CN109260416A - It is a kind of for alleviating the spontaneous heating ooze medicine paste of qi stagnation and blood stasis type pain in back and loin - Google Patents

It is a kind of for alleviating the spontaneous heating ooze medicine paste of qi stagnation and blood stasis type pain in back and loin Download PDF

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CN109260416A
CN109260416A CN201811177962.9A CN201811177962A CN109260416A CN 109260416 A CN109260416 A CN 109260416A CN 201811177962 A CN201811177962 A CN 201811177962A CN 109260416 A CN109260416 A CN 109260416A
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parts
ooze
spontaneous heating
stagnation
loin
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乔野
张立德
成泽东
程岩岩
董佳梓
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Liaoning University of Traditional Chinese Medicine
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Liaoning University of Traditional Chinese Medicine
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
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    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H39/00—Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
    • A61H39/06—Devices for heating or cooling such points within cell-life limits
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    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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Abstract

The present invention relates to science of TCM formulas and pharmaceutics of Chinese drugs field, and in particular to utilizes ooze in conjunction with Chinese medicinal formulae to kind, alleviates the spontaneous heating ooze medicine paste of pain in back and loin for qi stagnation and blood stasis type.Spontaneous heating ooze medicine paste in the present invention, is divided into medical ointment plaster and spontaneous heating material upper layer and lower layer, and ooze and traditional Chinese medicine ingredients are wherein contained in medical ointment plaster, and the mass ratio of the ooze and traditional Chinese medicine ingredients is 1:1.The spontaneous heating ooze medicine paste has effects that alleviation qi stagnation and blood stasis type pain in back and loin, can replace the product of traditional moxibustion, easy to use, easy to carry, significant in efficacy, can be in and enjoy ooze moxibustion.

Description

It is a kind of for alleviating the spontaneous heating ooze medicine paste of qi stagnation and blood stasis type pain in back and loin
Technical field
The invention belongs to science of TCM formulas and pharmaceutics of Chinese drugs field, and in particular to a kind of to utilize ooze and Chinese medicinal formulae knot It closes, for alleviating the spontaneous heating ooze medicine paste of qi stagnation and blood stasis type pain in back and loin.
Background technique
Traditional Chinese Medicine think life rely yang-energy be it is basic, obtain its then life insurance, lose its then people die young, therefore yang disease then yin excess, Yin excess is then cold, or first deficiency of vital energy is fallen into, and weak pulse is intended to take off, at this point, the yang-energy that will be collapsed with moxibustion come temperature compensation.According to Chinese medicine meridian theory And holographic theory, it is believed that physiological function can be adjusted by Moxa, improve immune function, reach keep fit and healthy, the mesh of disease-prevention health 's.Hot moxibustion is one kind of moxibustion in acupuncture system, is listed as the big therapy of Chinese medicine three with decoction of medicinal ingredients, needle thorn, oneself has thousands of years so far History, the unearthed the Spring and Autumn and the Warring States Periods book copied on silk " sufficient 11 arteries and veins moxibustion warp of arm " " 11 arteries and veins moxibustion warp of yin-yang " in Mawangdui is just about moxibustion therapy Record.Ancient Chinese medicine doctor has the greatest esteem " Ling Shu Miraculous Pivot or Divine Axis function " cloud to moxibustion therapy: " needle is not that the institute of moxibustion is suitable ", " Bian Que's heart book " is said: " method saved one's life, moxibustion the first ", " Elementary Medicine " then emphasize " all disease medicines it is too late, needle less than, it is necessary to moxibustion it ".
Traditional puncture is all to make heater with wormwood, but use inconvenience, because of its slow, inefficient, cigarette of burning Mist is larger, pungent, smoked eye, the defects of being easy to burn, is inconvenient.And in the cigarette that ends phenol, catechol hydroquinone etc. at Certain toxicity is had when point high concentration.There is scholar to carry out environmental monitoring to moxa-moxibustion consulting room, discovery moxa-moxibustion product is to environment sky Gas generates certain influence, and indoor PM10 content is examined in increase, and fine grained especially offspring occupies in moxa-moxibustion consulting room PM10 Sizable ratio, 10 concentration of moxa-moxibustion consulting room PM are more than hospital's waiting room sanitary standard (GB 9671-1996).Modern biotechnology doctor It learns and thinks that moxa-moxibustion is the heat radiation stimulation based on infrared, next is only drug effect, i.e. the essence of moxibustion is a kind of warm thorn It is sharp as a result, by stimulation skin receptor, the function of excitation and adjustment nervous system.
There are many type of hot moxibustion patch currently on the market, and the work of eliminating cold to stop pain is mainly reached using the heat that its hot moxibustion is pasted With because its therapeutic effect is single, therefore not being widely popularized in clinic.
Ancients' cloud: " master of the native person five-element, female body.Water is the source of ten thousand changes, and soil is the universal mother.Former times people distinguishes nine divisions of China in remote antiquity Water and soil, to distinguish that the beauty of people dislikes the longevity day ".At all times, it is often cured the disease with soil, also with soil skin maintenance and cosmetic benefits.Ooze is a kind of deep-sea Minerals mud, includes a variety of needed by human body biotic components and minerals abundant, and distinctive cavernous structure has suction free from worldly cares Attached ability.The complex compound formed under organic matter with more biological originality can be complexed, it is easier to by flesh in minerals in ooze Skin is absorbed and is utilized, and mineral active ingredient has physiotherapy function to various skin diseases;It is promoted blood circulation, is increased by ion-permeable Into metabolism, skin impurities are excluded, restore skin elasticity.Ooze can also discharge a large amount of far infrared, the minerals that include, Bentonite ingredient in algae element and cosmetic composition, is beneficial to beautifying skin, prevents skin aging, contract skin pore. It can be said that ooze is the superfine product in natural beauty and skin care.But ooze combination Chinese medicine external field is had not been reported.Inventor Long campaigns find there is preferable clinical effectiveness in terms of ooze combination compound of Chinese herbal medicine soft tissue pain in clinical position. If can not only increase curative effect in conjunction with ooze Chinese medicine compound prescription using the heat that hot moxibustion is pasted, and easy to carry, it is easy to connect By.
Summary of the invention
The purpose of the present invention is to provide a kind of oozes to combine with Chinese medicine and is fabricated to hot moxibustion patch, has and alleviates qi depression to blood stasis The effect of type pain in back and loin, can replace the product of traditional moxibustion, easy to use, easy to carry, significant in efficacy, can be in Enjoy ooze moxibustion.
To achieve the above object, the present invention adopts the following technical scheme: one is alleviate qi stagnation and blood stasis type pain in back and loin Spontaneous heating ooze medicine paste is divided into ointment layer and spontaneous thermosphere upper layer and lower layer, and ooze and traditional Chinese medicine ingredients are wherein contained in medical ointment plaster, The ooze and the mass ratio of traditional Chinese medicine ingredients are 1:1, deep-sea of the ooze of the present invention both from Yingkou Bohai Offshore Ooze.
The traditional Chinese medicine ingredients are made of the raw material of following parts by weight: 2-6 parts of turmeric, 2-6 parts of the root of Dahurain angelica, 2-6 parts of radix saposhnikoviae, 2-6 parts of myrrh, 2-6 parts of rheum officinale, 1-4 parts of gentianae macrophyllae, 2-6 parts of rhizoma corydalis, 2-6 parts of Radix Notoginseng, 6-10 parts of peach kernel, 2-6 parts of safflower, olibanum 2-6 parts, 1-4 parts of curcuma zedoary, 1-2 parts of asarum, 1-3 parts of borneol, 2-6 parts of Radix Angelicae Sinensis, 3-9 parts of lycopodium calvatum.
Compatibility paraphrase of the invention: the party is by 4 parts of turmeric, 4 parts of the root of Dahurain angelica, windproof 4 parts, 4 parts of myrrh, 4 parts of rheum officinale, gentianae macrophyllae 2 Part, 4 parts of rhizoma corydalis, 4 parts of Radix Notoginseng, 8 parts of peach kernel, 4 parts of safflower, 4 parts of olibanum, 2 parts of curcuma zedoary, 1 part of asarum, 1.5 parts of borneol, radix achyranthis bidentatae 2 Part, 6 parts of lycopodium calvatum.Composition, has the effect of activating microcirculation and removing stasis medicinal, eliminating cold to stop pain.Using turmeric as monarch drug in a prescription in side, turmeric nature and flavor are pungent, it is bitter, Temperature；Return liver, the spleen channel.Breaking blood and promoting the circulation of qi, it is inducing meastruation to relieve menalgia, match the root of Dahurain angelica, radix saposhnikoviae, plays expel pathogenic wind from the body surface altogether, expel endogenous wind to relieve convulsion, peach kernel, safflower, three Seven temperature three-way meridians, especially with the logical four limbs passages through which vital energy circulates of temperature, Chinese angelica blood supplementing, gas is light and pungent, thus again can promoting circulation of blood, bowl spares has, have benefit in row, For the key medicine in blood.Thus, it can enrich blood and invigorate blood circulation, not only can promoting menstruation, but also can be active.Olibanum, curcuma zedoary: blood-activating and qi-promoting stops Bitterly, clearing stagnation and killing pain.Asarum: relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping.Lycopodium calvatum: bitter, micro-pungent, it is warm-natured.Liver,spleen,kidney warp.For joint Ache, joint stuffiness.Assistant is with borneol: it is arduous, it is cool.Heat-clearing dissipates poison dissipates fire removing toxic substances.To take a broad view of full side, temperature three-way meridian is played altogether, is invigorated blood circulation The function of dissolving stasis, for qi stagnation and blood stasis type pain in back and loin.Rationally, medicine card is consistent complete square compatibility 5, therefore rapid-action, clinical symptoms and sign It is relieved.
The preparation method of the Chinese medicine preparation, includes the following steps.
Step 1, pretreatment: get material with production ordering and check material code name, the name of an article, specification, number and weight etc., And carry out coat and disinfection.
Step 2, drying: weighing ooze and the prepared slices of Chinese crude drugs respectively, be dried, and drying temperature is controlled at 35-40 DEG C.
Step 3, Cheng Fen: ooze and the prepared slices of Chinese crude drugs are put into pulverizer break into ooze powder and Chinese medicine powder, sample respectively Sieve is 200 mesh.
Step 4, at cream: by medical pressure-sensing plaster glue be heated to 130 DEG C melt after, be successively put into Chinese medicine powder and ooze powder Agent is made ointment and is put into seepage-proofing ring.
Step 5, mixing filling: by the medical ointment plaster and spontaneous heating packet (iron powder (Fe), activated carbon (C), nothing in step 4 Machine salt (NaCl), water (H2O), oxygen (O2), vermiculite (Mg0.5(H2O)4Mg3[ AlSi3O10(OH)2), water-absorbing resins Mixing) (Hebei Hou De Chinese prescription Medical Treatment Equipment Co., Ltd is provided) be pasted together.
Step 6 is heat-shrinked: ready-made inner wrapping product being accomplished fluently the corresponding date of manufacture, packaging film is packaged and is heat-shrinked.
Step 7, storage: finished product is put into the product qualification area of storehouse.
The pharmacological action of traditional Chinese medicine ingredients is as follows.
Turmeric: arduous, temperature.Major function: blood-breaking, promoting the circulation of qi, promoting menstruation, analgesic.
The root of Dahurain angelica: warm-natured, acrid flavour, gas fragrance, slight bitter.Major function: wind-damp dispelling, apocenosis of invigorating blood circulation, myogenic pain relieving.
Radix saposhnikoviae: acrid flavour, sweet, slightly warm in nature.It expels pathogenic wind from the body surface, the effect of expel endogenous wind to relieve convulsion, relieving convulsion.
Myrrh: acrid flavour, hardship, it is mild-natured.Scattered stasis pain, detumescence and promoting granulation.
Rheum officinale: bitter and micro-puckery.With attacking stagnant, clearing away damp-heat, purging intense heat, cool blood, dissolving stasis, removing toxic substances and other effects.
Gentianae macrophyllae: it is pungent, bitter, it puts down.Return stomach, liver, gallbladder channel.Wind-damp dispelling, clearing away damp-heat, stopping numbness pain.
Rhizoma corydalis: pungent；It is bitter；Temperature；Liver；Stomach；The heart；Lung；The spleen channel.Promoting blood circulation；Dissipate the stasis of blood；Qi-regulating；Analgesic.
Radix Notoginseng: sweet, slight bitter, temperature.Return liver, stomach meridian.Dissipating stasis and stanching bleeding, detumescence ding-tong.
Peach kernel: bitter, sweet, flat.Return heart, liver, large intestine channel.Promoting blood circulation, relax bowel and defecation is relieving cough and asthma.
Safflower: nature and flavor: acrid in flavour and warm in nature.Channel tropism: enter the heart, Liver Channel.Major function: blood circulation, stasis eliminatings analgesic.
Olibanum: pungent, bitter, temperature.Return heart, liver, the spleen channel.Blood-activating and qi-promoting analgesic, detumescence and promoting granulation.
Curcuma zedoary: pungent, bitter, temperature.Return liver, the spleen channel.Breaking blood and promoting the circulation of qi, clearing stagnation and killing pain.
Asarum: acrid in flavour and warm in nature.Return heart, lung, kidney channel.Relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping is sensible, warming lung and resolving fluid.
Radix Angelicae Sinensis: nature and flavor: sweet, pungent, warm.Channel tropism: return liver, the heart, the spleen channel.Major function: Radix Angelicae Sinensis is sweet in flavor and weighs, therefore can specially mend Blood, gas is light and pungent, thus again can promoting circulation of blood, bowl spares has, has benefit in row, is the key medicine in blood.Thus, it can enrich blood and Promoting blood circulation, not only can promoting menstruation, but also can be active.
Lycopodium calvatum: bitter, micro-pungent, it is warm-natured.Liver,spleen,kidney warp.For joint pain, joint stuffiness.
Borneol: it is arduous, it is cool.Enter the heart, Liver Channel.Lead to all keys, dissipate stagnated fire, go screen improving eyesight, swelling and pain relieving, heat-clearing dissipates poison dissipates fire Removing toxic substances.
The present invention is to provide the Chinese medicine preparations for alleviating qi stagnation and blood stasis type pain in back and loin, according to the combination principle of traditional Chinese medicine, Nine traditional Chinese medicines are subjected to prescription, effectively enhances original drug effect of each ingredient, each ingredient is made to complement each other, good collaboration is generated and makees With.In addition, raw material used in the Chinese medicine preparation derives from the genunie medicinal materials of " Chinese Pharmacopoeia ", toxic side effect is small.By a large amount of Clinical test confirms that the above recipe combination TDP irradiation has apparent relaxation effect for soft tissue pain.By inventor's Improvement effective prescription, ooze and spontaneous heating body triplicity together, not only will have the function that treat disease, but also side above Just the use of patient has potential social benefit.
Specific embodiment
Embodiment 1.
It is a kind of for alleviating the spontaneous heating ooze medicine paste of qi stagnation and blood stasis type pain in back and loin, the medicine paste is divided into medical ointment plaster With spontaneous heating material upper layer and lower layer, ooze and traditional Chinese medicine ingredients, the quality of the ooze and traditional Chinese medicine ingredients are contained in the medical ointment plaster Than for 1:1.The traditional Chinese medicine ingredients are made of the raw material of following parts by weight: 2 parts of turmeric, 2 parts of the root of Dahurain angelica, windproof 2 parts, myrrh 2 Part, 2 parts of rheum officinale, 1 part of gentianae macrophyllae, 2 parts of rhizoma corydalis, 2 parts of Radix Notoginseng, 6 parts of peach kernel, 2 parts of safflower, 2 parts of olibanum, 1 part of curcuma zedoary, 1 part of asarum, 1 part of borneol, 2 parts of Radix Angelicae Sinensis, 3 parts of lycopodium calvatum.The preparation method of the Chinese medicine preparation, includes the following steps.
Step 1, pretreatment: get material with production ordering and check material code name, the name of an article, specification, number and weight etc., And carry out coat and disinfection.
Step 2, drying: weighing ooze and the prepared slices of Chinese crude drugs in proportion respectively, be dried, and drying temperature control exists 35-40℃。
Step 3, Cheng Fen: ooze and the prepared slices of Chinese crude drugs are put into pulverizer (Yongli YF10-1) respectively break into ooze powder and Chinese medicine powder, sample sifter are 200 mesh.
Step 4, at cream: by medical pressure-sensing plaster glue be heated to 130 ° melt after, be successively put into Chinese medicine powder and ooze powder Agent is made ointment and is put into 6 × 9cm seepage-proofing ring.
Step 5, mixing filling: by the medical ointment plaster and spontaneous heating packet (iron powder (Fe), activated carbon (C), nothing in step 4 Machine salt (NaCl), water (H2O), oxygen (O2), vermiculite (Mg0.5(H2O)4Mg3[ AlSi3O10(OH)2), water-absorbing resins Mixing) (Hebei Hou De Chinese prescription Medical Treatment Equipment Co., Ltd is provided) be pasted together.
Step 6 is heat-shrinked: ready-made inner wrapping product being accomplished fluently the corresponding date of manufacture, heat shrink films is packaged and carries out hot receipts Contracting (capable 14885).
Step 7, storage: finished product is put into the product qualification area of storehouse.
Embodiment 2.
It is a kind of for alleviating the spontaneous heating ooze medicine paste of qi stagnation and blood stasis type pain in back and loin, the medicine paste is divided into medical ointment plaster With spontaneous heating material upper layer and lower layer, ooze and traditional Chinese medicine ingredients, the quality of the ooze and traditional Chinese medicine ingredients are contained in the medical ointment plaster Than for 1:1.The traditional Chinese medicine ingredients are made of the raw material of following parts by weight: 4 parts of turmeric, 4 parts of the root of Dahurain angelica, windproof 4 parts, myrrh 4 Part, 4 parts of rheum officinale, 2 parts of gentianae macrophyllae, 4 parts of rhizoma corydalis, 4 parts of Radix Notoginseng, 8 parts of peach kernel, 4 parts of safflower, 4 parts of olibanum, 2 parts of curcuma zedoary, asarum 1.5 Part, 2 parts of borneol, 4 parts of Radix Angelicae Sinensis, 6 parts of lycopodium calvatum.The preparation method is the same as that of Example 1.
Embodiment 3.
It is a kind of for alleviating the spontaneous heating ooze medicine paste of qi stagnation and blood stasis type pain in back and loin, the medicine paste is divided into medical ointment plaster With spontaneous heating material upper layer and lower layer, ooze and traditional Chinese medicine ingredients, the quality of the ooze and traditional Chinese medicine ingredients are contained in the medical ointment plaster Than for 1:1.The traditional Chinese medicine ingredients are made of the raw material of following parts by weight: 6 parts of turmeric, 6 parts of the root of Dahurain angelica, windproof 6 parts, myrrh 6 Part, 6 parts of rheum officinale, 4 parts of gentianae macrophyllae, 6 parts of rhizoma corydalis, 6 parts of Radix Notoginseng, 10 parts of peach kernel, 6 parts of safflower, 6 parts of olibanum, 4 parts of curcuma zedoary, asarum 2 Part, 3 parts of borneol, 6 parts of Radix Angelicae Sinensis, 9 parts of lycopodium calvatum.The preparation method is the same as that of Example 1.
4 Clinical control experiment of embodiment.
Applicant by the way that 75% alcohol is merged the study found that the Chinese medicinal formulae of embodiment 1 is broken into after powder, in conjunction with TDP irradiation makes it play activating microcirculation and removing stasis medicinal, the effect of eliminating cold to stop pain, can get good curative effect, but inconvenient to use.To understand Certainly above-mentioned technical problem, applicant combine Chinese medicinal formulae with ooze and spontaneous material, use simple and convenient, and effect is aobvious It writes, can easily be in and enjoy ooze moxibustion.
This research collect 40 qi stagnation and blood stasis type lumbago cases, be in March, 2017 in December, 2017 in our hospital's bone Section's consulting patients in out-patient department, treatment group's patient age 22-57 years old, average (39.90 ± 9.65) year, it is the course of disease 2-33 months, average (11.00 ± 7,78) a month, treatment group is using ooze medicine paste made from embodiment 1.
Control group patient age 20-52 years old, average (38.35 ± 8.75) year, the course of disease 2-36 months, it is average (11.60 ± 8.72) a month, control group added the moxibustion of promoting flow of qi and blood circulation class Chinese medicinal composition to paste using ooze, composition: 4 parts of turmeric, safflower 4 Part, 4 parts of rhizoma corydalis, 2 parts of olibanum, 2 parts of myrrh, 6 parts of lycopodium calvatum, 4 parts of Radix Curcumae, 4 parts of green peel, 2 parts of the dried immature fruit of citron orange, 4 parts of radix aucklandiae, rhizoma cyperi 2 Part, 2 parts of Rhizoma Chuanxiong, 2 parts of orange peel, 4 parts of citron, 2 parts of Radix Glycyrrhizae.The same treatment group of production method.
All patients approve through the court's Medical Ethics Committee, and patient signs informed consent form.By completely random number Word table method is divided into treatment group (20), control group (20).Two groups of Genders, age, course of disease comparing difference are anticipated without statistics Adopted (equal P > 0.05), is comparable.It is shown in Table 1..
1.2 case inclusion criterias.
1.2.1 diagnostic criteria.
Referring to Standards for Diagnosis and Curative Effect of Chinese Medical Symptom: (1) can have the diseases such as malpractice, strain or affection of exogenous wind-cold after wound History；(2) back is ached, and muscle rigidity sends out plate, has sense of heaviness, pain is often related with Changes in weather, can make after rainy days and fatigue Exacerbation of symptoms；(3) back has fixed tender point or tenderness relatively broad；(4) muscle of back deadlock is obstructed, normal along musculus sacrospinalis direction of travel It can contact streak change, normal (5) x ray photograph checks no positive sign to back functional activity mostly；(6) back plate is hard from morning Shouting pain mitigates after activity.Dark purple tongue, or have ecchymosis, stringy and tense pulse or puckery.
1.2.2 it is included in standard.
(1) meet above-mentioned diagnostic criteria；(2) age 18-80 years old；(3) research and signature informed consent form person are voluntarily participated in.
1.2.3 exclusion criteria.
(1) diagnostic criteria is not met；(2) age is in under-18s or 80 years old or more；(3) with serious cardiovascular, liver, kidney And the patient of disease of hematopoietic system；(4) suffer from the Diseases such as fracture, spondylolishesis, tumour；(5) gestational patients；(6) skin mistake Quick history person.
1.2.4 standard is rejected.
It has been included in research patient, has met with the next item down, should reject: (1) mistaken diagnosis；(2) take disabling therapy cannot be objectively Evaluate curative effect person；(3) not curer on time.
1.2.5 blind design and implementation.
This research is blind using patient, i.e., which kind for the treatment of method patient does not know using.By third party carry out therapeutic evaluation and Statistical procedures.
2 therapeutic schemes.
2.1 treatment groups: it is pasted using ooze moxibustion of the invention, the specific method is as follows.
It takes a little: taking patient's tender point.
Operating method: patient lies prone position, disinfection, patient's local skin are externally applied to part without red and swollen heat pain, by ooze moxibustion patch. It treats within 1 day 1 time, treats 14 times altogether.
2.2 control groups: the same treatment group for the treatment of method.
3 observation of curative effect.
3.1 observation index.
Before record treatment, 1 week after treatment, 1 month, 3 months, 6 months visual simulation amounts scoring (visual Analogue scale, VAS)；The efficacy evaluation for treating latter 3 months, 6 months；Observe adverse reaction a situation arises (skin mistake Quick, skin lesion, infection etc.).
3.2 efficacy assessment standard.
Referring to Standards for Diagnosis and Curative Effect of Chinese Medical Symptom, cure: pain in the loins symptom disappears, and waist activity is freely.Improve: pain in the loins subtracts Gently, waist movable function restores substantially.Be not cured: symptom does not improve.
Therapeutic evaluation is carried out after treatment is finished and is recorded.
4 statistical procedures.
Related data is handled using SPSS20.0 statistical software, measurement data mean ± standard deviation (x ± s) indicates, in full According to normal distribution is met, compare between group using independent samples t test, comparison in group is carried out using paired-sample t test, with P < 0.05 is that difference is statistically significant；If data do not meet normal distribution, examined using Mann-whitney U between carrying out group Comparison, Wilcoxon inspection carry out comparison in group, are that difference is statistically significant with P < 0.05.
5 treatment results.
VAS scoring and ODI value compare before two groups of patients treat, no significant difference (P > 0.05)；With ratio before treatment Compared with each time point VAS scoring and ODI value reduce after two groups of patient's treatments, and difference is statistically significant (P < 0.05)；Two groups Each time point VAS scoring and ODI value compare after treatment, and treatment group is superior to control group (P < 0.05), is shown in Table 2,3.Two groups of patients Curative effect compares after treatment 3 months, 6 months, and difference is statistically significant (P < 0.05), is shown in Table 4.Two groups of adverse reaction knots Fruit shows that control group has 1 patient treatment local skin allergy occur, and treatment group has no obvious adverse reaction.
Note: compared with treatment group is preceding with treatment in control group group,*P <0.05；Treatment group and control group each time point same period Compare,#P <0.05。
Note: compared with treatment group is preceding with treatment in control group group,△P <0.05；Treatment group and control group each time point same period Compare,#P <0.05。
Note: concurrent treatment group compared with the control group, P < 0.05.
6 discuss.
This result of study display, application ooze moxibustion of the present invention patch patient treatment after each time point VAS score and ODI value is lower than before treating, and the VAS scoring of each time point for the treatment of group is significantly better than that control group with ODI index, after treatment 6 months total effective rates show that apparent advantage is posted in the invention ooze moxibustion obviously higher than control group after 3 months.Furthermore it controls VAS scoring in 6 months and ODI value are lower after the treatment for the treatment of group, it can be seen that the curative effect of ooze moxibustion patch treatment can remain longer Time.
In conclusion this patent research spontaneous heating ooze medicine paste can be relieved patient's pain in back and loin (qi depression to blood stasis Type), and curative effect adds blood-activating stasis-removing kind medicinal vesiculation moxibustion to paste better than ooze.Because curative effect of the present invention is high, conveniently, safely, it is inexpensive the advantages that, It is worth clinically further genralrlization.
5 clinical trial case 1 of embodiment.
Patient Huang, male, 64 years old, main suit: lumbago 1 week.Present illness history: the small of the back is caused because having a cold before patient's private prosecution 1 week Pain, symptom, which has no, after patient voluntarily lies up is relieved, and it is medical today to carry out our hospital's Orthopaedics Clinic.Past medical history: deny The medical histories such as hypertension, coronary heart disease, diabetes.Training physical examination: backbone physiological camber exists, lumbar vertebrae scope of activities: anteflexion 50 °, after Stretch 10 °, each 10 ° of left and right lateroflexion.Tenderness (+) between L4-S1 spinous process and at the 1.5cm of two sides, has no obvious lower limb rediating pain.Bilateral is straight Leg raises the equal 80 ° of (-)s of test, and all flesh muscular strengths of double lower limb are V grades equal, and double lower limb dermal sensation is shown no obvious abnormalities.Bilateral Babinski levies equal (-).Waist MR prompt: each centrum, dural sac, interverbebral disc and nerve root are shown no obvious abnormalities.Diagnosis: back Fascitis.Treatment: ooze moxibustion patch 2 external applications of day being practiced in example 1.Further consultation patient private prosecution lumbago is alleviated earlier above after 1 week, Physical examination: backbone physiological camber exists, and lumbar vertebrae scope of activities: anteflexion 70 °, extendes back 10 °, each 10 ° of left and right lateroflexion.Local skin has no Obvious red and swollen, ulceration.Tenderness (±) between L4-S1 spinous process and at the 1.5cm of two sides, has no obvious lower limb rediating pain.The lift of bilateral straight legs Height tests equal 80 ° of (-)s, and all flesh muscular strengths of double lower limb are V grades equal, and double lower limb dermal sensation is shown no obvious abnormalities.Bilateral Babinski sign Equal (-).Patient is advised to continue external application ooze moxibustion patch day 2 times.It is checked after 2 weeks, patient's private prosecution lumbago disappears, physical examination: backbone physiology Curvature exists, and lumbar vertebrae scope of activities: anteflexion 80 °, extendes back 15 °, each 15 ° of left and right lateroflexion.Local skin has no obvious red and swollen, broken It bursts.Tenderness (-) between L4-S1 spinous process and at the 1.5cm of two sides, has no obvious lower limb rediating pain.Equal 80 ° of bilateral straight-leg raising test (-), all flesh muscular strengths of double lower limb are V grades equal, and double lower limb dermal sensation is shown no obvious abnormalities.Bilateral Babinski levies equal (-).
6 clinical trial case 2 of embodiment.
Patient Liu, male, 48 years old, main suit: lumbago 4 days.Present illness history: the small of the back pain is caused because spraining before patient's private prosecution 4 days Bitterly, symptom, which has no, after patient voluntarily lies up is relieved, and today Lai Zhong our hospital Orthopaedics Clinic is medical.Past medical history: deny The medical histories such as hypertension, coronary heart disease, diabetes.Training physical examination: backbone physiological camber exists, lumbar vertebrae scope of activities: anteflexion 30 °, after Stretch 10 °, each 10 ° of left and right lateroflexion.Tenderness (+) at transverse process, has no obvious lower limb rediating pain on the left of L3.Bilateral straight-leg raising test is equal 80 ° of (-)s, all flesh muscular strengths of double lower limb are V grades equal, and double lower limb dermal sensation is shown no obvious abnormalities.Bilateral Babinski levies equal (-).Waist Portion MR prompt: each centrum, dural sac, interverbebral disc and nerve root are shown no obvious abnormalities.Diagnosis: L3 transverse process syndrome.Treatment: give 2 external applications of day are pasted in ooze moxibustion in embodiment 2.Further consultation patient private prosecution lumbago is alleviated earlier above after 1 week, physical examination: backbone physiology is bent Degree exists, and lumbar vertebrae scope of activities: anteflexion 60 °, extendes back 10 °, each 10 ° of left and right lateroflexion.Tenderness (+) at transverse process, has no bright on the left of L3 Aobvious lower limb rediating pain.The equal 80 ° of (-)s of bilateral straight-leg raising test, all flesh muscular strengths of double lower limb are V grades equal, and double lower limb dermal sensation has no It is obvious abnormal.Bilateral Babinski levies equal (-).Patient is advised to continue external application ooze moxibustion patch day 2 times.It is checked after 2 weeks, patient's private prosecution waist Backache disappears, physical examination: backbone physiological camber exists, and lumbar vertebrae scope of activities: anteflexion 80 °, extendes back 10 °, each 10 ° of left and right lateroflexion.L3 Tenderness (-) at the transverse process of left side, has no obvious lower limb rediating pain.The equal 80 ° of (-)s of bilateral straight-leg raising test, all flesh muscular strengths of double lower limb V grades, double lower limb dermal sensation is shown no obvious abnormalities.Bilateral Babinski levies equal (-).
7 clinical case 3 of embodiment.
Patient Mr. Wang, female, 32 years old, main suit: lumbago 4 hours.Present illness history: weight is lifted before patient's private prosecution 4 hours and causes back Portion's pain, symptom, which has no, after patient voluntarily lies up is relieved, and it is medical today to carry out our hospital's Orthopaedics Clinic.Past medical history: no Recognize the medical histories such as hypertension, coronary heart disease, diabetes.Training physical examination: backbone physiological camber exists, lumbar vertebrae scope of activities: anteflexion 30 °, Extend back 5 °, each 5 ° of left and right lateroflexion.Extensive tenderness at the 1.5cm of the two sides L3-S1, has no obvious lower limb rediating pain.Bilateral leg raising straight Equal 80 ° of (-)s are tested, all flesh muscular strengths of double lower limb are V grades equal, and double lower limb dermal sensation is shown no obvious abnormalities.Bilateral Babinski sign is equal (-).Waist MR prompt: each centrum, dural sac, interverbebral disc and nerve root are shown no obvious abnormalities.Diagnosis: acute lumbar muscle sprain.Treatment: Ooze moxibustion patch 2 external applications of day being practiced in example 3.Further consultation patient private prosecution lumbago is alleviated earlier above after 1 week, physical examination: backbone is raw It manages curvature to exist, lumbar vertebrae scope of activities: anteflexion 60 °, extendes back 10 °, each 10 ° of left and right lateroflexion.Tenderness at the 1.5cm of the two sides L3-S1 (±) has no obvious lower limb rediating pain.The equal 80 ° of (-)s of bilateral straight-leg raising test, all flesh muscular strengths of double lower limb are V grades equal, double lower limb skin Skin is felt to show no obvious abnormalities.Bilateral Babinski levies equal (-).Waist MR prompt: each centrum, dural sac, interverbebral disc and nerve Root is shown no obvious abnormalities.Check after 2 weeks, patient's private prosecution lumbago disappears, physical examination: backbone physiological camber exists, lumbar vertebrae activity model It encloses: anteflexion 85 °, extending back 10 °, each 10 ° of left and right lateroflexion.Tenderness (-) at the 1.5cm of the two sides L3-S1, has no obvious lower limb rediating pain. The equal 80 ° of (-)s of bilateral straight-leg raising test, all flesh muscular strengths of double lower limb are V grades equal, and double lower limb dermal sensation is shown no obvious abnormalities.Bilateral Babinski levies equal (-).Waist MR prompt: each centrum, dural sac, interverbebral disc and nerve root are shown no obvious abnormalities.

Claims (6)

1. a kind of for alleviating the spontaneous heating ooze medicine paste of qi stagnation and blood stasis type pain in back and loin, it is characterised in that: be divided into ointment layer With spontaneous thermosphere upper layer and lower layer, ooze and traditional Chinese medicine ingredients, the mass ratio of the ooze and traditional Chinese medicine ingredients are wherein contained in medical ointment plaster For 1:1, deep-sea ooze of the ooze of the present invention both from Yingkou Bohai Offshore；The traditional Chinese medicine ingredients are by following weight The raw material of number forms: 2-6 parts of turmeric, 2-6 parts of radix saposhnikoviae, 2-6 parts of myrrh, 2-6 parts of rheum officinale, 1-4 parts of gentianae macrophyllae, prolongs 2-6 parts of the root of Dahurain angelica 2-6 parts of Hu rope, 2-6 parts of Radix Notoginseng, 6-10 parts of peach kernel, 2-6 parts of safflower, 2-6 parts of olibanum, 1-4 parts of curcuma zedoary, 1-2 parts of asarum, borneol 1- 3 parts, 2-6 parts of Radix Angelicae Sinensis, 3-9 parts of lycopodium calvatum.
2. the spontaneous heating ooze medicine paste according to claim 1 for alleviating qi stagnation and blood stasis type pain in back and loin, it is characterised in that: The traditional Chinese medicine ingredients are made of the raw material of following parts by weight: 2 parts of turmeric, 2 parts of the root of Dahurain angelica, radix saposhnikoviae 2 parts, 2 parts of myrrh, 2 parts of rheum officinale, 1 part of gentianae macrophyllae, 2 parts of rhizoma corydalis, 2 parts of Radix Notoginseng, 6 parts of peach kernel, 2 parts of safflower, 2 parts of olibanum, 1 part of curcuma zedoary, 1 part of asarum, 1 part of borneol, when Return 2 parts, 3 parts of lycopodium calvatum.
3. the spontaneous heating ooze medicine paste according to claim 1 for alleviating qi stagnation and blood stasis type pain in back and loin, it is characterised in that: The traditional Chinese medicine ingredients are made of the raw material of following parts by weight: 4 parts of turmeric, 4 parts of the root of Dahurain angelica, radix saposhnikoviae 4 parts, 4 parts of myrrh, 4 parts of rheum officinale, 2 parts of gentianae macrophyllae, 4 parts of rhizoma corydalis, 4 parts of Radix Notoginseng, 8 parts of peach kernel, 4 parts of safflower, 4 parts of olibanum, 2 parts of curcuma zedoary, 1.5 parts of asarum, 2 parts of borneol, 4 parts of Radix Angelicae Sinensis, 6 parts of lycopodium calvatum.
4. the spontaneous heating ooze medicine paste according to claim 1 for alleviating qi stagnation and blood stasis type pain in back and loin, it is characterised in that: The traditional Chinese medicine ingredients are made of the raw material of following parts by weight: 6 parts of turmeric, 6 parts of the root of Dahurain angelica, radix saposhnikoviae 6 parts, 6 parts of myrrh, 6 parts of rheum officinale, 4 parts of gentianae macrophyllae, 6 parts of rhizoma corydalis, 6 parts of Radix Notoginseng, 10 parts of peach kernel, 6 parts of safflower, 6 parts of olibanum, 4 parts of curcuma zedoary, 2 parts of asarum, 3 parts of borneol, when Return 6 parts, lycopodium calvatum 9.
5. a kind of for alleviating the spontaneous heating ooze medicine paste of qi stagnation and blood stasis type pain in back and loin, it is characterised in that: preparation method The following steps are included:
Step 1, pretreatment: get material with production ordering and check material code name, the name of an article, specification, number and weight etc., it goes forward side by side Row removes coat and disinfection；
Step 2, drying: weighing ooze and the prepared slices of Chinese crude drugs respectively, be dried, and drying temperature is controlled at 35-40 DEG C；
Ooze and the prepared slices of Chinese crude drugs: being put into pulverizer break into ooze powder and Chinese medicine powder respectively by step 3, Cheng Fen, and sample sifter is 200 mesh；
Step 4, at cream: by medical pressure-sensing plaster glue be heated to 130 ° melt after be successively put into Chinese medicine powder and ooze pulvis, make It is put into seepage-proofing ring at ointment；
Step 5, mixing filling: by step 4 medical ointment plaster and spontaneous heating packet be pasted together；
Step 6 is heat-shrinked: ready-made inner wrapping product being accomplished fluently the corresponding date of manufacture, packaging film is packaged and is heat-shrinked；
Step 7, storage: finished product is put into the product qualification area of storehouse.
6. it is a kind of for alleviating the spontaneous heating ooze medicine paste of qi stagnation and blood stasis type pain in back and loin, in addition spontaneous heating body, can make drug Effective component directly penetrates into diseased region, gives full play to drug effect, plays detumescence, analgesic, promoting blood circulation, dredging collateral and releases muscle cramp The effects of, to reach therapeutic purposes.
CN201811177962.9A 2018-10-10 2018-10-10 It is a kind of for alleviating the spontaneous heating ooze medicine paste of qi stagnation and blood stasis type pain in back and loin Pending CN109260416A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
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CN110368478A (en) * 2019-08-14 2019-10-25 辽宁旺裕和健康科技发展有限公司 It is a kind of for alleviating the spontaneous heating sea salt mud Traditional Chinese medicine plaster of neck shoulder pain in back and loin

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102579195A (en) * 2012-03-19 2012-07-18 葛纪宏 Novel mud and wax therapy application
CN105288058A (en) * 2015-12-10 2016-02-03 辽宁中医药大学 Medicinal and edible formula for specific endowment constitution
CN105597008A (en) * 2016-01-30 2016-05-25 辽宁中医药大学附属医院 External analgesic traditional Chinese medicine preparation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102579195A (en) * 2012-03-19 2012-07-18 葛纪宏 Novel mud and wax therapy application
CN105288058A (en) * 2015-12-10 2016-02-03 辽宁中医药大学 Medicinal and edible formula for specific endowment constitution
CN105597008A (en) * 2016-01-30 2016-05-25 辽宁中医药大学附属医院 External analgesic traditional Chinese medicine preparation

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110368478A (en) * 2019-08-14 2019-10-25 辽宁旺裕和健康科技发展有限公司 It is a kind of for alleviating the spontaneous heating sea salt mud Traditional Chinese medicine plaster of neck shoulder pain in back and loin

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