CN115103857B - 表达免疫调节分子的细胞和表达免疫调节分子的系统 - Google Patents

表达免疫调节分子的细胞和表达免疫调节分子的系统

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Publication number
CN115103857B
CN115103857B CN202080090804.9A CN202080090804A CN115103857B CN 115103857 B CN115103857 B CN 115103857B CN 202080090804 A CN202080090804 A CN 202080090804A CN 115103857 B CN115103857 B CN 115103857B
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domain
gly
polypeptide
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CN115103857A (zh
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钱其军
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Shanghai Cell Therapy Group Pharmaceutical Technology Co ltd
Shanghai Cell Therapy Group Co Ltd
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Shanghai Cell Therapy Group Pharmaceutical Technology Co ltd
Shanghai Cell Therapy Group Co Ltd
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4203—Receptors for growth factors
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    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
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    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4214—Receptors for cytokines
    • A61K40/4215—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR], CD30
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4254—Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
    • A61K40/4255—Mesothelin [MSLN]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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CN202080090804.9A 2019-12-28 2020-12-28 表达免疫调节分子的细胞和表达免疫调节分子的系统 Active CN115103857B (zh)

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US201962954448P 2019-12-28 2019-12-28
US62/954,448 2019-12-28
PCT/IB2020/001079 WO2021130535A2 (en) 2019-12-28 2020-12-28 Cell expressing immune modulatory molecules and system for expressing immune modulatory molecules

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CN115103857B true CN115103857B (zh) 2025-12-19

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US (1) US20230058519A1 (enExample)
EP (1) EP4081545A2 (enExample)
JP (1) JP2023515747A (enExample)
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CN116410332B (zh) * 2021-12-29 2025-04-15 上海细胞治疗集团股份有限公司 抗间皮素纳米抗体嵌合抗原受体及其应用
CN118206620A (zh) * 2022-12-09 2024-06-18 上海细胞治疗集团股份有限公司 一种多肽标签及其应用
CN119269786A (zh) * 2023-06-29 2025-01-07 上海细胞治疗集团股份有限公司 一种评估car产生细胞免疫应答的方法
WO2025209437A1 (zh) * 2024-04-02 2025-10-09 原启生物科技(上海)有限责任公司 经修饰的免疫细胞及其用途

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CN108699124A (zh) * 2016-01-21 2018-10-23 辉瑞大药厂 靶向表皮生长因子受体变体iii的嵌合抗原受体
CN110494451A (zh) * 2017-01-13 2019-11-22 塞尔达拉医疗有限责任公司 靶向tim-1的嵌合抗原受体

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WO2007042289A2 (en) * 2005-10-11 2007-04-19 Ablynx N.V. Nanobodies™ and polypeptides against egfr and igf-ir
US9670275B2 (en) * 2012-01-23 2017-06-06 Ablynx N.V. Sequences directed against hepatocyte growth factor (HGF) and polypeptides comprising the same for the treatment of cancers and/or tumors
CN113684185A (zh) * 2013-02-26 2021-11-23 纪念斯隆-凯特琳癌症中心 用于免疫疗法的组合物和方法
WO2015197582A1 (en) * 2014-06-27 2015-12-30 Innate Pharma Monomeric multispecific antigen binding proteins
EP4643874A3 (en) * 2015-12-22 2026-02-11 Novartis AG Mesothelin chimeric antigen receptor (car) and antibody against pd-l1 inhibitor for combined use in anticancer therapy
US20190048085A1 (en) * 2016-02-25 2019-02-14 Cell Medica Switzerland Ag Modified cells for immunotherapy
JP7611705B2 (ja) * 2018-06-22 2025-01-10 ザ ジェネラル ホスピタル コーポレイション Ｃｄ３７及びｃｄ１９を標的とするキメラ抗原受容体
EP3930754A4 (en) 2019-02-27 2023-08-16 Zhejiang Nanomab Technology Center Co. Ltd. HIGH-THROUGHPUT SEQUENCE-BASED PROCEDURE FOR GENERATION OF CAMELID ANTIBODIES TO COVER WIDE EPITOPES WITH HIGH RESOLUTION

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CN108699124A (zh) * 2016-01-21 2018-10-23 辉瑞大药厂 靶向表皮生长因子受体变体iii的嵌合抗原受体
CN110494451A (zh) * 2017-01-13 2019-11-22 塞尔达拉医疗有限责任公司 靶向tim-1的嵌合抗原受体

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CN115103857A (zh) 2022-09-23
US20230058519A1 (en) 2023-02-23
WO2021130535A9 (en) 2021-09-16
EP4081545A2 (en) 2022-11-02
JP2023515747A (ja) 2023-04-14

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