CN115089604A

CN115089604A - A topical lotion for treating dermatoses, and its preparation method

Info

Publication number: CN115089604A
Application number: CN202210831664.7A
Authority: CN
Inventors: 李志鹏
Original assignee: Inner Mongolia Railway Union Industrial Co ltd
Current assignee: Inner Mongolia Railway Union Industrial Co ltd
Priority date: 2022-07-15
Filing date: 2022-07-15
Publication date: 2022-09-23

Abstract

The invention discloses an external emulsion for treating skin diseases and a preparation method thereof, wherein the external emulsion for treating skin diseases comprises a substrate and hydrogen nanobubbles, and the substrate comprises the following components in parts by weight: 20-50 parts of vitamin E and 800-1500 parts of glycerol. Compared with the prior art, the invention has the beneficial effects that at least: the external emulsion disclosed by the invention can enable hydrogen molecules to enter skin tissues by utilizing a nano bubble technology, improve the microenvironment and inflammatory state of the skin, improve peripheral microcirculation, and achieve the purposes of treating and improving skin diseases by compounding the moisture retention and oxidation resistance of vitamin E and glycerol, and has an obvious effect; in addition, the invention does not use the emulsion, has fine texture but not greasy, and the hydrogen nano bubbles form a stable state and are not easy to volatilize, the vitamin E can be prevented from being oxidized, can be stored for a long time, and has obvious antioxidation effect.

Description

A topical lotion for treating dermatoses, and its preparation method

Technical Field

The invention relates to the technical field of skin disease treatment, and particularly relates to an external emulsion for treating skin diseases and a preparation method thereof.

Background

Skin diseases (dermatasis) are a general term for diseases occurring in the skin and its appendages. The skin is the largest organ of the human body, the skin diseases are not only various, but also diseases occurring in various internal organs can be shown on the skin. The skin diseases caused by various reasons, such as skin diseases caused by infection factors, such as leprosy, scabies, mycosis, skin bacterial infection and the like, have certain infectivity, not only affect the physical health, but also cause panic and social discrimination, but with the improvement of the living standard of people and the improvement of scientific and technological processes, the infectious diseases such as leprosy and the like are obviously controlled all over the world. Other internal and external factors causing skin diseases, such as mechanical, physical, chemical, biological, endocrine, and immune factors, are receiving more and more attention at present.

The skin is used as the first physiological defense line and the largest organ of the human body, constantly participates in the functional activities of the body, maintains the unity of opposition between the body and the natural environment, and the abnormal conditions of the body can be reflected on the surface of the skin. The skin has nearly perfect physiological protection function: such as barrier function, sensory function, body temperature regulation, absorption function, secretion and excretion function, etc., and plays an important role in maintaining the health of the body. The physiological function of the skin is impaired, causing skin diseases.

The most common causative factors of skin diseases are infectious diseases and allergic dermatitis, but degenerative changes with aging are also important skin diseases such as senile skin diseases and skin cancer, and various skin disorders causing side effects due to drug treatment of the diseases need to be noted. The method specifically comprises the following steps: 1. physical and chemical factors: skin diseases can be caused by pressure and friction, rapid local temperature change, radiation, light, heat radiation, chemical agents and other factors. Several factors can exacerbate skin disease. Secondary infection such as excessive scratching; hot water scalding, soap washing, improper medication and aggravation of eczema lesion; exposure to light can exacerbate the photosensitive disease. 2. Biological factors: insect bites, contact with certain plants, parasites and microbial infections are common pathogenic factors, such as various viral skin diseases caused by viral infections. 3. Food and other diseases: some foods such as shrimp are susceptible to allergic diseases. Visceral diseases, topical infection, blood and lymph circulation disorder can cause related dermatoses, such as diabetic susceptibility to pruritus, infectious eczema dermatitis caused by topical infection, cyanosis, and plasticization caused by circulatory disorder. 4. Inheritance: some diseases have obvious family history, such as ichthyosis, albinism, etc.

At present, some medicines are mainly used for treating skin diseases, but the medicines can generate certain drug resistance for a long time and have certain side effects.

Disclosure of Invention

The invention aims to provide an external emulsion for treating skin diseases and a preparation method thereof.

In order to achieve the above purpose of the present invention, the following technical solutions are adopted:

the invention provides an external emulsion for treating skin diseases, which comprises a matrix and hydrogen nanobubbles, wherein the matrix comprises the following components in parts by weight:

20-50 parts of vitamin E and 800-1500 parts of glycerol.

Preferably, the content of hydrogen nanobubbles in the external emulsion for treating skin diseases is 7-9 ppm.

Preferably, the matrix comprises the following components in parts by weight:

30 parts of vitamin E and 1000 parts of glycerol.

Preferably, the matrix further comprises: 10-100 parts of distilled water.

Preferably, the matrix comprises the following components in parts by weight:

30 parts of vitamin E, 1000 parts of glycerol and 50 parts of distilled water.

Preferably, the skin disease comprises psoriasis, parapsoriasis, atopic dermatitis, cutaneous T-cell lymphoma, vasculitis, acute pityriasis versicolor, behcet's disease, spotting vasculitis, urticaria vasculitis, su of lichen and chloasma.

In a second aspect, the present invention provides a method for preparing the above external emulsion for treating skin diseases, comprising the steps of:

(a) mixing vitamin E and glycerol, and stirring to obtain mixture;

(b) under the condition of stirring, injecting hydrogen nano bubbles into the mixture by adopting a nano bubble generator to obtain the external emulsion for treating the skin diseases.

Preferably, the particle size of the hydrogen nanobubble is 50-150 nm.

Preferably, the injection time is not less than 30 min.

Preferably, the step (a) further comprises: distilled water was added to the mixture and mixed well.

Compared with the prior art, the invention has the beneficial effects that at least:

the external emulsion disclosed by the invention can enable hydrogen molecules to enter skin tissues by utilizing a nano bubble technology, improve the microenvironment and inflammatory state of the skin, improve peripheral microcirculation, and achieve the purposes of treating and improving skin diseases by compounding the moisture retention and oxidation resistance of vitamin E and glycerol, and has an obvious effect; in addition, the invention does not use the emulsion, has fine texture but not greasy, and the hydrogen nano bubbles form a stable state and are not easy to volatilize, the vitamin E can be prevented from being oxidized, can be stored for a long time, and has obvious antioxidation effect.

The external emulsion can better improve the content of hydrogen nanobubbles for preparing the external emulsion by adjusting the proportion of the raw materials, and further can better improve the curative effect on skin diseases.

Detailed Description

The embodiments of the present invention will be described in detail with reference to the following examples. The following examples are only for illustrating the technical solutions of the present invention more clearly, and therefore are only examples, and the protection scope of the present invention is not limited thereby.

It is to be noted that, unless otherwise specified, technical or scientific terms used herein shall have the ordinary meaning as understood by those skilled in the art to which the invention pertains.

Example 1

External emulsion for treating skin diseases

The external emulsion for treating skin diseases comprises a substrate and hydrogen nanobubbles, wherein the content of the hydrogen nanobubbles is 9 ppm;

the matrix comprises the following components in parts by weight:

20 parts of vitamin E and 800 parts of glycerol.

Second, preparation method

The preparation method of the external emulsion for treating skin diseases comprises the following steps:

(a) mixing vitamin E and glycerol, and stirring to obtain mixture;

(b) under the condition of stirring, injecting hydrogen nano bubbles with the particle size of 50-150 nm into the mixture by using a nano bubble generator for 30min to obtain the external emulsion for treating the skin diseases.

Example 2

External emulsion for treating skin diseases

The topical lotion for treating dermatoses

Comprises a substrate and hydrogen nanobubbles, wherein the content of the hydrogen nanobubbles is 8 ppm;

the matrix comprises the following components in parts by weight:

50 parts of vitamin E and 1500 parts of glycerol.

Second, the preparation method

(a) mixing vitamin E and glycerol, and stirring to obtain mixture;

(b) under the condition of stirring, injecting hydrogen nanobubbles with the particle size of 50-150 nm into the mixture by using a nanobubble generator for 35min to obtain the external emulsion for treating the skin diseases.

Example 3

External emulsion for treating skin diseases

The external emulsion for treating skin diseases comprises a substrate and hydrogen nanobubbles, wherein the content of the hydrogen nanobubbles is 8 ppm;

the matrix comprises the following components in parts by weight:

30 parts of vitamin E and 1000 parts of glycerol.

Second, the preparation method

(a) mixing vitamin E and glycerol, and stirring to obtain mixture;

(b) under the condition of stirring, injecting hydrogen nano bubbles with the particle size of 50-150 nm into the mixture by using a nano bubble generator for 40min to obtain the external emulsion for treating the skin diseases.

Example 4

External emulsion for treating skin diseases

The external emulsion for treating skin diseases comprises a substrate and hydrogen nanobubbles, wherein the content of the hydrogen nanobubbles is 7 ppm;

the matrix comprises the following components in parts by weight:

vitamin E40 parts, glycerol 1200 parts and distilled water 100 parts.

Second, preparation method

(a) mixing vitamin E, distilled water and glycerol, and stirring to obtain mixture;

Example 5

External emulsion for treating skin diseases

the matrix comprises the following components in parts by weight:

30 parts of vitamin E, 1000 parts of glycerol and 50 parts of distilled water.

Second, preparation method

The method for detecting the content of the hydrogen nanobubbles in the external emulsion of each embodiment is as follows:

putting the nano-bubble hydrogen-rich vitamin E glycerol into a closed container, and firstly heating to increase the vibration strength to quickly release hydrogen in the nano-bubbles; then, the released hydrogen is measured by adopting a gas chromatography, and the concentration of the hydrogen in the nanobubble hydrogen-rich vitamin E glycerol is calculated.

Case 1

Introduction of disease conditions: the patients, male, 36 years old, bed sore patients for long-term bed rest, skin itch, ulceration, multiple medication does not improve.

The treatment process comprises the following steps: the external emulsion prepared in example 5 was applied 3 to 5 times a day.

The treatment results are as follows: after 1 month, the rash and the bedsore basically subside, the patient complaints of pruritus and relieves and the sleep quality is improved.

Case 2

Introduction of disease conditions: li Shi, male, 50 years old, will be diagnosed with a disease aggravated by "every month with skin rash and desquamation itching for five years". The patient initially has red rash with coin size on the dorsal side of the elbow joints at both sides, has white scales on the surface without obvious discomfort, and only externally coats the ointment until the rash is relieved in summer next year. After that, the disease condition is repeated, the disease is mild and heavy, the rash is gradually expanded when the disease is induced by cold in winter, the rash involves the scalp, the trunk and the lower legs, and the skin is dry and itchy, so the psoriasis is diagnosed.

The treatment process comprises the following steps: in view of the fact that blood pressure, blood sugar, blood fat and blood uric acid of a patient are increased in different degrees, the patient is willing to take traditional Chinese medicine treatment, then oral traditional Chinese medicine decoction for cooling blood and detoxifying, purging liver and clearing heat is given, compound glycyrrhizin and Xiyanping injection is intravenously dripped, meanwhile traditional Chinese medicine fumigation and ultraviolet physical treatment are matched, calcipotriol ointment is externally applied, then rash is aggravated in red color and swelling is enlarged, namely the traditional Chinese medicines 'folium isatidis cream' and urea cream are externally applied, the patient is continuously treated for 2 weeks, the condition of the patient is gradually stabilized, a small amount of new eruptions and burning itching are relieved, dry skin and desquamation are still remained, particularly, the patient is written before legs, scratching bleeding occurs, the blood pressure is slightly high, and the reexamination of the blood sugar, the blood fat and the blood uric acid is still abnormal. It is recommended to apply the external lotion prepared in example 5 to the affected part of the skin 3 to 5 times a day for 1 month since 1 month and 16 days 2022.

The treatment results are as follows: the rash basically subsided after 3 months into spring in 2022 years, the disease condition is basically stable, and the physical examination is repeated to check the functions of liver and kidney, the hematuria is normal, and the CEA and AFP are normal.

Case 3

Introduction of disease conditions: patients, male, 45 years old, suffer from psoriasis for more than ten years, have used various oral medicines including abamectin A, cyclosporine and the like during the period, cause blood fat increase and lower limb venous thrombosis, and have been treated by surgical embolectomy and thrombolysis; no improvement in rash was observed after using the recombinant human type 2 tumor necrosis factor receptor antibody fusion protein for injection (Yisaipu); meanwhile, topical zinc pyrithione aerosol (suitable for the current) and a large amount of corticosteroid ointment cause local skin thinning and wide expansion of capillary vessels. Administration after the initial visit in 2021: methotrexate, XIAOYIN mixture (Chinese patent medicine produced by Huashan Hospital), and compound glycyrrhizin tablet (MEINTENG) for oral administration; coating the moisturizing cream; regular follow-up visits to blood routine and liver and kidney function. The red spot-type rash still spreading on the trunk and limbs is observed in the 12-month reexamination in 2021, accounts for more than 50% of the body surface area, tends to increase day by day and is accompanied with severe pruritus.

The treatment process comprises the following steps: the external emulsion prepared in example 5 was applied 3 to 5 times a day for 2 months from 1 st ten days in 2022 on the basis of the original treatment.

The treatment results are as follows: after 2 months, the rash of the patient is improved; the rash is nearly eliminated, the original pruritus is obviously relieved, and the subjective quality of life (including sleep and mood) of the patient is obviously improved.

Case 4

Introduction of disease conditions: patient, female, year 50, with a history of arthropathic psoriasis for years. The rash recurred 12 months and 16 days in 2021, the red swelling and pain of the toe joints can not be normally worn and stretched, the red plaque of the limbs is accompanied by the scale, the red swelling of the toe joints of both feet is accompanied by the tenderness, and the traditional treatment is adopted.

The treatment process comprises the following steps: conventional treatments were not improved and presented with joint deformities. The external emulsion prepared in example 5 was applied 3 to 5 times a day from 2022 months.

The treatment results are as follows: the skin rash and the joint swelling and pain of the patient are both obviously improved, and then the patient receives the treatment of the nano bubble hydrogen-rich vitamin E glycerol for a long time. After the patient is treated by the nano-bubble hydrogen-rich vitamin E glycerol, the joint swelling and pain basically subsides, the psoriasis skin rash subsides ideally, and the patient wears the short sleeve which is not worn for many years in summer. It is very pleasing due to the improvement of skin smoothness and the regression of pigmentation.

Case 5

Introduction of disease conditions: patients and women, 58 years old and 2020, have the symptoms of pain and swelling of the left upper limb after breast cancer operation, no dressing, obvious increase of myocardial zymogram indexes shown by laboratory indexes, myogenic damage prompted by electromyography, and dermatomyositis diagnosis considered by the outside hospital. The body was examined to show dark purple red spots around the orbit, erythema, pigmentation and telangiectasia (heterosis-like rash) on the face and back, and the left upper limb was obviously thickened, swollen and difficult to ascend, and four limbs muscle strength were examined. Consider paraneoplastic dermatomyositis and lymphedema after surgery for left upper limb breast cancer.

The treatment process comprises the following steps: given methylprednisolone 4-grain and large-dose intravenous gamma globulin shock therapy, muscle symptoms are obviously improved, but lymphedema and skin heterosis changes cannot be relieved. The application of the external emulsion prepared in example 5 was administered 3 to 5 times a day from 11 months of 2021.

The treatment results are as follows: by 2022 years, the lymphedema in the left upper limb of the patient resolved in 5 months (6 months of treatment), and the skin pigment was also near normal. The skin heterochromosis-like rash is also well-documented, and the skin presents normal skin color. The nano bubble hydrogen-rich vitamin E glycerin proves good anti-inflammatory, penetrability and oxidation resistance again, and provides a new method for treating lymphedema and skin rash of dermatomyositis patients which are difficult to solve after surgical operations.

Case 6

Introduction of disease conditions: the patient was male, 48 years old. In 2018, the trunk appears white spots and gradually expands, and the disease is diagnosed as 'leucoderma' in a hospital, and corresponding treatment is given, which is not detailed. The patients have intermittent treatment for years, repeated disease conditions and gradually enlarged leukoplakia area. The patients have large leukoplakia on the neck, chest, armpit, abdomen, hands and inner side of thigh, the white spot boundary is clear, and occupies about 30% of the body surface area. Patients complain about no systemic treatment for many years, and the area of the white spot has stabilized for several years, and whether a new treatment method exists is inquired. The patient is recommended to try to treat the leucoderma by the nano bubble hydrogen-rich vitamin E glycerin.

The treatment process comprises the following steps: the patient should apply the external lotion prepared in example 5 3-5 times a day from 9 months of 2021.

The treatment results are as follows: after 2 months of treatment, the disease condition of the patient is obviously improved, and the normal skin color is gradually recovered.

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; such modifications and substitutions do not depart from the spirit and scope of the present invention, and they should be construed as being included in the following claims and description.

Claims

1. The external emulsion for treating the skin diseases is characterized by comprising a substrate and hydrogen nanobubbles, wherein the substrate comprises the following components in parts by weight:

20-50 parts of vitamin E and 800-1500 parts of glycerol.

2. The external emulsion for treating skin diseases according to claim 1, wherein the content of hydrogen nanobubbles in the external emulsion for treating skin diseases is 7 to 9 ppm.

3. The topical lotion for treating skin disorders according to claim 1, wherein said base comprises the following components in parts by weight:

30 parts of vitamin E and 1000 parts of glycerol.

4. The topical lotion for treating skin disorders according to claim 1, further comprising in said matrix: 10-100 parts of distilled water.

5. The topical lotion for treating skin disorders according to claim 4, wherein said base comprises the following components in parts by weight:

30 parts of vitamin E, 1000 parts of glycerol and 50 parts of distilled water.

6. The topical emulsion for the treatment of skin diseases according to claim 1, characterized in that the skin diseases comprise psoriasis, parapsoriasis, atopic dermatitis, cutaneous T-cell lymphoma, vasculitis, acute pityriasis versicolor, behcet's disease, vasculitis pigmentosa, urticaria vasculitis, SU.

7. A method for preparing an external emulsion for treating skin diseases according to any one of claims 1 to 6, comprising the steps of:

(a) mixing vitamin E and glycerol, and stirring to obtain mixture;

(b) under the condition of stirring, injecting hydrogen nanobubbles into the mixture by using a nanobubble generator to obtain the external emulsion for treating the skin diseases.

8. The method according to claim 7, wherein the hydrogen nanobubbles have a particle diameter of 50 to 150 nm.

9. The method of claim 7, wherein the injection time is not less than 30 min.

10. The method according to claim 7, wherein the step (a) further comprises: distilled water was added to the mixture and mixed well.