CN115136899A - IVC cage for biological experiment - Google Patents
IVC cage for biological experiment Download PDFInfo
- Publication number
- CN115136899A CN115136899A CN202210572168.4A CN202210572168A CN115136899A CN 115136899 A CN115136899 A CN 115136899A CN 202210572168 A CN202210572168 A CN 202210572168A CN 115136899 A CN115136899 A CN 115136899A
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- China
- Prior art keywords
- air inlet
- pipe
- air
- cage
- branch pipe
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- 238000002474 experimental method Methods 0.000 title claims abstract description 41
- 230000003542 behavioural effect Effects 0.000 claims abstract description 14
- 238000007789 sealing Methods 0.000 claims description 25
- 238000005286 illumination Methods 0.000 claims description 23
- 238000009423 ventilation Methods 0.000 claims description 9
- 230000000903 blocking effect Effects 0.000 claims description 8
- 238000004166 bioassay Methods 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 abstract 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract 1
- 239000007789 gas Substances 0.000 description 50
- 241000699666 Mus <mouse, genus> Species 0.000 description 17
- 241000700159 Rattus Species 0.000 description 10
- 125000006850 spacer group Chemical group 0.000 description 9
- 238000005192 partition Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 239000006052 feed supplement Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 238000013016 damping Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
- 239000002912 waste gas Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
- A01K1/03—Housing for domestic or laboratory animals
- A01K1/031—Cages for laboratory animals; Cages for measuring metabolism of animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/0047—Air-conditioning, e.g. ventilation, of animal housings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
- A01K1/035—Devices for use in keeping domestic animals, e.g. fittings in housings or dog beds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- General Health & Medical Sciences (AREA)
- Ventilation (AREA)
Abstract
The invention claims an IVC cage for biological experiments, which comprises a cage frame and a cage box; the cage frame is provided with a plurality of ethology bins, biology bins and a placement bin for placing cage boxes, the cage frame is internally provided with an air inlet main pipe, an air outlet main pipe, a plurality of air inlet branch pipes communicated with the air inlet main pipe and a plurality of air outlet branch pipes communicated with the air outlet main pipe, and each ethology bin, the biology bins and the placement bin corresponds to one air inlet branch pipe and one air outlet branch pipe. Still including gaseous generating device, gaseous generating device passes through the air inlet branch pipe intercommunication that gas pipeline and biological storehouse correspond, is provided with the regulation structure in the gas pipeline. Settle the storehouse and be used for placing the cage box, behavioural science storehouse and biology storehouse are used for carrying out relevant experiment, and the air inlet is responsible for and be used for carrying the air of sterilization for each storehouse with the air-out, and gas generator passes through the air inlet branch pipe intercommunication that gas pipeline and biology storehouse correspond for carry out relevant gas experiment, carry the air of different gaseous components for the laboratory mouse.
Description
Technical Field
The invention relates to the field of test cage boxes, in particular to an IVC cage for biological experiments.
Background
The IVC (independent ventilated cages) cage box is miniature SPF-level experimental animal raising and experimental equipment which is used for experiments, wherein the miniature SPF-level experimental animal raising and experimental equipment is sealed and independent in the cage box, independently circulates clean air flow with high ventilation frequency (20-60 times/hour), intensively discharges waste gas and can be operated in an ultra-clean workbench or a biological safety cabinet. At present, a Chinese patent with the publication number of CN109089891A discloses an IVC cage, which comprises a cage frame, a plurality of cage boxes and a ventilation assembly arranged on the cage frame, wherein the cage boxes are connected with the ventilation assembly, the cage frame is provided with a plurality of cage box accommodating bins, and the ventilation assembly comprises an air inlet main pipe, an air outlet main pipe, a plurality of air inlet branch pipes connected with the air inlet main pipe and a plurality of air outlet branch pipes connected with the air outlet main pipe, which are arranged on the cage frame; each cage box placing bin is at least provided with two air inlet branch pipes and two air outlet branch pipes. Current IVC cage utensil mainly used raises the laboratory mouse, because the cage of raising the laboratory mouse is very big, has occupied a large amount of spaces, so when needs are tested the laboratory mouse, just will take out the laboratory mouse to another laboratory and carry out the experiment, such IVC cage utensil has occupied a large amount of spaces and function singleness.
Therefore, it is the question of the present application how to make IVC cages have experimental functions.
Disclosure of Invention
Aiming at the defects in the prior art, the IVC cage is provided, and the IVC cage is provided with a placing cabin for feeding experimental rats, and a behavioristics cabin and a biology cabin for experiments.
In order to realize the purpose, the following technical scheme is provided:
an IVC cage for biological experiments, which comprises a cage frame and a cage box; the cage has been seted up a plurality of behavioural science storehouses, biology storehouse and the storehouse of settling that is used for placing the cage box, it is responsible for to have seted up the air inlet in the cage, the air-out is responsible for, be responsible for many air inlet branch pipes of intercommunication and be responsible for many air outlet branch pipes of intercommunication with the air inlet, every behavioural science storehouse all corresponds an air inlet branch pipe and an air outlet branch pipe, every biology storehouse all corresponds an air inlet branch pipe and an air outlet branch pipe, every settles the storehouse and all corresponds an air inlet branch pipe and an air outlet branch pipe.
Still including gaseous generating device, gaseous generating device passes through the air inlet branch pipe intercommunication that gas pipeline and biological storehouse correspond, is provided with the regulation structure in the gas pipeline.
When the gas generating device generates gas, the adjusting structure controls the gas pipeline to be communicated with the corresponding air inlet branch pipe and controls the air inlet main pipe to be separated from the corresponding air inlet branch pipe.
When the gas generating device stops generating gas, the adjusting structure controls the gas pipeline to be separated from the corresponding air inlet branch pipe and controls the air inlet main pipe to be communicated with the corresponding air inlet branch pipe.
To sum up, the above technical scheme has the following beneficial effects: the behavioural cabin is arranged on the cage frame, the biological cabin and the settling cabin are arranged, the settling cabin is used for placing cage boxes, the behavioural cabin and the biological cabin are used for carrying out related experiments, an air inlet main pipe and an air outlet main pipe are respectively connected with air supply equipment and negative pressure equipment, air for conveying sterilized air to each cabin, an air generating device is communicated with an air inlet branch pipe corresponding to the biological cabin through a gas pipeline, the air is used for carrying out related gas experiments, air with different gas components is conveyed to a laboratory mouse, when the gas generating device is used for providing gas to the biological cabin, the air inlet branch pipe of the biological cabin is automatically cut off, the biological cabin can be used for feeding the laboratory mouse and carrying out biological experiments, the behavioural cabin is provided with a plurality of behavioural cabins, each behavioural cabin can have different space sizes, the behavioural cabin is used for carrying out related behavioural experiments, sterilized air can be still provided by using the air inlet branch pipe and the air outlet branch pipe corresponding to the behavioural cabin when the behavioural experiments are carried out the experimental experiments, the experimental mouse, the IVC cage can provide a feeding space for the laboratory mouse, the experimental mouse, and can greatly save the experimental environment and can not influence other experimental environment on the experimental mouse.
Drawings
FIG. 1 is a schematic diagram of a cage structure of an IVC cage-box feed adding device;
FIG. 2 is a schematic view of a first section of an adjustment structure of the IVC cage feed addition device;
FIG. 3 is an enlarged schematic view of FIG. 2;
FIG. 4 is a schematic view of a second section of an adjustment structure of the IVC cage feed addition device;
FIG. 5 is an enlarged schematic view of FIG. 4;
FIG. 6 is a schematic structural view of a movable core of the IVC cage-box feed adding device;
FIG. 7 is a schematic view of the gas piping of an IVC cage feed supplement apparatus;
FIG. 8 is a schematic structural diagram of an air inlet pipe and an air outlet pipe of the IVC cage-box feed adding device;
FIG. 9 is a schematic diagram of a cage structure of an IVC cage feed adding device;
FIG. 10 is a schematic illustration in cross-section of a cage of an IVC cage feed supplementation device;
FIG. 11 is a schematic view of an illuminating lamp of the IVC cage-box feed-adding device;
FIG. 12 is a first schematic sectional view of the sealing structure of an IVC cage feed supplement;
FIG. 13 is an enlarged schematic view of FIG. 12;
FIG. 14 is a second schematic sectional view of the sealing structure of the IVC cage feed supplement device;
FIG. 15 is an enlarged schematic view of FIG. 14;
FIG. 16 is a schematic view of a structure of a clamping part of an IVC cage feed adding device;
fig. 17 is a schematic view of a slide groove of an IVC cage feed adding device.
Reference numerals are as follows: 10. a cage frame; 11. a behavioristic cabin; 12. a biological bin; 13. arranging a bin; 14. an air inlet main pipe; 141. an air inlet branch pipe; 15. an air outlet main pipe; 151. an air outlet branch pipe; 16. a sealing door; 17. an illuminating lamp; 18. a vent; 19. buckling; 20. a cage box; 21. an illumination zone; 211. an illumination cover; 212. an illumination aperture; 22. an air inlet pipe; 23. an air outlet pipe; 30. a gas generating device; 40. a gas conduit; 41. entering the cavity; 42. a movable cavity; 43. a reset chamber; 50. an adjustment structure; 51. a movable core; 52. an air intake passage; 53. a first reset portion; 531. a stopper; 532. a first elastic member; 61. an air supply pipe; 62. an exhaust duct; 71. an arc-shaped outer wall portion; 711. a sliding groove; 72. an end face blocking part; 721. an outer spacer block; 80. a sealing structure; 81. a second reset portion; 811. a reset block; 812. a second elastic member; 82. a fastening part; 821. a sliding strip; 822. a limiting block; 823. an inner spacer block; 824. and a contact block.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings and examples. In which like parts are designated by like reference numerals. It should be noted that as used in the following description, the terms "front", "back", "left", "right", "upper" and "lower" refer to directions in the drawings, and the terms "bottom" and "top", "inner" and "outer" refer to directions toward and away from, respectively, the geometric center of a particular component.
As shown in fig. 1-4, an IVC cage for biological experiments comprises a cage 10 and a cage box 20; the cage 10 is provided with a plurality of ethological bins 11, biological bins 12 and a placing bin 13 for placing the cage box 20, the cage 10 is internally provided with an air inlet main pipe 14, an air outlet main pipe 15, a plurality of air inlet branch pipes 141 communicated with the air inlet main pipe 14 and a plurality of air outlet branch pipes 151 communicated with the air outlet main pipe 15, each ethological bin 11 corresponds to one air inlet branch pipe 141 and one air outlet branch pipe 151, each biological bin 12 corresponds to one air inlet branch pipe 141 and one air outlet branch pipe 151, and each placing bin 13 corresponds to one air inlet branch pipe 141 and one air outlet branch pipe 151; the device also comprises a gas generating device 30, wherein the gas generating device 30 is communicated with an air inlet branch pipe 141 corresponding to the biological bin through a gas pipeline 40, and an adjusting structure 50 is arranged in the gas pipeline 40; when the gas generating device 30 generates gas, the adjusting structure 50 controls the gas pipeline 40 to be communicated with the corresponding air inlet branch pipe 141, and controls the air inlet main pipe 14 to be separated from the corresponding air inlet branch pipe 141; when the gas generator 30 stops generating gas, the adjusting structure 50 controls the gas pipeline 40 to be isolated from the corresponding air inlet branch pipe 141, and controls the main air inlet pipe 14 to be communicated with the corresponding air inlet branch pipe 141. The experimental cage 10 is provided with a ethology bin 11, a biology bin 12 and a placement bin 13, the placement bin 13 is used for placing cage boxes 20, the ethology bin 11 and the biology bin 12 are used for carrying out related experiments, an air inlet main pipe 14 and an air outlet main pipe 15 are respectively connected with air supply equipment and negative pressure equipment and are used for conveying sterilized air for each bin, a gas generation device 30 is communicated with an air inlet branch pipe 141 corresponding to the biology bin 12 through a gas pipeline 40 and is used for carrying out related gas experiments and conveying air with different gas components for experimental rats, when the gas generation device 30 is used for providing gas for the biology bin 12, the air inlet branch pipe 141 of the biology bin 12 is automatically cut off, the biology bin 12 can be used for feeding experimental rats and carrying out biological experiments, the ethology bin 11 is provided with a plurality of experimental rats, each ethology bin 11 can have different space sizes, the ethology bin 11 is used for carrying out related ethology experiments, the experimental rat can still use the air inlet branch pipe 141 and the air outlet 151 corresponding to provide sterilized air when the experimental rats are used for performing the ethology experiments, the experimental rats, the experimental cage can also provide air for experimental rats, and the experimental rats, the experimental environment can be greatly reduced, and the experimental rats.
As shown in fig. 5-7, the adjusting structure 50 includes a movable core 51, the movable core 51 is provided with an air inlet channel 52, and the movable core 51 is provided with a first resetting portion 53; the gas pipeline 40 comprises an inlet cavity 41, a movable cavity 42 and a reset cavity 43, one end of the inlet cavity 41 is communicated with the gas generating device 30, the other end of the inlet cavity is communicated with the movable cavity 42, the movable cavity 42 is communicated with the corresponding air inlet branch pipe 141, and the reset cavity 43 is communicated with the inlet cavity 41; the movable core 51 is arranged in the inlet cavity 41 in a sliding manner, and the first resetting part 53 is arranged in the resetting cavity 43; when the gas generating device 30 generates gas, the movable core 51 slides from the inlet chamber 41 to the movable chamber 42, and the first reset portion 53 is compressed; when the movable core 51 slides from the inlet cavity 41 to the movable cavity 42, the inlet cavity 41 is communicated with the air inlet branch pipes 141 through the air inlet channel 52, and the movable core 51 controls the air inlet main pipe 14 to be separated from the corresponding air inlet branch pipes 141; when the gas generating device 30 stops generating gas, the first reset part 53 resets and drives the movable core 51 to slide from the movable cavity 42 to the inlet cavity 41; when the movable core 51 slides from the movable cavity 42 to the inlet cavity 41, the air inlet passage 52 is blocked from the air inlet branch pipes 141, and the air inlet main pipe 14 is communicated with the corresponding air inlet branch pipes 141. The gas generating device 30 is used for delivering nitrogen, oxygen and carbon dioxide gases with different proportions and is used for biological experiments for researching the influence of different air components on the vital signs of the laboratory mice. After the gas generating device 30 generates gas, it will push the movable core 51 entering the cavity 41, so that the movable core 51 moves along the direction of the movable cavity 42, when the movable core 51 enters the movable cavity 42 and is supported by the movable cavity 42, the air inlet branch pipe corresponding to the biological chamber 12 is blocked by the movable core 51, and the air inlet channel 52 will communicate the inlet cavity 41 with the air inlet branch pipe corresponding to the biological chamber 12, thereby providing air with different gas components to the biological chamber 12.
As shown in fig. 6, the first reset portion 53 includes a stopper 531 and a first elastic member 532, the stopper 531 is connected to the movable core 51, the first elastic member 532 is connected to the stopper 531, the stopper 531 and the first elastic member 532 are both disposed in the reset chamber 43, the stopper 531 is configured to slide along the reset chamber 43, and the first elastic member 532 is configured to control the reset of the movable core 51. The sliding direction of the first reset part 53 is consistent with the sliding direction of the movable core 51, and both the first reset part 53 and the movable core 51 slide along the extending direction of the inlet cavity 41 and the movable cavity 42, and the first elastic member 532 is compressed after the first reset part 53 moves in the reset cavity 43 along the direction of the movable cavity 42, and the first elastic member 532 is always in a compressed state because the gas generating device 30 always generates gas.
As shown in fig. 7, the inner diameters of the inlet chamber 41, the movable chamber 42 and the corresponding air inlet branch pipes 141 are the same, the central axes of the inlet chamber 41 and the movable chamber 42 are overlapped, the central axis of the movable chamber 42 is perpendicular to the central axis of the corresponding air inlet branch pipe 141, the first end of the air inlet channel 52 is opened at one end of the movable core 51 close to the gas generating device 30, and the second end is opened at the arc-shaped outer wall of the movable core 51. When the gas generating device 30 generates gas and the movable core 51 slides from the inlet cavity 41 to the movable cavity 42, the inlet cavity 41 is communicated with the first end of the air inlet channel 52, the second end of the air inlet channel 52 is communicated with the corresponding air inlet branch pipe 141, and the movable core 51 controls the air inlet main pipe 14 to be separated from the corresponding air inlet branch pipe 141; when the gas generating device 30 stops generating gas, the first reset part 53 resets and drives the movable core 51 to slide from the movable cavity 42 to the inlet cavity 41; when the movable core 51 slides from the movable cavity 42 to the inlet cavity 41, the inlet cavity 41 is communicated with the first end of the air inlet channel 52, the second end of the air inlet channel 52 is blocked by the inlet cavity 41, and the main air inlet pipe 14 is communicated with the corresponding branch air inlet pipe 141 because the movable core 51 is not arranged in the movable cavity 42.
As shown in fig. 1, the ethology bin 11 is provided with a sealing door 16, and the sealing door 16 is hinged with the bin opening of the ethology bin 11. The sealing door 16 is made of transparent material, such as glass or transparent plastic. The door frame edge of sealing door 16 all is provided with the sealing layer, soft material such as rubber layer, silica gel layer for sealing door 16 closes the back and carries out the separation with the behavioural science storehouse 11 with the external world. Behaviourology storehouse 11 is used for carrying out the behaviourology experiment, if spacious field experiment, overhead cross experiment, the bar experiment changes, hang the tail experiment, scene fear experiment and maze experiment etc, the experiment according to the difference can carry out corresponding scene to behaviourology storehouse 11 and arrange, behaviourology storehouse 11's space is greater than places the storehouse, be used for satisfying great experimental environment, behaviourology storehouse 11 has a plurality ofly and size can be non-uniform, behaviourology storehouse 11 still uses the air inlet to be responsible for 14, the air-out is responsible for 15, air inlet branch pipe 141 and air outlet branch pipe 151 carry out the air exchange, thereby need not provide other oxygen supply equipment at experimental environment, and use same air supply equipment and negative pressure equipment to provide the experimental mouse in behaviourology storehouse 11 and sterilize the air and can reduce the interference of other environmental factors to the behaviourology experiment.
As shown in fig. 8-11, the behavior cabin 11, the biology cabin 12 and the installation cabin 13 are all provided with illuminating lamps 17, the cage box 20 is provided with an illumination area 21, and the illuminating lamps 17 are used for illuminating the interior of the cage box 20 through the illumination area 21. The light 17 provides independent light source for every cage box 20 of placing on cage 10, because cage 10 is located the room, so the illumination time of laboratory mouse receives experimenter's activity influence, for letting the laboratory mouse obtain the illumination environment of law, it is long when setting up light 17 in every storehouse of cage 10 and providing the illumination that accords with the biological habit of laboratory mouse to the laboratory mouse in every storehouse to provide a better living environment for the laboratory mouse. In addition, the illuminating lamps 17 in each bin can be independently controlled, so that related illumination experiments can be performed in partial bins, and the influence of illumination on the behavior of the experimental mouse can be researched by controlling the illumination time of the illuminating lamps 17.
As shown in fig. 9 and 10, the illumination area 21 includes an illumination cover 211 and an illumination hole 212 opened on the cage 20, and the illumination cover 211 is located inside the cage 20 and connected at the illumination hole 212. The lighting cover 211 and the lighting hole 212 together form a lighting slot into which the lighting lamp 17 is put, and the lighting lamp 17 is used for lighting the inside of the cage 20 through the transparent lighting cover 211.
As shown in fig. 12 and 13, the cage 20 includes an air inlet pipe 22 and an air outlet pipe 23, each of the behavior cabin 11, the biology cabin 12 and the installation cabin 13 is provided with an air supply pipe 61 for connecting with the air inlet pipe 22 and an air outlet pipe 62 for connecting with the air outlet pipe 23, the air inlet branch pipe 141 is communicated with the air supply pipe 61, and the air outlet branch pipe 151 is communicated with the air outlet pipe 62 for exchanging air with the cage 20; the air supply pipe 61 and the exhaust pipe 62 are both provided with sealing structures 80, when the sealing structures 80 are clamped with the air supply pipe 61 and the exhaust pipe 62, the air inlet branch pipes 141 are isolated from the outside by the sealing structures 80 and the air supply pipe 61, and the air outlet branch pipes 151 are isolated from the outside by the sealing structures 80 and the exhaust pipe 62; when the cage 20 is placed in the housing compartment 13, the sealing structure 80 is separated from the air supply duct 61 and the air exhaust duct 62, the air inlet branch duct 141 is communicated with the air inlet duct 22 through the air supply duct 61, and the air outlet branch duct 151 is communicated with the air outlet duct 23 through the air exhaust duct 62. Cage box 20 places back in the storehouse 13 of settling of cage 10, air supply equipment and negative pressure equipment are responsible for 14 through the air inlet, the air-out is responsible for 15, carry out the air exchange in air inlet branch pipe 141 and air outlet branch pipe 151 and the cage box 20, because of not contradicted by cage box 20 for seal structure 80 in the storehouse 13 of settling of not placing cage box 20, so seal structure 80 can with blast pipe 61 and exhaust pipe 62 block, let blast pipe 61 and exhaust pipe 62 that settle in the storehouse 13 of not placing cage box 20 sealed, effectively prevent that the outside air from getting into the air inlet branch pipe 141 and air outlet branch pipe 151 through this blast pipe 61 and exhaust pipe 62 and polluting the air of other cage boxes 20.
The air inlet branch pipe 141 and the air outlet branch pipe 151 are provided with air vents 18; the air supply pipe 61 and the exhaust pipe 62 both comprise an arc-shaped outer wall part 71 and an end surface blocking part 72, the first end of the arc-shaped outer wall part 71 is connected with the ventilation opening 18 and used for sleeving the air inlet pipe 22 and the air outlet pipe 23, and the end surface blocking part 72 is arranged at the second end of the arc-shaped outer wall part 71; the sealing structure 80 comprises a second resetting part 81 and a clamping part 82, wherein the clamping part 82 is connected with the arc-shaped outer wall part 71 in a sliding manner, and the second resetting part 81 is connected with the clamping part 82 and is used for controlling the clamping part 82 to move along the direction of the second end of the arc-shaped outer wall part 71; when the cage 20 slides into the accommodating bin 13 and the air inlet pipe 22 and the air outlet pipe 23 slide along the first end of the arc-shaped outer wall part 71, the clamping part 82 slides along the first end of the arc-shaped outer wall part 71 to be separated from the arc-shaped outer wall part 71, the air inlet branch pipe 141 is communicated with the air inlet pipe 22 through the air supply pipe 61, and the air outlet branch pipe 151 is communicated with the air outlet pipe 23 through the air exhaust pipe 62; when the cage 20 slides out of the storage bin 13 and the air inlet pipe 22 and the air outlet pipe 23 slide along the direction of the second end of the arc-shaped outer wall 71, the second resetting portion 81 controls the engaging portion 82 to move along the direction of the second end of the arc-shaped outer wall 71 until the engaging portion 82 engages with the arc-shaped outer wall 71, when the engaging portion 82 engages with the arc-shaped outer wall 71, the engaging portion 82, the arc-shaped outer wall 71 and the end surface blocking portion 72 block the air inlet branch pipe 141 from the outside, and the engaging portion 82, the arc-shaped outer wall 71 and the end surface blocking portion 72 block the air outlet branch pipe 151 from the outside.
As shown in fig. 14 and 15, the second restoring portion 81 includes a restoring block 811 and a second elastic member 812, the restoring block 811 is disposed in the air inlet branch pipe 141 and the air outlet branch pipe 151, one end of the second elastic member 812 is connected to the restoring block 811, and the other end is connected to the engaging portion 82, for controlling the engaging portion 82 to move in the direction of the second end of the arc-shaped outer wall portion 71. Specifically, the second restoring block 811 is provided with a groove for mounting the elastic element, and the engaging portion 82 is provided with a protrusion for fixing the elastic element.
As shown in fig. 16 and 17, the arc-shaped outer wall portion 71 is provided with a slide groove 711, and the engaging portion 82 is provided with a slide bar 821 engaged with the slide groove 711. Specifically, the arc-shaped outer wall 71 is half of a cylinder, the two sliding grooves 711 are provided and respectively opened on two side surfaces of the arc-shaped outer wall 71 contacting with the engaging portion 82, the engaging portion 82 is provided with two sliding bars 821 at corresponding positions, the sliding bars 821 are used for limiting the engaging portion 82 to move along the sliding grooves 711, and when the arc-shaped outer wall 71 and the engaging portion 82 are engaged, the sliding bars 821 and the sliding grooves 711 can seal the left side and the right side of the arc-shaped outer wall 71, so that external air is prevented from entering the air inlet branch pipe 141 and the air outlet branch pipe 151 through the left side and the right side of the arc-shaped outer wall 71.
The inner diameters of the air inlet branch pipe 141 and the air outlet branch pipe 151 are larger than the inner diameter of the vent 18; the end surface blocking part 72 is provided with an outer spacer 721; a limiting block 822, an inner partition 823 and an abutting block 824 are arranged on the clamping portion 82, the limiting block 822 is arranged at one end of the clamping portion 82 and is positioned in the air inlet branch pipe 141 and the air outlet branch pipe 151, the inner partition 823 and the abutting block 824 are arranged at the other end of the clamping portion 82, when the clamping portion 82 is clamped with the arc-shaped outer wall portion 71, the limiting block 822 abuts against the ventilation opening 18, and the inner partition 823 abuts against the outer partition 721; the abutting block 824 is used for abutting against and pushing the engaging portion 82 when the air inlet pipe 22 and the air outlet pipe 23 slide along the direction of the first end of the arc-shaped outer wall portion 71. The stop block 822 is used for limiting the continuous movement of the clamping part 82 along the second end of the arc-shaped outer wall part 71; the inner spacers 823 abut the outer spacers 721 to provide a seal. The external diameter of arc outer wall portion 71 and block portion 82 equals the internal diameter of vent 18, the internal diameter of air inlet branch pipe 141 and air outlet branch pipe 151 all is greater than the internal diameter of vent 18, make form fixed edge in the vent 18, the external diameter of stopper 822 equals the internal diameter of air inlet branch pipe 141 and air outlet branch pipe 151, stopper 822 can block fixed edge, the displacement distance of block portion 82 can be blockked in the setting of interior spacer 823 and outer spacer 721, interior spacer 823 and outer spacer 721 form the gap of stairstepping simultaneously, can prevent that the front end that outside air passes through arc outer wall portion 71 from getting into air inlet branch pipe 141 and air outlet branch pipe 151.
As shown in fig. 1 and 8, the cage 10 is provided with a buckle 19 on both sides of each accommodating chamber 13, and the buckle 19 is rotatably connected with the cage 10. Specifically, the rotation junction of buckle 19 and cage 10 is provided with the rubber circle, be used for increasing buckle 19 pivoted damping, let buckle 19 can fix at arbitrary angle, place cage 20 back in settling storehouse 13, can fix cage 20 in settling storehouse 13 through rotating buckle 19 of settling storehouse 13 both sides, prevent that cage 20 from falling out settling storehouse 13, avoid the elastic component to release cage 20 simultaneously and settle storehouse 13, when will taking out cage 20, rotatory buckle 19, cage 20 receives the thrust roll-off of elastic component and settles storehouse 13 certain distance, thereby be convenient for take out cage 20.
The above is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above-mentioned embodiments, and all technical solutions belonging to the idea of the present invention belong to the protection scope of the present invention. It should be noted that modifications and embellishments within the scope of the invention may occur to those skilled in the art without departing from the principle of the invention, and are considered to be within the scope of the invention.
Claims (10)
1. An IVC cage for biological experiments, which is characterized by comprising a cage frame (10) and a cage box (20); the cage (10) is provided with a plurality of ethological bins (11), biological bins (12) and accommodating bins (13) for accommodating cage boxes (20), an air inlet main pipe (14), an air outlet main pipe (15), a plurality of air inlet branch pipes (141) communicated with the air inlet main pipe (14) and a plurality of air outlet branch pipes (151) communicated with the air outlet main pipe (15) are arranged in the cage (10), each ethological bin (11) corresponds to one air inlet branch pipe (141) and one air outlet branch pipe (151), each biological bin (12) corresponds to one air inlet branch pipe (141) and one air outlet branch pipe (151), and each accommodating bin (13) corresponds to one air inlet branch pipe (141) and one air outlet branch pipe (151);
the biological bin air inlet device is characterized by further comprising an air generating device (30), wherein the air generating device (30) is communicated with an air inlet branch pipe (141) corresponding to the biological bin through an air pipeline (40), and an adjusting structure (50) is arranged in the air pipeline (40);
when the gas generating device (30) generates gas, the adjusting structure (50) controls the gas pipeline (40) to be communicated with the corresponding air inlet branch pipe (141), and controls the air inlet main pipe (14) to be separated from the corresponding air inlet branch pipe (141);
when the gas generating device (30) stops generating gas, the adjusting structure (50) controls the gas pipeline (40) to be separated from the corresponding air inlet branch pipe (141), and controls the air inlet main pipe (14) to be communicated with the corresponding air inlet branch pipe (141).
2. The IVC cage for biological experiments of claim 1, wherein the adjustment structure (50) comprises a movable core (51), the movable core (51) is provided with an air inlet channel (52), and the movable core (51) is provided with a first reset portion (53);
the gas pipeline (40) comprises an inlet cavity (41), a movable cavity (42) and a reset cavity (43), one end of the inlet cavity (41) is communicated with the gas generating device (30), the other end of the inlet cavity is communicated with the movable cavity (42), the movable cavity (42) is communicated with the corresponding air inlet branch pipe (141), and the reset cavity (43) is communicated with the inlet cavity (41);
the movable core (51) is arranged in the inlet cavity (41) in a sliding manner, and the first resetting part (53) is arranged in the resetting cavity (43);
when the gas generating device (30) generates gas, the movable core (51) slides to the movable cavity (42) from the inlet cavity (41), and the first resetting part (53) is compressed; when the movable core (51) slides to the movable cavity (42) from the inlet cavity (41), the inlet cavity (41) is communicated with the air inlet branch pipes (141) through the air inlet channel (52), and the movable core (51) controls the air inlet main pipe (14) to be separated from the corresponding air inlet branch pipes (141);
when the gas generating device (30) stops generating gas, the first resetting part (53) resets and drives the movable core (51) to slide from the movable cavity (42) to the entering cavity (41); when the movable core (51) slides from the movable cavity (42) to the inlet cavity (41), the air inlet channel (52) is separated from the air inlet branch pipe (141), and the air inlet main pipe (14) is communicated with the corresponding air inlet branch pipe (141).
3. The IVC cage for biological experiments according to claim 2, wherein the first resetting part (53) comprises a stopper (531) and a first elastic member (532), the stopper (531) is connected with the movable core (51), the first elastic member (532) is connected with the stopper (531), the stopper (531) and the first elastic member (532) are both arranged in the resetting cavity (43), the stopper (531) is used for sliding along the resetting cavity (43), and the first elastic member (532) is used for controlling the resetting of the movable core (51).
4. The IVC cage for biological experiments as claimed in claim 2, wherein the inner diameters of the inlet chamber (41), the movable chamber (42) and the corresponding air inlet branch pipes (141) are the same, the central axes of the inlet chamber (41) and the movable chamber (42) coincide, the central axis of the movable chamber (42) is perpendicular to the central axis of the corresponding air inlet branch pipe (141), the first end of the air inlet channel (52) is opened at one end of the movable core (51) close to the gas generating device (30), and the second end is opened at the arc-shaped outer wall of the movable core (51).
5. The IVC cage for biological experiments according to claim 1, characterized in that the ethological chamber (11) is provided with a sealing door (16), the sealing door (16) being hinged to the mouth of the ethological chamber (11).
6. The IVC cage for biological experiments according to claim 1, characterized in that illuminating lamps (17) are arranged in the behavioural cabin (11), the biological cabin (12) and the settling cabin (13), an illumination zone (21) is arranged on the cage box (20), and the illuminating lamps (17) are used for illuminating the interior of the cage box (20) through the illumination zone (21).
7. IVC cage for biological experiments according to claim 6, characterized in that the illumination zone (21) comprises an illumination hood (211) and an illumination aperture (212) opening on the cage box (20), the illumination hood (211) being located inside the cage box (20) and being connected at the illumination aperture (212).
8. The IVC cage for biological experiments according to claim 1, wherein the cage (20) comprises an air inlet pipe (22) and an air outlet pipe (23), an air supply pipe (61) connected with the air inlet pipe (22) and an air exhaust pipe (62) connected with the air outlet pipe (23) are arranged in each of the behavior cabin (11), the biology cabin (12) and the placing cabin (13), the air inlet branch pipe (141) is communicated with the air supply pipe (61), and the air outlet branch pipe (151) is communicated with the air exhaust pipe (62) and used for exchanging air with the cage (20);
the air supply pipe (61) and the exhaust pipe (62) are respectively provided with a sealing structure (80), when the sealing structures (80) are clamped with the air supply pipe (61) and the exhaust pipe (62), the sealing structures (80) and the air supply pipe (61) separate the air inlet branch pipe (141) from the outside, and the sealing structures (80) and the exhaust pipe (62) separate the air outlet branch pipe (151) from the outside;
when the cage box (20) is placed in the placement bin (13), the sealing structure (80) is separated from the air supply pipe (61) and the exhaust pipe (62), the air inlet branch pipe (141) is communicated with the air inlet pipe (22) through the air supply pipe (61), and the air outlet branch pipe (151) is communicated with the air outlet pipe (23) through the exhaust pipe (62).
9. The IVC cage for use in bioassays of claim 8,
the air inlet branch pipe (141) and the air outlet branch pipe (151) are provided with ventilation openings (18);
the air supply pipe (61) and the exhaust pipe (62) both comprise an arc-shaped outer wall part (71) and an end face blocking part (72), the first end of the arc-shaped outer wall part (71) is connected with the ventilation opening (18) and used for sleeving the air inlet pipe (22) and the air outlet pipe (23), and the end face blocking part (72) is arranged at the second end of the arc-shaped outer wall part (71);
the sealing structure (80) comprises a second resetting part (81) and an engaging part (82), the engaging part (82) is connected with the arc-shaped outer wall part (71) in a sliding mode, and the second resetting part (81) is connected with the engaging part (82) and used for controlling the engaging part (82) to move along the direction of the second end of the arc-shaped outer wall part (71);
when the cage box (20) slides into the placing bin (13), and the air inlet pipe (22) and the air outlet pipe (23) slide along the direction of the first end of the arc-shaped outer wall part (71), the clamping part (82) slides along the direction of the first end of the arc-shaped outer wall part (71) to be separated from the arc-shaped outer wall part (71), the air inlet branch pipe (141) is communicated with the air inlet pipe (22) through the air supply pipe (61), and the air outlet branch pipe (151) is communicated with the air outlet pipe (23) through the exhaust pipe (62);
when the cage box (20) slides out of the placing bin (13) and the air inlet pipe (22) and the air outlet pipe (23) slide along the direction of the second end of the arc-shaped outer wall portion (71), the second resetting portion (81) controls the clamping portion (82) to move along the direction of the second end of the arc-shaped outer wall portion (71) until the clamping portion (82) is clamped with the arc-shaped outer wall portion (71).
10. The independent ventilation sealing cage according to claim 9, wherein the second reset portion (81) comprises a reset block (811) and a second elastic member (812), the reset block (811) is disposed in the air inlet branch pipe (141) and the air outlet branch pipe (151), one end of the second elastic member (812) is connected with the reset block (811), and the other end is connected with the engaging portion (82) for controlling the engaging portion (82) to move along the direction of the second end of the arc-shaped outer wall portion (71).
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| CN202210572168.4A CN115136899B (en) | 2022-05-24 | 2022-05-24 | IVC cage for biological experiment |
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| CN202210572168.4A CN115136899B (en) | 2022-05-24 | 2022-05-24 | IVC cage for biological experiment |
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| CN115136899B CN115136899B (en) | 2023-05-30 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117337775A (en) * | 2023-10-25 | 2024-01-05 | 苏州市苏杭科技器材有限公司 | Independent ventilation equipment for animal feeding |
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