged in the reset cavity 43; when the gas generating means 30 generates gas, the movable core 51 slides from the inlet chamber 41 to the movable chamber 42, and the first reset portion 53 is compressed; when the movable core 51 slides from the inlet cavity 41 to the movable cavity 42, the inlet cavity 41 is communicated with the air inlet branch pipe 141 through the air inlet channel 52, and the movable core 51 controls the air inlet main pipe 14 to be separated from the corresponding air inlet branch pipe 141; when the gas generating device 30 stops generating gas, the first reset portion 53 resets and drives the movable core 51 to slide from the movable cavity 42 to the inlet cavity 41; when the movable core 51 slides from the movable chamber 42 to the inlet chamber 41, the air inlet passage 52 is blocked from the air inlet branch pipe 141, and the air inlet main pipe 14 and the corresponding air inlet branch pipe 141 are communicated. The gas generating device 30 is used for delivering nitrogen, oxygen and carbon dioxide gases in different proportions, and is used for researching biological experiments of influences of different air components on vital signs of experimental mice. After the gas generating device 30 generates gas, the gas can push the movable core 51 entering the cavity 41, so that the movable core 51 moves along the direction of the movable cavity 42, when the movable core 51 enters the movable cavity 42 and is propped against the movable cavity 42, the air inlet branch pipe corresponding to the biological bin 12 is blocked by the movable core 51, and the air inlet channel 52 can communicate the air inlet cavity 41 with the air inlet branch pipe corresponding to the biological bin 12, so that air with different gas components is provided for the biological bin 12.
As shown in fig. 6, the first restoring portion 53 includes a stopper 531 and a first elastic member 532, the stopper 531 is connected with the movable core 51, the first elastic member 532 is connected with the stopper 531, the stopper 531 and the first elastic member 532 are both disposed in the restoring cavity 43, the stopper 531 is used for sliding along the restoring cavity 43, and the first elastic member 532 is used for controlling the movable core 51 to restore. The sliding direction of the first restoring portion 53 is consistent with the sliding direction of the movable core 51, and both slide along the extending directions of the inlet chamber 41 and the movable chamber 42, and after the first restoring portion 53 moves in the direction of the movable chamber 42 in the restoring chamber 43, the first elastic member 532 is compressed, and since the gas generating device 30 always generates gas, the first elastic member 532 is always in a compressed state.
As shown in fig. 7, the inner diameters of the inlet chamber 41, the movable chamber 42 and the corresponding air inlet branch pipe 141 are the same, the central axes of the inlet chamber 41 and the movable chamber 42 are coincident, the central axis of the movable chamber 42 is perpendicular to the central axis of the corresponding air inlet branch pipe 141, the first end of the air inlet channel 52 is arranged at one end of the movable core 51 close to the gas generating device 30, and the second end is arranged on the arc-shaped outer wall of the movable core 51. When the gas generating device 30 generates gas, the movable core 51 slides from the inlet cavity 41 to the movable cavity 42, the inlet cavity 41 is communicated with the first end of the air inlet channel 52, the second end of the air inlet channel 52 is communicated with the corresponding air inlet branch pipe 141, and the movable core 51 controls the air inlet main pipe 14 to be separated from the corresponding air inlet branch pipe 141; when the gas generating device 30 stops generating gas, the first reset portion 53 resets and drives the movable core 51 to slide from the movable cavity 42 to the inlet cavity 41; when the movable core 51 slides from the movable cavity 42 to the inlet cavity 41, the inlet cavity 41 is communicated with the first end of the air inlet channel 52, the second end of the air inlet channel 52 is blocked by the inlet cavity 41, and the air inlet main pipe 14 is communicated with the corresponding air inlet branch pipe 141 because the movable core 51 is not arranged in the movable cavity 42.
As shown in fig. 1, the behavioural bin 11 is provided with a sealing door 16, and the sealing door 16 is hinged with the bin opening of the behavioural bin 11. The sealing door 16 is made of transparent material, such as glass or transparent plastic. The edges of the door frame of the sealing door 16 are all provided with sealing layers, such as rubber layers, silica gel layers and other soft materials, which are used for blocking the outside from the behavioural bin 11 after the sealing door 16 is closed. The behavioural bin 11 is used for performing behavioural experiments, such as open field experiments, overhead cross experiments, stick rotating experiments, tail suspension experiments, scene fear experiments, maze experiments and the like, corresponding scene arrangement can be performed on the behavioural bin 11 according to different experiments, the space of the behavioural bin 11 is larger than the placing bin for meeting larger experimental environments, the behavioural bin 11 is provided with a plurality of air inlet main pipes 14, air outlet main pipes 15, air inlet branch pipes 141 and air outlet branch pipes 151 for air exchange, so that other oxygen supply equipment is not needed to be provided in experimental environments, and the interference of other environmental factors on the behavioural experiments can be reduced by using the same air supply equipment and negative pressure equipment to provide sterilizing air for laboratory mice in the behavioural bin 11.
As shown in fig. 8-11, the behavioural bin 11, the biological bin 12 and the placement bin 13 are respectively provided with an illumination lamp 17, the cage box 20 is provided with an illumination area 21, and the illumination lamps 17 are used for illuminating the inside of the cage box 20 through the illumination area 21. The illuminating lamp 17 provides an independent light source for each cage box 20 placed on the cage frame 10, because the cage frame 10 is located in a room, the illumination time of the laboratory mice is influenced by the activities of laboratory staff, and in order to enable the laboratory mice to obtain a regular illumination environment, the illuminating lamp 17 is arranged in each bin of the cage frame 10 to provide illumination time conforming to the biological habit of the laboratory mice for each laboratory mice, so that a better living environment is provided for the laboratory mice. In addition, the illumination lamps 17 in each bin can be independently controlled, so that related illumination experiments can be carried out in part of the bins, and the influence of illumination on the behavior of the laboratory mice can be studied by controlling the illumination time of the illumination lamps 17.
As shown in fig. 9 and 10, the illumination area 21 includes an illumination cap 211 and an illumination hole 212 formed in the cage 20, and the illumination cap 211 is located inside the cage 20 and connected at the illumination hole 212. The illumination cap 211 and the illumination hole 212 together form an illumination groove into which the illumination lamp 17 is placed, and the illumination lamp 17 is used for illuminating the interior of the cage 20 through the transparent illumination cap 211.
As shown in fig. 12 and 13, the cage 20 includes an air inlet pipe 22 and an air outlet pipe 23, and an air supply pipe 61 for connecting with the air inlet pipe 22 and an air exhaust pipe 62 for connecting with the air outlet pipe 23 are arranged in each of the behavioural bin 11, the biological bin 12 and the placement bin 13, the air inlet branch pipe 141 is communicated with the air supply pipe 61, and the air outlet branch pipe 151 is communicated with the air exhaust pipe 62 for exchanging air with the cage 20; sealing structures 80 are arranged on the air supply pipe 61 and the exhaust pipe 62, and when the sealing structures 80 are clamped with the air supply pipe 61 and the exhaust pipe 62, the sealing structures 80 and the air supply pipe 61 separate the air inlet branch pipe 141 from the outside, and the sealing structures 80 and the exhaust pipe 62 separate the air outlet branch pipe 151 from the outside; when the cage 20 is placed in the placement bin 13, the sealing structure 80 is separated from the air supply duct 61 and the air discharge duct 62, the air supply branch duct 141 is communicated with the air intake duct 22 through the air supply duct 61, and the air discharge branch duct 151 is communicated with the air outlet duct 23 through the air discharge duct 62. After the cage box 20 is placed in the placement bin 13 of the cage frame 10, air supply equipment and negative pressure equipment exchange air with the interior of the cage box 20 through the air inlet main pipe 14, the air outlet main pipe 15, the air inlet branch pipe 141 and the air outlet branch pipe 151, and the interior of the placement bin 13 where the cage box 20 is not placed is not interfered by the cage box 20 because of the sealing structure 80, so the sealing structure 80 can be clamped with the air supply pipe 61 and the air exhaust pipe 62, the air supply pipe 61 and the air exhaust pipe 62 in the placement bin 13 where the cage box 20 is not placed are sealed, and external air is effectively prevented from entering the air inlet branch pipe 141 and the air outlet branch pipe 151 to pollute the air of other cage boxes 20 through the air supply pipe 61 and the air exhaust pipe 62.
The air inlet branch pipe 141 and the air outlet branch pipe 151 are formed with ventilation openings 18; the air supply pipe 61 and the exhaust pipe 62 both comprise an arc-shaped outer wall portion 71 and an end surface blocking portion 72, wherein a first end of the arc-shaped outer wall portion 71 is connected with the ventilation opening 18 for sleeving the air inlet pipe 22 and the air outlet pipe 23, and the end surface blocking portion 72 is arranged at a second end of the arc-shaped outer wall portion 71; the sealing structure 80 comprises a second reset portion 81 and a clamping portion 82, the clamping portion 82 is slidably connected with the arc-shaped outer wall portion 71, and the second reset portion 81 is connected with the clamping portion 82 and used for controlling the clamping portion 82 to move along the direction of the second end of the arc-shaped outer wall portion 71; when the cage 20 slides into the placement bin 13 and the air inlet pipe 22 and the air outlet pipe 23 slide along the direction of the first end of the arc-shaped outer wall portion 71, the clamping portion 82 slides along the direction of the first end of the arc-shaped outer wall portion 71 and is separated from the arc-shaped outer wall portion 71, the air inlet branch pipe 141 is communicated with the air inlet pipe 22 through the air supply pipe 61, and the air outlet branch pipe 151 is communicated with the air outlet pipe 23 through the air outlet pipe 62; when the cage 20 slides out of the placement bin 13, and the air inlet pipe 22 and the air outlet pipe 23 slide along the direction of the second end of the arc-shaped outer wall portion 71, the second reset portion 81 controls the clamping portion 82 to move along the direction of the second end of the arc-shaped outer wall portion 71 until the clamping portion 82 is clamped with the arc-shaped outer wall portion 71, and when the clamping portion 82 is clamped with the arc-shaped outer wall portion 71, the clamping portion 82, the arc-shaped outer wall portion 71 and the end face blocking portion 72 block the air inlet branch pipe 141 from the outside, and the clamping portion 82, the arc-shaped outer wall portion 71 and the end face blocking portion 72 block the air outlet branch pipe 151 from the outside.
As shown in fig. 14 and 15, the second restoring portion 81 includes a restoring block 811 and a second elastic member 812, the restoring block 811 is provided in the air inlet branch pipe 141 and the air outlet branch pipe 151, one end of the second elastic member 812 is connected to the restoring block 811, and the other end is connected to the engaging portion 82 for controlling the movement of the engaging portion 82 in the direction of the second end of the arc-shaped outer wall portion 71. Specifically, the second resetting block 811 is provided with a groove for installing the elastic member, and the engaging portion 82 is provided with a protrusion for fixing the elastic member.
As shown in fig. 16 and 17, the arc-shaped outer wall portion 71 is provided with a sliding groove 711, and the engaging portion 82 is provided with a sliding bar 821 that cooperates with the sliding groove 711. Specifically, the arc-shaped outer wall portion 71 is in a half cylinder shape, the sliding grooves 711 are provided with two sliding strips 821 which are respectively arranged on two side surfaces of the arc-shaped outer wall portion 71, which are in contact with the clamping portions 82, the clamping portions 82 are provided with two sliding strips 821 at corresponding positions, the sliding strips 821 are used for limiting the clamping portions 82 to move along the sliding grooves 711, and meanwhile, when the arc-shaped outer wall portion 71 and the clamping portions 82 are clamped, the sliding strips 821 and the sliding grooves 711 can play a sealing role on the left side and the right side of the arc-shaped outer wall portion 71, so that external air is prevented from entering the air inlet branch pipe 141 and the air outlet branch pipe 151 through the left side and the right side of the arc-shaped outer wall portion 71.
The inner diameters of the air inlet branch pipe 141 and the air outlet branch pipe 151 are larger than the inner diameter of the ventilation opening 18; the end face blocking portion 72 is provided with an outer spacer 721; the clamping part 82 is provided with a limiting block 822, an inner spacer 823 and a collision block 824, the limiting block 822 is arranged at one end of the clamping part 82 and positioned in the air inlet branch pipe 141 and the air outlet branch pipe 151, the inner spacer 823 and the collision block 824 are arranged at the other end of the clamping part 82, when the clamping part 82 is clamped with the arc-shaped outer wall part 71, the limiting block 822 collides with the ventilation opening 18, and the inner spacer 823 and the outer spacer 721 collide; the abutting block 824 is used for abutting and pushing the engaging portion 82 when the air inlet pipe 22 and the air outlet pipe 23 slide along the direction of the first end of the arc-shaped outer wall portion 71. The limiting block 822 is used for limiting the clamping portion 82 to move along the second end of the arc-shaped outer wall portion 71; the inner spacer 823 and the outer spacer 721 interfere for sealing. The outer diameters of the arc-shaped outer wall portion 71 and the clamping portion 82 are equal to the inner diameter of the ventilation opening 18, the inner diameters of the air inlet branch pipe 141 and the air outlet branch pipe 151 are larger than the inner diameter of the ventilation opening 18, a fixed edge is formed in the ventilation opening 18, the outer diameter of the limiting block 822 is equal to the inner diameters of the air inlet branch pipe 141 and the air outlet branch pipe 151, the limiting block 822 can clamp the fixed edge, the inner partition 823 and the outer partition 721 can block the moving distance of the clamping portion 82, meanwhile, the inner partition 823 and the outer partition 721 form a stepped gap, and external air can be prevented from entering the air inlet branch pipe 141 and the air outlet branch pipe 151 through the front end of the arc-shaped outer wall portion 71.
As shown in fig. 1 and 8, the cage 10 is provided with a buckle 19 on both sides of each of the placement bins 13, and the buckle 19 is rotatably connected with the cage 10. Specifically, the rotation junction of buckle 19 and cage 10 is provided with the rubber circle for increase buckle 19 pivoted damping, let buckle 19 can fix at arbitrary angle, after placing cage box 20 in place storehouse 13, can fix cage box 20 in place storehouse 13 through the buckle 19 of rotating the storehouse 13 both sides, prevent that cage box 20 from falling out and place storehouse 13, avoid the elastic component to release cage box 20 and place storehouse 13 simultaneously, when taking out cage box 20, rotatory buckle 19, cage box 20 receives the thrust roll-off of elastic component and places storehouse 13 a certain distance, thereby be convenient for take out cage box 20.
The above is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above examples, and all technical solutions belonging to the concept of the present invention belong to the protection scope of the present invention. It should be noted that modifications and adaptations to the present invention may occur to one skilled in the art without departing from the principles of the present invention and are intended to be within the scope of the present invention.
Claims (9)
1. An IVC cage for biological experiments is characterized by comprising a cage frame (10) and a cage box (20); the cage frame (10) is provided with a plurality of behavioral bins (11), biological bins (12) and placement bins (13) for placing cage boxes (20), an air inlet main pipe (14), an air outlet main pipe (15), a plurality of air inlet branch pipes (141) communicated with the air inlet main pipe (14) and a plurality of air outlet branch pipes (151) communicated with the air outlet main pipe (15) are arranged in the cage frame (10), each behavioral bin (11) corresponds to one air inlet branch pipe (141) and one air outlet branch pipe (151), each biological bin (12) corresponds to one air inlet branch pipe (141) and one air outlet branch pipe (151), and each placement bin (13) corresponds to one air inlet branch pipe (141) and one air outlet branch pipe (151);
the biological treatment device also comprises a gas generation device (30), wherein the gas generation device (30) is communicated with an air inlet branch pipe (141) corresponding to the biological bin through a gas pipeline (40), and an adjusting structure (50) is arranged in the gas pipeline (40);
when the gas generating device (30) generates gas, the regulating structure (50) controls the gas pipeline (40) to be communicated with the corresponding air inlet branch pipe (141) and controls the air inlet main pipe (14) to be separated from the corresponding air inlet branch pipe (141);
when the gas generating device (30) stops generating gas, the regulating structure (50) controls the gas pipeline (40) to be separated from the corresponding air inlet branch pipe (141) and controls the air inlet main pipe (14) to be communicated with the corresponding air inlet branch pipe (141);
the adjusting structure (50) comprises a movable core (51), wherein an air inlet channel (52) is formed in the movable core (51), and a first reset part (53) is arranged on the movable core (51);
the gas pipeline (40) comprises an inlet cavity (41), a movable cavity (42) and a reset cavity (43), one end of the inlet cavity (41) is communicated with the gas generating device (30), the other end of the inlet cavity is communicated with the movable cavity (42), the movable cavity (42) is communicated with a corresponding air inlet branch pipe (141), and the reset cavity (43) is communicated with the inlet cavity (41);
the movable core (51) is slidably arranged in the entering cavity (41), and the first reset part (53) is arranged in the reset cavity (43);
when the gas generating device (30) generates gas, the movable core (51) slides from the inlet cavity (41) to the movable cavity (42), and the first reset portion (53) is compressed; when the movable core (51) slides from the inlet cavity (41) to the movable cavity (42), the inlet cavity (41) is communicated with the air inlet branch pipe (141) through the air inlet channel (52), and the movable core (51) controls the air inlet main pipe (14) to be separated from the corresponding air inlet branch pipe (141);
when the gas generation device (30) stops generating gas, the first reset part (53) resets and drives the movable core (51) to slide from the movable cavity (42) to the inlet cavity (41); when the movable core (51) slides from the movable cavity (42) to the inlet cavity (41), the air inlet channel (52) is separated from the air inlet branch pipe (141), and the air inlet main pipe (14) is communicated with the corresponding air inlet branch pipe (141).
2. The IVC cage for biological experiments according to claim 1, wherein the first reset portion (53) comprises a stop (531) and a first elastic member (532), the stop (531) is connected with the movable core (51), the first elastic member (532) is connected with the stop (531), the stop (531) and the first elastic member (532) are both arranged in the reset cavity (43), the stop (531) is used for sliding along the reset cavity (43), and the first elastic member (532) is used for controlling the movable core (51) to reset.
3. The IVC cage for biological experiments according to claim 1, wherein the inner diameters of the inlet cavity (41), the movable cavity (42) and the corresponding air inlet branch pipe (141) are the same, the central axes of the inlet cavity (41) and the movable cavity (42) are coincident, the central axis of the movable cavity (42) is perpendicular to the central axis of the corresponding air inlet branch pipe (141), the first end of the air inlet channel (52) is arranged at one end of the movable core (51) close to the gas generating device (30), and the second end is arranged on the arc-shaped outer wall of the movable core (51).
4. IVC-cage for biological experiments according to claim 1, characterized in that the behavioural bin (11) is provided with a sealing door (16), the sealing door (16) being hinged with the mouth of the behavioural bin (11).
5. IVC cage for biological experiments according to claim 1, characterized in that the behavioural bin (11), the biological bin (12) and the placement bin (13) are provided with illumination lamps (17), the cage (20) is provided with illumination areas (21), and the illumination lamps (17) are used for illuminating the inside of the cage (20) through the illumination areas (21).
6. The IVC cage for biological experiments according to claim 5, wherein the illumination zone (21) comprises an illumination cap (211) and an illumination hole (212) opened on the cage (20), the illumination cap (211) being located inside the cage (20) and being connected at the illumination hole (212).
7. IVC-cage for biological experiments according to claim 1, characterized in that the cage box (20) comprises an air inlet pipe (22) and an air outlet pipe (23), an air supply pipe (61) for connecting with the air inlet pipe (22) and an air outlet pipe (62) for connecting with the air outlet pipe (23) are arranged in each of the behavioural bin (11), the biological bin (12) and the placement bin (13), the air inlet branch pipe (141) is communicated with the air supply pipe (61), and the air outlet branch pipe (151) is communicated with the air outlet pipe (62) for exchanging air with the cage box (20);
sealing structures (80) are arranged on the air supply pipe (61) and the exhaust pipe (62), and when the sealing structures (80) are clamped with the air supply pipe (61) and the exhaust pipe (62), the sealing structures (80) and the air supply pipe (61) separate the air inlet branch pipe (141) from the outside, and the sealing structures (80) and the exhaust pipe (62) separate the air outlet branch pipe (151) from the outside;
when the cage box (20) is placed in the placement bin (13), the sealing structure (80) is separated from the air supply pipe (61) and the exhaust pipe (62), the air inlet branch pipe (141) is communicated with the air inlet pipe (22) through the air supply pipe (61), and the air outlet branch pipe (151) is communicated with the air outlet pipe (23) through the exhaust pipe (62).
8. The IVC cage for biological experiments according to claim 7, wherein,
the air inlet branch pipe (141) and the air outlet branch pipe (151) are provided with ventilation openings (18);
the air supply pipe (61) and the exhaust pipe (62) comprise an arc-shaped outer wall part (71) and an end surface blocking part (72), a first end of the arc-shaped outer wall part (71) is connected with the ventilation opening (18) and is used for sleeving the air inlet pipe (22) and the air outlet pipe (23), and the end surface blocking part (72) is arranged at a second end of the arc-shaped outer wall part (71);
the sealing structure (80) comprises a second reset part (81) and a clamping part (82), the clamping part (82) is in sliding connection with the arc-shaped outer wall part (71), and the second reset part (81) is connected with the clamping part (82) and is used for controlling the clamping part (82) to move along the direction of the second end of the arc-shaped outer wall part (71);
when the cage (20) slides into the placement bin (13) and the air inlet pipe (22) and the air outlet pipe (23) slide along the direction of the first end of the arc-shaped outer wall part (71), the clamping part (82) slides along the direction of the first end of the arc-shaped outer wall part (71) to be separated from the arc-shaped outer wall part (71), the air inlet branch pipe (141) is communicated with the air inlet pipe (22) through the air supply pipe (61), and the air outlet branch pipe (151) is communicated with the air outlet pipe (23) through the air outlet pipe (62);
when the cage (20) is slidably moved out of the placement bin (13), and the air inlet pipe (22) and the air outlet pipe (23) slide along the direction of the second end of the arc-shaped outer wall portion (71), the second reset portion (81) controls the clamping portion (82) to move along the direction of the second end of the arc-shaped outer wall portion (71) until the clamping portion (82) is clamped with the arc-shaped outer wall portion (71).
9. The IVC cage for biological experiments according to claim 8, wherein the second resetting portion (81) comprises a resetting block (811) and a second elastic member (812), the resetting block (811) is arranged in the air inlet branch pipe (141) and the air outlet branch pipe (151), one end of the second elastic member (812) is connected with the resetting block (811), and the other end is connected with the clamping portion (82) for controlling the clamping portion (82) to move along the direction of the second end of the arc-shaped outer wall portion (71).
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| CN117337775B (en) * | 2023-10-25 | 2024-05-17 | 苏州市苏杭科技器材有限公司 | Independent ventilation equipment for animal feeding |
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