KR102430704B1 - Method for manufacturing medical thread including net - Google Patents

Abstract

The medical thread including the mesh according to the present invention according to the present invention, the main office; It is characterized in that it consists of; a mesh body made of a porous structure surrounding the head office.
According to the present invention, it can be inserted into a specific part of the human body to regenerate the inserted part and at the same time improve elasticity, thereby improving sexual function.

Description

Method for manufacturing a medical thread including a mesh body {METHOD FOR MANUFACTURING MEDICAL THREAD INCLUDING NET

The present invention relates to a medical thread including a mesh body and a method for manufacturing the same, and in more detail, it can be inserted into a specific part of the face or genitals of the human body to regenerate the insertion site and improve elasticity, thereby improving the elasticity of the skin tissue. It relates to a medical thread including a mesh body, which can improve elasticity or sexual function, and a method for manufacturing the same.

Aging of the skin naturally occurs throughout life due to the effects of wastes and free radicals in the body, hormonal action, contraction and relaxation of pores, and the influence of gravity. The aging of the skin starts to become more noticeable from the 20s, and the aging of the skin accelerates in the 30s.

Accordingly, as an anti-aging means that can return the aging of the skin to a certain extent, the demand for skin lifting procedures is increasing. In this case, the skin lifting procedure generally uses a thread lifting method using a thread, and thread lifting is a method of pulling the skin using a thread that is harmless to the human body.

At this time, as a prior art that can be inserted into the skin and subcutaneous muscle to produce a lifting effect, Korean Patent No. 10-1155817 (Title of the Invention: Tissue Elevation Implant) has been registered.

The prior art relates to a tissue lifting implant used in a procedure to pull or unfold tissue by inserting either a mesh-type implant or a living body insertion thread into the sagging or wrinkled skin (S) and subcutaneous muscle (m) layer. , The tissue lifting implant (2), the protrusion (8) is formed on the surface of the living body insertion thread (6), and the living body insertion thread (6) leaving a certain length on both sides, both ends are tied with a thread to be coupled Presenting an implant for tissue lifting, characterized in that it includes a mesh member (4).

According to the prior art, the traction force is increased by binding a mesh having a certain shape to the surface of the tissue lifting implant and inserting it into the skin tissue, but the diameter of the thread itself is small and the mesh formed on the surface of the thread is also very small There is a lack of sufficient physical traction.

This lifting technique is mainly applied to the face and used to prevent aging, but it is applied to various parts of the body as well as the face to improve elasticity, which is a trend. In particular, although it can be applied to male and female genitalia, the above-described prior art may not be large in diameter and volume, so it may be insufficient to increase the thickness of the male penis or improve the elasticity of the female genitalia.

Therefore, in order to solve the above-described problems, there is a need to develop a new and advanced thread capable of improving elasticity while providing a structure having a sufficient volume than a known medical thread.

The present invention has been devised to overcome the problems of the above technology, and by including a mesh body in the head office, it is possible to maintain its function well in a desired local area in the body.

Another object of the present invention is to form a cog in the head office to strengthen the role and traction force as an anchor point.

Another object of the present invention is to assist the function of the core by applying an elasticity auxiliary agent to the surface of the mesh body to assist in improving the elasticity of the skin.

Another object of the present invention is to form a coating layer by additionally applying a coating agent to the mesh body to which the elasticity aid is applied, so that the elasticity aid is well fixed to the mesh body and can be physically supported so that it can perform its role, and the skin elasticity effect is improved to make it even better.

In order to achieve the above object, the medical thread including the mesh according to the present invention, the head office; It is characterized in that it consists of; a mesh body made of a porous structure surrounding the head office.

In addition, the mesh body is characterized in that it includes a plurality of meshes extending at regular intervals from each other along the extending direction of the plurality of cores.

In addition, on the surface of the head office, it is characterized in that a plurality of cogs are formed to protrude.

Furthermore, the mesh body is characterized in that the coating layer is formed by applying a coating agent containing polyvinyl alcohol (Poly (vinyl alcohol)) and polyethylene glycol (Poly (ethylene glycol)) after the elasticity aid containing collagen is applied. do it with

A thread for medical improvement including a mesh body according to the present invention and a method for manufacturing the same,

1) It can ensure that the traction and fixation function is well maintained in the desired local area of the body,

2) Not only can the elasticity of the skin be improved by applying an elasticity aid to the net body to support the function of the core,

3) By applying a coating agent to the mesh body, the elasticity aid is well fixed to the mesh body and can be physically supported so that it can perform its role, and the skin elasticity effect can be further improved.

1 is a perspective view showing a basic embodiment of a medical seal according to the present invention.
Figure 2 is a conceptual diagram showing a modified embodiment of the mesh body of the present invention.
Figure 3 is a flow chart showing a method for manufacturing the mesh of the present invention.
Figure 4 is a flow chart showing a method of manufacturing the elasticity aid of the present invention.
Figure 5 is a flow chart showing a method for preparing the coating agent of the present invention.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. The accompanying drawings are not drawn to scale, and like reference numbers in each figure refer to like components.

1 is a perspective view showing a basic embodiment of a medical seal according to the present invention.

As can be seen from FIG. 1 , the medical thread including the mesh body of the present invention is based on including the head office 10 and the mesh body 20 .

That is, the yarn of the present invention provides a structure in which the mesh body 20 surrounds the head office 10 formed with a predetermined length and diameter as is known.

The head office 10 is generally made of a material widely used as a material for the current lifting thread, for example, polydioxanone, poly-L-lactic acid, or polycaprolactone, etc. It may be made of a material of The above-mentioned substances can be decomposed and absorbed in the dermal layer of the skin to minimize side effects and allergic reactions.

Additionally, the head office 10 can maximize the lifting effect of the skin by forming the cog 11 in addition to the general shape of the thread.

The mesh body 20 is made of a porous structure surrounding the head office 10, and may be basically formed of a mesh structure taking a shape like a mesh network as shown in FIG. 1 .

In this case, the mesh 20 is generally made of the same material as the above-described head office 10 or a suture used as a medical thread may be used, and it is preferable to be absorbed and removed after being maintained in the skin for a certain period of time.

Such a mesh body 20 surrounds the above-mentioned head office 10 as a whole, and due to this function, the head office 10 does not spread widely in the skin and is well maintained in a local area so that it can stay in the corresponding area, for example, of the face. It can concentrate the lifting and elasticity effect of the skin tissue or the skin tissue of the genitals.

In addition, the reason why the mesh body 20 maintains the porous structure is to simultaneously perform physical protection without blocking the function of the core present in the mesh body 20 . In Figure 1, the mesh body 20 does not wrap the whole of the head office 10, but this is only one embodiment, and it exists in a length that is more extended than the core of the leading end and the core of the rear end, so that the shape surrounding the entire head office 10 is it might be

The medical thread including these components can be well maintained in the desired local area by including the mesh 20 in the well-known head office 10 .

Figure 2 is a conceptual diagram showing a modified embodiment of the mesh body of the present invention.

The mesh body 20 according to FIG. 2 may have a structure extending in plurality with a predetermined distance from each other along the extending direction of the plurality of cores.

More specifically, as can be seen from FIG. 2 , the mesh body 20 is extended in plurality at regular intervals along the longitudinal direction of the head office 10 , and exists in a form in which the mesh does not exist in the vertical direction of the longitudinal direction. can To put it simply, it may exist in the form of a mesh of a net, but it means that only a long vertical line exists, like the form of a curtain foot, so that the head office 10 can be wrapped.

When the mesh body 20 has such a structure, it is possible to preserve the shape of the head office 10 for as long as possible, as well as to allow the head office 10 to be exposed more in the skin to perform a function of improving elasticity. .

In another embodiment, the mesh body 20 is coated with a coating agent containing polyvinyl alcohol (Poly (vinyl alcohol)) and polyethylene glycol (Poly (ethylene glycol)) after the elasticity aid containing collagen is applied to form a coating layer can be

At this time, the elasticity adjuvant may serve to assist in improving the elasticity of the skin by assisting the function of the above-mentioned core, and the coating agent is such that the elasticity adjuvant is well fixed to the mesh body 20 to perform its role. It serves as a physical support. That is, the skin elasticity effect can be further improved, and the elasticity effect can be maintained in the skin for a long time due to the formed coating layer. The specific manufacturing method of these elasticity aids and coating agents will be described later.

Now, a method of manufacturing a thread for improving sexual function according to the above-described bar will be described.

The manufacturing method of the thread for improving sexual function of the present invention includes the steps of manufacturing the head office 10 by applying a known method and wrapping the head office 10 with a mesh body 20 .

In particular, the present invention intends to present an improved embodiment of the method for manufacturing the mesh body 20, which will be described in detail.

Figure 3 is a flow chart showing a method for manufacturing the mesh of the present invention.

The mesh body may be manufactured through the first step (S100), the second step (S200), the third step (S300), the fourth step (S400), and the fifth step (S500).

First, the first step (S100) is a process of preparing a spinning solution containing silk and calcium chloride dihydrate. At this time, the spinning solution is a solution that becomes a material of the mesh forming the mesh 20 , and may be spun through the processes to be described later to become the mesh 20 . The specific configuration of such a spinning solution will be described later. After preparing the spinning solution, it is preferable to stir the solution for 20 to 30 hours.

Next, the second step (S200) is a process of manufacturing a fiber by drying the spinning solution and then electrospinning. Here, it is preferable to proceed with the process of filtering the spinning solution through a wire mesh of 20 to 50 mesh in order to remove the insoluble content in the spinning solution before electrospinning. In addition, the spinning process may be performed through a syringe pump or the like under supply of a voltage of 30 to 50 kV, and it is preferable to proceed while maintaining constant humidity and temperature. The fiber spun through this process may be completed as a mesh body 20 by becoming a mesh through a process to be described later.

Then, the third step (S300) is a process of immersing the fiber in any one of methanol and ethanol and then heat-treating it at 30 to 45° C. for 2 to 6 hours, which is a process of crystallizing the fiber. Here, methanol and ethanol may insolubilize fibers including silk, and may crystallize fibers through heat treatment.

Next, in the fourth step (S400), the heat-treated fiber is washed 1 to 3 times with water, then vacuum dried, and then a carbon tetrafluoride (CF ₄ ) gas flows and is irradiated with radiation at 20 to 30° C. for 2 to 10 minutes. It is a process. Here, the surface of the fiber can be modified by flowing carbon tetrafluoride gas, and the fiber can be plasma-treated by irradiating radiation. At this time, it is preferable that the radiation irradiation process flows carbon tetrafluorocarbon at a flow rate of 100 cc/min, and the power consumption is preferably 20 to 50 W. Due to this treatment, carbon tetrafluorocarbons may be bound to the surface of the fibers, which may make the fibers hydrophobic. When the fiber is hydrophobically treated, the rate of hydrolysis in the body is slowed, so that the shape can be maintained for a longer time, and thus the effect on the present invention can be maintained for a long time. In particular, in the case of men, the core can maintain its shape in the body for a longer period of time, so there is an economic advantage that the cycle of the procedure can be prolonged.

Finally, the fifth step (S500) is a process of completing the mesh body 20 through the surface-modified fiber. That is, it is a process of manufacturing in the shape of the mesh body 20 (ie, a shape including a porous structure) through the spun mesh. The completed mesh body 20 can wrap the above-described core and connector, and can be naturally absorbed and removed after being injected into the body.

At this time, the above-mentioned spinning solution of the first step (S100) contains 25 to 40 parts by weight of purified silk, 20 to 35 parts by weight of poly(lactide-co-glycolide), based on the total weight of the spinning solution, Hexafluoroisopropanol (1,1,1,3,3,3-hexafluoro-2-propanol) may be a mixture of 25 to 40 parts by weight.

Here, as a main material of the mesh body 20, silk has the advantage of being suitable for injection into the body due to its high plasticity and tissue reaction, and is a material used for general skin suturing.

At this time, the purified silk is based on the total weight of the purified silk, 5 to 15 parts by weight of water, 10 to 25 parts by weight of calcium chloride (CaCl ₂ ), 40 to 60 parts by weight of ethanol (C ₂ H ₅ OH), 10 to 20 parts by weight of silk. It is obtained by mixing parts by weight, filtering, washing the residue with water, and then freeze-drying. This refined silk is obtained by dissolving silk in a mixed solution of water, calcium chloride, and ethanol, and sericin is removed from the silk component. In addition, polylactide coglycolide is a copolymer of poly(lactic acid) and poly(glycolic acid), a polymer approved by the US Food and Drug Administration (FDA), and It is characterized by being decomposed into lactic acid and glycogen by decomposition and converted into metabolites. In addition, hexafluoroisopropanol can act as a solvent and facilitate the spinning solution for electrospinning.

At this time, it has been described above that an elasticity aid can be applied to the mesh body 20, and when a thread is inserted into the body by applying an elasticity aid containing collagen to the mesh body 20, it can help improve skin elasticity in addition to the existing function. can The thread for improvement of the present invention basically performs a lifting role, and by additionally applying such an elasticity aid, elasticity is imparted to the skin, thereby assisting the function of the thread for improvement.

Figure 4 is a flow chart showing a method for manufacturing the elasticity aid of the present invention, this elasticity aid is a first solution preparation step (S510), a first material obtaining step (S511), a second material obtaining step (S512), the third It may be prepared through a solution preparation step (S513), a fourth solution preparation step (S514), a third material obtaining step (S515), and a firming aid completion step (S516).

First, the first solution preparation step (S510) is based on the total weight of the first solution, 50 to 60 parts by weight of water, 30 to 40 parts by weight of polyethylene glycol diglycidyl ether (Poly (ethylene glycol) diglycidyl ether), hyaluronic acid (Hyaluronic acid) 0.1 to 10 parts by weight is mixed and then heated at 50 to 70° C. for 1 to 3 hours to prepare a first solution, and the step of obtaining a first material (S511) is to prepare the first solution from -60 to - After freeze-drying at 40°C, the obtained product is washed 1 to 3 times with water and freeze-dried again to obtain the first material.

Here, hyaluronic acid forms a matrix in connective tissue as well as joint synovial fluid, skin, umbilical cord, etc. and exists in a gel state. It acts as an adhesive within the skin tissue and forms a tissue barrier to prevent the passage of infectious substances such as bacteria. can do. In addition, polyethylene glycol diglycidyl ether can be bonded to the alcohol group (-OH) of the hyaluronic acid structure to modify the hyaluronic acid. That is, the reactivity with collagen, which will be described later, can be improved. Therefore, the obtained first material can be said to be a surface-modified hyaluronic acid.

Thereafter, the second material obtaining step (S512) is performed by mixing 70 to 85 parts by weight of a phosphate buffered saline solution of pH 7.4, 15 to 30 parts by weight of the first material, and 15 to 30 parts by weight of the first material, based on the total weight of the second solution. It is a process of obtaining a second material as a residue by filtration after preparation. Here, the reason for using a phosphate buffered saline solution having a pH of 7.4 is that having this pH concentration is stable for application to living organisms. Accordingly, the second material is adjusted to adjust the first material to a pH concentration suitable for living organisms.

Next, the third solution preparation step (S513) is a process of preparing a third solution by mixing 90 to 99.9 parts by weight of a pH 3 hydrochloric acid solution and 0.1 to 10 parts by weight of collagen, based on the total weight of the third solution. Here, collagen is involved in maintaining the body shape of an animal as a protein structural material, and is contained in human tissues such as dermis, tendon, blood vessel, bone, and tooth. At this time, collagen is extracted through the skin of pigs, and the specific extraction process will be described later. In addition, hydrochloric acid solution can dissolve collagen and serves as a solvent.

Thereafter, the fourth solution preparation step (S514) is performed by mixing 70 to 90 parts by weight of the third solution and 10 to 30 parts by weight of the second material at 30 to 40° C. for 20 to 30 hours, based on the total weight of the fourth solution. In the process of preparing a , the third material obtaining step (S515) is a process of lyophilizing the fourth solution at -55 to -45° C., washing with water 1 to 3 times, and then freeze-drying again to obtain a third material.

Here, the fourth solution is a mixture of the second material, that is, the modified hyaluronic acid and the collagen solution, and a hyaluronic acid-collagen complex can be prepared. That is, the obtained third material is a hyaluronic acid-collagen complex.

Finally, the step of completing the elasticity aid (S516) is a process of completing the elasticity aid by mixing 5 to 30 parts by weight of the third material and 70 to 95 parts by weight of a phosphate buffered saline solution based on the total weight of the elasticity aid. Here, it is preferable to use a phosphate buffered saline solution having a pH of 7.4 as described above, and it is mixed in order to adjust the elasticity aid to a pH suitable for the body.

The elasticity aid produced through this process is a component of the human body and is a complex made from biocompatible collagen and hyaluronic acid, so it is harmless to the human body and has the effect of improving the elasticity of the skin. In addition, when the thread for improving sexual function of the present invention is put into the skin, the skin may be damaged, and it may help to alleviate this phenomenon.

In this case, the above-described collagen is prepared in the first solution preparation step, in the first material obtaining step, in the second material obtaining step, in the third material obtaining step, in the fourth solution preparing step, in the fourth material obtaining step, in the fifth solution preparing step, in the 5th step. It can be produced through a material obtaining step, a sixth solution preparation step, and a collagen completion step.

First, the first solution preparation step is based on the total weight of the first solution, 25 to 45 parts by weight of acetone, 25 to 45 parts by weight of water, 1 to 10 parts by weight of potassium hydroxide, 1 to 10 parts by weight of sodium hydroxide, 20 to 30 parts by weight of pig skin After mixing parts by weight, it is a process of preparing a primary solution by stirring at 1 to 5° C. for 3 to 10 hours. Here, pig skin is particularly rich in collagen, which is a good material for extracting collagen. Acetone, water, sodium hydroxide and potassium hydroxide were used to remove fat from pig skin.

Next, the step of obtaining the primary material is a process in which the primary material is obtained by filtering the primary solution and washing the residue 3 to 5 times with ethanol and then 1 to 3 times with water. Here, the primary material is pre-treated to facilitate collagen extraction by removing fat from pig skin.

Thereafter, the secondary material obtaining step is based on the total weight of the secondary solution, 75 to 90 parts by weight of water, 1 to 10 parts by weight of boric acid, and 5 to 15 parts by weight of the primary material to prepare a secondary solution, followed by filtering the residue is a process of obtaining a secondary material by washing 3 to 5 times with water. Here, the reason for washing after mixing the primary material with the boric acid solution is to neutralize the skin of the pig that has been basified through the above-described process. That is, the base is neutralized with boric acid.

Next, the tertiary material obtaining step is to prepare a tertiary solution by mixing 50 to 70 parts by weight of water and 30 to 50 parts by weight of the secondary material, based on the total weight of the tertiary solution, and then pulverize and centrifuge to obtain the tertiary material as a precipitate It is a process of obtaining, and the fourth solution preparation step is based on the total weight of the fourth solution, 5 to 25 parts by weight of the tertiary material, 55 to 70 parts by weight of tris-buffer, 15 to 35 parts by weight of 4M guanidine It is a process of preparing a fourth solution by stirring for 20 to 30 hours after mixing, and the fourth material obtaining step is to obtain a fourth material by filtering the fourth solution and washing the residue 1 to 5 times with water It is a process.

Here, the tertiary solution is crushed finely so that the secondary material can be well dissolved in acid and then centrifuged. In addition, Tris buffer and guanidine were added to remove proteoglycan and glycol protein from pig skin, and it is preferable that the above-described processes be performed at a temperature of 1 to 5°C. In addition, it is preferable to use a Tris buffer having a pH of 7.4, since it is the most appropriate concentration for biocompatibility.

Next, the fifth solution preparation step is based on the total weight of the fifth solution, 5 to 20 parts by weight of the quaternary material, 30 to 55 parts by weight of 0.5M acetic acid, 30 to 55 parts by weight of 0.2M sodium chloride, 0.1 to 5 parts by weight of pepsin After mixing the parts and stirring for 20 to 30 hours to prepare a 5th solution, the 5th material obtaining step is a 5th material, which is a supernatant from which the precipitate is removed after centrifuging the 5th solution at a speed of 10,000 to 13,000 rpm is the process of obtaining

The fifth solution preparation step is a process of extracting collagen from the inside of pig skin in earnest, and pepsin is a proteolytic enzyme that can remove immunity from pig skin. In addition, the reason for centrifuging the fifth solution is to remove impurities other than collagen.

Next, the sixth solution preparation step is based on the total weight of the sixth solution, after mixing 40 to 50 parts by weight of the fifth material, 40 to 50 parts by weight of 0.5M acetic acid, and 10 to 20 parts by weight of 0.9M sodium chloride, 20 to 30 parts by weight through a cellulose membrane It is a process of preparing a sixth solution by dialysis 3 to 5 times for an hour.

Here, dialysis uses the principle that a colloid or polymer solution is placed in a bag of a semipermeable membrane and suspended in a large amount of solvent or placed in a new solvent that flows continuously, that is, the low molecular weight substance is diffused to the outside through the semipermeable membrane, that is, acetic acid is the solvent Sodium chloride plays a role in controlling the ionic concentration of the solvent. In addition, collagen can be obtained by dialysis so that collagen, which is a polymer material, remains inside the cellulose membrane.

Finally, the collagen completion step is the process of completing collagen by freeze-drying the 6th solution. Collagen produced through this process has the advantage of higher biocompatibility to the human body than collagen extracted from marine organisms, and can be applied to the surface of the thread for improving sexual function to help improve skin elasticity around the treatment site.

In addition, a coating agent is additionally applied to the surface of the mesh body 20 to which the elasticity aid is applied to form a coating layer, and through this, the elastic aid applied to the mesh body 20 surface can be stably fixed. In addition, since the coating agent is biocompatible and biodegradable, it is preferable to be applied to the thread for improving sexual function of the present invention and used, and by fixing the elasticity aid, it can be applied to the local area desired by the operator.

5 is a flowchart showing a method for manufacturing a coating agent of the present invention, such a coating agent can be produced through the first mixed solution preparation step (S520), the second mixed solution preparation step (S521), and the coating agent completion step (S522). have.

First, the first mixed solution preparation step (S520) is based on the total weight of the first mixed solution, 55 to 70 parts by weight of water, 25 to 35 parts by weight of polyvinyl alcohol (Poly (vinyl alcohol)), and polyethylene glycol (Poly (ethylene glycol) )) After mixing 5 to 15 parts by weight, heating to 80 to 95° C. is a process of preparing a first mixed solution. Here, polyvinyl alcohol has excellent mechanical properties and may be solidified later to form a gel-type film. In addition, polyethylene glycol is an additive for inducing intermolecular or intramolecular hydrogen bonding of polyvinyl alcohol chains.

Next, the secondary mixed solution preparation step (S521) is based on the total weight of the secondary mixed solution, 30 to 80 parts by weight of dichloromethane, and 20 to 70 parts by weight of poly(lactic-co-glycolic acid)) As a process of preparing a secondary mixed solution by mixing the parts, it is preferable to prepare by stirring at a speed of 15,000 to 25,000 rpm for 5 to 10 minutes.

Here, dichloromethane serves as a solvent capable of dissolving polylacticcoglycosic acid, and polylacticcoglycolic acid is a biotype polymer that can be simply hydrolyzed without the action of an enzyme in the body and is solidified to form a membrane. have.

Finally, the coating agent completion step (S522) is a process of completing the coating agent by mixing 50 to 70 parts by weight of the first mixed solution and 30 to 50 parts by weight of the second mixed solution based on the total weight of the coating agent. The coating agent completed through this process can be solidified to form a coating film with excellent physical properties, thereby stably fixing the above-described elasticity aid to the surface of the mesh body 20 . In addition, since it is biodegradable and can be naturally decomposed and removed after a certain time elapses in the body, there is an advantage that it can provide convenience.

In addition, the secondary mixed solution of the coating agent may further include acetone and dexamethasone to perform an anti-inflammatory action.

Specifically, the secondary mixed solution containing acetone and dexamethasone is based on the total weight of the secondary mixed solution, 30 to 45 parts by weight of dichloromethane, poly(lactic-co-glycolic acid) ) 20 to 35 parts by weight, 20 to 40 parts by weight of acetone, and 10 to 30 parts by weight of dexamethasone may be a mixture.

Here, acetone serves as a solvent capable of dissolving dexamethasone, and dexamethasone has an anti-inflammatory action, and when the thread for improving sexual function of the present invention is injected into the skin, there is a possibility of inflammation. can help

As described so far, the thread for improving sexual function and the manufacturing method thereof, including the mesh according to the present invention, have been expressed in the above description and drawings, but this is merely an example and the spirit of the present invention is not limited to the above description and drawings. , of course, various changes and modifications are possible without departing from the technical spirit of the present invention.

10: Headquarters 11: Cog
20: mesh
S100: first step S200: second step
S300: third step S400: fourth step
S500: fifth step S510: first solution preparation step
S511: obtaining a first material S512: obtaining a second material
S513: preparing a third solution S514: preparing a fourth solution
S515: Step of obtaining the third material S516: Step of completing the elasticity aid
S520: First mixed solution preparation step S521: Second mixed solution preparation step
S522: coating agent completion stage

Claims (10)

A method for manufacturing a medical thread including a mesh body, the method comprising:
creating a headquarters;
Including; enclosing the head office with a mesh body of a porous structure;
The mesh is
A first step of preparing a spinning solution containing silk and calcium chloride dihydrate;
A second step of drying the spinning solution and then electrospinning to produce a fiber;
After immersing the fiber in any one of methanol and ethanol, heat treatment at 30 to 45° C. for 2 to 6 hours, a third step;
After washing the heat-treated fibers with water 1 to 3 times and then vacuum drying, a fourth step of irradiating radiation for 2 to 10 minutes at 20 to 30° C. while flowing a carbon tetrafluoride (CF ₄ ) gas;
A method of manufacturing a medical thread including a mesh body, comprising a; a fifth step of completing the mesh body through the fiber whose surface is modified. The method of claim 1,
The mesh is
Manufacturing of a medical thread including a mesh body, characterized in that after the elasticity aid containing collagen is applied, a coating agent containing PVA (Poly (vinyl alcohol)) and PEG (Poly (ethylene glycol)) is applied to form a coating layer Way. The method of claim 1,
The spinning solution is
Based on 100 parts by weight of the total spinning solution, 25 to 40 parts by weight of purified silk, 20 to 35 parts by weight of poly(lactide-co-glycolide), hexafluoroisopropanol (1,1,1,3) , 3,3-hexafluoro-2-propanol) is a mixture of 25 to 40 parts by weight,
The refined silk is, relative to 100 parts by weight of the total purified silk, 5 to 15 parts by weight of water, 10 to 25 parts by weight of calcium chloride (CaCl ₂ ), 40 to 60 parts by weight of ethanol (C ₂ H ₅ OH), 10 parts by weight of silk (Silk) To 20 parts by weight of the mixture, filtered and washed with water, the residue, characterized in that prepared by freeze-drying, a method for manufacturing a medical thread including a mesh body. 3. The method of claim 2,
The elasticity adjuvant,
Based on 100 parts by weight of the total first solution, 50 to 60 parts by weight of water, 30 to 40 parts by weight of polyethylene glycol diglycidyl ether, 0.1 to 10 parts by weight of hyaluronic acid After mixing, heating at 50 to 70° C. for 1 to 3 hours to prepare a first solution, a first solution preparation step;
After freeze-drying the first solution at -60 to -40°C, the obtained product is washed 1 to 3 times with water and freeze-dried again to obtain a first material, obtaining a first material;
Based on 100 parts by weight of the total second solution, 70 to 85 parts by weight of a phosphate buffered saline solution of pH 7.4 and 15 to 30 parts by weight of the first material are mixed to prepare a second solution, and then filtered to prepare a second solution. obtaining a second material, obtaining a second material;
A third solution preparation step of preparing a third solution by mixing 100 parts by weight of the total third solution, 90 to 99.9 parts by weight of a pH 3 hydrochloric acid solution, and 0.1 to 10 parts by weight of collagen;
Based on 100 parts by weight of the total fourth solution, 70 to 90 parts by weight of the third solution and 10 to 30 parts by weight of the second material are mixed at 30 to 40° C. for 20 to 30 hours to prepare a fourth solution, a fourth solution manufacturing steps;
Obtaining a third material, obtaining a third material by freeze-drying the fourth solution at -55 to -45°C and then lyophilizing it with water 1 to 3 times and then freeze-drying again;
Based on 100 parts by weight of the total elasticity aid, 5 to 30 parts by weight of the third material and 70 to 95 parts by weight of the phosphate buffered saline solution are mixed to complete the elasticity aid; A method for manufacturing a medical thread. 5. The method of claim 4,
The collagen is
After mixing 100 parts by weight of the total primary solution, 25 to 45 parts by weight of acetone, 25 to 45 parts by weight of water, 1 to 10 parts by weight of potassium hydroxide, 1 to 10 parts by weight of sodium hydroxide, and 20 to 30 parts by weight of pig skin To prepare a first solution by stirring at 5 ° C. for 3 to 10 hours, a first solution preparation step;
After filtering the first solution, the residue is washed 3 to 5 times with ethanol and then 1 to 3 times with water to obtain a first material, obtaining a first material;
Based on 100 parts by weight of the total secondary solution, 75 to 90 parts by weight of water, 1 to 10 parts by weight of boric acid, and 5 to 15 parts by weight of the primary material are mixed to prepare a secondary solution, and then filtered to remove the residue with water 3 to 5 Washing twice to obtain a secondary material, obtaining a second material;
Compared to 100 parts by weight of the total tertiary solution, 50 to 70 parts by weight of water and 30 to 50 parts by weight of the secondary material are mixed to prepare a tertiary solution, and then pulverized and centrifuged to obtain a tertiary material as a precipitate, tertiary obtaining material;
Based on 100 parts by weight of the total quaternary solution, 5 to 25 parts by weight of the tertiary material, 55 to 70 parts by weight of tris-buffer, and 15 to 35 parts by weight of 4M guanidine are mixed for 20 to 30 hours A quaternary solution preparation step of preparing a quaternary solution by stirring;
After filtering the quaternary solution, the residue is washed 1 to 5 times with water to obtain a quaternary material, obtaining a quaternary material;
Based on 100 parts by weight of the total fifth solution, 5 to 20 parts by weight of the quaternary material, 30 to 55 parts by weight of 0.5M acetic acid, 30 to 55 parts by weight of 0.2M sodium chloride, and 0.1 to 5 parts by weight of pepsin are mixed 20 To prepare a fifth solution by stirring for 30 hours, a fifth solution preparation step;
After centrifuging the fifth solution at a speed of 10,000 to 13,000 rpm to obtain a fifth material, which is a supernatant from which the precipitate is removed, a fifth material obtaining step;
Based on 100 parts by weight of the total 6th solution, 40 to 50 parts by weight of the 5th material, 40 to 50 parts by weight of 0.5M acetic acid, and 10 to 20 parts by weight of 0.9M sodium chloride are mixed and then 3 to 5 for 20 to 30 hours through a cellulose membrane Dialysis twice to prepare a sixth solution, a sixth solution preparation step;
Completing collagen by freeze-drying the sixth solution; characterized in that it is produced through, a method of manufacturing a medical thread including a mesh body. 3. The method of claim 2,
The coating agent,
After mixing 55 to 70 parts by weight of water, 25 to 35 parts by weight of poly(vinyl alcohol), and 5 to 15 parts by weight of polyethylene glycol, based on 100 parts by weight of the total primary mixed solution heating to 80 to 95° C. to prepare a first mixed solution, a first mixed solution preparation step;
A second mixed solution is prepared by mixing 30 to 80 parts by weight of dichloromethane and 20 to 70 parts by weight of poly(lactic-co-glycolic acid) relative to 100 parts by weight of the total secondary mixed solution. to, a second mixed solution preparation step;
Compared to 100 parts by weight of the total coating agent, 50 to 70 parts by weight of the first mixed solution, 30 to 50 parts by weight of the second mixed solution to complete the coating; manufacturing method. 7. The method of claim 6,
The second mixed solution is
Additionally comprising acetone and dexamethasone,
Based on 100 parts by weight of the total secondary mixed solution, 30 to 45 parts by weight of dichloromethane, 20 to 35 parts by weight of poly(lactic-co-glycolic acid), 20 to 40 parts by weight of the acetone , The dexamethasone (dexamethasone), characterized in that the mixture of 10 to 30 parts by weight, a method for manufacturing a medical thread including a mesh body. delete delete delete

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