CN115105647B

CN115105647B - Beauty pulling wire and preparation method thereof

Info

Publication number: CN115105647B
Application number: CN202210693253.6A
Authority: CN
Inventors: 陶秀梅; 郭杰; 徐小雨; 冷鸿飞
Original assignee: Beijing Nuokangda Pharmaceutical Technology Co ltd
Current assignee: Beijing Nuokangda Pharmaceutical Technology Co ltd
Priority date: 2022-06-17
Filing date: 2022-06-17
Publication date: 2023-06-30
Anticipated expiration: 2042-06-17
Also published as: CN115105647A; WO2023241357A1

Abstract

The invention relates to the field of medical materials, and particularly provides a beautifying pull wire and a preparation method thereof. The cosmetic pull wire is prepared by melting a matrix material after physical mixing, wherein the matrix material comprises PCL and PEG. According to the invention, PEG is introduced into PCL, so that the melting point of the matrix material can be further reduced, the material can be injection molded at a lower temperature, and the guarantee of maintaining the activity of the bioactive functional component which is not resistant to high temperature is provided for the addition of the bioactive functional component into the matrix material. The amphipathic pulling wire can further increase the biocompatibility, and is beneficial to cell adhesion and proliferation. Furthermore, the degradation period of the beauty pulling wire is more accurately regulated and controlled by adjusting the molecular weight of PCL and PEG and the ratio between the PCL and PEG.

Description

Beauty pulling wire and preparation method thereof

Technical Field

The invention relates to the field of medical materials, in particular to a beautifying pull wire and a preparation method thereof.

Background

The implantation line is a special cosmetic pulling line implanted in the skin to stimulate the skin to proliferate collagen, thereby achieving the purpose of improving the skin relaxation state. The implantation line is implanted to the part to be lifted by utilizing absorbable lines (mainly comprising bell lines, midecan, mi Nuowa and the like) and is pulled by the wire body, so that the phenomena of wrinkles, looseness and the like are improved.

The lifting wire can be divided into a smooth wire, a spiral wire, a sawtooth wire and the like according to different wire types, wherein the smooth wire mainly plays roles of filling, whitening, spot fading and the like, and the sawtooth wire mainly plays roles of lifting and reshaping.

The existing pulling wire materials in the market are mainly absorbable materials such as PPDO, PGA, PLA, but the type of materials have short degradation period in vivo and can not keep the face pulling effect for a long time.

In addition, in order to achieve a good cosmetic effect of the pull wire, the prior art generally adopts a dipping mode to load functional components such as epidermal growth factors on the surface of the pull wire, which plays an important role in regulating cell growth, proliferation and differentiation, and has the effects of tendering skin, moisturizing skin, eliminating wrinkles, repairing wounds and preventing color spots. However, the biological activity of the functional components in the product obtained by impregnation is susceptible to influence, thereby affecting the cosmetic effect.

Disclosure of Invention

Aiming at the defects existing in the prior art, the invention provides a beauty lifting wire and a preparation method thereof.

In a first aspect, the invention provides a cosmetic pull wire, which is prepared by physically mixing and melting a matrix material, wherein the matrix material comprises PCL and PEG.

The degradation cycle of PCL is longer than that of the commonly used absorbable materials such as PPDO, PGA, PLA. In addition, the melting point of the pure PCL is 57-63 ℃, and is much lower than that of PPDO, PGA and other materials, and the PEG is introduced into the PCL to further reduce the melting point of the matrix material, so that the material can be injection molded at a lower temperature, thereby providing a guarantee for maintaining the activity of the bioactive functional components which are not resistant to high temperature when being added into the matrix material. In addition, PEG is hydrophilic, PCL is lipophilic, and the amphiphilic pull wire can further increase the biocompatibility of the pull wire, so that the pull wire is favorable for cell adhesion and proliferation.

According to some embodiments of the invention, the matrix material has a melting point of 55-60 ℃.

According to some embodiments of the invention, in the matrix material, PEG has a weight average molecular weight of 4000-10000 and a mass content of 5-20%; the weight average molecular weight of PCL is 10-25 ten thousand.

According to the invention, the degradation period of the beauty treatment lifting wire is regulated more accurately by regulating the molecular weight of PCL and PEG and the ratio between the PCL and PEG, and the lifting effect of the beauty treatment lifting wire is considered.

Preferably, the weight average molecular weight of PEG in the matrix material is 6000-10000, and the mass content is 10-20%; the weight average molecular weight of PCL in the matrix material is 18-25 ten thousand.

Further preferably, the weight average molecular weight of PEG in the matrix material is 6000-8000, and the mass content is 10-15%; the weight average molecular weight of PCL in the matrix material is 22-25 ten thousand.

According to some embodiments of the invention, the matrix material further comprises a functional ingredient that is mixed with PCL and PEG in the matrix material to form a homogeneous material.

Because the melting point of the mixed material of PCL and PEG is low, the functional components and the PCL and PEG can be mixed together to serve as a matrix material, and compared with the traditional method of dipping and loading the functional components on the surface of the lifting wire, the method can reduce the activity loss of the functional components, exert the efficacy of the functional components as much as possible, and has good slow release effect.

According to some embodiments of the invention, the functional ingredient is an epidermal growth factor. Preferably, the mass of the epidermal growth factor in the matrix material is 0.2-1 per mill of the mass of the PEG in the matrix material.

EGF plays an important role in regulating cell growth, proliferation and differentiation, has the effects of tendering skin, moistening skin, eliminating wrinkles, repairing wounds and preventing color spots, is easy to inactivate at high temperature and is easy to inactivate in an organic solvent. The long degradation period of the matrix material of the pull wire ensures that the time for slowly releasing the epidermal growth factor in the body is long, the lower melting point fully ensures the bioactivity of the epidermal growth factor, and the bioactivity can be exerted for a long time after the matrix material is implanted into the body.

The functional component of the present invention may be an epidermal growth factor, or may be other functional components, such as vitamin C, nicotinamide, etc. According to the specific product requirement, the functional components can be mixed with PCL and PEG in the matrix material to form a homogeneous material, and the functional components can be further attached to the surface layer of the lifting wire.

According to some embodiments of the invention, the total mass ratio of the epidermal growth factor to the PEG in the matrix material is 5-20%, and the mass ratio of the PCL in the matrix material is 80-95%.

The structure of the cosmetic pull wire according to the present invention may be a conventional structure in the art including a main wire and barbs or protrusions formed on the outer circumferential surface of the main wire. Wherein the main line and optionally the barbs, protrusions are made of said matrix material. Preferably, the main thread and the barbs or projections thereon are made of said matrix material. The materials are consistent, so that the integrated injection molding is convenient, and the process is simplified.

According to some embodiments of the invention, the protrusions may be in the shape of cones, funnels, cylinders, modified cones, modified cylinders, and the like.

According to some embodiments of the invention, the protrusion is a hollow bowl-shaped protrusion. The hollow bowl-shaped bulge comprises a bowl bottom and a bowl side wall, a bowl opening is formed at the extending end of the bowl side wall, and a main line part connected with the bottom end of the bowl side wall forms the bowl bottom. The hollow bowl-shaped bulge is provided with the cambered surface bulge with 360 degrees, so that the beautifying pull wire has larger pulling force.

According to some embodiments of the invention, the diameter of the main line is 0.4-1.0mm.

According to some embodiments of the invention, the diameter of the bowl is 2-3 times the diameter of the main line, and the depth of the bowl is 1-2 times the diameter of the main line.

According to the invention, the bowl mouth diameter, the bowl depth and the main line diameter are controlled within the above range, so that the lifting effect is better. Wherein the depth of the bowl is the distance between the plane of the bowl mouth and the plane of the bowl bottom.

According to some embodiments of the invention, the spacing between two adjacent hollow bowl-shaped protrusions is 2-5mm.

The hollow bowl-shaped bulges on the beauty treatment lifting wire can be oriented in one direction or different directions. Taking the example that the main line is horizontally arranged, the convex bowl mouths can all face left, can all face right, can all face left and can all face right. When the orientations are different, the orientations can be regularly alternated (such as two left and one right are alternately) or irregular.

In some embodiments of the invention, the hollow bowl-shaped protrusions on the cosmetic pull wire are bi-directional, with 8-12 protrusions in each direction (i.e., 8-12 protrusion bowl openings to the left, 8-12 protrusion bowl openings to the right, alternating in this manner), and adjacent protrusion spacing of 2-5mm.

According to some embodiments of the invention, the hollow bowl-shaped protrusion is filled with a slow release gel loaded with an antibacterial agent.

When the pull wire is used for lifting the face and the body, the pull wire is implanted into the skin, and infection is sometimes formed at a wound. According to the invention, the slow-release gel loaded with the antibacterial agent is filled in the hollow bowl-shaped bulge, and the degradation period of the gel is controlled to be 3-7 days, so that the antibacterial agent can be released in early stage after operation to prevent infection, and the mode has better effect than the simple placement of the antibacterial agent at the included angle of the barb of the lifting wire; on the other hand, the degraded hollow bowl-shaped structure provides a bracket space for regenerated cells.

According to some embodiments of the invention, the antibacterial agent is one or more of tetracycline, chloramphenicol, macrolides, clindamycin, vancomycin, and the like.

The gel for loading the antibacterial drug can meet the requirements of degradability, biocompatibility, no influence on the activity of the drug and the like.

According to some embodiments of the invention, the sustained release gel is prepared using a molar ratio of 2:1 to 1:1 of the four-arm polyethylene glycol succinimide succinate to the trilysine acetate.

In a second aspect, the invention also provides a preparation method of the beauty treatment lifting wire.

The preparation method provided by the invention comprises the step of forming after melting the matrix material.

In some embodiments of the invention, when the matrix material comprises an epidermal growth factor, the preparation method comprises the steps of:

dissolving the epidermal growth factor stock solution and PEG in water, and freeze-drying to obtain solid;

and melting the mixed solid of PEG and the epidermal growth factor and PCL at 60-65 ℃, and adopting a die to integrally injection-mold the mixed solid of PEG and the epidermal growth factor into the cosmetic pull wire.

In the preparation method, the epidermal growth factor is prepared into a solid state to keep the bioactivity (the stability is far better than that in an aqueous solution when the epidermal growth factor exists in a solid state, the stability can meet the general requirement of the preparation when the epidermal growth factor is stored in the solid state, the degradation time is more than 90 percent, and the epidermal growth factor is melted at 60-65 ℃ after the degradation time is more than three years, the melting temperature is lower, so that the inactivation of the epidermal growth factor is avoided, namely the bioactivity of the epidermal growth factor is basically not lost in the whole preparation process. Compared with the existing dipping method, the method not only can reduce the activity loss of the epidermal growth factor, but also can realize the slow release of the epidermal growth factor, simultaneously avoids using an organic solvent, and reduces the activity loss and the production cost. Compared with the stamping process, the injection molding is simple and is suitable for mass production.

According to some embodiments of the invention, when the protrusion of the cosmetic pull wire further comprises a slow release gel, the preparation method further comprises filling the protrusion with the slow release gel loaded with the antibacterial drug.

In the description of the present specification, a description referring to terms "one embodiment," "some embodiments," "examples," "specific examples," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the embodiments of the present invention. In this specification, schematic representations of the above terms are not necessarily directed to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, the different embodiments or examples described in this specification and the features of the different embodiments or examples may be combined and combined by those skilled in the art without contradiction.

Compared with the prior art, the invention has at least one of the following technical effects:

1. the introduction of PEG can reduce the melting point of PCL, can be injection molded at a lower temperature, has simplified injection molding process, is beneficial to safe large-scale production, and can ensure the activity of functional components such as solid EGF and the like; in addition, the amphipathic pulling wire can increase the biocompatibility, and is beneficial to cell adhesion and proliferation.

2. The weight average molecular weight of PCL and the proportion of the weight of PEG are controlled, so that the degradation period of the pulling wire can be controlled, and the EGF long-acting slow release is realized.

3. On structural design, the hollow bowl-shaped bulge increases the lifting effect of the lifting wire on one hand, and on the other hand, the space bracket serving as antibacterial gel can quickly release antibacterial drugs after operation, so that postoperative infection is avoided, and after degradation, a release space provides a channel for cells and nutrient substances.

Drawings

Fig. 1 is a schematic structural view of a cosmetic pull cord according to the present invention.

Detailed Description

For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more clear, the technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.

Unless otherwise specified, the raw materials according to the examples of the present invention are all commercially available.

Interpretation of key terms and technical abbreviations referred to herein:

PCL: polycaprolactone

PEG: polyethylene glycol

PPDO: poly (p-dioxanone)

PGA: polyglycolic acid

PLA: polylactic acid

PLGA: polylactic acid-glycolic acid copolymer

HA: hyaluronic acid

EGF: epidermal growth factor

PBS: phosphate buffer solution

4-arm-PEG-SS: four-arm polyethylene glycol succinimidyl succinate

The basic structure of the cosmetic pull wire referred in the following examples is as follows:

the bowl comprises a main line and a plurality of hollow bowl-shaped bulges formed on the peripheral surface of the main line, wherein each hollow bowl-shaped bulge comprises a bowl bottom and a bowl side wall, a bowl opening is formed at the extending end of each bowl side wall, and the main line part connected with the bottom end of each bowl side wall forms the bowl bottom; the hollow bowl-shaped protrusions are provided with cambered protrusions with 360 degrees, the distance between every two adjacent hollow bowl-shaped protrusions is 2-5mm, the bowl openings are bidirectional, and 8-12 protrusions are arranged in each direction, as shown in figure 1.

Example 1

The embodiment provides a beauty-care lifting wire, which is prepared by the following steps:

the first step: PEG4000 was dissolved and then added with 0.5% EGF for rapid lyophilization, followed by shearing into solid small particles (particle size less than 10mm, the same applies below).

And a second step of: solid small particles and PCL (weight average molecular weight 12 ten thousand) are put into an injection molding machine by the mass ratio of 20:80, and a special mold (the special mold refers to a mold matched with a beautifying pull wire structure, and the same applies below) is adopted to integrally mold the special-shaped pull wire with a hollow bowl-shaped bulge at 63 ℃, the diameter of a bowl opening is 3 times of the wire diameter, the depth of the bowl is 2 times of the wire diameter, and the wire diameter is 0.4mm.

And a third step of: 4-arm-PEG-SS and trilysine acetate (molar ratio 1.5:1) and antibacterial vancomycin are dissolved by PBS (pH=7.3) (the PBS with pH=7.3 is close to the pH of a human body, at the moment, the 4-arm-PEG-SS has high activity and short gel forming time), and then gel is formed at a hollow bowl-shaped position under the promotion of borax solution, so that the obtained beauty pulling line is frozen and stored in a dark place.

Example 2

the first step: after PEG6000 is dissolved, 0.2 per mill EGF is added for quick freeze-drying, and then the mixture is sheared into solid small particles.

And a second step of: solid small particles and PCL (weight average molecular weight 18 ten thousand) are put into an injection molding machine by the mass ratio of 10:90, a special mold is adopted for integrally molding into a hollow bowl-shaped convex special-shaped lifting wire at 63 ℃, the diameter of a bowl opening is 2 times of the wire diameter, the depth of the bowl is 2 times of the wire diameter, and the wire diameter is 0.4mm.

And a third step of: gel was formed at the hollow bowl-shaped position under the accelerated crosslinking of borax solution after dissolution with PBS (ph=7.3) using 4-arm-PEG-SS with trilysine acetate (molar ratio 1:1) and the antibacterial vancomycin.

Example 3

the first step: PEG4000 is dissolved, then EGF 1 per mill is added for quick freeze-drying, and then the mixture is sheared into solid small particles.

And a second step of: solid small particles and PCL (weight average molecular weight 25 ten thousand) are put into an injection molding machine by the mass ratio of 20:80, a special mold is adopted for integrally molding into a hollow bowl-shaped convex special-shaped lifting wire at 63 ℃, the diameter of a bowl opening is 3 times of the wire diameter, the depth of the bowl is 1 time of the wire diameter, and the wire diameter is 1mm.

And a third step of: gel was formed at the hollow bowl-shaped position under the accelerated crosslinking of borax solution after dissolution with PBS (ph=7.3) using 4-arm-PEG-SS with trilysine acetate (molar ratio 2:1) and the antibacterial vancomycin.

Example 4

the first step: PEG10000 is dissolved, then 0.5 per mill EGF is added for quick freeze-drying, and then the mixture is sheared into solid small particles.

And a second step of: solid small particles and PCL (weight average molecular weight 10 ten thousand) are put into an injection molding machine by the mass ratio of 10:90, a special mold is adopted for integrally molding into a special-shaped lifting wire with a hollow bowl-shaped bulge at 60 ℃, the diameter of a bowl opening is 3 times of the wire diameter, the depth of the bowl is 2 times of the wire diameter, and the wire diameter is 0.6mm.

And a third step of: gel was formed at the hollow bowl-shaped position under the promotion of borax solution after dissolution with PBS (ph=7.3) using 4-arm-PEG-SS with trilysine acetate (molar ratio 1.5:1) and the antibacterial vancomycin.

Example 5

the first step: PEG8000 is dissolved, then EGF of 0.5 per mill is added for quick freeze-drying, and the mixture is cut into solid small particles.

And a second step of: solid small particles and PCL (weight average molecular weight of 22 ten thousand) are put into an injection molding machine by the mass ratio of 15:85, a special mold is adopted for integrally molding into a hollow bowl-shaped convex special-shaped lifting wire at 63 ℃, the diameter of a bowl opening is 2 times of the wire diameter, the depth of the bowl is 2 times of the wire diameter, and the wire diameter is 0.4mm.

Comparative example 1

The difference compared to example 1 is that the PCL used has a weight average molecular weight of 30000 and the remaining steps are identical.

Comparative example 2

The difference compared to example 1 is that the mass ratio of solids of PEG and EGF to PCL is 50:50, the remaining steps are identical.

Comparative example 3

The difference compared to example 1 is that the diameter of the bowl mouth of the hollow bowl-shaped bulge is 1.5 times of the wire diameter, and the rest is the same.

Comparative example 4

The difference compared with example 1 is that the mixed solid of PEG and EGF is changed to the mixed solid of PVA and EGF, and then the mixed solid of PEG and EGF is co-melt-injection molded with PCL, and the rest steps are identical.

Experimental example 1: breaking strength and breaking elongation

Sample 1 is the sample prepared in example 1;

sample 2 is a sample prepared in comparative example 1;

sample 3 is the sample prepared in example 2;

sample 4 is the sample prepared in example 5;

the experimental method comprises the following steps: adopt intelligent electron pulling force machine to measure the breaking strength of two kinds of samples: the length of the marker was measured to be L mm, the stretching rate was 2L mm/min, and the breaking strength and breaking elongation of the pull-up wire were recorded. The results are shown in the following table.

TABLE 1

Numbering device	Length of the marking tool, mm	Stretching rate, mm/min	Breaking strength, N	Elongation at break
					Sample 1	35	70	26.864	49.2％
Sample 2	35	70	6.101	2715％
					Sample 3	35	70	35.327	54.0％
Sample 4	35	70	38.624	57.0％

From the above results, the higher the molecular weight of PCL, the higher the breaking strength of the pull wire, the smaller the breaking elongation, and the higher the pull effect in the body, and the less likely deformation. However, when the molecular weight of PCL is higher than 25 ten thousand, the degradation period of the pulling wire is too long, the EGF in the inner part cannot be completely released, and the effect of stimulating collagen regeneration is weakened. In addition, PEG is less than 700 and is liquid, PEG700-2000 is in a waxy structure, is not solid at room temperature after freeze-drying, has an effect on EGF activity, and the research of the invention finds that the molecular weight of the selected PEG is 4000-10000 and is better.Experimental example 2: ductility and flexibility experiments

Sample 5 is the sample prepared in example 1;

sample 6 is a sample prepared in comparative example 2;

the experimental method comprises the following steps: slightly pulling or bending the two samples, and observing whether deformation and fracture occur; adopt intelligent electron pulling force machine to measure the breaking strength of two kinds of samples: the length of the marker was measured to be L mm, the stretching rate was 2L mm/min, and the breaking strength and breaking elongation of the pull-up wire were recorded. The results are shown in the following table.

TABLE 2

From the above results, the sample in comparative example 2 was easily broken after bending, and had no ductility and flexibility, so that the higher the PEG ratio, the greater the brittleness, and the easy breaking; the breaking strength is small, and the stretching force is almost absent.

Experimental example 3: suspension force test

Sample 7 is the sample prepared in example 1;

sample 8 is a sample prepared in comparative example 3;

the experimental method comprises the following steps: sodium alginate and calcium chloride wires of sample 5 and sample 6 were implanted to the same length before the gel was cured and the intelligent electronic tensile machine was moved at the same rate (100 mm/min) and the maximum force of the two pull wires pulled from the gel was recorded. The results are shown in the following table.

TABLE 3 Table 3

Numbering device	Stretching rate, mm/min	Maximum lifting force of gel, N
			Sample 7	100	1.476
Sample 8	100	0.394

From the above results, the larger the bowl mouth of the hollow bowl-shaped bulge is relative to the bowl bottom, the stronger the lifting effect is.

Experimental example 4: melting Point test of Mixed solid and PCL mixture

Sample 9 is the sample prepared in example 1;

sample 10 is a sample prepared in comparative example 4;

the experimental method comprises the following steps: the mixed solid and PCL were ground into powder, and the powder was placed in a melting point apparatus, heated at 10℃per minute, and the melting point was measured. The results are shown in the following table.

TABLE 4 Table 4

Numbering device	Heating rate, DEG C/min	Melting point, DEG C
			Sample 9	10	58.9
Sample 10	10	73.4

As can be seen from Table 4, the melting point of the material increases after PVA is used, and thus the injection molding temperature should be greater than 73℃and the temperature increase decreases the EGF activity.

Experimental example 5: EGF Activity test

The experimental method comprises the following steps: weighing the quality of the lifting wire in the example 1, adding Sorensen degradation liquid according to the ratio of 1g/50ml, degrading for 1 month at 37 ℃, and taking the degradation liquid to pass through a 0.22um filter membrane to be used as a sample 11 solution; 5ng/EGF solution (prepared with Sorensen degradation solution) was incubated at 37℃for 1 month as sample 12; a5 ng/EGF solution was prepared as sample 13. Using MTT method, using cell BALB3T3 as culture cell, mixing three sample solutions and cell 37 deg.C 5% CO ₂ Culturing for 24 hours under the condition, changing the liquid with 1640 liquid containing 0.4% fetal bovine serum, starving cells for culturing for 24 hours, diluting the test sample with maintenance culture liquid, adding the maintenance culture liquid after the dilution of the test sample by 4 times, continuously culturing for 48-72 hours every 2 holes which are a parallel group, adding 20ul MTT (5 mg/ml), continuously culturing for 4-6 hours, discarding the culture liquid, adding 100ul DMSO into each hole, standing for 40 minutes at room temperature, and measuring absorbance at 570 nm. The results are shown in the following table.

TABLE 5

Numbering device	Absorbance of light
		Sample 11	0.65
Sample 12	0.28
		Sample 13	0.73

Results: the higher the EGF activity is, the more favorable to BALB3T3 growth, the higher the absorbance after MTT dyeing is, the higher the absorbance of the degradation liquid is when the sample 11 is degraded for 1 month, compared with the sample 12, which indicates that the EGF activity can be reserved by the slow release of the pull wire, compared with the sample 13, the higher the retention degree of the EGF activity in the pull wire is, and the reserved activity is up to 90%.

Experimental example 6: degradation experiment

Sample 14 is the sample prepared in example 1;

sample 15 is a sample prepared in comparative example 1;

sample 16 is a sample prepared in comparative example 2;

the experimental method comprises the following steps: precisely weighing the mass of the lifting wire, adding Sorensen degradation liquid according to 1g/50ml, carrying out water bath oscillation (100 r/min) at 37 ℃ for degradation, sampling for 1 month, 3 months and 6 months respectively, sucking external moisture by filter paper, carrying out vacuum drying for 1d, weighing the mass of the lifting wire again, and calculating the mass loss rate of the lifting wire according to the fact that the mass is less.

TABLE 6

Results: according to the degradation experiment of the table, the prepared pulling wire is degraded by 6.7% only after 6 months, and has a longer degradation period, and when the molecular weight of PCL is lower and the introduced PEG occupies a larger area, the degradation period is shortened, and generally not more than 1 year.

In summary, the invention provides a cosmetic pull wire and a preparation method thereof, and the problem of short degradation period of the existing cosmetic pull wire in vivo is solved by regulating and controlling the molecular weight and the proportion of PCL and PEG; in addition, the bowl-shaped bulge structure improves the lifting effect, the addition of PEG reduces the melting temperature of PCL, and fully protects the activity of the epidermal growth factor during injection molding; the antibacterial hydrogel degraded in a short period releases medicine in early stage after operation, avoids infection, leaves a space after rapid degradation, and is beneficial to aggregation of cells and collagen.

While the invention has been described in detail in the foregoing general description and with reference to specific embodiments thereof, it will be apparent to one skilled in the art that modifications and improvements can be made thereto. Accordingly, such modifications or improvements may be made without departing from the spirit of the invention and are intended to be within the scope of the invention as claimed.

Claims

1. The cosmetic pull wire is characterized by being prepared by melting a matrix material after physical mixing, wherein the matrix material comprises PCL and PEG; the cosmetic pull wire includes a main wire and a plurality of protrusions formed on an outer circumferential surface of the main wire; the main line and the optional protrusions are made of the base material; the bulge is a hollow bowl-shaped bulge, the hollow bowl-shaped bulge comprises a bowl bottom and a bowl side wall, a bowl opening is formed at the extending end of the bowl side wall, and a main line part connected with the bottom end of the bowl side wall forms the bowl bottom.

2. The cosmetic pull wire of claim 1, wherein the base material has a melting point of 55-60 ℃.

3. The cosmetic pull-cord according to claim 2, wherein the weight average molecular weight of PEG in the matrix material is 4000-10000 and the mass content is 5-20%; the weight average molecular weight of PCL is 10-25 ten thousand.

4. The cosmetic pull-cord according to claim 3, wherein the weight average molecular weight of PEG in the matrix material is 6000-10000, and the mass content is 10-20%; the weight average molecular weight of PCL in the matrix material is 18-25 ten thousand.

5. The cosmetic pull-cord according to claim 4, wherein the weight average molecular weight of PEG in the matrix material is 6000-8000 and the mass content is 10-15%; the weight average molecular weight of PCL in the matrix material is 22-25 ten thousand.

6. The cosmetic pull wire of claim 1, wherein the matrix material further comprises a functional ingredient that mixes with PCL and PEG in the matrix material to form a homogeneous material.

7. The cosmetic pull-cord of claim 6, wherein the functional ingredient is an epidermal growth factor.

8. The cosmetic pull-cord according to claim 7, characterized in that the mass of the epidermal growth factor in the matrix material is 0.2-1% by mass of PEG in the matrix material.

9. The cosmetic pull wire of claim 1, wherein the diameter of the main wire is 0.4-1.0mm;

and/or the diameter of the bowl opening is 2-3 times of the diameter of the main line, and the bowl depth is 1-2 times of the diameter of the main line;

and/or the distance between two adjacent hollow bowl-shaped bulges is 2-5mm.

10. The cosmetic pull wire of claim 1 or 9, wherein the hollow bowl-shaped protrusion is filled with a slow release gel loaded with an antibacterial agent.

11. The method for producing a cosmetic pull wire according to any one of claims 1 to 10, comprising a step of molding after melting the base material.

12. The method of producing a cosmetic pull-cord according to claim 11, wherein when the base material includes an epidermal growth factor, the method comprises:

and melting the mixed solid of PEG and the epidermal growth factor and PCL at 60-65 ℃, and then integrally injection molding to form the cosmetic pull wire.